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Researchers from Erasmus University Medical Center in Rotterdam, Netherlands, conducted a study on Alzheimer's disease, focusing on the genetic predisposition to accelerated hippocampal atrophy across sex and disease stages. The study included 1,051 participants from the ADNI cohort and found significant hippocampal subfield volume reductions, particularly in individuals with high genetic predisposition to AD. The research highlighted the importance of genetic factors, especially functional APOE variants, in understanding Alzheimer's disease progression and sex-specific trajectories, offering insights for improved detection and tailored interventions. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, explored the impact of parental temperament on the success of stuttering therapy programs for preschool-aged children. The research found that parents who exhibit novelty seeking and harm avoidance traits tend to have a positive influence on therapy outcomes. Additionally, the study highlighted the importance of parental characteristics in therapy success, with socially dependent parents potentially hindering progress in certain therapy types. Further research is needed to confirm and expand upon these preliminary findings. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, evaluated the content validity of the EQ-5D-Y questionnaire for Chinese children and adolescents. The research aimed to assess the comprehensiveness, relevance, and comprehensibility of the questionnaire's dimensions among healthy and diseased children in China. Findings suggested that while the EQ-5D-Y is relevant for measuring health-related quality of life in Chinese youth, improvements are needed, particularly in incorporating social health aspects. The study concluded that potential refinements could better capture the health experiences of children. [Extracted from the article] more...

A recent study conducted at the University of Applied Sciences in Rotterdam, Netherlands, focused on the psychological, disability, and somatosensory characteristics of individuals with low back pain. The research aimed to identify linear trends in these characteristics across different risk levels based on screening tools like the Start Back screening Tool (SBT) and Central Sensitization Inventory (CSI). The study found that kinesiophobia, pain catastrophizing, disability, and pain intensity were positively related to the severity levels based on the SBT and CSI, with somatosensory changes also being linked to the severity levels. This peer-reviewed research provides valuable insights into tailoring treatments for low back pain based on subgroup characteristics. [Extracted from the article] more...

A recent study conducted by Erasmus University Medical Center in the Netherlands focused on identifying predictors of cardiovascular symptoms among Long COVID patients. The study included 4000 participants and found that female gender and sleep disturbances were independently associated with cardiovascular complications in Long COVID patients. The research highlights the importance of considering demographic and psychological factors in clinical practice for Long COVID patients experiencing cardiovascular issues. For more information, the study can be found in the Journal of Clinical Medicine, volume 14, issue 3. [Extracted from the article] more...

A recent report from Erasmus University Medical Center in Rotterdam, Netherlands, discusses unresolved ethical issues surrounding genetic counseling and testing in clinical psychiatry. The report highlights four main ethical topics, including the dualism between somatic and psychiatric disorders, the impact of genetic testing on stigma, fulfilling professional responsibilities, and ethical issues in public health services. The researchers advocate for the development of pan-European ethical standards to address these issues and emphasize the need for interdisciplinary collaboration in defining standards for psychiatric counseling and public communication. The study underscores the importance of addressing these ethical concerns for mental health professionals, clinical geneticists, patients, families, and society as a whole. [Extracted from the article] more...

Researchers at Erasmus University Medical Center in Rotterdam, Netherlands, have developed a dual-transducer acoustic stack for combined intravascular ultrasound and photoacoustic imaging, aimed at improving diagnostic accuracy for cardiovascular diseases like atherosclerosis. The acoustic stack design allows for high-resolution, multifrequency imaging within a compact catheter form factor, potentially enhancing sensitivity and bandwidth. This research, supported by the Netherlands Government, offers promising advancements in cardiovascular imaging technology. [Extracted from the article] more...

Researchers from Erasmus University Medical Center in Rotterdam, Netherlands, conducted a study on urinary retention during and after labor in women receiving programmed intermittent epidural bolus (PIEB) analgesia. The study found that urinary retention occurred in 20.6% of women during labor and in 6.7% postpartum, with specific risk factors identified. The researchers recommended catheterization every 3 to 4 hours for women unable to urinate spontaneously or void less than 50 ml during labor. This peer-reviewed study provides valuable insights into bladder management strategies for women in labor. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, evaluated the predictive performance of population pharmacokinetic models using only trough concentrations to estimate the area under the concentration-time curve (AUC24h) of vancomycin in pediatric patients. The research found that trough concentration-based AUC24h estimation is a feasible approach in model-informed precision dosing (MIPD) of vancomycin therapy in pediatrics. The study recommended further investigation into clinical outcomes and endorsed specific models for advanced MIPD vancomycin therapy in pediatric patients. [Extracted from the article] more...

A study conducted in Rotterdam, Netherlands, aimed to establish a core set of quality indicators for Hirschsprung's disease care in Europe. Through a consensus-driven process involving healthcare professionals and patient representatives, 12 baseline characteristics and 14 quality indicators were identified. These indicators are intended to improve care quality and outcomes for children with Hirschsprung's disease within the European Paediatric Surgical Audit framework. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on parents' perspectives on continuity of care in maternity care and child health services. The research highlighted the importance of easily accessible, family-centered care that promotes interprofessional collaboration and empowers parents. The study emphasized the need for well-prepared parents entering the postnatal period, limited care transfers, and consistent, tailored information to maintain meaningful relationships with care providers. This qualitative systematic review provides valuable insights into enhancing integrated care services for families. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in the Netherlands focused on pharmacogenetic testing to predict methylphenidate treatment outcomes in children with ADHD in Turkey. The research examined genetic polymorphisms in CES1, LPHN3, and COMT and their association with adverse effects in children receiving methylphenidate. The study found significant relationships between specific genotypes and adverse effects in children treated with methylphenidate, suggesting a potential link between genetic variations and treatment outcomes in ADHD. The research was peer-reviewed and published in the American Journal of Medical Genetics Part B. [Extracted from the article] more...

A report from Erasmus University Medical Center in Rotterdam, Netherlands, discusses the real-world clinical experience with [177Lu]Lu-PSMA-I&T targeted radionuclide therapy in patients with metastatic castration-resistant prostate cancer. The study included 50 heavily pretreated patients, showing that the treatment was well tolerated and safe, with some patients experiencing PSA declines and radiological responses. However, the efficacy of [177Lu]Lu-PSMA in this setting appeared lower compared to data from recent phase-3 clinical trials using a different radioligand. Further research is needed to determine if patients with metastatic castration-resistant prostate cancer may benefit more from this treatment when initiated earlier in their treatment. [Extracted from the article] more...

A recent study conducted by Erasmus University Medical Center in Rotterdam, Netherlands, examined the psychological health status of major trauma patients one and two years post-trauma across different levels of trauma care in trauma networks. The research found that patients admitted to a level I trauma center reported more symptoms of anxiety, depression, and post-traumatic stress compared to those admitted to a non-level I trauma center. The study concluded that the level of trauma care and trauma region are significant factors in analyzing psychological health status after major trauma. [Extracted from the article] more...

A recent study conducted at the University Medical Centre Rotterdam in the Netherlands focused on integrated care for pregnant women with multi-domain vulnerability, including psychiatric illness, social factors, and substance use. The study found that 83% of pregnant women exhibited multi-domain vulnerability, with common patterns such as psychiatric illness with social factors and chronic physical illness. The researchers concluded that there is a need for a new approach to care for vulnerable pregnant women. The study was peer-reviewed and published in the Archives of Women's Mental Health journal. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, explored the effects of acute aerobic exercise on associative learning in regular versus non-regular exercisers. The research found that acute exercise significantly enhanced the acquisition of conditioned eyelid responses, but this effect was only observed in regularly exercising individuals. The study highlights the importance of considering long-term exercise habits when investigating the acute effects of exercise on brain functioning. [Extracted from the article] more...

A recent study conducted at Erasmus University in Rotterdam, Netherlands, explores the concept of "study crafting," where students personalize their education based on their strengths, interests, and goals. The research suggests that study crafting positively impacts psychological well-being, self-directed learning skills, academic satisfaction, and academic achievement, while reducing burnout. By fostering a partnership between students and educators, the study advocates for a more student-centered education approach, empowering learners to actively shape their educational journey for a more engaged and healthier life. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on the impact of sarcoidosis on patients' quality of life. The research highlighted the importance of improving quality of life for individuals with sarcoidosis, as current evidence and treatment options are limited. The study reviewed various aspects of daily life affected by sarcoidosis, identified determinants of health-related quality of life, and explored interventions to enhance quality of life for those with the condition. The research, which has been peer-reviewed, provides valuable insights into addressing the challenges faced by individuals living with sarcoidosis. [Extracted from the article] more...

A recent study from Erasmus University Medical Center in Rotterdam, Netherlands, explored the role of PD-L1 expression as a potential biomarker for predicting response to Bacillus Calmette-Guérin (BCG) treatment in high-risk non-muscle invasive bladder cancer (HR-NMIBC) patients. The research found that PD-L1 expression was not a reliable biomarker for response to BCG, but it was higher in tumors that failed BCG treatment. Further research is needed to understand the significance of PD-L1 in tumors that do not respond to BCG therapy. The study was published in the World Journal of Urology and has been peer-reviewed. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on predicting depression and post-traumatic stress disorder (PTSD) symptoms following traumatic brain injury (TBI). The study found that certain factors such as psychiatric history, employment status, sex, injury cause, and alcohol intoxication can increase the risk of mental health problems after TBI. Early screening for mental health issues in TBI patients was recommended based on the study's findings. The research was peer-reviewed and published in BMJ Mental Health. [Extracted from the article] more...

A recent study conducted by the Department of Psychology Education & Child Studies in Rotterdam, Netherlands, explored the relationship between psychopathy and lying. The research found that individuals with higher levels of psychopathy were more likely to lie for personal gain in an experimental puzzle task. Specifically, psychopathic boldness was associated with lying behavior. This study provides valuable insights into the connection between psychopathy and deceitful behavior. [Extracted from the article] more...

A recent study conducted at the University Medical Center Rotterdam focused on the treatment of pregnant women with Von Willebrand Disease (VWD) during delivery. The study aimed to evaluate the effects of a specific VWF/FVIII concentrate on factor levels in women with VWD during delivery and the postpartum period. The results showed that targeted VWF:Act/FVIII:C peak levels were achieved with the prescribed dosing regimens, and monitoring these levels is recommended for optimizing target levels and improving dosing effectiveness. The study was supported by the Netherlands Organization for Scientific Research (NWO) and was published in HemaSphere. [Extracted from the article] more...

A study conducted by researchers at Erasmus University Medical Center in Rotterdam, Netherlands, focused on the association between early postoperative changes in Von Willebrand factor (VWF) activity and the risk of gastrointestinal bleeding and stroke in HeartMate 3 patients. The study found that patients with VWF activity ratios <= 0.7 in the early postoperative phase were more likely to experience gastrointestinal bleeding and hemorrhagic stroke events during the late postoperative period. Conversely, patients with VWF activity ratios <= 0.7 had a lower risk of ischemic stroke events. The research concluded that VWF activity ratios <= 0.7 could serve as biomarkers to predict hemocompatibility-related adverse events during long-term left ventricular assist device (LVAD) support. [Extracted from the article] more...

Researchers at University Medical Center Rotterdam have conducted a study on the role of RNF43 and ZNRF3 in cancer, particularly in gastrointestinal tumors. These genes are crucial regulators of Wnt/β-catenin signaling and mutations in them can lead to abnormal activation of this pathway. The study also explores the impact of these genes on other tumor-related proteins and the mechanisms through which mutations support tumor growth. The research challenges existing views on the effects of specific mutations in these genes on tumor formation. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, explored management strategies and corticophobia among healthcare professionals caring for patients with atopic dermatitis (AD). The research found that general practitioners and pharmacy assistants showed greater reluctance towards prescribing topical corticosteroids compared to dermatologists. The study highlighted the need for more education to reduce corticophobia and improve care for AD. This peer-reviewed research provides valuable insights into the differences in managing AD and attitudes towards treatment among healthcare professionals. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on the prevalence of domestic violence and abuse (DVA) among individuals with severe mental illness (SMI). The research aimed to assess rates of DVA victimization and perpetration in patients with SMI, as well as the role of dispositional anger in moderating these relationships. The study found high rates of DVA among patients with SMI, with anger mediating the link between victimization of psychological aggression and perpetration of DVA. The findings underscore the importance of addressing violence in SMI care and the need for further research on interventions for victims and perpetrators of DVA. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, compared the effectiveness of MALDI and DESI mass spectrometry imaging in identifying lipids in atherosclerotic plaques. The research found that both techniques are suitable for detecting a wide range of lipids, with DESI showing higher ion counts and sharper images compared to MALDI. The study concluded that DESI and MALDI complement each other as techniques for lipid research in mass spectrometry imaging. For more information, readers can contact Gijs van Soest at Erasmus University Medical Center in Rotterdam. [Extracted from the article] more...

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, compared the outcomes of two surgical techniques, dorsal capsulodesis and 3-ligament tenodesis, for nontraumatic midcarpal instability. The study found that both techniques led to significant improvements in pain and function scores at 12 months postoperatively, with the capsulodesis group showing quicker recovery and a higher return-to-work rate at 3 months. While both techniques were effective, the study recommended favoring capsulodesis over 3LT due to its faster recovery time. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, compared time-restricted immunosuppression with standard-duration immunosuppression after allogeneic hematopoietic stem cell transplantation. The research aimed to determine the optimal duration of immunosuppression to prevent graft-versus-host disease (GVHD) without overtreatment. The study found that time-restricted immunosuppression did not increase the proportion of patients with non-severe GVHD, and secondary outcomes were not significantly different compared to standard-duration immunosuppression. For more information, readers can refer to the HemaSphere journal article titled "Time-restricted Versus Standard-duration Immunosuppression After Allogeneic Hematopoietic Stem Cell Transplantation: Results of the Prospective Randomized Hovon-96 Trial." [Extracted from the article] more...

A study from Erasmus University in Rotterdam, Netherlands, explores the use of storytelling as a method in energy futures research, focusing on engaging diverse perspectives and community voices in envisioning alternative energy futures. The research highlights the value of storytelling in deepening understanding of socio-technical energy systems and positioning laypeople's visions at the center of energy discussions. This peer-reviewed article advances storytelling as a valuable tool in interdisciplinary energy futures research, emphasizing its creative and participatory potential. [Extracted from the article] more...

A recent study conducted by Erasmus University Medical Center-Sophia Children's Hospital in Rotterdam, Netherlands, focused on exploring the diversity of enteric glia in the human intestine, particularly in the context of Hirschsprung disease (HSCR). The research identified two major enteric glial classes in pediatric intestines: Schwann-like enteric glia and classical enteric glia. The study also highlighted the potential therapeutic implications of targeting these glial subtypes, particularly in the treatment of HSCR using serotonin-receptor agonists. This peer-reviewed research offers new avenues for understanding and potentially treating Hirschsprung disease. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, explored the impact of genetic and environmental risk factors on brain development in children without multiple sclerosis (MS) diagnoses. The research found that genetic factors interacted with household smoking to influence brain volumes in childhood, potentially indicating a window for preventing MS in genetically susceptible individuals. The study highlights the importance of reducing exposure to household smoking as a preventive measure for MS. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, developed an open-source algorithm for monitoring cerebral autoregulation in pediatric severe traumatic brain injury (sTBI). The algorithm compared optimal cerebral perfusion pressure (CPPopt) with real-time CPP in relation to long-term outcomes. The research, which included 50 children, found that mean and median pressure-reactivity index (PRx) and CPPopt yield were associated with unfavorable outcomes, with specific thresholds resulting in increased odds ratios. The study concluded that the algorithm can provide optimal targets for pediatric neuromonitoring that are linked to long-term outcomes. [Extracted from the article] more...

A study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on postoperative infections in pediatric patients with inflammatory bowel disease (IBD) following bowel resection surgery. The research found that postoperative infections are common in children after IBD-related bowel resection, with postoperative fever indicating infection in half of the patients. Laboratory tests, such as C-reactive protein levels, did not significantly differentiate between complicated and non-complicated postoperative courses. The study concluded that postoperative infections are a significant concern for pediatric patients undergoing bowel resection for IBD. [Extracted from the article] more...

A recent study from the University Medical Center Rotterdam delves into the genomics and genetics of ZNRF3 mutations in cancer. The research challenges the notion that certain ZNRF3 mutations have dominant-negative activity, suggesting that they behave as loss-of-function mutations instead. This study sheds light on the mechanisms through which ZNRF3 variants contribute to cancer development. [Extracted from the article] more...

Researchers at Erasmus University conducted a study on cardiovascular disease risk and socioeconomic inequality across 57 low- and middle-income countries. They found that economic development was associated with higher and more unequal cardiovascular disease risk, particularly among socially disadvantaged groups. The study used nationally representative data on 88,559 individuals aged 40-80 years and was funded by various organizations including the Swiss National Science Foundation. The findings suggest a need to target cardiovascular disease prevention efforts towards marginalized populations. [Extracted from the article] more...