1. Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial
- Author
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Beigel, John H, Aga, Evgenia, Elie-Turenne, Marie-Carmelle, Cho, Josalyn, Tebas, Pablo, Clark, Carol L, Metcalf, Jordan P, Ozment, Caroline, Raviprakash, Kanakatte, Beeler, Joy, Holley, H Preston, Warner, Stephanie, Chorley, Carla, Lane, H Clifford, Hughes, Michael D, Davey, Richard T, Beigel, John H, Aga, Evgenia, Elie-Turenne, Marie-Carmelle, Cho, Josalyn, Tebas, Pablo, Clark, Carol L, Metcalf, Jordan P, Ozment, Caroline, Raviprakash, Kanakatte, Beeler, Joy, Holley, H. Preston, Warner, Stephanie, Chorley, Carla, Lane, H. Clifford, Hughes, Michael D, Davey, Richard T, Barron, Michelle, Bastani, Aveh, Bauer, Philippe, Borkowsky, William, Cairns, Charles, Deville, Jaime, Elie, Marie-Carmelle, Fichtenbaum, Carl, Finberg, Robert, Jain, Mamta, Kaufman, David, Lin, Michael, Lin, John, Maves, Ryan, Morrow, Lee, Nguyen, Minh-Hong, Park, Pauline, Polk, Christopher, Randolph, Adrienne, Rao, Suchitra, Rubinson, Lewis, Schofield, Christina, Shoham, Shmuel, Stalets, Erika, and Stapleton, Renee D
- Abstract
Infection with influenza virus causes substantial morbidity and mortality globally, although antiviral treatments are available. Previous studies have suggested that anti-influenza immune plasma could be beneficial as treatment, but they were not designed as randomised, blinded, placebo-controlled trials. Therefore, we aimed to prospectively evaluate the clinical efficacy of high-titre immune plasma compared with standard low-titre plasma to improve outcomes in patients with severe influenza A infection.
- Published
- 2019
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