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The search for new active substances against SARS-CoV-2 is still a central challenge after the COVID-19 pandemic. Antiviral agents to complement vaccination are an important pillar in the clinical situation. Selected cannabinoids such as cannabigerol, cannabicyclol, cannabichromene, and cannabicitran from Cannabis sativa and synthetic homologues of cannabigerol and cannabicyclol were evaluated for effects on the cell viability of Vero cells (CC50 of cannabigerol and cannabicyclol 40 resp. 38 µM) and reduced virus entry of vesicular stomatitis pseudotyped viruses with surface-expressed SARS-CoV-2 spike protein at 20 µM. In addition to a reduction of pseudotyped virus entry, a titer reduction assay on Vero cells after preincubation of Wuhan SARS-CoV-2 significantly confirmed antiviral activity. Investigations on the molecular targets addressed by cannabigerol and cannabicyclol indicated that both compounds are inhibitors of SARS-CoV-2 spike protein-mediated membrane fusion, as could be shown by a virus-free reporter fusion inhibition assay (EC50 for cannabigerol 5.5 µM and for cannabicyclol 10.8 µM) and by monitoring syncytia formation in Vero reporter cells. Selectivity indices were calculated as 7.4 for cannabigerol and 3.5 for cannabicyclol. Systematic semisynthetic alterations of cannabigerol and cannabicyclol indicated that the side chains of both compounds do not contribute to the observed anti-membrane fusion activity. [ABSTRACT FROM AUTHOR]

Competing Interests: The authors declare no competing interests.

Presents information on the dramatization of the leadership principle Führerprinzip in the Nazi motion pictures. List of characters used by film-makers to project the personality of Nazi leader Adolf Hitler; Background on several films related to the Nazis; Criteria for measuring the relevance of historical films for the Nazis in Germany; Details on how historical films were used to propagate anti-parliamentarianism themes and the concept of an individual leader genius.

Focuses on New York State Governor Mario Cuomo. Claim of Cuomo that he is a progressive reformist; View that Cuomo is not now, and never has been, a liberal; Reasons why Cuomo and his strategists did nothing to discourage press stories that described him as the most attractive and well-spoken liberal in the U.S.; Information on the state budget unveiled by Cuomo; Information on some of the speeches delivered by Cuomo.

The article offers news briefs in Connecticut. Consultancy D. P. Consulting Corp. has filed for bankruptcy voluntarily which is presented by Teresa Sandutto-Carley and Clifford A Katz. Lawsuit was filed against general contractor Anchorage Construction Corp. for delinquent contributions. A fine of $385,251 was imposed on food company Andrew Depoala Mushrooms Inc.

National Socialist Cultural Policy. Ed. by Glenn R. Cuomo. Oct. 1995. 256p. index. St. Martin's, $49.95 (0-312-09094-3). DDC:943.08. University of South Florida professor Cuomo gathers studies of the complex, sometimes [...]

CEE LO GREEN Anyway (3:34) Producers: Wallpaper, Daniel Ledinsky Writers: E. Frederic, R. Golan, R. Cuomo, J. Alexander Publishers: various Elektra Cee Lo Green's latest single, 'Anyway,' comes from the [...]

WEEZER (If You're Wondering If I Want You To) I Want You To (3:27) Producer: Butch Walker Writers: R. Cuomo, B. Walker Publishers: E.O. Smith Music (BMI), I Eat Publishing [...]

WEEZER Pork and Beans (3:09) Producer: Jacknife Lee Writer: R. Cuomo Publisher: E.O. Smith, BM/DGC/Interscope ** Modern rock quartet Weezer gases up the genre with surprising insta-hit 'Pork and Beans,' [...]

The article announces Christopher R. Cuomo's appointment as an associate in the real estate and real estate finance practice roups of the White Plains, New York office of the national law firm Eckert Seamans Cherin & Mellott LLC.

The article announces Lisamarie Desanto's appointment as project manager and digital strategist at digital marketing and web design company MarkNet.

The article announces Anson Augustine's appointment as partner at New York City accounting firm Marcum LLP.

The article reports on Westchester County (New York) Executive Robert P. Astorino's partnership with the organization Volunteer NY! to host the 9/11: Serve and Remember event, as well as the launch of the Westchester County Diaper Bank in partnership with the Junior League of Central Westchester.

The article reports on a $500,000 funding secured by Attorney General Mark Andrew M. Cuomo to finance clean air projects in several counties in New York. The funds are part of a $9.5 million settlement that Cuomo reached with American Electric Power. Projects in Westchester, Putnam and Dutchess counties will receive an initial disbursement of $500,000 from the settlement to reduce diesel air pollution emissions through truck stop electrification.

Despite growing concern in the social innovation (SI) literature about the tackling of grand challenges, our understanding of the role of multinational enterprises (MNEs) remains in its infancy. This article examines foreign MNE subsidiaries' SI investments focusing on United Nations' Sustainable Development Goals (UNSDGs) in host countries. Using financial data from large, listed subsidiaries of foreign MNEs operating in India, along with hand-collected data from firms' disclosures of corporate social responsibility (CSR) activity for five years starting in 2015, we utilise the externalities framework propounded by Montiel et al. (2021). This neatly translates the 17 UNSDGS into actionable goals to examine the efforts of foreign MNE subsidiaries in increasing positive externalities as opposed to reducing negative externalities via Si-related investment in host countries. The study also evaluates the effects of the local embeddedness of the foreign MNE subsidiaries on SI investment. We find that MNE subsidiaries tend to favour increasing positive externalities as compared to reducing negative externalities through their SI investments. Also, older subsidiaries tend to prioritize greater investments in SI projects related to reducing negative externalities and subsidiaries with higher MNE ownership tend to reduce investments in SI projects related to increasing positive externalities. We discuss possible interpretations of the exploratory results using the institutional logics perspective and conclude with implications for policy and future research. Keywords Social innovation * Institutional logics * India * MNE * UNSDG, 1 Introduction Societal grand challenges (e.g. poverty, hunger, migration, climate change) are receiving increasing attention from international business (IB) scholars primarily focusing on the role of MNEs because they '...transcend [...]

PRESIDENTIAL PATRONS $25,000 or more Lead Patron: Jesuit Conference, Inc. * Mr. and Mrs. Rick Braddock * Benjamin and Barbara Denihan * E. Rhodes and Leona B. Carpenter Foundation* * [...]

PRESIDENTIAL PATRONS $25,000 or more Lead Patron: The Society of Jesus of Canada and the United States * Anonymous - 1 * Ms. Jo Ann Bonot (+) * Mr. and [...]

2020 JAN 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Surgery - Bariatric Surgery have been presented. According to [...]

2018 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Digestive System Diseases and Conditions - Irritable [...]

2018 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Digestive System Diseases and Conditions - Inflammatory Bowel [...]

IF THE NUMBERS ARE ANY indication, anticipation for Drake's upcoming album Views From the 6, arriving April 29, is sky high. Singles seemingly slated for the release have topped Billboard's [...]

AMERICAN IDOL IS BASKING in one last spotlight with its April 7 series finale. But on the charts, the product of another, already-defunct Fox music show is stealing headlines. More [...]

THE CHAINSMOKERS charge into the Billboard Hot 100's top 10 for the first time as 'Roses' (featuring Rozes) rises 11-8. The No. 1 title on the Hot Dance/ Electronic Songs [...]

Macrophages are multifunctional immune cells that may either drive or modulate disease pathogenesis depending on their activation phenotype. Autoimmune type 1 diabetes (TID) is a chronic proinflammatory condition characterized by [...]

2017 DEC 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Drugs and Therapies - Ketorolac Therapy have been presented. [...]

2017 OCT 28 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Drugs and Therapies - Hormones have been published. [...]

2017 AUG 26 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Digestive System Diseases and Conditions - Diverticulitis. [...]

2017 MAR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Enzymes and Coenzymes - Glycoside Hydrolases are presented in [...]

DURING THE THIRD REICH the state commissioned a number of extravagant historical films, intended to strike a chord with German audiences, and to reinforce the notion of Fuhrerprinzip (the leadership [...]

2016 JUL 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Oncology. According to news reporting out of [...]

Dear Friends and Benefactors, Thanks to the generosity of more than 3,300 donors, we are proud to announce that America Media received 47 awards from the Catholic Press Association for [...]

HOT ROCK SONGS[TM] 2WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 #1 HIGH HOPES (1) 15 WKS J. SINCLAIR, LIEBERG (B.URIE, J. SINCLAIR, LOWEN YOUNG, [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 17 WKS] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON. [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 15 WKS] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON. [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON, B. MCKEE, D. […]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 12 WKS] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLOS, W. SERMON, [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 11 WKS][DG] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON, [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 9 WKS][DG] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON, [...]

Byline: Josh Keller Forget baking cookies. Forget writing a glowing teacher evaluation. Angelica Chavez wanted to do a little something extra to celebrate her favorite public-administration professor, Michael Clarke. So [...]

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HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 2 1 1 [#1 2 WKS] RENEGADES (a) ALEX DA KID (A. GRANT, S.N. HARRIS, N. [...]

Objectives: To evaluate the effect of preanaesthetic administration of oral Nizatidine on pH and volume of gastric contents excluding samples contaminated with duodenogastric reflux.Design: Prospective, triple blind, randomized and placebo controlled clinical trial. Methods: The patients in Group C (Control) received Placebo while Group N (Nizatidine 300 mg) orally at 9.00 p.m., a night before elective surgery. Next day, gastric contents were aspirated with a large bore, multi-orifices gastric tube passed through an endotracheal tube placed blindly in esophagus after tracheal intubation and analyzed for the presence of bile salts, pH and volume.Results: Thirty five samples (29.66 %) out of 118 were contaminated with duodenal contents. One sample was contaminated with blood while one patient has no gastric contents. Duodenogastric reflux significantly affected pH and volume. Nizatidine, after excluding those samples contaminated either with duodenal fluid or blood, did not decrease significantly pH (p 0.0554), volume (p 0.5202) and the proportion of the patients (28.57% versus 24.39%) considered' at risk' compared with Placebo (p 0.8044) according to the criteria defined (pH [less than or equal to] 2.5 and volume [greater than or equal to] 25 ml).Conclusion: Nizatidine 300 mg given orally, a night before surgery did not afford adequate prophylaxis for the acid aspiration syndrome excluding those samples contaminated with duodenogastric reflux. Keywords: Aspiration | duodenogastric refluxate | gastric pH & volume | Nizatidine, Introduction Pulmonary aspiration of gastric contents is the inhalation of gastric contents into the larynx and lower respiratory tract. General anesthesia itself is a potential major risk factor that predisposes [...]

According to a study from Naples, Italy, "Sweetened carbonated beverages are widely consumed, which has fuelled several conflicting opinions about their effects on upper digestive tract functions. We aimed to [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 6 WKS] THUNDER ALEX DA KID, J. DEZUZIO (D. REYNOLDS, W. SERMON, […]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 2 2 1 THUNDER ALEX DA KID, J. DEZUZIO (O. REYNOLDS, W. SERMON, B. MCKEE, D. [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 BELIEVER MATTMAN & ROBIN (O. REYNOLDS, W. SERMON, B. MCKEE, D. PLATZMAN, R. [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 24 WKS] BELIEVER MATTMAN & ROBIN (D. REYNOLDS, W. SERMON, B. MCKEE [...]

HOT ROCK SONGS[TM] 2 WKS. LAST THIS TITLE CERTIFICATION AGO WEEK WEEK PRODUCER (SONGWRITER) 1 1 1 [#1 24 WKS] BELIEVER MATTMAN & ROBIN (D. REYNOLDS, W. SERMON, B. MCKEE [...]