1. ß-Carboline Alkaloids from Galianthe ramosa Inhibit Malate Synthase from Paracoccidioides spp.
- Author
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de Freitas, Carla S., Kato, Lucilia, de Oliveira, Cecília M. A., Queiroz jr., Luiz H. K., Santana, Mábio J., Schuquel, Ivânia T., Delprete, Piero G., da Silva, Roosevelt A., Quintino, Guilherme O., da Silva Neto, Benedito R., Soares, Célia M. A., and Pereira, Maristela
- Subjects
ENZYME inhibitors ,ALKALOIDS ,CLUSTER analysis (Statistics) ,ENZYMES ,MEDICINAL plants ,MICROBIAL sensitivity tests ,THIN layer chromatography ,IN vitro studies - Abstract
As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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