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Iron nitrides with the merits of high theoretical capacities, cost-effectiveness, and good electronic/ionic conductivity have been recognized as attractive anode candidates for lithium-ion batteries (LIBs). Carbon compositing, pore engineering, and nanostructure construction have proved to be effective strategies to prepare high-performance metal nitride anodes for LIBs. Herein, we synthesized a series of Fe3N-embedded and N-doped carbon nanorods (Fe3N@NCNR) with a hierarchical porous system and controllable topography by metal-catalyzed graphitization-nitridization of the Fe(III)-triazole framework (Fe-MOF) and thermal evaporation of the triblock copolymer F127 template assembled in Fe-MOF via hydrogen bonding interaction, followed by the air oxidation and urea-assisted ammonolysis processes. The Fe3N@NCNR as anodes for LIBs display extraordinary lithium storage capabilities with a high reversible capacity of 830 mA h g–1at 0.1 C, a good rate performance of 576 mAh g–1at 5 C, and a long-term cycling stability of 742 mA h g–1over 600 cycles at 1 C. Such outstanding performance benefits from the spongy carbon nanorods with rich macropores for rapid electronic/ionic transport and effective accommodation of electrode volume expansion, abundant N-doped meso-/microporous carbon for the additional storage of Li+via capacitive effect, and the efficient utilization of Fe3N nanoparticles uniformly distributed through carbon nanorods. Importantly, this work introduces an effective strategy to construct superior performance nitride anodes from MOF surfactants based on hydrogen bonding-driven interface self-assembly and provides insight into the preparation of highly efficient nanoarchitectures for Li+storage.

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP and nine healthy volunteers were enrolled in the study. As soluble immunomodulatory molecules, more sCD25 and sGalectin-9 were detected in ITP patients. On the cell surface, co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T cells. In contrast, co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell subsets. Taking a platelet count of 30×109L−1as the cutoff value, ITP patients with high and low platelet counts showed different T cell immune profiles. Antigen-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions, respectively, and participate in the pathogenesis of ITP. In conclusion, the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of ITP. They may offer novel targets to develop personalized immunotherapies.

Here, we explore a dehydrogenative 6π photocyclization method for N-substituted naphthalene carboxamides, which can be conducted in air. This method employs DMSO as both the reaction solvent and oxidant while also stabilizing the excited state of the substrate. Furthermore, the addition of photosensitizer enables the reaction to proceed under a 440–445 nm LED source viaenergy transfer. The proposed mechanism is initially validated through DFT calculations.

Synergistic reinforcement of dual-phase particles with different sizes was always considered superior to single-phase reinforcement in composites, but there were few studies to investigate the role of each part in enhancing properties. In this work, 40 vol% (TiB2p-TiCp)/Al–Cu–Mg composites with different proportions of TiB2pand TiCp(3:1, 2:1, 1:1, 1:2 and 1:3), were fabricated by the combustion synthesis to contrast the strengthening effect of dual-phase particles from the interface stability and the characteristics of dual-phase particles. Calculated by the first principle, TiB2(3.12 J/m2) presented better interfacial stability with Al matrix than TiC (1.61 J/m2). Under the circumstance of the same volume fraction, the composites with a higher proportion of TiB2pusually show higher yield and maximum compressive strength and effectively prevent the crack growth of composites. However, excess submicron sized TiB2ptends to produce cracks at the hexagon edge when the loads were applied and formed crack loops delaminating materials. When the TiB2p/TiCpproportion was 1:1, the plasticity and strength were beneficially balanced at the elevated temperature. Otherwise, the composite with TiB2: TiC = 3:1 possessed the best wear resistance (coefficient of friction: 0.22) at a sliding velocity of 0.32 mm/s, 30 N load) among other composites (AR12, AR11, AR21, and AR31) at 473 K, which reduced 45%, 64%, 73% and 86%, respectively. The main wear mechanism was abrasive wear when the TiB2proportion was dominant. Submicron sized TiB2pwith better interface bonding can keep the rigidity of the composites to resist the plastic flow, while TiC nanoparticles are easier to be extracted during the wear process.

AbstractBackgroundThe potential influence of tinnitus on cardiovascular disease (CVD) and all-cause mortality has yet to be explored. We aim to examine the correlations between tinnitus and the risk of cardiovascular events and all-cause mortality.MethodsWe conducted a prospective cohort study utilising data from the UK Biobank. The presence of tinnitus was evaluated through a questionnaire. The primary outcome was defined as a composition of cardiovascular events, including myocardial infarction (MI), stroke, and mortality from CVD, as well as all-cause mortality. Cox proportional hazard models were employed to examine the associations between tinnitus and both the primary outcome and its individual components. Sensitivity analyses were conducted to evaluate the robustness of the primary analysis.ResultsA total of 140,146 participants were included in the study. The presence of tinnitus was found to be associated with a higher incident rate of the primary outcome (HR = 1.057, 95%CI: 1.017–1.099, p = 0.005), MI (HR = 1.139, 95%CI: 1.061–1.222, p < 0.001) and all-cause mortality (HR = 1.053, 95%CI: 1.003–1.105, p = 0.038) after adjusting for confounders. However, there was no significant association between tinnitus and stroke or mortality from CVD. Subgroup analysis revealed that the association between tinnitus and the primary outcome was significant in females, participants with abnormal BMI, and those without hearing difficulty, depression or anxiety. Sensitivity analyses yielded consistent results.ConclusionThe findings from this study contribute to the existing body of evidence suggesting an association between tinnitus and an increased risk of cardiovascular events and all-cause mortality.

ABSTRACTThe precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration, remain poorly understood. We assessed sirtuins 3 (SIRT3) levels in HCC tissues and Huh7 cells cultured under hypoxic condition. We investigated the effects of SIRT3 on cell proliferation, glycolytic metabolism, mitochondrial respiration, mitophagy, and mitochondrial biogenesis in Huh7 cells. Besides, we explored the potential mechanisms regulating SIRT3 expression in hypoxically cultured Huh7 cells. Gradual reduction in SIRT3 expressions were observed in both adjacent tumor tissues and tumor tissues. Similarly, SIRT3 expressions were diminished in Huh7 cells cultured under hypoxic condition. Forced expression of SIRT3 attenuated the growth of hypoxically cultured Huh7 cells. SIRT3 overexpression led to a decrease in extracellular acidification rate while increasing oxygen consumption rate. SIRT3 downregulated the levels of hexokinase 2 and pyruvate kinase M2. Moreover, SIRT3 enhanced mitophagy signaling, as indicated by mtKeima, and upregulated key proteins involved in various mitophagic pathways while reducing intracellular reactive oxygen species levels. Furthermore, SIRT3 increased proxisome proliferator-activated receptor-gamma coactivator 1α levels and the amount of mitochondrial DNA in Huh7 cells. Notably, β-catenin expressions were elevated in Huh7 cells cultured under hypoxic condition. Antagonists and agonists of β-catenin respectively upregulated and downregulated SIRT3 expressions in hypoxically cultured Huh7 cells. The modulationsof glycolysis and mitochondrial respiration represent the primary mechanism through which SIRT3, suppressed by β-catenin, inhibits HCC cell proliferation.

Separating ethane (C2H6) from ethylene (C2H4) is an essential and energy-intensive process in the chemical industry. Here, we report two flexible diamondoid coordination networks, X-dia-1-Niand X-dia-1-Ni0.89Co0.11, that exhibit gate-opening between narrow-pore (NP) and large-pore (LP) phases for C2H6, but not for C2H4. X-dia-1-Ni0.89Co0.11thereby exhibited a type F–IV isotherm at 273 K with no C2H6uptake and a high uptake (111 cm3g–1, 1 atm) for the NP and LP phases, respectively. Conversely, the LP phase exhibited a low uptake of C2H4(12.2 cm3g–1). This C2H6/C2H4uptake ratio of 9.1 for X-dia-1-Ni0.89Co0.11far surpassed those of previously reported physisorbents, many of which are C2H4-selective. In situvariable-pressure X-ray diffraction and modeling studies provided insight into the abrupt C2H6-induced structural NP to LP transformation. The promise of pure gas isotherms and, more generally, flexible coordination networks for gas separations was validated by dynamic breakthrough studies, which afforded high-purity (99.9%) C2H4in one step.

This article presents a concise two-port asymmetric reciprocal filtering network, which mainly consists of short- and open-ended coupled lines for designing reflectionless bandpass filters (RBPFs). The network form is evolved from the lumped-element circuit to the distributed-element one. According to our theoretical analysis, it can be found that the network has the same transmission coefficients, i.e., $S_{\mathbf {12}}$ = $S_{\mathbf {21}}$ . However, the reflection coefficients at the two ports are opposite. In other words, the magnitudes of $S_{\mathbf {11}}$ and $S_{\mathbf {22}}$ are the same ( $\vert S_{\mathbf {11}}~\vert $ = $\vert S_{\mathbf {22}}\vert$ ) while their phase difference is 180°. Remarkably, this special 180° relationship is frequency-independent. By resorting to this property, an asymmetric reciprocal filtering network can be developed by incorporating the filtering sections into the coupled lines. As a result, balanced-circuit-based RBPFs have been constructed without adding an extra phase shifter by arranging two filtering networks in a rotationally symmetrical manner. Benefiting from the frequency-independent antiphase reflection, the reflection signals of the two paths are canceled out in the stopband of the RBPF and absorbed by the isolation resistor of the employed power dividers (PDs). For demonstration, second- and fourth-order RBPFs using interdigital line resonators and split-ring resonators are, respectively, designed. Good agreements between the measured and simulated results can be observed.

Effects of high-frequency cyclic loading on the banded ferrite–pearlite steel were analyzed through crack initiation and propagation. Interfaces of ferrite and pearlite colony with a small angle deviation from the loading axis were verified to be the most potential sites to fabricate the microcracks caused by the high strain gradient. The initial crack extension inside ferrite grain was driven by shear stress in model II along the direction with a 45° angle to the loading axis. Banded pearlite colony and the high-angle grain boundaries were considered as the dominant factors that promote the fatigue resistance of the material through arousing crack deflection in short crack propagation range and crack branching in long crack propagation range to reduce the crack propagation driving force in the crack tip. P–S–Ncurves were used to quantify the dispersion of fatigue lifetimes and evaluate the effect of elevated volume content of pearlite colony on the fatigue performance of the material.

Chloroform is a volatile organic solvent and a contaminant that is slightly soluble in water, making the reversible separation of chloroform from water a critical and challenging task within the chemical and environmental industries. In this study, we present a newly developed coordination framework, [Zn(4-pmntd)(opa)] [4-pmntd, N,N′-bis(4-pyridylmethyl)naphthalene diimide; opa, o-phthalic acid], which demonstrates a high adsorption capacity for chloroform (2.5 mmol/g) and an excellent ability to separate chloroform from water. The effectiveness of chloroform extraction by Zn(4-pmntd)(opa) was confirmed through vapor sorption, grand canonical Monte Carlo simulation, and 1H nuclear magnetic resonance spectroscopy. The porous framework was also utilized to create a filtration film using natural rubber, which successfully separated chloroform from water with a minimum test concentration of approximately 1 × 10–6mol/L and a chloroform purity of 99.2%. [Zn(4-pmntd)(opa)] therefore has significant potential for low-energy separation and recycling of chloroform from water under ambient conditions.

The magnetic spring is a practical element to isolate external vibration to instruments in ultra-precision manufacturing and ultra-precision testing. Accurate magnetic force and stiffness models are necessary to analyze and optimize the design of magnetic spring isolators. Thus, this study proposes an accurate magnetic force and stiffness model to design and analyze a variable stiffness nonlinear magnetic spring (VSNMS) considering the permanent magnet’s (PM’s) relative permeability, positions, sizes, and magnetic properties. Firstly, the VSNMS’s structure is designed and introduced, and its magnetic force and stiffness models are derived. Secondly, the established model is validated by comparison with the numerical simulation. Thirdly, the VSNMS prototype is fabricated, and then tested through an electronic universal testing machine. The model has the advantage of high accuracy, high efficiency, and ease of use compared with numerical simulations and experimental tests. Furthermore, parametric studies are conducted to learn the effect of PMs’ sizes, positions, and magnetic properties on VSNMS’s magnetic force and stiffness characteristics. Finally, the optimized structural size parameters of VSNMS are obtained using the derived model and the interior-point algorithm. As a result, the established model contributes to the analysis and optimal design of VSNMS, supporting the design of magnetic spring isolators in ultra-precision applications.

The sympathetic nerve is known to regulate immune responses in autoimmunity. Aberrant T cell immunity plays a vital role in immune thrombocytopenia (ITP) pathogenesis. The spleen is the primary site of platelet destruction. However, little is known whether and how splenic sympathetic innervation and neuroimmune modulation contribute to ITP pathogenesis.

ABSTRACT Geopolymeric recycled concrete (GRC) is a new construction material which takes environmental sustainability into account. In this paper, an experimental study was carried on 12 concrete filled steel tubular [...]

As the most abundant organelles in oocytes, mitochondria play an important role in maintaining oocyte quality. Here, we report that March5, encoding a mitochondrial ubiquitin ligase that promotes mitochondrial elongation, plays a critical role in mouse oocyte meiotic maturation via regulating mitochondrial function. The subcellular localization of MARCH5 was similar to the mitochondrial distribution during mouse oocyte meiotic progression. Knockdown of March5caused decreased ratios of the first polar body extrusion. March5-siRNA injection resulted in oocyte mitochondrial dysfunctions, manifested by increased reactive oxygen species, decreased ATP content as well as decreased mitochondrial membrane potential, leading to reduced ability of spindle formation and an increased ratio of kinetochore–microtubule detachment. Further study showed that the continuous activation of the spindle assembly checkpoint and the failure of Cyclin B1 degradation caused MI arrest and first polar body (PB1) extrusion failure in March5knockdown oocytes. Taken together, our results demonstrated that March5plays an essential role in mouse oocyte meiotic maturation, possibly via regulation of mitochondrial function and/or ubiquitination of microtubule dynamics- or cell cycle-regulating proteins.Knockdown of MARCH5 blocks mouse oocyte maturation at MI stage with the continuous activation of the spindle assembly checkpoint (SAC) and the failure of Cyclin B1 degradation, perhaps through inducing mitochondrial dysfunctions.Graphical AbstractSchematic diagram of MARCH5 functions in mouse oocyte maturation, as March5-siRNA injection resulted in oocyte mitochondrial dysfunctions, manifested by increased ROS, decreased ATP content, and decreased mitochondrial membrane potential, leading to reduced ability of spindle formation and an increased ratio of kinetochore–microtubule detachment. Further study showed that the continuous activation of the SAC and accumulation of MPF caused MI arrest and PB1 extrusion failure in March5knockdown oocytes.

Scaling superconducting nanowire single-photon detectors into a large array to obtain imaging capability is desired for applications in photon-starved conditions, considering the outstanding performance already demonstrated on a single detector. However, this is challenging because the ultralow operation temperature only allows specific electronics of ultralow power dissipation to work. Here we develop a kilopixel imager by introducing an orthogonal time–amplitude-multiplexing method. This readout is solely built in the superconducting nanowire by geometrically designing the nanowire structure to manipulate its hotspot growth and microwave propagation after photon detection. As a result, pixel locations are encoded on both time and amplitude domains of the output pulses. This dual multiplexing method overcomes the previous limitation of a time-multiplexing readout, where the time measurement uncertainty deteriorates the spatial resolution and scalability. Experimentally, with two readout lines, we have demonstrated a 32 × 32 imager with an average readout pixel fidelity of 97% and an average temporal resolution of 67.3 ps. The performance of this imager is further verified by single-photon imaging experiments at a low photon flux down to one detected photon per pixel. This orthogonal time–amplitude-multiplexing readout and corresponding nanowire designs give the most efficient readout compared with previous methods, which would speed up the development of large-scale single-photon imagers for quantum measurements, remote sensing, astronomical telescopes and so on.

The practical application of Na-superionic conductor structured materials is hindered by limited energy density and structure damage upon activating the third Na+. We propose a bimetal substitution strategy with cheaper Fe and Ni elements for costive vanadium in the polyanion to improve both ionic and electronic conductivities, and a single two-phase reaction during Na+intercalation/deintercalation and much reduced Na+diffusion barrier are uncovered by ex-situ X-ray diffraction and density functional theory calculations. Thus, the obtained cathode, Na3Fe0.8VNi0.2(PO4)3, shows excellent electrochemical performances including high specific capacity (102.2 mAh g–1at 0.1C), excellent rate capability (79.3 mAh g–1at 20C), cycling stability (84.6% of capacity retention over 1400 cycles at 20C), low-temperature performance (89.7 mAh g–1at 2C and −10 °C), and structure stability in an extended voltage window for the third Na+utilization. A competitive energy density of ≈287 Wh kg–1for full batteries based on cathode and anode materials is also confirmed.

The capture and separation of fluorinated gases (F-gases) from N2has the potential to not only reduce greenhouse gas emissions but also provide economic benefits for the semiconductor industry. In this work, two Ni-based metal–organic frameworks (MOFs), Ni-MOF(Ni(ina)2, ina = isonicotinic acid) and amine-functionalized NH2–Ni-MOF(Ni(3-ain)2, 3-ain = 3-aminoisonicotinic acid), were constructed for capturing F-gases (CF4and NF3). At ambient conditions, both materials exhibit very high CF4sorption capacities (2.92 mmol g–1for Ni-MOFand 2.69 mmol g–1for NH2–Ni-MOF). In addition, NH2–Ni-MOFexhibited a record selectivity of 46.3 for the CF4/N2mixture at 298 K and 100 kPa, surpassing all benchmark adsorbents, including Ni-MOF(34.7). The kinetic adsorption tests demonstrated that Ni-MOFand NH2–Ni-MOFperformed well for CF4/N2and NF3/N2mixtures. According to grand canonical Monte Carlo (GCMC) simulations, CF4or NF3interacts with NH2–Ni-MOFby multiple van der Waals interactions, resulting in stronger interaction than N2. More importantly, dynamic breakthrough experiments verified the practical separation potential of the two materials for CF4/N2and NF3/N2mixtures.

That physisorbents can reduce the energy footprint of water vapor capture and release has attracted interest because of potential applications such as moisture harvesting, dehumidification, and heat pumps. In this context, sorbents exhibiting an S-shaped single-step water sorption isotherm are desirable, most of which are structurally rigid sorbents that undergo pore-filling at low relative humidity (RH), ideally below 30% RH. Here, we report that a new flexible one-dimensional (1D) coordination network, [Cu(HQS)(TMBP)] (H2HQS = 8-hydroxyquinoline-5-sulfonic acid and TMBP = 4,4′-trimethylenedipyridine), exhibits at least five phases: two as-synthesized open phases, α ⊃ H2O and β ⊃ MeOH; an activated closed phase (γ); CO2(δ ⊃ CO2) and C2H2(ϵ ⊃ C2H2) loaded phases. The γ phase underwent a reversible structural transformation to α ⊃ H2O with a stepped sorption profile (Type F-IV) when exposed to water vapor at <30% RH at 300 K. The hydrolytic stability of [Cu(HQS)(TMBP)] was confirmed by powder X-ray diffraction (PXRD) after immersion in boiling water for 6 months. Temperature-humidity swing cycling measurements demonstrated that working capacity is retained for >100 cycles and only mild heating (<323 K) is required for regeneration. Unexpectedly, the kinetics of loading and unloading of [Cu(HQS)(TMBP)] compares favorably with well-studied rigid water sorbents such as Al-fumarate, MOF-303, and CAU-10-H. Furthermore, a polymer composite of [Cu(HQS)(TMBP)] was prepared and its water sorption retained its stepped profile and uptake capacity over multiple cycles.

To investigate comparative short-term outcomes of robotic-assisted surgery (RAS) versus video-assisted thoracoscopic surgery (VATS) for older non-small cell lung cancer (NSCLC) patients. Patients ≥ 65 years old with stage I–III NSCLC operated with RAS or VATS from 2016 to 2018 were consecutively included. Propensity score-matched (PSM) method was implemented to balance inter-group biases. Totally 376 participants (224 with VATS and 152 with RAS) were included. After PSM, a cohort (144 with VATS and 107 with RAS) was generated with balanced baseline characteristics. RAS was significantly superior over VATS in the majority of perioperative outcomes, such as operating time (120.8 vs. 165.1 min), conversion rate (0.0% vs. 19.4%), and length of stay (8.6 vs. 10.8 days). RAS versus VATS was significantly associated with comparable rates of postoperative complications (OR 0.642, 95% CI 0.311–1.327), except the rate of pneumonia (OR 0.161, 95% CI 0.048–0.544). RAS leads to analogous postoperative complications and seemingly accelerates the recovery time of older NSCLC patients compared with VATS.

ABSTRACTPosttraumatic cerebral infarction (PTCI) is a serious complication of traumatic brain injury (TBI), and the prevalence and risk factors of PTCI in TBI patients are in dispute. We systematically searched the literature in the PubMed, Embase, and Cochrane library up to October 2021 to identify studies on the prevalence and risk factors of PTCI in patients with TBI. The quality of observational studies was assessed by the Newcastle–Ottawa scale tool. Random-effects model was conducted. The Higgins` I2statistic was used to measure heterogeneity between trials. Moreover, sensitive analyses were conducted to assess whether the pooled result was credible and robust. Eleven studies (3696 total TBI patients) were included. The pooled prevalence of PTCI in TBI patients was 14% (95% CI, 0.11–0.17; I2 = 83.1%). Sensitive analyses showed that the pooled prevalence of PTCI was 13% (95% CI, 0.10–0.15; I2 = 69.2%) by omitting Su et al. The prevalence of PTCI was associated with a lower Glasgow Coma Scale (GCS) score (OR, 0.33; 95% CI, 0.14–0.77; I2 = 99.2%), pupillary dilation (OR, 4.73; 95% CI, 4.30–5.19; I2 = 85.6%), abnormal PT (OR, 1.16; 95% CI,1.05–2.47; I2 = 99.2%), hematoma location (OR, 1.16; 95% CI,1.05–2.47; I2 = 99.2%) and hematoma volume (OR, 1.16; 95% CI,1.05–2.47; I2 = 99.2%). Whereas hypotensive shock, duraplasty, cerebral herniation, and thrombocytopenia were not statistically associated with PTCI. Lower GCS, pupillary dilation, abnormal PT, hematoma location, and hematoma volume were risk factors for PTCI. Considering some limitations, the conclusion of our study should be interpreted with caution.

The 2,3-dihydrobenzofuran scaffold is widely found in natural products and biologically active compounds. Herein, dearomatizing 2,3-fluoroaroylation of benzofurans with aroyl fluorides as bifunctional reagents to access 2,3-difunctionalized dihydrobenzofurans is reported. The reaction that occurs by cooperative NHC/photoredox catalysis provides 3-aroyl-2-fluoro-2,3-dihydrobenzofurans with moderate to good yield and high diastereoselectivity. Cascades proceed via radical/radical cross-coupling of a benzofuran radical cation generated in the photoredox catalysis cycle with a neutral ketyl radical formed through the NHC catalysis cycle. The redox-neutral transformation exhibits broad substrate scope and high functional group compatibility. With anhydrides as bifunctional reagents, dearomatizing aroyloxyacylation of benzofurans is achieved and the strategy can also be applied to N-acylated indoles to afford 3-aroyl-2-fluoro-dihydroindoles.

It is of practical significance to use the updated Coupled Model Intercomparison Project Phase 6 (CMIP6) models to study the impact of changes in land‒sea thermodynamic contrast (TC) on the Asian summer monsoon under different scenarios and to compare the similarities and differences of the impact mechanisms between different monsoon regions. In this study, we investigated future changes of the Asian summer monsoon under four Shared Socioeconomic Pathway (SSP) scenarios using 19 CMIP6 models. The intensity of the South Asian summer monsoon (SASM) is projected to decrease by 2.6%, 6.3%, 10.1%, and 11.1%, while the East Asian summer monsoon (EASM) intensity is projected to increase by 4.6%, 7.9%, 7.4%, and 9.8% until the end of the 21st century for SSP126, SSP245, SSP370, and SSP585 scenarios, respectively. Moreover, summer precipitation in Asia is projected to increase remarkably in 2015–2099 under all four scenarios. The inconsistent warming trends over the Tibetan Plateau (TP), Northwest Pacific, and tropical Indian Ocean would greatly impact the monsoon circulations. The upper-troposphere warming trend over the surrounding oceans is remarkably greater than that over the TP, while the near-surface warming trend over the surrounding oceans is smaller than that over the TP. The decrease of upper-troposphere TC between the TP and tropical Indian Ocean results in a weakening of the SASM circulation. The enhancement of the lower-troposphere TC between the TP and Northwest Pacific would strengthen the EASM circulation. Moisture budget analysis shows that the water-vapor would increase in the future, which would thermodynamically enhance summer precipitation through the anomalous vertical moisture transport associated with mean flow. The strengthening of the meridional circulation of the EASM would increase monsoon precipitation, while the weakening of zonal circulation of the SASM would dynamically reduce South Asian summer precipitation.

An anion-exchange-based chromatographic separation approach was developed to selectively recover zinc and copper from the high-chlorine raffinate generated in the process of germanium chlorination distillation using 717 resins based on the coordination difference between Zn2+/Cu2+and Cl–. The theoretical calculation and spectroscopic analyses suggested that the coordination between Zn2+and Cl–is much stronger than that between Cu2+and Cl–, and the Cl–concentration significantly affects Zn(II) and Cu(II) species. The factors involving Cl–concentration, resin dosage, shaking speed, and temperature were investigated to determine the optimal condition, and the maximum separation factor of Zn/Cu reached as high as 479.2. The results of the adsorption isotherms, adsorption kinetics, SEM, FTIR, and XPS analyses indicated that the process followed the monolayer uniform chemisorption. Through the continuous adsorption experiments, Zn(II) and Cu(II) in the high-chlorine raffinate were separately recovered, allowing the reuse of residual waste acid and germanium.

Many integral membrane proteins might act as indispensable coordinators in specific functional microdomains to maintain the normal operation of known receptors, such as Notch. Gm364 is a multi-pass transmembrane protein that has been screened as a potential female fertility factor. However, there have been no reports to date about its function in female fertility. Here, we found that global knockout of Gm364decreased the numbers of primordial follicles and growing follicles, impaired oocyte quality as indicated by increased ROS and γ-H2AX, decreased mitochondrial membrane potential, decreased oocyte maturation, and increased aneuploidy. Mechanistically, Gm364 directly binds and anchors MIB2, a ubiquitin ligase, on the membrane. Subsequently, membrane MIB2 ubiquitinates and activates DLL3. Next, the activated DLL3 binds and activates Notch2, which is subsequently cleaved within the cytoplasm to produce NICD2, the intracellular active domain of Notch2. Finally, NICD2 can directly activate AKT within the cytoplasm to regulate oocyte meiosis and quality.

The vast superiority in resource sustainability and volumetric energy density enables metallic zinc (Zn) to construct cost-effective and environment-benign battery systems for the energy storage. However, the problems of Zn dendrites and poor Coulombic efficiency (CE) during cell’s whole life cycle stump its advancement as a rechargeable battery choice. The solution is to modulate the Zn2+desolvation prior to electro-reduction and subsequent deposition. Herein, a transferred protection tactic viaa bifunctional sulfonated covalent polymer interlayer is proposed to regulate the Zn2+desolvation, which affects the formation of solid-electrolyte interphase, and guides its plating along with preferable (002) crystal plane. Thus, the high initial CE of 96.3% and the long-term average CE of 99.8% for 310 cycles are achieved in Zn||Cu cells and 570-h circulation is also realized at 2 mA cm−2/10 mAh cm−2in Zn||Zn cells. Besides, Zn||hydrated vanadium oxide-based full batteries with the low-concentration organic electrolytes are also demonstrated with the high specific capacity of 173.8 mAh g−1at 0.5 A g−1and 64% capacity retention over 305 cycles and oriented Zn deposition.

We investigated the influence of hydrogen (H) on the stability and mobility of small vacancy clusters in tungsten (W) using the first-principles calculations. It is found that the presence of H not only increases the binding energy of small vacancy clusters but also changes their most favorable configurations, owing to the strong attractive interaction between H and vacancies in W. Specifically, the binding energy of di-vacancy changes from negative to positive when the H atoms are introduced. These results suggest that the H addition can significantly promote the stability of small vacancy clusters in W. More importantly, although the migration energy barriers of H-vacancy (H-V) complexes are slightly higher than that of pure vacancy clusters, the activation energy required for complexes migration is always lower than that for dissociation. Therefore, contrary to the conventional view, the collaborative motion of H and small vacancy clusters is possible, because of the low migration energy barriers. Based on the energetic results obtained by first-principles calculations, the mean lifetime and mean diffusion distance of small H–V complexes at different temperatures are examined by the object kinetic Monte Carlo simulations. The small H–V complexes are found to be stable and mobile at moderate temperature, and thus may affect the co-evolution of H and vacancies. These results shed light on the important role of H on the vacancy behaviors and provide a good reference for understanding the defects evolution in W.

Transplant-associated thrombotic microangiopathy (TA-TMA) is a potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Information on markers for early prognostication remains limited, and no predictive tools for TA-TMA are available. We attempted to develop and validate a prognostic model for TA-TMA. A total of 507 patients who developed TA-TMA following allo-HSCT were retrospectively identified and separated into a derivation cohort and a validation cohort, according to the time of transplantation, to perform external temporal validation. Patient age (odds ratio [OR], 2.371; 95% confidence interval [CI], 1.264-4.445), anemia (OR, 2.836; 95% CI, 1.566-5.138), severe thrombocytopenia (OR, 3.871; 95% CI, 2.156-6.950), elevated total bilirubin (OR, 2.716; 95% CI, 1.489-4.955), and proteinuria (OR, 2.289; 95% CI, 1.257-4.168) were identified as independent prognostic factors for the 6-month outcome of TA-TMA. A risk score model termed BATAP (Bilirubin, Age, Thrombocytopenia, Anemia, Proteinuria) was constructed according to the regression coefficients. The validated c-statistic was 0.816 (95%, CI, 0.766-0.867) and 0.756 (95% CI, 0.696-0.817) for the internal and external validation, respectively. Calibration plots indicated that the model-predicted probabilities correlated well with the actual observed frequencies. This predictive model may facilitate the prognostication of TA-TMA and contribute to the early identification of high-risk patients.

Magnetic-based driving applications are receiving increasing attention. This study proposed a novel reciprocating permanent magnetic actuator (PMA) to manipulate magnetic micro robots to impact and clear blockages inside fluid pipes in a linear path. The PMA consisted of a cylindrical permanent magnet and a crank slider structure. A straight pipe with a circular cross-sectional area was located in front of the actuator to study the driving performance of PMA. A micro permanent magnet with a cylinder shape was employed as a working robot for manipulation inside the pipe. Firstly, analytical formulas were derived to obtain the magnetic driving force acting on the micro robot and determine the most suitable magnet configuration. The finite element simulation verified the analytical calculation. The developed reciprocating PMA prototype was then introduced, and the PMA and micro robot’s motion performance was analysed. Lastly, preliminary experiments were carried out for evaluating the micro robot’s motion characteristics. Performance tests for different excitation frequencies, flow rates, viscosities, and axial distances, indicating that PMA could manipulate the magnetic micro robot inside the pipe. The results confirmed that the developed PMA could effectively drive the micro robot with the advantage of consecutive magnetic driving. Especially, the micro robot featured good flexibility, rapid response, and a simple structure, suggesting that this micro robot may play an important role in industrial and medical applications, such as blockage elimination and thrombus clearance.

Ag2Te is one of the most promising semiconductors with a narrow band gap and low toxicity; however, it remains a challenge to tune the emission of Ag2Te quantum dots (QDs) precisely and continuously in a wide range. Herein, Ag2Te QDs emitting from 950 to 2100 nm have been synthesized via trialkylphosphine-controlled growth. Trialkylphosphine has been found to induce the dissolution of small-sized Ag2Te QDs due to its stronger ability to coordinate to the Ag ion than that of 1-octanethiol, predicated by the density functional theory. By controlling this dissolution effect, the monomer supply kinetics can be regulated, achieving precise size control of Ag2Te QDs. This synthetic strategy results in state-of-the-art silver-based QDs with emission tunability. Only by taking advantage of such an ultrawide emission has the sizing curve of Ag2Te been obtained. Moreover, the absolute photoluminescence quantum yield of Ag2Te QDs can reach 12.0% due to their well-passivated Ag-enriched surface with a density of 5.0 ligands/nm2, facilitating noninvasive in vivofluorescence imaging. The high brightness in the long-wavelength near-infrared (NIR) region makes the cerebral vasculature and the tiny vessel with a width of only 60 μm clearly discriminable. This work reveals a nonclassical growth mechanism of Ag2Te QDs, providing new insight into precisely controlling the size and corresponding photoluminescence properties of semiconductor nanocrystals. The ultrasmall, low-toxicity, emission-tunable, and bright NIR-II Ag2Te QDs synthesized in this work offer a tremendous promise for multicolor and deep-tissue in vivofluorescence imaging.

RNA-binding proteins (RBPs) have essential functions during germline and early embryo development. However, current methods are unable to identify the in vivo targets of a RBP in these low-abundance cells. Here, by coupling RBP-mediated reverse transcription termination with linear amplification of complementary DNA ends and sequencing, we present the LACE-seq method for identifying RBP-regulated RNA networks at or near the single-oocyte level. We determined the binding sites and regulatory mechanisms for several RBPs, including Argonaute 2 (Ago2), Mili, Ddx4 and Ptbp1, in mature mouse oocytes. Unexpectedly, transcriptomics and proteomics analysis of Ago2−/−oocytes revealed that Ago2 interacts with endogenous small interfering RNAs (endo-siRNAs) to repress mRNA translation globally. Furthermore, the Ago2 and endo-siRNA complexes fine-tune the transcriptome by slicing long terminal repeat retrotransposon-derived chimeric transcripts. The precise mapping of RBP-binding sites in low-input cells opens the door to studying the roles of RBPs in embryonic development and reproductive diseases.

Hip aspirations used to detect a periprosthetic joint infection (PJI) are usually performed under fluoroscopy or ultrasound. The aim of this study was to evaluate the results of simply using anatomic landmarks for aspiration and detecting PJI without the use of any complicated technologies. The authors retrospectively reviewed a total of 186 consecutive hip aspirations performed between April 2015 and December 2018. All patients were suspected to have infections after total hip arthroplasty. The procedures were performed with the patients in the supine position. The authors aimed to aspirate at the neck of the prosthesis. They located the y-axis of the puncture point approximately 2 to 3 cm lateral to the pulse of the femoral artery in the region of the inguinal ligament. The x-axis was estimated by using the pubic symphysis or greater trochanter according to an anteroposterior radiograph of the hip joint. The aspiration failure rate, incidence of complications, and culture results were recorded. The overall aspiration failure rate was 3.8% (7 of 186). No obvious complications related to aspiration were observed. The saline lavage and reaspiration rate was 45.3% (81 of 179) due to “dry taps.” The sensitivity, specificity, positive predictive value, and negative predictive value of the remaining 169 patients with definite diagnoses were 0.781 (95% CI, 0.678–0.860), 0.939 (95% CI, 0.857–0.977), 0.931 (95% CI, 0.841–0.975), and 0.802 (95% CI, 0.706–0.874), respectively. Anatomic landmark-guided hip aspiration was a convenient method that could provide satisfactory detection of PJI. [Hip aspirations used to detect a periprosthetic joint infection (PJI) are usually performed under fluoroscopy or ultrasound. The aim of this study was to evaluate the results of simply using anatomic landmarks for aspiration and detecting PJI without the use of any complicated technologies. The authors retrospectively reviewed a total of 186 consecutive hip aspirations performed between April 2015 and December 2018. All patients were suspected to have infections after total hip arthroplasty. The procedures were performed with the patients in the supine position. The authors aimed to aspirate at the neck of the prosthesis. They located the y-axis of the puncture point approximately 2 to 3 cm lateral to the pulse of the femoral artery in the region of the inguinal ligament. The x-axis was estimated by using the pubic symphysis or greater trochanter according to an anteroposterior radiograph of the hip joint. The aspiration failure rate, incidence of complications, and culture results were recorded. The overall aspiration failure rate was 3.8% (7 of 186). No obvious complications related to aspiration were observed. The saline lavage and reaspiration rate was 45.3% (81 of 179) due to “dry taps.” The sensitivity, specificity, positive predictive value, and negative predictive value of the remaining 169 patients with definite diagnoses were 0.781 (95% CI, 0.678–0.860), 0.939 (95% CI, 0.857–0.977), 0.931 (95% CI, 0.841–0.975), and 0.802 (95% CI, 0.706–0.874), respectively. Anatomic landmark-guided hip aspiration was a convenient method that could provide satisfactory detection of PJI. [Orthopedics. 2021;44(1):e85–e90.]

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization.

The thermal interaction of continuously welded rails with railway bridges has attracted the wide attention of researchers. In this paper, the model of a continuously welded rail and a bridge with longitudinal nonlinear stiffness has been considered. The detailed mechanics equation of the rail on the bridge and the embankment with longitudinal nonlinear stiffness has been presented using the finite element analysis. The validity of the presented model and the compiled program is illustrated. The influences of nonlinear stiffness, span number of the bridge, constant longitudinal restoring force, bridge bearing arrangement, and the span length of the bridge on the additional longitudinal stress and displacement of rails are investigated for multispan simply supported bridges. The results show that (1) the responses of rails for the nonlinear stiffness are less than those for the linear stiffness; (2) when the bridge span reaches a certain number, the maximum additional longitudinal stress and the displacement of the rail tend to be constant; (3) with the increase of the value of the constant longitudinal restoring stress, the maximum additional longitudinal stress and the displacement of the rail increase; (4) the maximum additional longitudinal stress of the rail on multispan simply supported bridges can be reduced by using alternate bearings on one pier; and (5) the maximum additional longitudinal stress and displacement of the rail increase with the increase of the span length of the bridge.

Protein phosphatase 6 (PP6) is a member of the PP2A-like subfamily, which plays a critical role in many fundamental cellular processes. We recently reported that PP6 is essential for female fertility. Here, we report that PP6 is involved in meiotic recombination and that germ cell-specific deletion of PP6 by Stra8-Crecauses defective spermatogenesis. The PP6-deficient spermatocytes were arrested at the pachytene stage and defects in DSB repair and crossover formation were observed, indicating that PP6 facilitated meiotic double-stranded breaks (DSB) repair. Further investigations revealed that depletion of PP6 in the germ cells affected chromatin relaxation, which was dependent on MAPK pathway activity, consequently preventing programmed DSB repair factors from being recruited to proper positions on the chromatin. Taken together, our results demonstrate that PP6 has an important role in meiotic recombination and male fertility.

The coronavirus disease 2019 (COVID-19) outbreak has been designated a public health emergency of international concern. To prepare for a pandemic, hospitals need a strategy to manage their space, staff, and supplies so that optimum care is provided to patients. In addition, infection prevention measures need to be implemented to reduce in-hospital transmission. In the operating room, these preparations involve multiple stakeholders and can present a significant challenge. Here, we describe the outbreak response measures of the anesthetic department staffing the largest (1,700-bed) academic tertiary level acute care hospital in Singapore (Singapore General Hospital) and a smaller regional hospital (Sengkang General Hospital). These include engineering controls such as identification and preparation of an isolation operating room, administrative measures such as modification of workflow and processes, introduction of personal protective equipment for staff, and formulation of clinical guidelines for anesthetic management. Simulation was valuable in evaluating the feasibility of new operating room set-ups or workflow. We also discuss how the hierarchy of controls can be used as a framework to plan the necessary measures during each phase of a pandemic, and review the evidence for the measures taken. These containment measures are necessary to optimize the quality of care provided to COVID-19 patients and to reduce the risk of viral transmission to other patients or healthcare workers.

Many classic and quantum devices need to operate at cryogenic temperatures, demanding advanced cryogenic digital electronics for processing the input and output signals on a chip to extend their scalability and performance. Here, we report a superconducting binary encoder with ultralow power dissipation and ultracompact size. We introduce a multigate superconducting nanowire cryotron (nTron) that functions as an 8-input OR gate within a footprint of approximately 0.5 μm2. Four cryotrons compose a 4-bit encoder that has a bias margin of 18.9%, an operation speed greater than 250 MHz, an average switching jitter of 75 ps, and a power dissipation of less than 1 μW. We apply this encoder to read out a superconducting-nanowire single-photon detector array whose pixel location is digitized into a 4-bit binary address. The small size of the nanowire combined with the low power dissipation makes nTrons promising for future monolithic integration.

Closed-to-open structural transformations in flexible coordination networks are of potential utility in gas storage and separation. Herein, we report the first example of a flexible SiF62–-pillared square grid material, [Cu(SiF6)(L)2]n(L = 1,4-bis(1-imidazolyl)benzene), SIFSIX-23-Cu. SIFSIX-23-Cuexhibits reversible switching between nonporous (β1) and several porous (α, γ1, γ2, and γ3) phases triggered by exposure to N2, CO2, or H2O. In addition, heating β1to 433 K resulted in irreversible transformation to a closed polymorph, β2. Single-crystal X-ray diffraction studies revealed that the phase transformations are enabled by rotation and geometrical contortion of L. Density functional theory calculations indicated that L exhibits a low barrier to rotation (as low as 8 kJmol–1) and a rather flat energy surface. In situ neutron powder diffraction studies provided further insight into these sorbate-induced phase changes. SIFSIX-23-Cucombines stability in water for over a year, high CO2uptake (ca. 216 cm3/g at 195 K), and good thermal stability.

Improvements in temporal resolution of single-photon detectors enable increased data rates and transmission distances for both classical and quantum optical communication systems, higher spatial resolution in laser ranging, and observation of shorter-lived fluorophores in biomedical imaging. In recent years, superconducting nanowire single-photon detectors (SNSPDs) have emerged as the most efficient time-resolving single-photon-counting detectors available in the near-infrared, but understanding of the fundamental limits of timing resolution in these devices has been limited due to a lack of investigations into the timescales involved in the detection process. We introduce an experimental technique to probe the detection latency in SNSPDs and show that the key to achieving low timing jitter is the use of materials with low latency. By using a specialized niobium nitride SNSPD we demonstrate that the system temporal resolution can be as good as 2.6 ± 0.2 ps for visible wavelengths and 4.3 ± 0.2 ps at 1,550 nm.

Nearly all adaptive control techniques require that the control directions of dynamical systems are known in advance. In this paper, for a class of pure-feedback nonaffine discrete-time systems with unknown control directions (UCDs), a high-order neural network (HONN)-based adaptive iterative learning control (ILC) approach is presented to address a repetitive tracking control issue. The implicit function theorem is adopted to cope with the difficulty resulting from the nonaffine structure of control input. Employing a discrete Nussbaum-type function in the neural network weight adaptation law to suit the UCD, an HONN is used to iteratively estimate the ideal control signals. In addition, a novel dead-zone method is developed in the HONN-based adaptive ILC algorithm to enhance its robustness against nonrepetitive desired trajectories and random uncertainties in iterative initial errors and external disturbance. Consequently, the system output, except at the initial $n$ time instants, is demonstrated to asymptotically converge to an adjustable range of the desired trajectory along the iteration axis, while all of the system signals remain bounded during the entire ILC process. Two simulation examples show the feasibility of the adaptive ILC approach. [ABSTRACT FROM AUTHOR]

CtBP-interacting protein (CtIP) is known for its multifaceted roles in DNA repair and genomic stability, directing the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway via DNA end resection, an essential error-free repair process vital for genome stability. Mammalian oocytes are highly prone to DNA damage accumulation due to prolonged G2/prophase arrest. Here, we explore the functions of CtIP in meiotic cell cycle regulation via a mouse oocyte model. Depletion of CtIP by siRNA injection results in delayed germinal vesicle breakdown and failed polar body extrusion. Mechanistically, CtIP deficiency increases DNA damage and decreases the expression and nuclear entry of CCNB1, resulting in marked impairment of meiotic resumption, which can be rescued by exogenous CCNB1 overexpression. Furthermore, depletion of CtIP disrupts MTOCs coalescence at spindle poles as indicated by failed accumulation of γ-tubulin, p-Aurora kinase A, Kif2A, and TPX2, leading to abnormal spindle assembly and prometaphase arrest. These results provide valuable insights into the important roles of CtIP in the G2/M checkpoint and spindle assembly in mouse oocyte meiotic cell cycle regulation.

Penicillium daleaeL3SO is a fungus isolated from the rhizospheric soil of the chloroplast-deficient plant Monotropa uniflora. A chemical study on the rice fermentation of this fungus led to the isolation and identification of two cage-like polyketides, penidaleodiolide A (1) and its biosynthetic-related congener penidaleodiolide B (2). The structures of 1and 2were determined by a combination of extensive spectroscopic analysis, biosynthetic consideration, chemical derivatization, and computational methods. Compound 1harbors an unusual tricyclo[4.3.04,9]nonane scaffold, unprecedented in polyketide natural products. The hypothetical biosynthetic pathways for 1and 2were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (1) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.

One-step He purification from natural gas represents a crucial solution for addressing the global He shortages. The prevailing method to produce high-grade He involves cryogenic distillation and ultralow temperature adsorption processes, which is highly cost- and energy-intensive. Separating and purifying He at ambient temperature is a great challenge because the fundamental limitation lies in the boiling point, polarizability, and kinetic diameters of CH4/N2/He gases. In this study, we seek to implement a relay adsorption strategy using Ni(ina)2and MIL-100(Cr) metal-organic frameworks (MOFs) to produce high-purity He from ternary mixtures (CH4, N2, and He) at ambient temperature. The CH4/He selectivity in Ni(ina)2and N2/He selectivity in MIL-100(Cr) both reach record 15.39 and 128.49, respectively, making the relay adsorption for helium purification highly efficient. The breakthrough experiments show that the two MOFs can sequentially adsorb CH4and N2in ternary mixtures, producing He with a purity of up to 99.99% in one step. The remarkable separation performance and stability of these MOFs underscore the industrial potential in purifying He at ambient temperature.

We used intravascular ultrasound (IVUS) to analyze the features of coronary artery atheromatous plaque in patients with impaired glucose tolerance and mild-to-moderate angiographic coronary stenosis. The aim was to determine the clinical significance of plaque characteristics as well as the relationship between hemoglobin A1c (HbA1c) levels and coronary artery lesions.

Environmental factors such as diet and lifestyle can influence the health of both mothers and offspring. However, its transgenerational transmission and underlying mechanisms remain largely unknown. Here, using a maternal lactation-period low-protein diet (LPD) mouse model, we show that maternal LPD during lactation causes decreased survival and stunted growth, significantly reduces ovulation and litter size, and alters the gut microbiome in the female LPD-F1 offspring. The transcriptome of LPD-F1 metaphase II (MII) oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic processes. Moreover, maternal LPD causes early stunted growth and impairs metabolic health, which is transmitted over two generations. The methylome alteration of LPD-F1 oocytes can be partly transmitted to the F2 oocytes. Together, our results reveal that LPD during lactation transgenerationally affects offspring’s health, probably via oocyte epigenetic changes.

Cochlear implant is currently the most widely proven interventions for auditory rehabilitation for children with severe sensorineural hearing impairment. However, there are obvious limitations in these current evaluation methods. This study aims to develop an evaluation system for quantitatively evaluating the effectiveness of cochlear implants for hearing-impaired children.

Ideal cardiovascular health (CVH) has been associated with reduced cardiovascular disease risk and mortality, but its association with cardiac arrhythmias was still unsettled. In this prospective cohort study, we investigated the relationship between CVH and subsequent arrhythmias risk, including atrial fibrillation (AF)/flutter, ventricular arrhythmias, and bradyarrhythmias.