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Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium brevestrain (CCFM1025) were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test), but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system, for example to increase melatonin levels, and by regulating the expression of circadian clock genes such as those encoding the adenosine A2Areceptor and period circadian regulator 1. Collectively, administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

In this work, we measure the oxygen kinetic properties of double perovskite PrBa0.5Sr0.5Co1.5Fe0.5O5+δ(PBSCF), a material widely used as the air electrode in solid oxide electrochemical cells, by mass relaxation (MR) and electrical conductivity relaxation (ECR) experiments. MR studies are carried out using thin films deposited on a gallium phosphate piezocrystal microbalance, and ECR studies are performed using a bulk bar sample with 97% theoretical density. Measurements are performed at 600 °C over the temperature oxygen partial pressure range from 10–4to 0.21 atm. Despite the differences in experimental formats and surface microstructural features, the ksvalues extracted from the two methods are found to be in good agreement with one another. The rate constant is found to increase with oxygen partial pressure with a power law dependence, rising from 1.0 × 10–6cm/s at 3.2 × 10–4atm to 1.2 × 10–4cm/s at 0.24 atm, as averaged over the oxidation and reduction directions. The rates in the oxidation direction are observed to be slightly higher than those in the reduction direction for a given pair of pO2values, suggesting that the final pO2value controls the overall relaxation behavior. The power law exponent describing the dependence of kson pO2is found to be 0.74 ± 0.01. The ECR study of the bulk sample reveals that even with a diffusion length of 1.8 mm, the relaxation process is largely free of diffusion limitations, indicating that PBSCF has the high bulk transport properties required for a double-phase boundary oxidation/reduction pathway.

ABSTRACT Recycled concrete aggregates (RCAs) have inferior qualities compared with natural aggregates (NAs) because of a layer of residual cement mortar coated on the surface of the NAs. The porous [...]

ABSTRACTMetakaolin has emerged as a popular supplementary cementitious material to partially replace ordinary Portland cement (OPC) due to its high pozzolanic reactivity and surface area. In this study, a new [...]

Purine metabolism plays a pivotal role in numerous biological processes with potential implications for brain function and emotional regulation. This study utilizes gene-edited probiotics and pseudo-germ-free mice to unravel this intricate interplay. Transcriptomic analysis identified a ribonucleoside-diphosphate reductase β chain (nrdB)as a pivotal gene in purine metabolism within Bifidobacterium breveCCFM1025. Comparative evaluation between the wild-type and nrdBmutant strains revealed CCFM1025’s effective reduction of xanthine and xanthosine levels in the serum and brain of stressed mice. Concomitantly, it downregulated the expression of the adenosine receptor gene (Adora2b) and inhibited the overactivation of microglia. These findings emphasize the potential of psychobiotics in modulating emotional responses by regulating purine metabolites and adenosine receptors. This study sheds light on novel pathways that influence emotional well-being through gut microbiota interactions and purine metabolic processes.

AimsTo evaluate the effectiveness of glaucoma screening using glaucoma suspect (GS) referral criteria assessed on colour fundus photographs in Singapore’s Integrated Diabetic Retinopathy Programme (SiDRP).MethodsA case–control study. This study included diabetic subjects who were referred from SiDRP with and without GS between January 2017 and December 2018 and reviewed at Singapore National Eye Centre. The GS referral criteria were based on the presence of a vertical cup-to-disc ratio (VCDR) of ≥0.65 and other GS features. The final glaucoma diagnosis confirmed from electronic medical records was retrospectively matched with GS status. The sensitivity, specificity and positive predictive value (PPV) of the test were evaluated.ResultsOf 5023 patients (2625 with GS and 2398 without GS) reviewed for glaucoma, 451 (9.0%, 95% CI 8.2% to 9.8%) were confirmed as glaucoma. The average follow-up time was 21.5±10.2 months. Using our current GS referral criteria, the sensitivity, specificity and PPV were 81.6% (95% CI 77.7% to 85.1%), 50.6% (95% CI 49.2% to 52.1%) and 14.0% (95% CI 13.4% to 14.7%), respectively, resulting in 2257 false positive cases. Increasing the VCDR cut-off for referral to ≥0.80, the specificity increased to 93.9% (95% CI 93.1% to 94.5%) but the sensitivity decreased to 11.3% (95% CI 8.5% to 14.6%), with a PPV of 15.4% (95% CI 12.0% to 19.4%).ConclusionsOpportunistic screening for glaucoma in a lower VCDR group could result in a high number of unnecessary referrals. If healthcare infrastructures are limited, targeting case findings on a larger VCDR group with high specificity will still be beneficial.

ABSTRACT Mineral precipitation is a promising surface treatment method to enhance the mechanical properties and durability of concrete and similar porous materials. Both chemically and microbiologically induced mineral precipitations have [...]

ABSTRACT This study proposes a low-cost method to convert cenospheres into an admixture carrier for concrete manufacturing. Cenospheres are hollow fly ash particles generated in coal burning power plants, having [...]

In the field of array sensing, researchers are committed to miniaturizing array sensing systems while ensuring the acquisition of multiple sensing information. Here, a new strategy called “stimulus responsive array sensing” was presented to obtain virtual multiple sensing without constructing multiple physical sensing units. Based on bioluminescence resonance energy transfer, where luciferase acts as the donor and temperature stimulus response polymers act as the receptors, by using only one sensing unit to output multiple stimulus responsive sensing signals in temperature dimension, an equivalent array sensing could be achieved. This strategy can distinguish and quantify a variety of proteins. More importantly, glucose responsive monomers were doped in polymers; thus, more virtual sensing units can be further increased to obtain more sensing signals, greatly increasing the accuracy of protein recognition, and it can also be used to differentiate several compositions of protein under different glucose concentrations in urine caused by different renal diseases. The results show the potential of the “stimulus responsive array sensing” for analyzing molecular compositions in complex biological systems and show a new tack in array sensing.

Mesozoic granitoids in Peninsular Malaysia provide crucial information on the temporal–spatial relationship between the Tethyan and Palaeo-Pacific domains. This paper presents new ages and geochemical data for newly identified Jurassic–Cretaceous granites and meta-granites from East Malaya. These granitoids can be divided into three groups. Group 1 consists of high-K calc-alkaline granites and granodiorites (171–162 Ma) with variable εNd(t) values of −7.4–+0.5, zircon εHf(t) values of −7.4–+8.6, and high initial ratios for 206Pb/204Pb (20.04–20.65), 207Pb/204Pb (15.73–15.79) and 208Pb/204Pb (39.80–40.20). The melting of metasedimentary rocks with a juvenile mafic component formed Group 1 samples. Group 2 granite porphyries (c. 131 Ma) with A-type affinities and Group 3 granitic gneisses (c. 130 Ma) with I-type affinities share similar εNd(t) values (−7.2 to −5.5), zircon εHf(t) values (−10.1–+6.5), and initial ratios for 206Pb/204Pb (18.81–19.02), 207Pb/204Pb (15.71–15.77) and 208Pb/204Pb (38.95–39.59). Although Group 2 and 3 samples were derived from an 'ancient' meta-mafic source region, Group 2 shows evidence for the involvement of a juvenile mafic component. All these granitoids are akin to the Permian–Triassic igneous rocks in East Malaya. The Jurassic–Cretaceous igneous rocks in Eastern Peninsular Malaysia were formed during multiple stages of continental rifting in response to Palaeo-Pacific slab rollback pulses rather than by Tethyan evolutionary processes. Supplementary material: Data for the Middle Jurassic–Early Cretaceous granitoids of East Malaya are available at https://doi.org/10.6084/m9.figshare.c.6689085 Thematic collection: This article is part of the Mesozoic and Cenozoic tectonics, landscape and climate change collection available at: https://www.lyellcollection.org/topic/collections/mesozoic-and-cenozoic-tectonics-landscape-and-climate-change [ABSTRACT FROM AUTHOR]

AgBi3S5is a new n-type thermoelectric material that is environmentally friendly and composed of elements of earth-abundant, non-toxic and high performance-cost ratio. This compound features an intrinsically low thermal conductivity derived from its complex monoclinic structure. However, the terrible electrical transport properties greatly limited the improvement of thermoelectric performance. Most previous studies considered that carrier concentration is the main reason for low electrical conductivity and focused on improving carrier concentration by aliovalent ion doping. In this work, we found that the critical parameter that restricts the electric transport performance of AgBi3S5was the extremely low carrier mobility instead of the carrier concentration. According to the Pisarenko relationships and density functional theory calculations, Nb doping can sharpen the conduction band of AgBi3S5, which contributes to reducing the effective mass and improving the carrier mobility. With a further increase of the Nb doping content, the conduction band convergence can enlarge the effective mass and preserve the carrier mobility. Combined with the decrease in lattice thermal conductivity due to the intensive phone scattering, a maximum ZTvalue of ∼0.50 at 773 K was achieved in Ag0.97Nb0.03Bi3S5, which was ∼109.6% higher than that of pure AgBi3S5. This work will stimulate the new exploration of high-performance thermoelectric materials in ternary metal sulfides.

ABSTRACT Recycled concrete aggregates (RCAs) have inferior qualities compared with natural aggregates, mainly attributed to the porous nature of the attached cement mortar. To improve the quality of the RCAs, [...]

Aim:To detect the gut colonization capacity of Bifidobacterium breveCCFM1025 with clinical antidepressant-like effects. Materials & methods:A unique gene sequence of B. breveCCFM1025 was discovered based on the genome analysis of 104 B. brevestrains and a strain-specific primer (1025T5) was designed. In vitroand in vivosamples were used to validate the specificity and quantitative capability of this primer in the PCR system. Results:Quantitative PCR using strain-specific primers enabled absolute quantification of CCFM1025 in fecal samples within 104–1010cells/g (R2>0.99). CCFM1025 remained highly detectable in volunteer feces 14 days after cessation of administration, demonstrating its favorable colonization characteristics. Conclusion:CCFM1025 can colonize the healthy human gut.

The grinding profile directly affects the wheel–rail contact relationship, so it is necessary to study the design method of rail grinding profiles for the curve section. Based on the Frechet distance method, the selection method of representative profile for worn rails was established. Based on the non-uniform rational B-spline theory, the description model of the rail profile was constructed. The reduction of rail grinding material removed and improvement of wheel–rail contact geometry were taken as the optimization objectives, and the multi-objective function of the grinding profile of the outer rail in the transition curve and circular curve section was established. The optimized design results show that compared with the measured grinding profile in the field, the rail grinding amount is reduced by 80.1% and 11.3% by using grinding profiles designed for the transition curve section and the circular curve section, respectively, and the distribution of wheel–rail contact points is more uniform. The dynamic indexes under different velocities and different radii are significantly reduced, and the curve passing performance is improved. The area of wheel–rail contact spot changes uniformly with the lateral displacement of the wheelset, and the maximum von Mises stress is improved obviously. The wear index and surface fatigue index decreased significantly. The optimized grinding profile can effectively extend the maintenance cycle and service life of the curved rail.

The widespread use of orthopedic implants to support or replace bones is increasingly threatened by the risk of incurable bacterial infections, impenetrable microbial biofilms, and irreversible antibiotic resistance. In the past, the development of anti-infective biomaterials focused solely on direct antibacterial properties while ignoring the host's immune response. Inspired by the clearance of infection by the innate neutrophil response and participation in anti-infectious immunity of Zn ions, we report an innovative neutrophil extracellular traps (NETs) strategy, induced by biodegradable pure Zn, which achieved therapeutic efficacy toward biomaterial-related infections. Our in vitroand in vivodata showed that pure Zn was favorable for NETs formation by promoting the release of DNA fibers and granule proteins in a reactive oxygen species (ROS)-dependent manner, thereby retraining and degrading bacteria with an efficiency of up to 99.5%. Transcriptome analysis revealed that cytoskeletal rearrangement and toll-like receptor (TLR) signaling pathway were also involved in Zn-induced NETs formation. Furthermore, the in vivoresults of a Staphylococcus aureus(S. aureus)-infected rat model verified that pure Zn potentiated the bactericidal capability of neutrophils around implants, and promoted osseointegration in S. aureus-infected rat femurs. This antibacterial immunity concept lays a foundation for the development of other antibacterial biomaterials and holds great promise for treating orthopedic infections.

The activation of the monocyte-macrophage system and the damage to the renal and pancreatic tissue are common complications in patients with diabetes induced by hyper-glycemia. This study aimed to evaluate the effect and mechanism of butyrate (NaB), a metabolite of intestinal flora, on inhibiting the inflammatory response of human monocyte-macrophages (THP-1 cells) induced by high glucose and the damage of pancreatic and renal tissue in diabetic mice. The results showed that high concentration glucose significantly up-regulated the expressions of IL-1β, TNF-α, and NLRP3 in THP-1 cells and mouse spleen, and that NaB could inhibit the overexpression of those genes. The abundance of Beclin-1, LC3B and reactive oxygen species (ROS) in THP-1 cells is increased due to the high glucose concentration, and NaB can inhibit the genes responsible for upregulating the expression. In diabetic mice, vacuolar degeneration of renal tubules was observed. Then we observed that some of the epithelial cells of the renal tubules were exfoliated and some formed tubules. NaB could alleviate these pathological lesions, but NaB cannot alleviate pancreatic injury. Our results indicated that NaB could be used for the prevention and adjuvant treatment of diabetic kidney injury.

Visual data storytelling is gaining importance as a means of presenting data-driven information or analysis results, especially to the general public. This has resulted in design principles being proposed for data-driven storytelling, and new authoring tools being created to aid such storytelling. However, data analysts typically lack sufficient background in design and storytelling to make effective use of these principles and authoring tools. To assist this process, we present ChartStory for crafting data stories from a collection of user-created charts, using a style akin to comic panels to imply the underlying sequence and logic of data-driven narratives. Our approach is to operationalize established design principles into an advanced pipeline that characterizes charts by their properties and similarities to each other, and recommends ways to partition, layout, and caption story pieces to serve a narrative. ChartStory also augments this pipeline with intuitive user interactions for visual refinement of generated data comics. We extensively and holistically evaluate ChartStory via a trio of studies. We first assess how the tool supports data comic creation in comparison to a manual baseline tool. Data comics from this study are subsequently compared and evaluated to ChartStory’s automated recommendations by a team of narrative visualization practitioners. This is followed by a pair of interview studies with data scientists using their own datasets and charts who provide an additional assessment of the system. We find that ChartStory provides cogent recommendations for narrative generation, resulting in data comics that compare favorably to manually-created ones.

Resistive tactile sensor has excellent anti-interference characteristics in daily environment. Inspired by the short-circuit effect in electricity, a new design of flexible resistive tactile sensor was proposed in this study. We utilized conductive graphite paint and conductive silver paint as sensing materials to fabricate the high-impedance element (100–150 $\Omega$ ) on the polyimide (PI) film and the low-impedance element (2– $10~\Omega$ ) on the silicone rubber, respectively. The output signal depends on the contact area between the high-impedance and the low-impedance elements caused by the applied pressure, which employs the short-circuit effect for the transduction mechanism. Besides, the spherical microstructure in silicone rubber layer was used to enlarge the measuring range of pressure. The experimental results show a wide range of pressure response up to above 3 MPa, and the resolution of the sensor with spherical structure is 79.6 kPa (0.25 N). The force sensing sensitivity of the sensor $S = - 5.733\times 10^{-4}$ kPa $^{-1}$ (from 0 to 799.4 kPa) and $S = - 1.744\times 10^{-4}$ kPa $^{-1}$ (from 799.4 to 2834.4 kPa). Furthermore, an air gap between the high-impedance and the low-impedance elements was designed for restraining the interference of adjacent sensor arrays. Finally, we demonstrated the application in teleoperation and letter recognition, which implies that the proposed sensor has a great application potential in the field of robotics.

C27H26N9O10Pr, monoclinic, P21/c, a= 13.2280(12) Å, b= 5.5628(5) Å, c= 41.140(3) Å, β= 105.109(2)°, V= 2922.6(4) Å3, Z= 4, Rgt(F) = 0.0426, wRref(F2) = 0.0803, T= 298.15 K.

The Jurassic magmatism in the southeastern South China Block has been interpreted as extension-related, yet its tectonic drivers remain unclear. Tectonic models vary between two end-members: (1) Palaeopacific subduction-related; and (2) intracontinental extension-related. This study presents new geochronological and geochemical data for the Late Jurassic mafic rocks in the southeastern South China Block that allow us to differentiate between these tectonic models. The Late Jurassic mafic rocks yielded crystallization ages of 162–157 Ma. Our new geochemical data, together with previously published data, can be divided into three groups: group A with variable ε Nd(t) (+0.1 to +3.4) and zircon ε Hf(t) (−4.1 to +15.9) values has slightly negative Nb–Ta anomalies; group B is characterized by negative Nb–Ta anomalies with varying ε Nd(t) (+1.4 to +1.5) and ε Hf(t) (–3.0 to +2.6) values; and group C displays significant Nb–Ta anomalies with high ε Nd(t) (+4.5 to +6.6) and ε Hf(t) (+6.4 to +14.4) values. The geochemical characteristics suggest that groups A and B are mainly the products of asthenosphere–lithosphere interactions and group C was derived from the asthenosphere. Our new data, together with geological observations, suggest that the Late Jurassic magmatism in the southeastern South China Block probably resulted from asthenospheric upwelling in an intracontinental extension setting due to the far-field effects of the subduction of the Palaeopacific Ocean. Supplementary material: Tables of geochronological data, geochemical data, and additional figures are available at https://doi.org/10.6084/m9.figshare.c.6080871 [ABSTRACT FROM AUTHOR]

The Prototethyan Ocean has been suggested as an Early Paleozoic Ocean developed at the Gondwana northern margin. However, its spatial pattern, subduction style and closure time in SW Yunnan and SE Asia still remain unknown. The Prototethyan evolution in SW Yunnan and SE Asia and its internal connection with the South China Kwangsian (Ordo-Silurian) intracontinental orogenesis are also poorly constrained. By summarizing and analyzing the Early Paleozoic geological records in the Sibumasu and Indochina blocks, the eastern South China and SW Japan, this paper proposes the existence of a giant Ordo-Silurian igneous belt along the Gondwana northern margin. A preliminary limitation has been obtained regarding the source nature and migration pattern of the igneous belt. Our data allow us to propose a model of the Early Paleozoic Andean-type active continental margin along the East Gondwana northern margin. This is the foundation to determine the southward subduction of the southern branch of the eastern Prototethyan Ocean underneath the Sibumasu and Indochina blocks along the Yunxian-Menghai (SW Yunnan)-Thailand Peninsula and the Tam Ky-Phouc Son suture in Central Vietnam, respectively, and the eastward linkage with the Early Paleozoic Osaka subduction zone in SW Japan across the peripheral Sanya area. These data synthetically indicate an easterly-diachronous andpropagating Andean-type Cambrian (Furongian)-Silurian (Llandovery) orogenesis along the Gondwana northern margin from Nepal, NW India, South Tibet, Qiangtang to Central Vietnam across South Indochina and Sibumasu. This paper reconstructs the Early Paleozoic locations of the Sibumasu and Indochina fragments, as well as SW Japan and South China continent in the Gondwana northern margin, and proposes the far-field effect on the South China Kwangsian intra-continental orogenesis from the subduction of the Early Paleozoic Prototethyan southern branch.

Long-term continuous monitoring (LTCM) of water quality can provide high-fidelity datasets essential for executing swift control and enhancing system efficiency. One roadblock for LTCM using solid-state ion-selective electrode (S-ISE) sensors is biofouling on the sensor surface, which perturbs analyte mass transfer and deteriorates the sensor reading accuracy. This study advanced the anti-biofouling property of S-ISE sensors through precisely coating a self-assembled channel-type zwitterionic copolymer poly(trifluoroethyl methacrylate-random-sulfobetaine methacrylate) (PTFEMA-r-SBMA) on the sensor surface using electrospray. The PTFEMA-r-SBMA membrane exhibits exceptional permeability and selectivity to primary ions in water solutions. NH4+S-ISE sensors with this anti-fouling zwitterionic layer were examined in real wastewater for 55 days consecutively, exhibiting sensitivity close to the theoretical value (59.18 mV/dec) and long-term stability (error <4 mg/L). Furthermore, a denoising data processing algorithm (DDPA) was developed to further improve the sensor accuracy, reducing the S-ISE sensor error to only 1.2 mg/L after 50 days of real wastewater analysis. Based on the dynamic energy cost function and carbon footprint models, LTCM is expected to save 44.9% NH4+discharge, 12.8% energy consumption, and 26.7% greenhouse emission under normal operational conditions. This study unveils an innovative LTCM methodology by integrating advanced materials (anti-fouling layer coating) with sensor data processing (DDPA).

• Uniform CsPbBr 3 QDs with diameter of 12-18 nm were obtained via heat injection method quickly. • Electrical and thermal properties were improved by Cs doping and QDs embedding synchronously. • The PF of CsPbBr 3 QDs/HMS composite was enhanced owing to the combined effect of element doping and energy filtering. • The κ l decreased ∼22% because of the broadband phonon scattering effect that resulted from the Cs doping and QDs inclusions. • A high zT value of 0.57 at 823 K is was achieved in CsPbBr 3 QDs/HMS composites. Higher manganese silicide (HMS) is a P-type medium temperature thermoelectric (TE) material, which has attracted widespread attention over the past few decades due to its remarkable mechanical properties, excellent chemical and thermal stability, as well as the non-toxicity, abundance and competitive price. The peak power factor (PF) of HMS is as high as ∼1.50 × 10−3 W m−1 K−2 because of its intrinsic high electrical conductivity and Seebeck coefficient. However, the thermal conductivity of HMS is also high, resulting in relatively low zT values. Introducing nano-dispersion in the matrix is one of the most effective methods to enhance the TE properties via reducing the lattice thermal conductivity significantly without drastic changes on the other parameters. In this study, CsPbBr 3 QDs with uniform size were synthesized and introduced into HMS bulks. The PF (at 823 K) was enhanced to 1.71 × 10−3 W m−1 K−2, which is improved 14.0% approximately compared with that of pure HMS owing to the combined effect of element doping and energy filtering. The lattice thermal conductivity (at 823 K) decreased from 2.56 W m−1 K−1 to 1.99 W m−1 K−1 synchronously (∼22.0%) due to the intensive phonon scattering caused by Cs doping, and the embedding of Pb riched CsPbBr 3 QDs and Pb QDs. A maximum zT value of 0.57 (823 K) is achieved in CsPbBr 3 QDs/HMS composites, which is 36.0% higher than that of pure HMS. Predictably, for other TE materials, it is also feasible to improve the TE properties via introducing metastable quantum dots. The zT value of HMS increased from 0.42 to 0.57 (∼36.0%) via introducing CsPbBr 3 QDs. The PF (at 823 K) was enhanced to 1.71 × 10−3 W m−1 K−2, which is improved 14.0% approximately compared with that of pure HMS owing to the combined effect of element doping and energy filtering. The lattice thermal conductivity (at 823 K) decreased from 2.56 W m−1 K−1 to 1.99 W m−1 K−1 synchronously (∼22.0%) due to the intensive phonon scattering caused by Cs doping, and the embedding of Pb riched CsPbBr 3 QDs and Pb QDs. Introducing metastable QDs into matrix is a novel and feasible means to enhance the zT , which is probably applicable to other materials. [Display omitted] [ABSTRACT FROM AUTHOR]

ABSTRACTCircular RNA (circRNA) plays an important role in cancer progression. Here, we investigated the function of circ_0086414 in the malignant progression of esophageal cancer (EC). RNA expression of circ_0086414, microRNA-1290 (miR-1290), and SPARC like 1 (SPARCL1) was detected by quantitative real-time polymerase chain reaction. The protein levels of N-cadherin, E-cadherin, and SPARCL1were checked by Western blotting analysis. Cell proliferation was investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 5-Ethynyl-29-deoxyuridine (EdU), and cell colony formation assays. Cell invasion and apoptosis were analyzed by transwell invasion assay and flow cytometry analysis, respectively. Glycolysis was evaluated by analyzing glucose consumption and lactate production. In an xenograft mouse model, the effect of circ_0086414 on tumor tumorigenesis was investigated. The interactions among circ_0086414, miR-1290, and SPARCL1were identified by dual-luciferase reporter and RNA pull-down assays. Results showed that circ_0086414 and SPARCL1expression were significantly downregulated, while miR-1290 was upregulated in EC tissues and cells. EC patients with low circ_0086414 expression had a poor prognosis. Increasing circ_0086414 expression led to decreased EC cell proliferation, invasion and glycolysis and increased cell apoptosis, accompanied by a decrease of N-cadherin expression and an increase of E-cadherin expression. Also, the enforced expression of circ_0086414 delayed tumor tumorigenesis. Besides, circ_0086414 acted as a miR-1290 sponge and regulated EC cell processes by binding to the miRNA. MiR-1290 also participated in EC malignant progression through SPARCL1. Further, circ_0086414 stimulated SPARCL1production by negatively regulating miR-1290. Thus, circ_0086414 inhibited EC cell malignancy through the miR-1290/SPARCL1pathway, providing a reliable target for the therapy of EC.

Accurate and continuous monitoring of soil nitrogen is critical for determining its fate and providing early warning for swift soil nutrient management. However, the accuracy of existing electrochemical sensors is hurdled by the immobility of targeted ions, ion adsorption to soil particles, and sensor reading noise and drifting over time. In this study, polyacrylamide hydrogel with a thickness of 0.45 μm was coated on the surface of solid-state ion-selective membrane (S-ISM) sensors to absorb water contained in soil and, consequently, enhance the accuracy (R2> 0.98) and stability (drifting < 0.3 mV/h) of these sensors monitoring ammonium (NH4+) and nitrate (NO3−)ions in soil. An ion transport model was built to simulate the long-term NH4+dynamic process (R2> 0.7) by considering the soil adsorption process and soil complexity. Furthermore, a soil-based denoising data processing algorithm (S-DDPA) was developed based on the unique features of soil sensors including the nonlinear mass transfer and ion diffusion on the heterogeneous sensor–hydrogel–soil interface. The 14 day tests using real-world soil demonstrated the effectiveness of S-DDPA to eliminate false signals and retrieve the actual soil nitrogen information for accurate (error: <2 mg/L) and continuous monitoring.

Phytohormone signalling pathways have an important role in defence against pathogens mediated by cell-surface pattern recognition receptors and intracellular nucleotide-binding leucine-rich repeat class immune receptors1,2(NLR). Pathogens have evolved counter-defence strategies to manipulate phytohormone signalling pathways to dampen immunity and promote virulence3. However, little is known about the surveillance of pathogen interference of phytohormone signalling by the plant innate immune system. The pepper (Capsicum chinense) NLR Tsw, which recognizes the effector nonstructural protein NSs encoded by tomato spotted wilt orthotospovirus (TSWV), contains an unusually large leucine-rich repeat (LRR) domain. Structural modelling predicts similarity between the LRR domain of Tsw and those of the jasmonic acid receptor COI1, the auxin receptor TIR1 and the strigolactone receptor partner MAX2. This suggested that NSs could directly target hormone receptor signalling to promote infection, and that Tsw has evolved a LRR resembling those of phytohormone receptors LRR to induce immunity. Here we show that NSs associates with COI1, TIR1 and MAX2 through a common repressor—TCP21—which interacts directly with these phytohormone receptors. NSs enhances the interaction of COI1, TIR1 or MAX2 with TCP21 and blocks the degradation of corresponding transcriptional repressors to disable phytohormone-mediated host immunity to the virus. Tsw also interacts directly with TCP21 and this interaction is enhanced by viral NSs. Downregulation of TCP21 compromised Tsw-mediated defence against TSWV. Together, our findings reveal that a pathogen effector targets TCP21 to inhibit phytohormone receptor function, promoting virulence, and a plant NLR protein has evolved to recognize this interference as a counter-virulence strategy, thereby activating immunity.

The combination of vascular endothelial growth factor (VEGF) inhibitors and tyrosine kinase inhibitors (TKIs) is newly available for molecular targeted therapy against non-small cell lung cancer (NSCLC) in clinic. However, the therapeutic benefits remain unsatisfying due to the poor drug delivery to targets of interest. In this study, we developed bevacizumab-coated gefitinib-loaded nanoparticles (BCGN) with dual-responsive drug release for inhibiting tumor angiogenesis and phosphorylation of epidermal growth factor receptor (EGFR). Through an exogenous corona strategy, bevacizumab is easily coated on gefitinib-loaded nanoparticles via electrostatic interaction. After intravenous injection, BCGN are efficiently accumulated in NSCLC tumors as confirmed by dual-model imaging. Bevacizumab is released from BCGN upon oxidation in tumor microenvironment, whereas gefitinib is released after being internalized by tumor cells and disassembled in reduction cytoplasm. The dual-responsive release of bevacizumab and gefitinib significantly inhibits tumor growth in both A549 and HCC827 human NSCLC models. Our approach provides a promising strategy to improve combinational molecular targeted therapy of NSCLC with precisely controlled drug release.

Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound 8m, with the best DHPS inhibitory potency (IC50= 0.014 μM), exhibited excellent inhibition against melanoma cells, which was superior to that of GC7. Besides, molecular docking and molecular dynamics (MD) simulations further proved that compound 8mwas tightly bound to the allosteric site of DHPS. Flow cytometric analysis and enzyme-linked immunosorbent assay (ELISA) showed that compound 8mcould inhibit the intracellular reactive oxygen species (ROS) level. Furthermore, by western blot analysis, compound 8meffectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. Moreover, both Transwell analysis and wound healing analysis showed that compound 8mcould inhibit the invasion and migration of melanoma cells. In the in vivostudy, the tumor xenograft model showed that compound 8meffectively inhibited melanoma development with low toxicity.

Heterojunction plays an important role in enhancing the photocatalysis performance of materials. In this paper, van der Waals g-C3N4/BiLuWO6heterojunction forms a Z-scheme energy band configuration through interlayer binding energy, energy band, work function, and charge density difference calculations. Photogenerated electrons transfer from the conduction band (CB) of g-C3N4to the valence band (VB) of BiLuWO6. Based on theoretical predictions, 13 heterojunctions were synthesized and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS) mapping, X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Photocurrent response, impedance, Mott–Schottky curve, and free radical tests further confirm the rapid separation of the photogenerated carriers in the n-type g-C3N4/BiLuWO6heterojunction. Degradation efficiencies of rhodamine B (RhB) and methylene blue (MB) are 93 and 85% under mercury lamp irradiation, respectively. The values are higher than 50 and 64% for g-C3N4as well as 14 and 8% for BiLuWO6. Except for pollutant degradation, the H2evolution rate of the heterojunction is 289.08 μmol/g/h using xenon lamp irradiation, which is higher than 161.08 μmol/g/h of g-C3N4and 13.13 μmol/g/h of BiLuWO6. The decomposition path of RhB and the improved mechanism of H2production activity are revealed by high-performance liquid chromatography–mass spectrometry (HPLC–MS) and Gibbs free energy analysis.

Materials with ultrahigh or low thermal conductivity are desirable for many technological applications, such as thermal management of electronic and photonic devices, heat exchangers, energy converters and thermal insulation. Recent advances in simulation tools (first principles, the atomistic Green’s function and molecular dynamics) and experimental techniques (pump–probe techniques and microfabricated platforms) have led to new insights on phonon transport and scattering in materials and the discovery of new thermal materials, and are enabling the engineering of phonons towards desired thermal properties. We review recent discoveries of both inorganic and organic materials with ultrahigh and low thermal conductivity, highlighting heat-conduction physics, strategies used to change thermal conductivity, and future directions to achieve extreme thermal conductivities in solid-state materials.

Early Paleozoic trondhjemites, gneissic granites and alkali granites in southern Yunnan preserve important records of the tectonic evolution of the Prototethyan Ocean and regional correlations. Zircon ages suggest that these granitoids were emplaced from 476 to 436 Ma. The trondhjemites are characterized by high Na2O and low K2O contents, with εNd(t) values of −1.9 to −3.5 and εHf(t) values of −2.8 to +3.9. The trondhjemites were derived from an amphibolite source with a juvenile mafic component. The gneissic granites belong to the metaluminous low-K calc-alkaline series with an εNd(t) value of −6.2 and εHf(t) values of −5.0 to −0.4. The alkali granites belong to the high-K calc-alkaline series and yield εNd(t) values of −10.1 to −10.7 and εHf(t) values of −7.9 to −2.3. The gneissic granites were derived from an 'ancient' lower mafic crust, whereas the alkali granites were derived from a meta-sedimentary source. These granitoids were formed during the subduction of the Prototethyan Ocean beneath the Simao Block and can be compared with similar igneous rocks from the Truong Son and Tam Ky-Phuoc Son zones in southern Laos. Our study, along with Early Paleozoic igneous suites from southern Laos, central Vietnam and the Malay Peninsula, suggests an arc–back-arc system along the northern margin of Gondwana. Supplementary material: Tables of zircon U–Pb and in-situ Hf and geochemical data are available at https://doi.org/10.6084/m9.figshare.c.5322386 [ABSTRACT FROM AUTHOR]

A stab-resistant substrate was designed and realized with a triangular pyramidal structure, inspired by the biological armor model in nature. The stab-resistance behavior and dynamic response mechanisms were studied through numerical simulation and experimental testing of a knife impacting a substrate, and an optimal structural design was obtained accordingly, with a tilted angle of 22.5° and optimal thickness of 1.2 mm. It was shown that the triangular pyramidal structure generated twice the internal energy of the knife than the flat substrate due to the dispersing effect of the structure. The force parallel to the inclination caused a significant scratch on the substrate surface, while the force perpendicular caused obvious substrate deformation. A new riveting method was used to form the total layer, which passed the GA 68–2008 standard. The stab-resistant clothing coupled with the reduced wearing burden could provide effective protection and avoid fatal injuries on security personnel working in dangerous environments. The method provided may enlighten the future design and manufacturing of stab-resistant clothing.

Capacitive deionization (CDI) is a promising cost-effective and low energy consumption technology for water desalination. However, most of the previous works focus on only one side of the CDI system, i.e., Na+ion capture, while the other side that stores chloride ions, which is equally important, receives very little attention. This is attributed to the limited Cl–storage materials as well as their sluggish kinetics and poor stability. In this article, we demonstrate that a N-doped porous carbon framework is capable of suppressing the phase-transformation-induced performance decay of bismuth, affording an excellent Cl–storage and showing potential for water desalination. The obtained Bi-carbon composite (Bi/N-PC) shows a capacity of up to 410.4 mAh g–1at 250 mA g–1and a high rate performance. As a demonstration for water desalination, a superior desalination capacity of 113.4 mg g–1is achieved at 100 mA g–1with excellent durability. Impressively, the CDI system exhibits fast ion capturing with a desalination rate as high as 0.392 mg g–1s–1, outperforming most of the recently reported Cl–capturing electrodes. This strategy is applicable to other Cl–storage materials for next-generation capacitive deionization.

Variable valence oxides of the perovskite crystal structure have emerged as promising candidates for solar hydrogen production via two-step thermochemical cycling. Here, we report the exceptional efficacy of the perovskite CaTi0.5Mn0.5O3–δ(CTM55) for this process. The combination of intermediate enthalpy, ranging between 200 and 280 kJ (mol-O)−1, and large entropy, ranging between 120 and 180 J (mol-O)−1K−1, of CTM55 create favorable conditions for water splitting. The oxidation state changes are dominated by Mn, with Ti stabilizing the cubic phase and increasing its reduction enthalpy. A hydrogen yield of 10.0 ± 0.2 mL g−1is achieved in a cycle between 1,350°C (reduction) and 1,150°C (water splitting) and a total cycle time of 1.5 h, exceeding all previous fuel production reports. The gas evolution rate suggests rapid material kinetics, and, at 1,150°C and higher, a process primarily limited by the magnitude of the thermodynamic driving force.

Production of high-purity hydrogen by thermal-electrochemical decomposition of ammonia at an intermediate temperature of 250°C is demonstrated. The process is enabled by use of a solid-acid-based electrochemical cell (SAEC) in combination with a bilayered anode, comprising a thermal-cracking catalyst layer and a hydrogen electrooxidation catalyst layer. Cs-promoted Ru on carbon nanotubes (Ru/CNT) serves as the thermal decomposition catalyst, and Pt on carbon black mixed with CsH2PO4is used to catalyze hydrogen electrooxidation. Cells were operated at 250°C with humidified dilute ammonia supplied to the anode and humidified hydrogen supplied to the counter electrode. A current density of 435 mA/cm2was achieved at a potential of 0.4 V and ammonia flow rate of 30 sccm. With a demonstrated faradic efficiency for hydrogen production of 100%, the process yields hydrogen at a rate of 1.48 molH2/gcath.

Two-step, solar thermochemical splitting of water using nonstoichiometric redox-active metal oxides has emerged as an intriguing approach for large-scale hydrogen production. Perovskites have been proposed as alternatives to state-of-the-art fluorite CeO2−δbecause of their potential for lowering reduction temperature while maintaining high fuel productivity. Guided by computational insights, we explore the thermodynamic properties and water splitting efficacy of the cubic perovskite SrTi0.5Mn0.5O3−δ(STM55). Thermogravimetric analysis is performed under controlled oxygen partial pressures (pO2) and temperatures up to 1500 °C, from which both the enthalpy and entropy of reduction as a function of oxygen nonstoichiometry are determined. STM55 provides an attractive combination of moderate enthalpy, 200–250 kJ (mol-O)−1, and high entropy, with unusual δ dependence. Using a water splitting cycle in which the material is thermally reduced at 1350 °C (pO2, ∼10–5atm) and subsequently exposed to steam at 1100 °C (steam partial pressure of pH2O = 0.4 atm), we demonstrate a hydrogen yield of 7.4 mL g–1. Through both half-cycles, the material remains largely in quasi-equilibrium with the gas phase, as reflected in the agreement of the measured data with predicted profiles based on the thermodynamic data. This behavior indicates rapid surface and bulk diffusion kinetics. Cyclic operation showed the material to be free of degradation and always resulted in a 2:1 yield of H2/O2. Overall, STM55 provides outstanding performance characteristics for thermochemical hydrogen production.

The Cretaceous igneous rocks in the South China Block (SCB) were associated with the slab subduction and roll-back of the Pacific Plate. Thus, they provide excellent opportunities to examine the spatial–temporal geochemical migration of magmatism in the retreating subduction margins. The Cretaceous mafic–intermediate igneous rocks from the southeastern SCB were aged between 142 and 71 Ma, and can geochemically be subdivided into three groups: Group A (126–129 Ma and 83–93 Ma), Group B (126–142 Ma and 71–108 Ma) and Group C (116–142 Ma and 70–110 Ma). Group A and B were mainly distributed in the SCB interior and derived from asthenosphere and asthenosphere–lithosphere interaction sources, respectively. Group C occurred to the east of the Ganjiang Fault and originated from slab–lithosphere interaction. From the coastal provinces to the interior, these mafic–intermediate igneous rocks show increasing incompatible element ratios and Nd isotopic compositions, reflective of a westerly decreasing involvement of slab-derived components. They show two similar age-pulses at c. 125 Ma and c. 90 Ma as well as the Cretaceous A-type granites, indicating two episodes of subduction retreat of the Pacific slab during the Cretaceous. This spatial–temporal pattern of the Cretaceous mafic–intermediate igneous rocks suggests that the Cretaceous slab metasomatism of Pacific subduction retreat was limited to the east of the Ganjiang Fault. Supplementary material: Tables of geochemical data and additional figures are available at https://doi.org/10.6084/m9.figshare.c.4938576 [ABSTRACT FROM AUTHOR]

Coarse-grained molecular dynamics simulations were performed to investigate the mobility of nanoparticles (NPs) embedded in end-linked polymer networks, considering both the entangled and unentangled cases. For the entangled case, where the network strand length Nxis longer than the entanglement length Ne, the strand dynamics exhibits a heavily entangled subdiffusive feature before being restricted within the fluctuation distance dfluctby the permanent cross-links. The dynamics of NPs with size dNPsmaller than the entanglement tube length dTin such network follows the same behavior as that in entangled linear polymers, while for NPs with size comparable to dT, their motion is suppressed by the entanglements. The constraint release of the entanglements would allow the particles to pass through but is slightly restricted by the permanent network junctions. For the unentangled case, where Nx/Ne< 1, the network strands can move only locally with suppressed subdiffusive behavior due to the restrictions imposed by the adjacent network junctions. Consequently, the coupled NP dynamics is also reduced. In addition, when dNPis larger than the strand fluctuation distance dfluct, the NPs are trapped by the network cages and can diffuse at long times through hopping, which is partially masked by the NP thermal fluctuations, as reflected from the NP trajectories. Such hopping fashion of NP motion becomes more apparent with increasing the network confinement ratio before being permanently localized within the network. Increasing the NP–polymer attraction would further hamper the NP mobility. In general, this work provides some insights into understanding how the permanent cross-links affect the network dynamics and thereby the coupled NP mobility.

The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are 2 markers of inflammation, which are associated with worse cardiovascular disease outcomes. Here, we aimed to determine the association between these ratios and disease severity and evaluate predictive validity of the NLR and PLR in lower limb arteriosclerosis obliterans (ASO).

Radiotherapy (RT) is one of the most widely used cancer treatments in the clinical setting, while hypoxia-associated resistance often occurs. Herein, a PEGylated TaOx-based oxygen-carrying nanoplatform was constructed for triple sensitizing tumor radiotherapy. The high-Z element based hollow mesoporous TaOx nanospheres were prepared following the in situ growth of ultrasmall CuS nanocrystals and then packaged with O2-saturated perfluoropentane (PFP). NIR laser-triggered mild hyperthermia would lead to the increase of intratumoral blood flow, together with the release of O2, the radiotherapeutic efficiency would be enhanced. Alternatively, radiant energy would be deposited inside the tumor by the Ta element, therefore triple sensitization of radiotherapy could be achieved. The in vivo studies showed that the as-prepared nanospheres could achieve almost total inhibition of tumor growth without obvious side effects, which provides new possibilities for multisensitizing tumor radiotherapy.

The escalating global prevalence of depression demands effective therapeutic strategies, with psychobiotics emerging as a promising solution. However, the molecular mechanisms governing the neurobehavioral impact of psychobiotics remain elusive. This study reveals a significant reduction in hippocampal indole-3-lactic acid (ILA) levels in depressed mice, which is ameliorated by the psychobiotic Bifidobacterium breve. In both human subjects and mice, the ILA increase in the circulatory system results from bifidobacteria supplementation. Further investigation identifies the key aromatic lactate dehydrogenase (Aldh) gene and pathway in bifidobacteria responsible for ILA production. Importantly, the antidepressant effects are nullified in the Aldhmutants compared to the wild-type strain. At the bifidobacteria species level, those with Aldhexhibit heightened antidepressant effects. Finally, this study emphasizes the antidepressant efficacy of psychobiotic-derived ILA, potentially mediated by aryl hydrocarbon receptor (AhR) signaling activation to alleviate neuroinflammation. This study unveils the molecular and genetic foundations of psychobiotics’ antidepressant effects, offering insights for microbial therapies targeting mood disorders.

Renal tubular ectopic lipid deposition (ELD) plays a significant role in the development of chronic kidney disease, posing a great threat to human health. The present work aimed to explore the intervention effect and potential molecular mechanism of a purified tea polysaccharide (TPS3A) on renal tubular ELD. The results demonstrated that TPS3A effectively improved kidney function and slowed the progression of tubulointerstitial fibrosis in high-fat-diet (HFD)-exposed ApoE–/–mice. Additionally, TPS3A notably suppressed lipogenesis and enhanced lipolysis, as shown by the downregulation of lipogenesis markers (SREBP-1 and FAS) and the upregulation of lipolysis markers (HSL and ATGL), thereby reducing renal tubular ELD in HFD-fed ApoE–/–mice and palmitic-acid-stimulated HK-2 cells. The AMPK-SIRT1-FoxO1 axis is a core signal pathway in regulating lipid deposition. Consistently, TPS3A significantly increased the levels of phosphorylated-AMPK, SIRT1, and deacetylation of Ac-FoxO1. However, these effects of TPS3A on lipogenesis and lipolysis were abolished by AMPK siRNA, SIRT1 siRNA, and FoxO1 inhibitor, resulting in exacerbated lipid deposition. Taken together, TPS3A shows promise in ameliorating renal tubular ELD by inhibiting lipogenesis and promoting lipolysis through the AMPK-SIRT1-FoxO1 signaling pathway.

High ambient temperature is a major environmental stressor affecting poultry production, especially in the tropical and subtropical regions of the world. Nutritional interventions have been adopted to combat thermal stress in poultry, including the use of amino acids. L-citrulline is a nonessential amino acid that is involved in nitric oxide generation and thermoregulation, however, the molecular mechanisms behind L-citrulline's regulation of body temperature are still unascertained. This study investigated the global gene expression in the hypothalamus of chickens fed either basal diet or L-citrulline-supplemented diets under different housing temperatures. Ross 308 broilers were fed with basal diet (CON) or 1% L-citrulline diet (LCT) from day-old, and later subjected to 2 environmental temperatures in a 2 by 2 factorial arrangement as follows; basal diet-fed chickens housed at 24°C (CON-TN); L-citrulline diet-fed chickens housed at 24°C (LCT-TN); basal diet-fed chickens housed at 35°C (CON-HS), and L-citrulline diet-fed chickens housed at 35°C (LCT-HS) from 22 to 42 d of age. At 42-days old, hypothalamic tissues were collected for mRNA analyses and RNA sequencing. A total of 1,019 million raw reads were generated and about 82.59 to 82.96% were uniquely mapped to genes. The gene ontology (GO) term between the CON-TN and LCT-TN groups revealed significant enrichments of pathways such as central nervous system development, and Wnt signaling pathway. On the other hand, GO terms between the CON-HS and LCT-HS groups revealed enrichments in the regulation of corticosteroid release, regulation of feeding behavior, and regulation of inflammatory response. Several potential candidate genes were identified to be responsible for central nervous system development (EMX2, WFIKKN2, SLC6A4 Wnt10a, and PHOX2B), and regulation of feed intake (NPY, AgRP, GAL, POMC, and NMU) in chickens. Therefore, this study unveils that L-citrulline can influence transcripts associated with brain development, feeding behavior, energy metabolism, and thermoregulation in chickens raised under different ambient temperatures.

Few studies have focused on the association between previous particulate matter (PM) exposure and antioxidant defense response to a haze challenge. In this study, a combined exposure model was used to investigate whether and how PM exposure history affected the antioxidant defense response to haze episodes. At first, C57BL/6 male mice were randomly assigned to three groups and exposed for 5 weeks to whole ambient air, ambient air containing a low (≤75 μg/m3) PM concentration, and filtered air, which simulated different exposure history of high, relatively low, and almost zero PM concentrations. Thereafter, all mice underwent a 3-day haze exposure followed by a 7-day exposure to filtered air. The indexes involved in the primary and secondary antioxidant defense response were determined after pre-exposure and haze exposure, as well as 1 day, 3 days, and 7 days after haze exposure. Our research demonstrated repeated exposure to a high PM concentration compromised the antioxidant defense response and was accompanied by an increased susceptibility to a haze challenge. Conversely, mice with a lower PM exposure developed an oxidative stress adaption that protected them against haze challenge more efficiently and in a more timely manner than was the case in mice without PM exposure history.

Lifestyle interventions can delay the onset of type 2 diabetes in people with impaired glucose tolerance, but whether this leads subsequently to fewer complications or to increased longevity is uncertain. We aimed to assess the long-term effects of lifestyle interventions in people with impaired glucose tolerance on the incidence of diabetes, its complications, and mortality.

During the on-orbit operation of BeiDou satellites, the on board atomic clocks of these satellites are easily affected by changes in the space environment. Since the clock offsets of BeiDou satellites derived from multi-satellite clock estimation exhibit correlation among one another. In this study, the correlation among the clock offsets of BeiDou satellites is analyzed and the influence of correlation among satellites on clock offset prediction accuracy is investigated. To obtain accurate analysis results, the Baarda outlier detection method is initially improved. The improved method can effectively eliminate small errors in clock offset data. Then, the correlation coefficient among BeiDou satellites is calculated, and the method based on the correlation among BeiDou satellite clocks is used to predict the clock offsets of the satellites. Experimental results show that clock offset prediction accuracy can be improved by 7.3% compared with that of the traditional method when the method that considers correlation among satellite clocks is used.