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In the wake of the East Palestine derailment and an unsuccessful takeover bid, US Class 1 Norfolk Southern is working hard to improve service delivery and become the industry standard [...]

While the Middle Corridor through Kazakhstan, Azerbaijan and Georgia has been receiving increased attention as an alternative route for containers moving between China and Europe, a recent World Bank report [...]

Objective. Motivation is critically important for rehabilitation, exercise, and motor performance, but its neural basis is poorly understood. Recent correlational research suggests that the dorsomedial prefrontal cortex (dmPFC) may be involved in motivation for walking activity and/or descending motor output. This study experimentally evaluated brain activity changes in periods of additional motivation during walking exercise and tested how these brain activity changes relate to self-reported exercise motivation and walking speed. Methods. Adults without disability (N = 26; 65% women; 25 [standard deviation = 5] years old) performed a vigorous exercise experiment involving 20 trials of maximal speed overground walking. Half of the trials were randomized to include "extra-motivation" stimuli (lap timer, tracked best lap time, and verbal encouragement). Wearable near-infrared spectroscopy measured oxygenated hemoglobin responses from frontal lobe regions, including the dmPFC, primary sensorimotor, dorsolateral prefrontal, anterior prefrontal, supplementary motor, and dorsal premotor cortices. Results. Compared with standard trials, participants walked faster during extra-motivation trials (2.43 vs 2.67 m/s; P Conclusion. Simple motivational stimuli during walking exercise seem to upregulate widespread brain regions. Results suggest that dmPFC may be a key brain region linking affective signaling to motor output. Impact. These findings provide a potential biologic basis for the benefits of motivational stimuli, elicited with clinically feasible methods during walking exercise. Future clinical studies could build on this information to develop prognostic biomarkers and test novel brain stimulation targets for enhancing exercise motivation (eg, dmPFC). Keywords: Aerobic Exercise, Behavior Regulation, Brain, fNIRS, Gait, Locomotion, Introduction Human motor behavior emerges from the interaction between environmental and individual constraints that are further bounded by a task goal. (1-7) Motivation is a critical constraint to consider in [...]

Britain's infrastructure manager is spending 2.8bn [pounds sterling] over the next five years to mitigate the impact on its network of climate change and the extreme weather that it produces. [...]

The European technical specification for signalling and train control systems has been recast to support greater cross-border interoperability through the deployment of ERTMS, while making provision for ETCS enhancements that [...]

The International Association of Public Transport has produced a report setting out how operators can improve user experience at every stage of a passenger's journey through a station. Robert Preston [...]

The Channel Tunnel infrastructure manager is working to double the number of destinations that can be reached from London by high-speed rail. Robert Preston speaks exclusively to Eurotunnel's rail network [...]

The European Parliament is currently considering a proposed regulation on rail Infrastructure capacity that alms to eliminate differences in national practice and make better use of existing capacity, particularly for [...]

A simpler and more affordable alternative to the power and data transmission functions of the Digital Automatic Coupler has been developed by Railfreight Consulting of Britain. Robert Preston spoke to [...]

Imagine que su PC con Windows hiciera capturas de pantalla de todo lo que hace en él, incluidos datos personales, tarjetas de crédito y otra información financiera, contraseñas, inicios de [...]

In this interview, Michael S. Leapman, MD, MHS, and Preston C. Sprenkle, MD, discuss the study 'Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage,' (1) for which [...]

IN July, Skoda Group achieved two major milestones in its long-term programme to bring automatic train operation (ATO) to the light rail environment. The company is working to develop a [...]

INNOTRANS in Berlin this year will be marked by the world premiere of the RS Zero, as Stadler unveils the prototype of its new zero-emission train for regional and local [...]

Ultrasonic gauge technology has evolved to simplify measurement of very thin layers in plastic containers. Today's gauges with high-frequency capabilities and specialized software can make multilayer container measurement quick and [...]

How Europe is making progress with developing satellite technology for more cost-effective secure communications and train location under ERTMS was debated at the Space for Innovation in Rail conference held [...]

The British rail industry has warned of the long-term consequences of the government's decision to cancel the remaining sections of the high-speed project to Manchester and Leeds. Robert Preston reports. [...]

Irish Rail is embarking on a programme of electrification and route upgrades to enable the Dublin Area Rapid Transit network to handle up to 62,000 passengers per hour by 2030. [...]

EMERGING intact from the Covid-19 pandemic, RATP Dev suffered 'a massive shock,' according to its CEO, Ms Hiba Fares. 'Our profit and loss is mostly about labour and energy, we [...]

I love attending events as a photographer--you get to capture all the natural atmosphere and unique moments and add an element of storytelling. My personal experience of the military only [...]

Five years of work led by the International Union of Railways (UIC) to develop a successor to GSM-R are bearing fruit, with physical trials now underway of the first elements [...]

Fifty years ago, in July 1973, providing care to patients with end stage kidney disease changed dramatically with the implementation of legislation (PL 92-603) that deemed chronic renal disease to be a disability and provided coverage under Medicare for the treatment of the disease. In this article, we discuss the impact of the implementation of PL 92-603. Keywords: End stage kidney disease, Medicare, legislation, chronic kidney disease, chronic renal disease., In October 2022, the kidney community recognized the 50th anniversary of the passage of PL 92-603, which deemed chronic renal disease to be a disability and extended Medicare coverage for [...]

In April 2023, New York Mayor Eric Adams gave an unusually testy press conference about the Biden administration's border policies. Over the previous year, more than 57,000 asylum seekers had [...]

Bad, bawdy and bankable during its 1880s heyday, Colorado City blossomed as one of the Lone Star State's major cattle towns, only to wilt away within the decade like a [...]

Las grandes empresas tecnológicas no suelen construirse únicamente de su tecnología. Con frecuencia, también adquieren prominencia y éxito gracias a las hazañas o personalidades de sus fundadores o líderes. Bill [...]

Microsoft is sitting on top of the world right now, thanks to its lead in AI. It’s the most valuable company on the planet, with a valuation of more than [...]

Loose cannon, always-looking-for-attention Elon Musk has again thrust himself into the public eye, https://www.computerworld.com/article/3713188/elon-musk-sues-openai-alleging-breach-of-founding-agreement.html for breaching its founding agreement by turning the company away from its non-profit roots and cashing [...]

Autor(en): Preston Gralla Microsoft OneNote und Evernote verfolgen unterschiedliche Ansätze in ihrem Bestreben um die Vorherrschaft unter den Notiz-Apps. Geht es um die richtige Notiz-App, fällt die Entscheidung im Regelfall [...]

Q / What is tislelizumab's mechanism of action? Preston / This is an anti-PD-1 antibody that binds to the PD-1 receptor and blocks interactions between PD-1 and its ligand PD-L1, [...]

Your organization's leadership has announced a new initiative that you'll be responsible for conveying to your team. While your peers in management are excited about the upcoming change, you dread [...]

As the European Commission prepares to publish its Green Freight Transport Package in the second quarter of this year, Robert Preston considers what changes in policy the rail freight sector [...]

Objective. Research on burnout among physical therapists and occupational therapists in the context of the coronavirus disease 2019 (COVID-19) pandemic is limited. Resilience may be important for reducing burnout and promoting well-being among rehabilitation specialists, especially during periods of elevated occupational demand and stress. The purpose of this study was to investigate experiences of burnout, COVID-19 pandemic-related distress, and resilience among physical therapists and occupational therapists during the first year of the COVID-19 pandemic. Methods. Physical therapists and occupational therapists working in a university-affiliated health system were invited to complete an online survey assessing burnout, COVID-19 pandemic-related distress, state- and trait-like resilience, physical activity, sleep disturbance, and financial concerns. Multiple linear regressions were used to examine variables associated with burnout as well as the contribution of specific aspects of resilience to burnout. Results. Greater COVID-19 pandemic-related distress was associated with greater emotional exhaustion and deper-sonalization, whereas state-like resilience at work was associated with lower emotional exhaustion, greater personal accomplishment, and lower depersonalization. Analyses examining the impact of specific components of resilience at work suggested that several components are associated with less burnout, with finding one's calling being particularly relevant for all 3 domains of burnout. Conclusion. Symptoms of burnout were reported by many physical therapists and occupational therapists. COVID-19-related distress and state-like resilience at work, particularly the perception of finding one's calling, emerged as consistently being associated with burnout in the context of the COVID-19 pandemic. Impact. These findings can inform the development of interventions to reduce burnout among physical therapists and occupational therapists amid the continuing COVID-19 pandemic. Keywords: Resilience, Physical Therapists, Occupational Therapists, COVID-19, Burnout, Introduction High occupational stress is associated with burnout, a syndrome characterized by emotional exhaustion (EE), depersonalization (DP), and feelings of ineffectiveness at work. (1-8) Burnout negatively impacts nearly every aspect [...]

Eliminating lineside signalling by installing ETCS Level 2 on the southern end of Britain's East Coast Main Line aims to reduce capital and maintenance costs while improving operational performance. The [...]

'AT the moment we do not have a high-speed network in Europe,' says Mr Carlo Borghini, the outgoing executive director of the Europe's Rail joint research undertaking (p42). 'We have [...]

I have a lot of socks. My favorite pair is red. I tried them on my hands. And even on my head. They don't fit on my ears. Should I [...]

PKP Cargo, the freight business of Polish national operator PKP, has appealed to the prime minister and the minister of state assets to compensate the company for policy decisions made [...]

There can be little doubt that Rail Baltica is an ambitious project in every regard, from the sheer scale of building 870km of new electrified double-track railway to connect the [...]

The Canadian government is hoping to encourage modal shift and fight climate change by introducing faster, more frequent passenger services between the biggest cities along the Toronto--Quebec City corridor. Robert [...]

Of all the potential nightmares about the dangerous effects of generative AI (genAI) tools like https://www.computerworld.com/article/3710293/openais-chatgpt-turns-one-year-old-what-it-did-and-didnt-do.html and https://www.computerworld.com/article/3700709/m365-copilot-microsofts-generative-ai-tool-explained.html, one is near the top of the list: their use by hackers [...]

The last few weeks have been a PR bonanza for Taylor Swift in both good ways and bad. On the good side, her boyfriend Travis Kelce was on the winning [...]

Another day, another hack of Microsoft technology. Ho-hum, you might think, this has happened before and will happen again — as surely as the sun rises in the morning and [...]

For years, Microsoft has managed to fly under the radar of government agencies looking at potential violations of antitrust laws, even though it’s the second largest company in the world [...]

Durante años, Microsoft se las ha arreglado para volar bajo el radar de los organismos gubernamentales que buscan posibles violaciones de las leyes antimonopolio, a pesar de que es https://www.computerworld.es/empresas/microsoft-le-arrebata-a-apple-el-titulo-de-empresa-mas-valiosa-del-mundo-momentaneamente#:~:text=Empresa-,Microsoft%20le%20arrebata%20a%20Apple%20el%20t%C3%ADtulo%20de%20empresa%20m%C3%A1s,en%20la%20nube%20e%20IA., [...]

Whether you believe AI will be the salvation of humankind or the death of it, whether you think it’s little more than a plaything to while away your time or [...]

Here come the lawyers. Last week, the https://nytco-assets.nytimes.com/2023/12/NYT_Complaint_Dec2023.pdf, in which Microsoft has invested $13 billion and counting, for copyright violations. The Times claims https://www.computerworld.com/article/3700709/m365-copilot-microsofts-generative-ai-tool-explained.html and OpenAI’s ChatGPT, which powers Copilot, [...]

Aquí vienen los abogados. La semana pasada, el New York Times demandó a Microsoft y OpenAI, en la que Microsoft ha invertido 13.000 millones de dólares y subiendo, por violación [...]

As disturbers of the peace, neither celebrating cowboys nor dueling gunmen could hold a candle to the feral cats that roamed the streets and disrupted the dreams of folks in [...]

Want your Windows 10 PC to run faster? We're here to help. By tweaking some of the operating settings, your machine will be zippier and less prone to performance and [...]

Since 2011, Apple has been the world’s biggest company by market capitalization on almost a daily basis, dropping on occasion to second place. When it first took the title, Apple [...]

Desde 2011, Apple ha sido la mayor empresa del mundo por capitalización bursátil casi a diario, cayendo en ocasiones al segundo puesto. Cuando se hizo con el título por primera [...]