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Le baricitinib, un inhibiteur sélectif des Janus kinases (JAK)1/JAK2, est approuvé en Europe, au Japon et dans de nombreux autres pays pour le traitement de la dermatite atopique (DA) modérée à sévère chez les adultes candidats à un traitement systémique. Nous présentons ici les données de tolérance concernant le baricitinib chez des patients pédiatriques atteints de DA modérée à sévère.

A 68‐year‐old woman was submitted to a mediastinal lymphangioleiomyoma resection found in a follow‐up study of lower left lung resection due to bronchiectasis complicated by chylothorax. This led to a revaluation of the pulmonary specimen that revealed, in addition to inflammatory bronchiectasis, small spindle cell nodules in the lung parenchyma, similar to minute pulmonary meningothelial‐like nodules, but with smooth muscle actin immunohistochemical positivity. The possibility of initial pulmonary development of lymphangioleiomyomatosis is discussed.

In this work, we analyze a remote optical sensor system based on Raman amplification, composed by one Long Period Grating (LPG) as a sensor head, separated by 50 km from the optical source, and the interrogation unit composed by two Fiber Bragg Gratings (FBGs) modulated by two Piezoelectrics Transductors (PZTs). Optical fiber sensor systems are typically limited to operate at distances of only few kilometers due to the attenuation effects and noise present in the optical fiber that adversely affects the performance of the sensor interrogation process. We present experimental and simulated results obtained in the context of the analysis of remote optical fiber sensors. The simulation models compute the Raman interaction between the pumps and the sensor signals and allow speeding up the analyses regarding the setup to be experimentally implemented in order to measure/monitor environmental temperature. Experimental results obtained in the implemented setup show that under Raman amplification the power ratio between the two central wavelengths of the FBGs has a linear relation with the change of the LPG resonance induced by environmental temperature.

The unavailability due to rain of VSAT star networks operating on Ku and Ka bands in Brazil is analysed in this paper. A large number of simulations performed over the Earth–space links resulting from combinations of four (real and hypothetical) satellites with six Brazilian Earth stations provide a good characterization of the rain unavailability in tropical and equatorial regions subject to heavy rainfall and thunderstorms. The simulations also compare the influence on the estimated unavailability of the use of two different ITU‐R rain attenuation models and two values (calculated and measured) for the rainfall rate exceeded during 10−2% of the time, the climatic parameter in the models, in addition to the link polarization employed. The results obtained point to VSAT star networks as a practical solution to provide telecommunications services to remote communities. Copyright © 2006 John Wiley & Sons, Ltd.

The unavailability due to rain of VSAT star networks operating on Ku and Ka bands in Brazil is analysed in this paper. A large number of simulations performed over the Earth–space links resulting from combinations of four (real and hypothetical) satellites with six Brazilian Earth stations provide a good characterization of the rain unavailability in tropical and equatorial regions subject to heavy rainfall and thunderstorms. The simulations also compare the influence on the estimated unavailability of the use of two different ITU‐R rain attenuation models and two values (calculated and measured) for the rainfall rate exceeded during 10−2% of the time, the climatic parameter in the models, in addition to the link polarization employed. The results obtained point to VSAT star networks as a practical solution to provide telecommunications services to remote communities. Copyright © 2006 John Wiley & Sons, Ltd.

In this work, we analyze a remote optical sensor system composed of two Fiber Bragg Gratings (FBGs) and one Long Period Grading (LPG) capable of simultaneously sensing the temperature and the refractive index, separated by 50 km from the optical source and the interrogation unit. Since the active components of the system and the sensor head are separated over such a large distance, it is necessary to consider Raman amplification o strengthen the optical signal. We present both experimental measurements and the results of numerical simulations, which describe the signal evolution and predict the measurement results for a remote sensor based on a LPG. The simulation codes are also used to study a hybrid sensor composed of two FBGs with a LPG. We show that the power ratio between the two central wavelengths of the FBG has a linear relation with the change of refractive index of the sensored medium.