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Your search keyword '"Polycomb Repressive Complex 2 metabolism"' showing total 6 results
Start Over Descriptor "Polycomb Repressive Complex 2 metabolism" Publication Type Magazines
6 results on '"Polycomb Repressive Complex 2 metabolism"'

2. [PRC2 alterations in NF1-associated malignant peripheral nerve sheath tumors: schwann cells with no complex].

Author

Luscan A, Vidaud D, Ortonne N, Wolkenstein P, Vidaud M, and Pasmant E

Subjects
Biomarkers, Tumor metabolism, Gene Expression Regulation, Neoplastic, Histone Acetyltransferases metabolism, Histone Methyltransferases, Histone-Lysine N-Methyltransferase metabolism, Histones metabolism, Humans, Neurilemmoma pathology, Polycomb Repressive Complex 2 metabolism, Schwann Cells pathology, Carcinogenesis genetics, Genes, Neurofibromatosis 1 physiology, Mutation, Neurilemmoma genetics, Polycomb Repressive Complex 2 genetics, Schwann Cells metabolism
Published
2014
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3. Poly-combing the genome for RNA.

Author

Goff LA and Rinn JL

Subjects
Animals, Humans, Embryonic Stem Cells metabolism, Polycomb Repressive Complex 2 metabolism, Promoter Regions, Genetic, RNA, Messenger metabolism, RNA-Binding Proteins metabolism
Abstract

An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

Published
2013
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5. Stopping a chromatin enzyme.

Author

Simon JA

Subjects
Animals, Enzyme Inhibitors chemistry, Epigenesis, Genetic genetics, Gene Expression Regulation, Neoplastic genetics, Humans, Molecular Structure, Polycomb Repressive Complex 2 chemistry, Polycomb Repressive Complex 2 metabolism, Small Molecule Libraries chemistry, Structure-Activity Relationship, Transcriptome, Chromatin enzymology, Enzyme Inhibitors pharmacology, Epigenesis, Genetic drug effects, Gene Expression Regulation, Neoplastic drug effects, Polycomb Repressive Complex 2 antagonists & inhibitors, Small Molecule Libraries pharmacology
Published
2012
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6. New lysine methyltransferase drug targets in cancer.

Author

Wagner T and Jung M

Subjects
Enhancer of Zeste Homolog 2 Protein, Histocompatibility Antigens metabolism, Histone Methyltransferases, Histone-Lysine N-Methyltransferase metabolism, Humans, Methyltransferases antagonists & inhibitors, Methyltransferases metabolism, Polycomb Repressive Complex 2 antagonists & inhibitors, Polycomb Repressive Complex 2 metabolism, Enzyme Inhibitors therapeutic use, Histone-Lysine N-Methyltransferase antagonists & inhibitors, Molecular Targeted Therapy, Neoplasms drug therapy
Published
2012
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