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Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis1. Distinct metabolic and mitochondrial features guide the activation and the diverse functional states of myeloid cells2. However, how these metabolic features act to perpetuate inflammation of the central nervous system is unclear. Here, using a multiomics approach, we identify a molecular signature that sustains the activation of microglia through mitochondrial complex I activity driving reverse electron transport and the production of reactive oxygen species. Mechanistically, blocking complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in an animal disease model in vivo. Ccomplex I activity in microglia is a potential therapeutic target to foster neuroprotection in chronic inflammatory disorders of the central nervous system3.

Context. The presence of water has long been seen as a key condition for life in planetary environments. The Cassini spacecraft discovered water vapour in the Saturnian system by detecting absorption of UV emission from a background star. Investigating other possible manifestations of water is essential, one of which, provided physical conditions are suitable, is maser emission.

In 1997 the Sun and the Earth passed through the equatorial plane of Jupiter and therefore through the orbital planes of its main satellites. During this period, mutual eclipses and occultations occurred and were observed. We investigate the precision of the catalogue to produce improved data for the development of dynamical models. Light curves of mutual eclipses and occultations were recorded by the observers of the international campaign PHEMU97 organized by the Institut de Mécanique Céleste, Paris, France.
We made 275 observations of 148 mutual events from 42 sites. For each observation, information is given about the telescope, the receiver, the site and the observational conditions. This paper gathers together the data and gives a first estimate of the precision. The catalogue of these rare events represents a collection of improved accurate astrometric data useful for the development of dynamical models.

This paper describes two small aperture array demonstrators called Medicina and Sardinia Array Demonstrators (MAD and SAD, respectively). The objectives of these instruments are to acquire experience and test new technologies for a possible application to the low‐frequency aperture array of the low‐frequency telescope of the Square Kilometer Array phase 1 (SKA1‐LOW). The MAD experience was concluded in 2014, and it turned out to be an important test bench for implementing calibration techniques based on an artificial source mounted in an aerial vehicle. SAD is based on 128 dual‐polarized Vivaldi antennas and is 1 order of magnitude larger than MAD. The architecture and the station size of SAD, which is along the construction phase, are more similar to those under evaluation for SKA1‐LOW, and therefore, SAD is expected to provide useful hints for SKA1‐LOW. Italian demonstrators of low‐frequency aperture array for radio astronomyAerial unmanned vehicle for the instrumental calibration of an aperture arrayTechnological solutions implemented in the receiving chain of a low‐frequency aperture array

Sommario Si studia la trasmissione e riflessione di onde piane unidimensionali attraverso un'onda d'urto in un mezzo iperelastico non lineare isotropo e isotermo. Vengono determinate esplicitamente per una particolare classe di potenziali termodinamici le ampiezze sia delle onde trasmesse che di quelle riflesse come anche il salto dell'accelerazione d'urto. Si mostra che nel caso del potenziale di Tolotti l'interazione non influisce sulla propagazione di nessuno dei due tipi di onda.

Summary

Summary The sensitivity of various isolated organs to catecholamines was tested before and after block of catechol-O-methyl transferase (COMT) by U-0521 (3',4'-dihydroxy-2-methyl propiophenone; 18 µg/ml for 20 min).