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Los eventos adversos (EA) relacionados con la asistencia sanitaria son frecuentes por la propia naturaleza de esta actividad y, por ello, es necesario desarrollar herramientas que permitan detectarlos y prevenir su reaparición. Una de ellas son los sistemas de trigger tools, que son marcadores que permiten identificar EA de manera retrospectiva para su posterior análisis.

We studied age-and sex-specific mortality from multiple myeloma in Spain during the period 1957–1986. The presence of birth cohort and period effects was determined using a multivariate Poisson model. From an international perspective, multiple myeloma mortality in Spain during the 1980s was in the medium range. Adjusted rates for males and females were 1.36 and 0.96 per 100000 person-years, respectively. Multiple myeloma mortality rose exponentially during the study period, the annual increase was 11.0% in males and 10.5% in females, surpassing the increase observed in other countries. The analytical model ascribed most of this increase to a birth cohort effect. The interpretation of this phenomenon is difficult. Progressive improvements in detection and reporting, and an actual rising incidence may underlie the cohort effect.