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Objectif Comprendre la gestion des hypoglycémies sévères (HS) des personnes ayant un diabète (PAD) et des aidants.

The process of ultrafiltration plant used for remove dissolved and emulsifield oil of degreasing baths in Legrand electroplating surface treatments is discribed. In this way the bath life utilization is prolonged from 80 to 400 hours.Sequential batch operation is automaticaly programmed. Ultrafiltration membrane are of tubular configuration with polysulfone polymer which is resistant in the 2-13 pH range and thermally stable up to 60°C. The molecular cutoff is around 20,000: the concentrate stream is enriched up to 30% by weight by mineral oil and suspended solids are also removed. The permeate contained less than 80 mg.l-1 amount of oil. Operating cost 500 000 F (1986) will be compensed on 2 years.

To explore the antisecretory effect of methylated casein (MC) cholera toxin was placed in isolated jejunal loops, and in vivowater fluxes were measured 3 h later in the presence or absence of MC. Secretion was observed in the loops filled with Ringer's solution only, but net absorption was observed in all 10 loops to which MC was added. Its actions was evident within 20 min, and was exerted directly on the luminal side of the epithelium. This response was dose-dependent and the antisecretory effect vanished after boiling MC and after ultrafiltration. In vitro,the antisecretory effect of MC consisted of reversing net Na and CI fluxes from secretion to absorption (δJNanet= 6.18 ± 1.25 and δJClnet= 5.10 ± 1.66 μ Eq.h−1cm−2). This change was due to the enhancement of mucosal to serosal flux. Transepithelial potential difference and tissue conductance did not alter. Interestingly, MC did not interfere with intestinal function in the absence of stimulation by cholera toxin. In the presence of cholera toxin, MC and glucose both stimulated ionic absorption by different mechanisms, MC stimulating neutral NaCl absorption, and glucose stimulating electrogenic Na absorption. MC did not alter basal adenylate cyclase activity but it inhibited the cholera toxin-stimulated increase in activity. The present results indicate that methylated casein inhibits water and electrolyte secretion induced by cholera toxin in rat jejunum. Its availability, low cost, and curative effect from the luminal side constitute compelling indications for further investigation.