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In women younger than 50 years, benefits of early diagnosis with tomosynthesis plus mammography screening seemed appreciable and could increase diagnosis of slow-growing, invasive cancers for women over age 50.

Aim: To evaluate the impact of multidisciplinary team case discussion including computed tomography (CT) radiologic review on surgical outcome and overall survival (OS) of patients with pancreatic ductal adenocarcinoma (PDAC).Methods: Patients with PDAC evaluated in 2008–2011 and 2013–2016 (before and after multidisciplinary team introduction), aged <85 years and staged I–III, were included. Surgical failures and 2-year OS were compared in these periods. Available CT scans of preintervention period (2008–2011) cases were reviewed by two radiologists in consensus, assigning a resectability judgment to evaluate in how many cases a different recommendation would be achieved.Results: A total of 316 patients (49.3% female, age 71±10 years) were included: 132 in 2008–2011 and 184 in 2013–2016. The proportion of patients who underwent upfront surgery was similar in the two periods (51% vs 47% in 2008–2011 vs 2013–2016). Neoadjuvant referral increased from 7% to 21% and surgical resection was excluded for 42% patients in 2008–2011 vs 33% in 2013–2016 (p= 0.002). Adjusting by age, sex, and stage, surgical failures slightly decreased in 2013–2016 (odds ratio 0.89, 95% confidence interval 0.53–1.51); the decrease was stronger when therapeutic choice complied with CT indications (odds ratio 0.76, 95% confidence interval 0.36–1.63); in both cases, the decrease could be due to chance. After correction for age, sex, and stage, the hazard ratio of 2013–2016 for OS was 0.83 (95% confidence interval 0.64–1.09). In 33/114 (29%) patients, CT retrospective review produced a change in resectability judgment.Conclusion: Although differences could be due to chance or generic improvement, the consistency between process and outcome indicators suggests that multidisciplinary team approach with radiologic review may improve outcomes.

Tomosynthesis plus digital mammography detects 90% more cancers than digital mammography alone, with similar recall rate. This higher detection may have a beneficial impact on cancer prognosis.

Skeletal dysplasia with bowing long bones is a rare group of multiple characterized congenital anomalies.

Cleft lip and cleft palate are among the more common congenital abnormalities, present in 1.82 per 1000 live births. Although high-quality antenatal 2D sonography can diagnose clefts of the lips and the alveolar ridge, 3D may enhance detection by examining the fetal face in the frontal plane followed by a secondary rotation through 180 degrees on the vertical axis to examine the secondary palate, which has been called the “reverse face” view. Sonographically 3D targeted ultrafast magnetic resonance imaging (MRI) has been shown to improve the diagnostic accuracy of facial cleft by identifying whether a cleft in the primary palate extends to the secondary palate. Further investigation may confirm the ability of MRI to define the extent of the cleft to the secondary palate at a less advanced gestational age (18-23 weeks), where either fetal development or movements could reduce the accuracy of the technique.