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•Intracranial aneurysms are more prevalent than previously described, affecting 1 in 6 participants in our cohort.•Tissue-based cerebral blood flow may serve as a neuroimaging biomarker of hemodynamic stress underlying aneurysmal formation.

AbstractThe diagnosis of plasma-facing components in a fusion environment is challenging due to the limited number of measurement techniques that have been developed for in situ surface analysis. In this work, we assess the feasibility of using neutron reflectometry (NR) for the in situ diagnosis of deuterium accumulation in tungsten and dispersion-strengthened tungsten alloys. TRIM is used to simulate deuterium implantation at different energies to approximate the deuterium depth profiles in these materials in order to calculate the expected measurements from NR for various fluences. Our results suggest that NR should be an effective technique for testing hypotheses about the surface composition of materials under fusion-relevant fluences of deuterium irradiation.

Despite racial disparities in breast cancer mortality, Black women remain underrepresented in clinical trials. In this mixed methods research, 48 Black women were engaged via focus group discussions and in-depth interviews to better understand the lived experience of women with breast cancer. The results of this qualitative study informed the development of a subsequent online survey to identify barriers, motivators, and other factors that influence decision-making by Black women diagnosed with breast cancer when considering clinical trial participation. Among the 257 Black survey participants, most (95%) were aware of clinical trials; of those, most viewed them as lifesaving (81%) and/or benefiting others (90%). Negative perceptions such as serious side effects (58%), not receiving real treatment (52%), or risk of potential harm (62%) were indicated. Barriers included financial expenses (49%), concerns that their condition could be made worse (29%), that they would receive a placebo (28%), or that treatment was unapproved (28%). Participants were more likely than their health care providers (HCPs) to initiate discussions of clinical trials (53% versus 33%), and 29% of participants indicated a need for more information about risks and benefits, even after having those conversations. The most trustworthy sources of information on clinical trials were HCPs (66%) and breast cancer support groups (64%). These results suggest that trusted communities are key for providing education on clinical trials. However, there is also a need for HCPs to proactively discuss clinical trials with patients to ensure that they are adequately informed about all aspects of participation.

Regardless of quality, vision, or intended impact, no level or aspect of strategic planning can be successfully implemented unless the personnel charged with meeting the goals are capable of doing [...]

In a country the size of New Zealand, development of nursing degree programmes from a new tertiary education provider is rare. When it does happen, however, it does provide a [...]

Larger maximum tumor diameter (MTD) has been associated with worse prostate cancer (PCa) outcomes. However, the impact of MTD in PCa treated with external beam radiotherapy and brachytherapy boost (EBRT+BB) remains unknown.

Radiation therapy (RT) and intrathecal drug delivery systems (IDDS) are often used concurrently to optimize pain management in patients with cancer. Concern remains among clinicians regarding the potential for IDDS malfunction in the setting of RT. Here we assessed the frequency of IDDS malfunction in a large cohort of patients treated with RT. Cancer patients with IDDS and subsequent RT at our institution from 2011 to 2019 were eligible for this study. Patients were excluded in the rare event that their IDDS was managed by an outside clinic and follow‐up documentation was unavailable. Eighty‐eight patients aged 22–88 years old (43% female, 57% male) representing 106 separate courses of RT were retrospectively identified. Patients received varying levels of radiation for treatment of cancer and cumulative dose to the IDDS was calculated. IDDS interrogation was subsequently performed by a pain specialist. Malfunction was recorded as deviation from the expected drug volume and/or device errors reported upon interrogation as defined by the manufacturer. Total measured RT dose to the IDDS ranged from 0 to 18.0 Gy (median = 0.2 Gy) with median dose of 0.04 Gy/fraction (range, 0–3.2 Gy/fraction). Ten pumps received a total dose >2 Gy and three received ≥5 Gy. Eighty‐two percentage of patients had follow‐up with a pain specialist for IDDS interrogation and all patients underwent follow‐up with a healthcare provider following RT. There were zero incidences of IDDS malfunction related to RT. No patient had clinical evidence of radiation related pump malfunction at subsequent encounters. We found no evidence that RT in patients with IDDS led to device failure or dysfunction. While radiation oncologists and pain specialists should coordinate patient care, it does not appear that RT dose impacts the function of the IDDS to warrant significant clinical concern.

Knowledge of the key anatomic landmarks of the brachial plexus, as well as its normal and pathologic appearances at MRI, CT, and US, can help radiologists diagnose traumatic and nontraumatic brachial plexopathies.

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