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Throughout human history infectious diseases have emerged to become global threats once in a while. Sometimes the previously established infections surfaced due to geographical extension or by increasing their transmissibility or pathogenicity while in other instances new infections have periodically emerged by transmitting from animals to humans. A proper strengthening of the existing health care system, disease surveillance, advancement in medical technology and healthy lifestyle is a must for controlling the future re-emergence of pandemics. Similarly, a deeper understanding of (1) key medical and social elements; (2) treatment and prevention options; (3) epidemic preparedness of the health care system; and (4) investing in ethno medicine research is necessary to prevent the future devastating pandemic emergencies.

Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivation of G. lucidum strain Philippine in different culture media, including sawdust substrate, was performed and optimized on the Potato Dextrose Agar (PDA) media. Phytochemical, antibacterial, and antioxidant analyses were performed and compared between the ethanol extracts prepared from two different cultures (fruit from synthetic log culture and mycelia from PDA media culture). Both the 200 mg/mL and 100 mg/mL concentrations of extracts inhibited all the tested bacteria, and the results were promising than the corresponding control using antibiotics. The fruit extract showed higher antioxidant potential (150.6 ± 56.92 mg ascorbic acid equivalent/g extract) than mycelial extract (144.28 ± 81.72 mg ascorbic acid equivalent/g extract). The results indicate that fruiting bodies of G. lucidum cultivated in a complex dust medium possess higher antioxidant properties than mycelia culture, which can be further explored for therapeutic applications.