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The flexible strain sensors based on wrapped yarn have attracted wide attention in the field of smart textiles due to their excellent sensitivity and wide detection range. In this article, the polyamide/spandex wrapped yarn was prepared by using a fancy twisting machine, and the polyamide/spandex wrapped yarn flexible strain sensor was prepared by in situ polymerization and dip-coating process. Through studying the influence of process parameters on the properties of the yarn and the performance of the sensor, it was found that the wrapped yarns with a twist of 2500 T/m have a better performance. When the concentration of Py is 0.08% and the concentration of MWCNT is 9%, the sensor shows a maximum influence factor of 2.44 when the stretching range is less than 175%. Its resistance change rate is not affected by the stretching frequency and has outstanding repetition stability and washing resistance. The results show that the proposed strain sensor shows great potential for healthcare-related applications such as disease diagnosis, preventive healthcare, and rehabilitation care in the fields of health monitoring and smart textiles.

Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel and antibacterial gallic acid/copper MOFs. The hybrid wound dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells and can stimulate fibroblast migration, endothelial angiogenesis, and M2 macrophage polarization. Additionally, the dressing can scavenge reactive oxygen species (ROS) and provide antioxidant effects. Furthermore, DPP + MOF@Gel effectively inhibits the viability of S. aureusand E. coliin vitro and in vivo. The histological observations revealed enhanced granulation tissue formation, re-epithelialization, and angiogenesis in the DPP + MOF@Gel group compared to other groups. The local immune response also shifted from a pro-inflammatory to a pro-regenerative status with DPP + MOF@Gel treatment. The skin incision stitching experiment further exhibits DPP + MOF@Gel could reduce scar formation during wound healing. Taken together, the hybrid DPP + MOF@Gel holds great promise for treating bacteria-infected skin wounds and inhibiting scar formation during wound healing.

Background: Studies have shown that the reference equations for the six-minute walking distance (6MWD), which were mainly derived from healthy, normal-weight people, are not suitable for individuals with obesity. The main purpose of this study was to establish reference equations for the 6MWD in obese Chinese subjects. Methods: In our study, a total of 214 individuals with obesity performed the six-minute walking tests (6MWTs) according to the American thoracic society (ATS) guidelines, and the longer 6MWD was used for further analysis. The reference equations for the 6MWD were developed using stepwise multiple regression analysis. The newly established equations for the 6MWD were compared to the existing prediction equations. Results: The mean 6MWD for the cohort was 523 ± 56 m. We found that the reliability of two 6MWTs was good. Age and BMI were identified as independent factors, and explained 31% and 27% of the variance in the 6MWD for the male and female participants, respectively. Thus, the reference equations reported in the previous studies did not accurately predict the 6MWD in our subjects. Conclusion: Our study was the first to describe the 6MWD in obese Chinese subjects and to propose new predictive equations. These established equations can improve the assessment of the health of obese Chinese patients whose exercise capacity is affected by the disease. Level of evidence: III, Cohort study.

Designing the ferromagnetic/nonmagnetic (FM/NM) heterostructure with desirable low magnetic damping is important for spintronic devices to reduce the critical current density of magnetization switching. For ultrathin FM/NM films, magnetic damping from the two-magnon scattering (TMS) effect is a critical component, and suppressing TMS damping becomes one of the crucial ways to achieve low damping. In this paper, we have demonstrated the depressed linewidth in Ta (1 nm)/NiFe (3 nm)/NM (4 nm)/Ta (1.5 nm) heterostructure with Cu instead of Pt as the NM layer, where the maximal linewidth of ferromagnetic resonance (FMR) decreases from 440 to 190 Oe. And the decrease of TMS damping from 55 to 0 Oe is one of the main reasons for the lower FMR linewidth. The nonzero surface magnetic anisotropy implies that the suppression of interfacial defect scattering causes reduced TMS damping. Meanwhile, a noticeable enhancement of TMS damping from the lack of seed layer may be due to the lattice structure change. Thereby, our findings provide a way toward the design of low-damping spintronic devices.

Inorganic/organic dielectric composites with outstanding energy storage properties at a low electric field possess the advantages of low operating voltage and small probability of failure. Composites filled with two-dimensional inorganic nanosheets have attracted much attention owing to their fewer interfacial defects caused by the agglomeration of fillers. Continuous oxide films with a preferred orientation can play a significant role in enhancing energy storage. The challenge is to prepare large-sized, freestanding, single-crystal, ferroelectric oxide films and to combine them with polymers. In this work, a well-developed water-dissolvent process was used to transfer millimeter-sized (100)-oriented BaTiO3(BTO) films. Poly(vinylidene fluoride) (PVDF)-based heterojunctions sandwiched with the single-crystal films were synthesized viathe transferring process and an optimized hot-pressing technique. By virtue of high ion displacement polarization and inhibited conductive path formation of single-crystal BTO films, the energy storage density and efficiency of BTO/PVDF heterojunctions reach 1.56 J cm–3and 71.2% at a low electric field of 120 MV m–1, which are much higher than those of pure PVDF and BTO nanoparticles/PVDF composite films, respectively. A finite-element simulation was employed to further confirm the experimental results. This work provides an effective approach to enhance energy storage properties in various polymer-based composites and opens the door to advanced dielectric capacitors.

Aiming to realize the integration of signal processing with the human body, wearable and implantable radio frequency (RF)/microwave devices are rapidly developed. However, the insufficiency in skin commonality and biocompatibility brings up challenges in making such devices. In this study, an ultra-flexible and biocompatible CoFeB/silk film is developed potentially for on-skin and implantable RF/microwave applications. Moreover, the CoFeB/silk films present controllable dissolvability in aqueous solutions and exhibit great potentials in applications for environmentally friendly disposable devices. A strain-tunable bandstop filter based on the CoFeB/silk film was fabricated, which exhibited a large frequency tunability of 3 GHz and ability in monitoring the finger-joints’ motions. This concept and method of combining ferromagnetic materials with the biocompatible substrate offers a novel pathway for wearable/implantable applications.

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, whose etiology is intimately related to the overproduction of hypochlorous acid (HClO). Optical monitoring of HClO in the living body favors real-time diagnosis of inflammatory diseases. However, HClO-activated near-infrared (NIR) fluorescent probes with rapid response and high inflammatory cell uptake are still lacking. Herein, we report an activatable acceptor–π–acceptor (A–π–A)-type NIR fluorescent probe (Cy-DM) bearing two d-mannosamine groups for the sensitive detection of HClO in early IBD and stool testing. Once reacted with HClO, nonfluorescent Cy-DMcould be turned on within 2 s by generating a donor–π–acceptor (D–π–A) structure due to the enhanced intramolecular charge transfer mechanism, showing intense NIR fluorescence emission at 700 nm and a large Stokes shift of 115 nm. Moreover, it was able to sensitively and selectively image exogenous and endogenous HClO in the lysosomes of living cells with a detection limit of 0.84 μM. More importantly, because of the d-mannosamine modification, Cy-DMwas efficiently taken up by inflammatory cells in the intestine after intravenous administration, allowing noninvasive visualization of endogenous HClO in a lipopolysaccharide-induced IBD mouse model with a high fluorescence contrast of 6.8/1. In addition, water-soluble Cy-DMhas also been successfully applied in ex vivo optical fecal analysis, exhibiting a 3.4-fold higher fluorescence intensity in the feces excreted by IBD mice. We believe that Cy-DMis promising as an invaluable tool for rapid diagnosis of HClO-related diseases as well as stool testing.

The effect of the inlet guide vanes on cavitation performance of an axial pump is investigated to assess the mechanism for cavitation in pumps and improve their cavitation performance. The effect of inlet guide vane angles on cavitation performance was assessed experimentally, and computational fluid dynamics was used to analyze the inner flow field of the axial pump and to probe the cavitation mechanism. The simulation results agree qualitatively with the experimental data, showing that cavitation performance is improved with positive inlet guide vane angles but hampered with negative ones. The cavitation performance itself is controlled by the cavitation volume, which first expands circumferentially when the net positive suction head decreases from a certain large value and then develops toward the axis radially after the net positive suction head reaches a certain value. This is when the cavitation performance deteriorates. Comparing cavitation volume for the critical net positive suction head as determined by two different methods, the method based on efficiency drop (NPSHeff.,1%) is found to be more suitable than that based on head drop (NPSHhead.,3%). Furthermore, the distribution of swirl is shown to be closely related to the distribution of cavitation, a feature that may be used to predict cavitation along the impeller.

Low efficiency of targeting and delivery toward the thrombus site poses challenges to using thrombolytic drugs. Inspired by the biomimetic system of platelet membranes (PMs) and glucose oxidase (GOx) modification technologies, we develop a novel GOx-powered Janus nanomotor by asymmetrically attaching the GOx to polymeric nanomotors coated with the PMs. Then the PM-coated nanomotors were conjugated with urokinase plasminogen activators (uPAs) on their surfaces. The PM-camouflaged design conferred excellent biocompatibility to the nanomotors and improved their targeting ability to thrombus. The Janus distribution of GOx also allows the uneven decomposition of glucose in biofluids to produce a chemophoretic motion, increasing the drug delivery efficiency of nanomotors. In addition, these nanomotors are located at the lesion site due to the mutual adhesion and aggregation of platelet membranes. Furthermore, thrombolysis effects of nanomotors are enhanced in static and dynamic thrombus as well as in mouse models. It is believed that the novel PM-coated enzyme-powered nanomotors represent a great value for thrombolysis treatment.

There is no consensus regarding the most appropriate methods (i.e., the side-by-side versusthe stent-in-stent technique) for placing bilateral stents for malignant hilar biliary obstructions. We aimed to perform a quantitative review of the published data regarding the clinical efficacy of the side-by-side and stent-in-stent bilateral drainage techniques for hilar biliary obstructions.

Human body temperature not only reflects vital signs, but also affects the state of various organs through blood circulation, and even affects lifespan. Here a wireless body temperature detection scheme was presented that the temperature was extracted by investigating the out-of-plane (OP) ferromagnetic resonance (FMR) field of 10.2 nm thick La0.7Sr0.3MnO3(LSMO) film using electron paramagnetic resonance (EPR) technique. Within the range of 34–42 °C, the OP FMR field changes linearly with the increasing or decreasing temperature, and this variation comes from the linear responses of magnetization to the fluctuant temperature. Using this method, a tiny temperature change (< 0.1 °C) of organisms can be detected accurately and sensitively, which shows great potential in body temperature monitoring for humans and mammals.

Designing expandable sponges with biodegradability and effective antibacterial properties are the urgent challenge for incompressible hemorrhage and wound healing. In the present investigation, based on quaternized gelatin (QG) and oxidized dextran (OD), a series of expandable sponges (ODQG) with high-water absorption capacity and robust mechanical properties were prepared. ODQG had good biodegradability in vitroand in vivo, and had inherent antibacterial activity (90% for E. coliand 99.74% for S. aureus). Due to the synergy effect of electrostatic interaction and blood concentration, ODQG could effectively attract and activate red blood cells/platelets and accelerate the coagulation process. Therefore, ODQG showed better hemostatic performance than Kuaikang® gelatin sponges and gauzes in incompressible hemorrhage model. Furthermore, ODQG could regulate inflammatory factor (TNF-α) and cytokines (TGF-β, VEGF), and greatly promote wound healing process. The biodegradable sponges with excellent antibacterial properties might have potential application prospect for incompressible hemostasis and wound healing in the future.

Magnetoelectric coupling properties are limited to the substrate clamping effect in traditional ferroelectric/ferromagnetic heterostructures. Here, Fe3O4/BaTiO3nanopillar composites are successfully constructed. The well-ordered BaTiO3nanopillar arrays are prepared through template-assisted pulsed laser deposition. The Fe3O4layer is coated on BaTiO3nanopillar arrays by atomic layer deposition. The nanopillar arrays and heterostructure are confirmed by scanning electron microscopy and transmission electron microscopy. A large thermally driven magnetoelectric coupling coefficient of 395 Oe °C–1near the phase transition of BaTiO3(orthorhombic to rhombohedral) is obtained, indicating a strong strain-induced magnetoelectric coupling effect. The enhanced magnetoelectric coupling effect originated from the reduced substrate clamping effect and increased the interface area in nanopillar structures. This work opens a door toward cutting-edge potential applications in spintronic devices.

Congenital factor V deficiency is a rare bleeding disorder characterized by low coagulant activity, associated with variable phenotypic expression. Among rare inherited coagulopathies, the molecular basis of factor V deficiency is rarely described because of its relatively low prevalence in the general population. Recently, we detected two genetic variations in factor V of a Chinese patient with hereditary factor V deficiency. One was a heterozygous nonsense mutation, C67868T in exon 22, which resulted in Gln2031stop substitution in the C1 domain of factor V. The other was a previously described polymorphism, G1618A in exon10, leading to Arg485Lys substitution. We deduced that the nonsense mutation is responsible for the factor V deficiency, whereas the Arg485Lys polymorphism is expected to compensate for the low plasma factor V levels. Of note, the nonsense mutation has been confirmed to be a novel mutation.

La0.7Sr0.3MnO3(LSMO) is one of the most fascinating strongly correlated oxides in which the spin polarization and magnetic property are sensitive to strain, especially in the (111)-oriented LSMO. In the paper, epitaxial LSMO(111) thin films with different thicknesses were prepared, and they showed continuous dislocation defect arrays with thickness greater than 45 nm. Then, the thick LSMO(111) films were divided into a double-layer structure with two slightly different oriented cells. The LSMO(111) films present a stronger lattice–spin coupling, thus the double-layer structure triggers an obvious magnetic heterogeneity phenomenon (magnetic bi-states) by the way of creating a double-mode ferromagnetic resonance (FMR) spectrum. Therefore, the nanostructures, especially the ordered structure defects, may trigger enriched physical phenomena and offer new forms of spin coupling and device functionality in strain-sensitive strongly correlated oxide systems.

Permalloy with low ferromagnetic resonance linewidth has great application potential in spintronic/microwave devices. In this work, we demonstrated that the nonmagnetic (Cu) layer’s sputtering rate has a considerable impact on Ni0.81Fe0.19’s linewidth in Cu (4 nm)/Ni0.81Fe0.19(3 nm) bilayer heterostructures. A monotonically decreasing out-of-plane linewidth was displayed as the sputtering rates increased from 0.27 to 1.75 Å/s due to interdiffusion. Meanwhile, a large reduction of the in-plane linewidth from 18.54 to 7.83 mT was also obtained from suppressing the interfacial inhomogeneity and two-magnon scattering effects. The present work contributes to a clearer understanding of Cu/Ni0.81Fe0.19nanoscale films’ interfacial inhomogeneity and opens a new road on tailoring magnetodynamic properties.

Background and Aims. To investigate the association between serum albumin levels within 24 hrs of patient admission and the development of persistent organ failure in acute pancreatitis. Methods. A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. The diagnostic performance of serum albumin was evaluated by the area under Receiver Operating Characteristic (ROC) curves. Results. As levels of serum albumin decrease, the risk of persistent organ failure significantly increases (Ptrend<0.001). The incidence of organ failure was 3.5%, 10.6%, and 41.6% in patients with normal albumin and mild and severe hypoalbuminaemia, respectively. Decreased albumin levels were also proportionally associated with prolonged hospital stay (Ptrend<0.001) and the risk of death (Ptrend<0.001). Multivariate analysis suggested that biliary etiology, chronic concomitant diseases, hematocrit, blood urea nitrogen, and the serum albumin level were independently associated with persistent organ failure. Blood urea nitrogen and the serum albumin level were also independently associated with mortality. The area under ROC curves of albumin for predicting organ failure and mortality were 0.78 and 0.87, respectively. Conclusion. A low serum albumin is independently associated with an increased risk of developing of persistent organ failure and death in acute pancreatitis. It may also be useful for the prediction of the severity of acute pancreatitis.

Background and Aims. This study evaluated the prognostic accuracy of BUN for severe acute pancreatitis (SAP) and in-hospital mortality (IHM) in terms of the best timing for BUN measurement and the optimal BUN cutoff points. Methods. BUN determinants at the time of admission and 24 hrs after hospital admission were recorded and analyzed statistically. The ability of BUN in predicting the SAP and the occurrence of IHM were assessed using the area under the receiver-operating characteristic (ROC) curve. Results. For SAP, AUC of BUN at admission and 24 hrs after hospital admission was 0.75 and 0.80, respectively. For IHM in acute pancreatitis, it was 0.86 at admission and 0.84 after 24 hrs of hospital admission, respectively. The optimal cutoff point of BUN 24 hrs after hospital admission for SAP and at admission for IHM was 8.3 mmol/L and 13.3 mmol/L, respectively. Conclusion. BUN determination after 24 hrs of hospital admission has high accuracy for prediction of SAP while BUN at initial admission has high accuracy for prediction of IHM.