1. Geranyl Dihydrochalcones from Artocarpus altilis and Their Antiausteric Activity.
- Author
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Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Khang Duy Huu Nguyen, Hien Thu Thi Dau, Hai Xuan Nguyen, Phu Hoang Dang, Tam Minh Le, Trong Huu Nguyen Phan, Anh Hai Tran, Bac Duy Nguyen, Jun-ya Ueda, and Suresh Awale
- Subjects
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PANCREATIC tumors , *ALTERNATIVE medicine , *BIOLOGICAL models , *DOSE-effect relationship in pharmacology , *LEAVES , *MEDICINAL plants , *PHYTOCHEMICALS , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PREVENTION - Abstract
Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100% preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 μg/mL. Further investigation of this extract led to the isolation of eight new geranylated dihydrochalcones named sakenins A-H (1- 8) together with four known compounds (9-12). Among them, sakenins F (6) and H (8) were identified as potent preferentially cytotoxic candidates with PC50 values of 8.0μM and 11.1 μM, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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