Author: "P. Rohner" / Publication Type: Magazines - Searchworks@Jio Institute Digital Library Search Results

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1. Honor the Past Love the Present Dream the Future: A Conversation with Erin Althen.

Author: Rohner, James M.
Subjects: CONVERSATION, SCHOOL bands, MUSIC education, MENTORING in education
Published: 2024

2. Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial

Author: Rohner, Roman, Kneihsl, Markus, Goeldlin, Martina B., Hakim, Arsany, Branca, Mattia, Abend, Stefanie, Valenzuela Pinilla, Waldo, Fenzl, Sabine, Rezny-Kasprzak, Beata, Strbian, Daniel, Trelle, Sven, Paciaroni, Maurizio, Thomalla, Götz, Michel, Patrik, Nedeltchev, Krassen, Gattringer, Thomas, Sandset, Else C., Bonati, Leo, Aguiar de Sousa, Diana, Sylaja, P.N., Ntaios, George, Koga, Masatoshi, Gdovinova, Zuzana, Lemmens, Robin, Bornstein, Natan M., Kelly, Peter, Katan, Mira, Horvath, Thomas, Dawson, Jesse, and Fischer, Urs
Published: 2024
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3. Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial

Author: Goeldlin, Martina B., Hakim, Arsany, Branca, Mattia, Abend, Stefanie, Kneihsl, Markus, Valenzuela Pinilla, Waldo, Fenzl, Sabine, Rezny-Kasprzak, Beata, Rohner, Roman, Strbian, Daniel, Paciaroni, Maurizio, Thomalla, Goetz, Michel, Patrik, Nedeltchev, Krassen, Gattringer, Thomas, Sandset, Else Charlotte, Bonati, Leo, Aguiar de Sousa, Diana, Sylaja, P. N., Ntaios, George, Koga, Masatoshi, Gdovinova, Zuzana, Lemmens, Robin, Bornstein, Natan M., Kelly, Peter, Katan, Mira, Horvath, Thomas, Dawson, Jesse, and Fischer, Urs
Abstract: IMPORTANCE: Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown. OBJECTIVE: To assess whether infarct size modifies the safety and efficacy of early vs late DOAC initiation. DESIGN, SETTING, AND PARTICIPANTS: Post hoc analysis of participants from the multinational (>100 sites in 15 countries) randomized clinical Early Versus Later Anticoagulation for Stroke With Atrial Fibrillation (ELAN) trial who had (1) acute ischemic stroke, (2) atrial fibrillation, and (3) brain imaging available before randomization. The ELAN trial was conducted between October 2017 and December 2022. Data were analyzed from October to December 2023 for this post hoc analysis. INTERVENTION: Early vs late DOAC initiation after ischemic stroke. Early DOAC initiation was within 48 hours for minor or moderate stroke or on days 6 to 7 for major stroke; late DOAC initiation was on days 3 to 4 for minor stroke, days 6 to 7 for moderate stroke, and days 12 to 14 for major stroke. MAIN OUTCOMES AND MEASURES: The primary outcome was a composite of recurrent ischemic stroke, symptomatic intracranial hemorrhage, extracranial bleeding, systemic embolism, or vascular death within 30 days. The outcome was assessed according to infarct size (minor, moderate, or major) using odds ratios and risk differences between treatment arms. Interrater reliability for infarct size between the core laboratory and local raters was assessed, and whether this modified the estimated treatment effects was also examined. RESULTS: A total of 1962 of the original 2013 participants (909 [46.3%] female; median [IQR] age, 77 [70-84] years) were included. The primary outcome occurred in 10 of 371 participants (2.7%) with early DOAC initiation vs 11 of 364 (3.0%) with late DOAC initiation among those with minor stroke (odds ratio [OR], 0.89; 95% CI, 0.38-2.10); in 11 of 388 (2.8%) with early DOAC initiation vs 14 of 392 (3.6%) with late DOAC initiation among those with moderate stroke (OR, 0.80; 95% CI, 0.35-1.74); and in 8 of 219 (3.7%) with early DOAC initiation vs 16 of 228 (7.0%) with late DOAC initiation among those with major stroke (OR, 0.52; 95% CI, 0.21-1.18). The 95% CI for the estimated risk difference of the primary outcome in early anticoagulation was −2.78% to 2.12% for minor stroke, −3.23% to 1.76% for moderate stroke, and −7.49% to 0.81% for major stroke. There was no significant treatment interaction for the primary outcome. For infarct size, interrater reliability was moderate (κ = 0.675; 95% CI, 0.647-0.702) for local vs core laboratory raters and strong (κ = 0.875; 95% CI, 0.855-0.894) between core laboratory raters. CONCLUSIONS AND RELEVANCE: The treatment effect of early DOAC initiation did not differ in people with minor, moderate, or major stroke assessed by brain imaging. Early treatment was not associated with a higher rate of adverse events, especially symptomatic intracranial hemorrhage, for any infarct size, including major stroke. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03148457
Published: 2024
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4. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author: Blanchard-Rohner, Geraldine, Sanchez, Carlos, Andre, Maya C., Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia A., Trück, Johannes, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Severi Conti, Alessia, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L’Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Lütolf Erni, Michaela, Kaiser, Daniela, Schwendener Scholl, Katharina, Peter Kuen, Hans, Hrup, Katja, Stritt, Janine, Bailey, Douggl G. N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Pachlopnik Schmid, Jana, Seiler, Michelle, Meyer Sauteur, Patrick, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.
Abstract: Data on COVID-19 vaccine acceptability among parents of children with multisystem inflammatory syndrome (MIS-C) are limited. In this cohort of children with MIS-C, enrolled in the Swissped RECOVERY trial (NCT 04826588), comparing intravenous immunoglobulins or methylprednisolone, who, in accordance with Swiss guidelines, were recommended for SARS-CoV-2 vaccination, 65% (73/112) of parents reported being vaccinated against SARS-CoV-2 before the MIS-C, while 70% were vaccinated after the MIS-C episode of their child. None of the children were vaccinated before the occurrence of the MIS-C, and only 9% (5/56) received the COVID-19 vaccine after the MIS-C. The predominant barriers to COVID-19 vaccination were concerns over potential side effects and insufficient support from their doctors. This emphasizes the crucial role of health care providers in promoting COVID-19 vaccination among children.
Published: 2024
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5. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Author: Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goltzman, David, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Leon, Margot, González-Rivas, Juan P, González-Villalpando, Clicerio, González-Villalpando, María-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graça, Antonio Pedro, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregg, Edward W, Gregor, Ronald D, Gregório, Maria João, Grøholt, Else Karin, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guajardo, Viviana, Gualdi-Russo, Emanuela, Guallar-Castillón, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerchet, Maëlenn, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gutiérrez González, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Gwee, Xinyi, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harmer Lassen, Tina, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felső, Regina, Heier, Margit, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Heude, Barbara, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Höfelmann, Doroteia A, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Husseini, Abdullatif, Huu, Chinh Nguyen, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Iakupova, Ellina M, Ibarluzea, Jesús, Ibrahim, Mohsen M, Ibrahim Wong, Norazizah, Igland, Jannicke, Ijoma, Chinwuba, Ikram, M Arfan, Iñiguez, Carmen, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jacobs, Jeremy M, Jadoul, Michel, Jafar, Tazeen, Jallow, Bakary, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Jan, Nataša, Jansson, Anna, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jiang, Chao Qiang, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Jonnagaddala, Jitendra, Jøran Kjerpeseth, Lars, Jørgensen, Torben, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Judge, Debra S, Juolevi, Anne, Jurak, Gregor, Jurca Simina, Iulia, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kaj, Mónika, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kanala, Kodanda R, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Kårhus, Line L, Karki, Khem B, Karlsson, Omat, Kassi Anicet, Adoubi, Katchunga, Philippe B, Katibeh, 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Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
Abstract: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Published: 2024
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6. Cash and Conflict: Large-Scale Experimental Evidence from Niger†

Author: Premand, Patrick and Rohner, Dominic
Abstract: AbstractConflict undermines development, while adverse economic shocks, in turn, can increase conflict risk. Policy interventions such as cash transfers could attenuate conflict risk by raising poor households’ opportunity costs. However, cash transfers may also trigger looting, and expanding government programs may attract attacks to undermine state legitimacy. We study the net effect across these forces based on the large-scale randomization of a government-led cash transfer program and georeferenced conflict events. Cash transfers did not yield greater pacification but—if anything—triggered a short-term increase in conflict events (by 0.63 percentage points), substantially driven by terrorist attacks by foreign rebel groups. (JEL D72, D74, H53, I38, O15, O17)
Published: 2024
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7. One-year Longitudinal Study of Antibody Profiles in Children: MIS-C Versus Children With Uncomplicated COVID-19

Author: Bekliz, Meriem, Thiriard, Anaïs, Stringhini, Silvia, Marchant, Arnaud, Didierlaurent, Arnaud M., Meyer, Benjamin, and Blanchard-Rohner, Geraldine
Published: 2024
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8. Compartmentalized ocular lymphatic system mediates eye–brain immunity

Author: Yin, Xiangyun, Zhang, Sophia, Lee, Ju Hyun, Dong, Huiping, Mourgkos, George, Terwilliger, Gordon, Kraus, Aurora, Geraldo, Luiz Henrique, Poulet, Mathilde, Fischer, Suzanne, Zhou, Ting, Mohammed, Farrah Shalima, Zhou, Jiangbing, Wang, Yongfu, Malloy, Seth, Rohner, Nicolas, Sharma, Lokesh, Salinas, Irene, Eichmann, Anne, Thomas, Jean-Leon, Saltzman, W. Mark, Huttner, Anita, Zeiss, Caroline, Ring, Aaron, Iwasaki, Akiko, and Song, Eric
Abstract: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina1. Still, the possibility of an immunological nexus between the posterior eye and the rest of the CNS tissues remains unexplored. Here, studying immune responses to herpes simplex virus in the brain, we observed that intravitreal immunization protects mice against intracranial viral challenge. This protection extended to bacteria and even tumours, allowing therapeutic immune responses against glioblastoma through intravitreal immunization. We further show that the anterior and posterior compartments of the eye have distinct lymphatic drainage systems, with the latter draining to the deep cervical lymph nodes through lymphatic vasculature in the optic nerve sheath. This posterior lymphatic drainage, like that of meningeal lymphatics, could be modulated by the lymphatic stimulator VEGFC. Conversely, we show that inhibition of lymphatic signalling on the optic nerve could overcome a major limitation in gene therapy by diminishing the immune response to adeno-associated virus and ensuring continued efficacy after multiple doses. These results reveal a shared lymphatic circuit able to mount a unified immune response between the posterior eye and the brain, highlighting an understudied immunological feature of the eye and opening up the potential for new therapeutic strategies in ocular and CNS diseases.
Published: 2024
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9. Sensitive multicolor indicators for monitoring norepinephrine in vivo

Author: Kagiampaki, Zacharoula, Rohner, Valentin, Kiss, Cedric, Curreli, Sebastiano, Dieter, Alexander, Wilhelm, Maria, Harada, Masaya, Duss, Sian N., Dernic, Jan, Bhat, Musadiq A., Zhou, Xuehan, Ravotto, Luca, Ziebarth, Tim, Wasielewski, Laura Moreno, Sönmez, Latife, Benke, Dietmar, Weber, Bruno, Bohacek, Johannes, Reiner, Andreas, Wiegert, J. Simon, Fellin, Tommaso, and Patriarchi, Tommaso
Abstract: Genetically encoded indicators engineered from G-protein-coupled receptors are important tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a family of sensitive multicolor norepinephrine (NE) indicators, which includes nLightG (green) and nLightR (red). These tools report endogenous NE release in vitro, ex vivo and in vivo with improved sensitivity, ligand selectivity and kinetics, as well as a distinct pharmacological profile compared with previous state-of-the-art GRABNEindicators. Using in vivo multisite fiber photometry recordings of nLightG, we could simultaneously monitor optogenetically evoked NE release in the mouse locus coeruleus and hippocampus. Two-photon imaging of nLightG revealed locomotion and reward-related NE transients in the dorsal CA1 area of the hippocampus. Thus, the sensitive NE indicators introduced here represent an important addition to the current repertoire of indicators and provide the means for a thorough investigation of the NE system.
Published: 2023
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10. Moments That Matter.

Author: Rohner, James M.
Subjects: MUSIC education, MUSIC teachers, MUSICAL composition, ENSEMBLE music, SCHOOL bands
Published: 2024

11. Rituximab treatment in children with IgA vasculitis nephritis: a case series of an international cohort

Author: Rohner, Katharina, Marlais, Matko, Ali, Alaa, Decramer, Stephane, Didsbury, Madeleine, Forbes, Thomas A, Koskela, Mikael, Kurt Su¨ku¨r, Eda Didem, La Scola, Claudio, Lopez, Mercedes, Moussaoui, Nabila, Navarro, Ana Cecilia, Nuutinen, Matti, Oosterveld, Michiel, Pasini, Andrea, Roelofs, Joris, and Tullus, Kjell
Published: 2024
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12. Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1

Author: Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, and Nair, Sajiv K.
Abstract: Immune activating agents represent a valuable class of therapeutics for the treatment of cancer. An area of active research is expanding the types of these therapeutics that are available to patients via targeting new biological mechanisms. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of immune signaling and a target of high interest for the treatment of cancer. Herein, we present the discovery and optimization of novel amino-6-aryl pyrrolopyrimidine inhibitors of HPK1 starting from hits identified via virtual screening. Key components of this discovery effort were structure-based drug design aided by analyses of normalized B-factors and optimization of lipophilic efficiency.
Published: 2023
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13. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author: Welzel, Tatjana, Atkinson, Andrew, Schöbi, Nina, Andre, Maya C, Bailey, Douggl G N, Blanchard-Rohner, Geraldine, Buettcher, Michael, Grazioli, Serge, Koehler, Henrik, Perez, Marie-Helene, Trück, Johannes, Vanoni, Federica, Zimmermann, Petra, Sanchez, Carlos, Bielicki, Julia A, Schlapbach, Luregn J, Bieri, Andreas, Gysi, Spyridoula, Janz, Indra, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, Kohns Vasconcelos, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, von Kalckreuth, Clemens, Woerner, Andreas, Zutter, Andreas, Kottanattu, Lisa, Mazzara, Calogero, Severi Conti, Alessia, Aebi, Christoph, Agyeman, Philipp K A, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, L'Huillier, Arnaud G, Martin, Anne-Laure, Polito, Angelo, Rohr, Marie, Rodriguez, Maria Isabel, Wagner, Noemie, Chanez, Vivianne, Bressieux-Degueldre, Sabrina, Ferry, Thomas, Hofer, Michael, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Donas, Alex, Germann, Sara, Hrup, Katja, Kaiser, Daniela, Kuen, Hans Peter, Lütolf Erni, Michaela, Schwendener Scholl, Katharina, Stritt, Janine, Wechselberger, Katharina, Beck, Ingrid, Birkenmaier, André, Flade, Martin, Rogdo, Bjarte, Iglowstein, Ivo, Lorenz, Philip, Wachinger, Tanja, Zöhrer, Konstanze, Brotschi, Barbara, Meyer Sauteur, Patrick M, Pachlopnik Schmid, Jana, Prader, Seraina, Seiler, Michelle, Weber, Kathrin, Wütz, Daniela, Whittaker, Elizabeth, and Faust, Saul N
Abstract: The emergence of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) led to the widespread use of anti-inflammatory treatments in the absence of evidence from randomised controlled trials (RCTs). We aimed to assess the effectiveness of intravenous methylprednisolone compared with intravenous immunoglobulins.
Published: 2023
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14. Older adults’ reasons to participate in digital skills learning: An interdisciplinary, multiple case study from Austria, Finland, and Germany

Author: Pihlainen, Kaisa, Ehlers, Anja, Rohner, Rebekka, Cerna, Katerina, Kärnä, Eija, Hess, Moritz, Hengl, Lisa, Aavikko, Lotta, Frewer-Graumann, Susanne, Gallistl, Vera, and Müller, Claudia
Abstract: AbstractThe rapid development of digital technologies and their increasing application in many areas of everyday life challenge all citizens to continuously learn digital skills. This also applies to older adults, among whom digital literacy is on average less well-developed than among younger adults. This article investigates why retired older adults participate in opportunities to learn digital skills. Multiple case design with both qualitative and quantitative methods was used to include the views of older adults from Austria, Finland, and Germany. The results of this interdisciplinary study indicated individual, social and technical reasons for their participation in digital skills training. Practical implications and recommendations for future studies are suggested.
Published: 2023
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15. Mathematical Models for Evaluating Effectiveness and Cost-Effectiveness of Cervical Cancer Control Policies in Populations Including Women Living With Human Immunodeficiency Virus: A Scoping Review

Author: Iskandar, Rowan, Taghavi, Katayoun, Low, Nicola, Bramer, Wichor M., Egger, Matthias, and Rohner, Eliane
Abstract: Mathematical modeling is increasingly used to inform cervical cancer control policies, and model-based evaluations of such policies in women living with human immunodeficiency virus (HIV) are an emerging research area. We did a scoping review of published literature to identify research gaps and inform future work in this field.
Published: 2022
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16. The cavefish Astyanax mexicanus

Author: Rohner, Nicolas
Abstract: Astyanax mexicanusexists in two forms: a surface form that is abundantly distributed throughout freshwater bodies in Middle America and a blind subterranean form endemic to caves in northeastern Mexico. These diverse fish populations have become a vertebrate model for investigating the genetic basis of environmental adaptation.
Published: 2023
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17. Vaccine Immunity and Immune Reconstitution in Children After Hematopoietic Stem Cell Transplantation: A Retrospective Single-center Study

Author: Gualtieri, Renato, Bernard, Fanette, Posfay-Barbe, Klara, and Blanchard-Rohner, Geraldine
Published: 2024
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18. Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases

Author: Rosain, Jérémie, Le Voyer, Tom, Liu, Xian, Gervais, Adrian, Polivka, Laura, Cederholm, Axel, Berteloot, Laureline, Parent, Audrey V., Pescatore, Alessandra, Spinosa, Ezia, Minic, Snezana, Kiszewski, Ana Elisa, Tsumura, Miyuki, Thibault, Chloé, Esnaola Azcoiti, Maria, Martinovic, Jelena, Philippot, Quentin, Khan, Taushif, Marchal, Astrid, Charmeteau-De Muylder, Bénédicte, Bizien, Lucy, Deswarte, Caroline, Hadjem, Lillia, Fauvarque, Marie-Odile, Dorgham, Karim, Eriksson, Daniel, Falcone, Emilia Liana, Puel, Mathilde, Ünal, Sinem, Geraldo, Amyrath, Le Floc’h, Corentin, Li, Hailun, Rheault, Sylvie, Muti, Christine, Bobrie-Moyrand, Claire, Welfringer-Morin, Anne, Fuleihan, Ramsay L., Lévy, Romain, Roelens, Marie, Gao, Liwei, Materna, Marie, Pellegrini, Silvia, Piemonti, Lorenzo, Catherinot, Emilie, Goffard, Jean-Christophe, Fekkar, Arnaud, Sacko-Sow, Aissata, Soudée, Camille, Boucherit, Soraya, Neehus, Anna-Lena, Has, Cristina, Hübner, Stefanie, Blanchard-Rohner, Géraldine, Amador-Borrero, Blanca, Utsumi, Takanori, Taniguchi, Maki, Tani, Hiroo, Izawa, Kazushi, Yasumi, Takahiro, Kanai, Sotaro, Migaud, Mélanie, Aubart, Mélodie, Lambert, Nathalie, Gorochov, Guy, Picard, Capucine, Soudais, Claire, L’Honneur, Anne-Sophie, Rozenberg, Flore, Milner, Joshua D., Zhang, Shen-Ying, Vabres, Pierre, Trpinac, Dusan, Marr, Nico, Boddaert, Nathalie, Desguerre, Isabelle, Pasparakis, Manolis, Miller, Corey N., Poziomczyk, Cláudia S., Abel, Laurent, Okada, Satoshi, Jouanguy, Emmanuelle, Cheynier, Rémi, Zhang, Qian, Cobat, Aurélie, Béziat, Vivien, Boisson, Bertrand, Steffann, Julie, Fusco, Francesca, Ursini, Matilde Valeria, Hadj-Rabia, Smail, Bodemer, Christine, Bustamante, Jacinta, Luche, Hervé, Puel, Anne, Courtois, Gilles, Bastard, Paul, Landegren, Nils, Anderson, Mark S., and Casanova, Jean-Laurent
Abstract: Human inborn errors of thymic T cell tolerance underlie the production of autoantibodies (auto-Abs) neutralizing type I IFNs, which predispose to severe viral diseases. We analyze 131 female patients with X-linked dominant incontinentia pigmenti (IP), heterozygous for loss-of-function (LOF) NEMO variants, from 99 kindreds in 10 countries. Forty-seven of these patients (36%) have auto-Abs neutralizing IFN-α and/or IFN-ω, a proportion 23 times higher than that for age-matched female controls. This proportion remains stable from the age of 6 years onward. On imaging, female patients with IP have a small, abnormally structured thymus. Auto-Abs against type I IFNs confer a predisposition to life-threatening viral diseases. By contrast, patients with IP lacking auto-Abs against type I IFNs are at no particular risk of viral disease. These results suggest that IP accelerates thymic involution, thereby underlying the production of auto-Abs neutralizing type I IFNs in at least a third of female patients with IP, predisposing them to life-threatening viral diseases.
Published: 2024
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19. Parallel Operation of Electron Ionization and Chemical Ionization for GC–MS Using a Single TOF Mass Analyzer

Author: Bräkling, Steffen, Kroll, Kai, Stoermer, Carsten, Rohner, Urs, Gonin, Marc, Benter, Thorsten, Kersten, Hendrik, and Klee, Sonja
Abstract: This work describes a novel mass spectrometer coupled to gas chromatography (GC–MS) that simultaneously displays the mass spectral information of electron (EI)- and chemical ionization (CI)-generated ion populations for a single chromatographic peak. After GC separation, the eluent is equally split and supplied in parallel to an EI and a novel CI source, both operating continuously. Precise switching of the ion optics provides the exact timing to consecutively extract the respective ion population from both sources and transfer them into a time-of-flight (TOF) mass analyzer. This technique enables the acquisition of complementary information from both ion populations (EI and CI) within a single chromatographic run and with sufficient data points to retain the chromatographic fidelity. The carefully designed GC transfer setup, fast ion optical switching, and synchronized TOF data acquisition system provide an automatic and straightforward spectral alignment of two ion populations. With an eluent split ratio of about 50% between the two ion sources, instrument detection limits of <40 fg on the column (octafluoronaphthalene) for the EI and <2 pg (benzophenone) for the CI source were obtained. The system performance and the additional analytical value for compound identification are demonstrated by means of different common GC standard mixtures and a commercial perfume sample of unknown composition.
Published: 2022
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20. Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish

Author: Krishnan, Jaya, Seidel, Chris W., Zhang, Ning, Singh, Narendra Pratap, VanCampen, Jake, Peuß, Robert, Xiong, Shaolei, Kenzior, Alexander, Li, Hua, Conaway, Joan W., and Rohner, Nicolas
Abstract: Cis-regulatory changes are key drivers of adaptative evolution. However, their contribution to the metabolic adaptation of organisms is not well understood. Here, we used a unique vertebrate model, Astyanax mexicanus—different morphotypes of which survive in nutrient-rich surface and nutrient-deprived cave waters—to uncover gene regulatory networks underlying metabolic adaptation. We performed genome-wide epigenetic profiling in the liver tissues of Astyanaxand found that many of the identified cis-regulatory elements (CREs) have genetically diverged and have differential chromatin features between surface and cave morphotypes, while retaining remarkably similar regulatory signatures between independently derived cave populations. One such CRE in the hpdbgene harbors a genomic deletion in cavefish that abolishes IRF2 repressor binding and derepresses enhancer activity in reporter assays. Selection of this mutation in multiple independent cave populations supports its importance in cave adaptation, and provides novel molecular insights into the evolutionary trade-off between loss of pigmentation and adaptation to food-deprived caves.
Published: 2022
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21. Quantitation of lymphatic transport mechanism and barrier influences on lymph node-resident leukocyte access to lymph-borne macromolecules and drug delivery systems

Author: Archer, Paul A., Sestito, Lauren F., Manspeaker, Margaret P., O’Melia, Meghan J., Rohner, Nathan A., Schudel, Alex, Mei, Yajun, and Thomas, Susan N.
Abstract: Lymph nodes (LNs) are tissues of the immune system that house leukocytes, making them targets of interest for a variety of therapeutic immunomodulation applications. However, achieving accumulation of a therapeutic in the LN does not guarantee equal access to all leukocyte subsets. LNs are structured to enable sampling of lymph draining from peripheral tissues in a highly spatiotemporally regulated fashion in order to facilitate optimal adaptive immune responses. This structure results in restricted nanoscale drug delivery carrier access to specific leukocyte targets within the LN parenchyma. Herein, a framework is presented to assess the manner in which lymph-derived macromolecules and particles are sampled in the LN to reveal new insights into how therapeutic strategies or drug delivery systems may be designed to improve access to dLN-resident leukocytes. This summary analysis of previous reports from our group assesses model nanoscale fluorescent tracer association with various leukocyte populations across relevant time periods post administration, studies the effects of bioactive molecule NO on access of lymph-borne solutes to dLN leukocytes, and illustrates the benefits to leukocyte access afforded by lymphatic-targeted multistage drug delivery systems. Results reveal trends consistent with the consensus view of how lymph is sampled by LN leukocytes resulting from tissue structural barriers that regulate inter-LN transport and demonstrate how novel, engineered delivery systems may be designed to overcome these barriers to unlock the therapeutic potential of LN-resident cells as drug delivery targets.
Published: 2021
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22. Pediatric Acute B-Cell Lymphoblastic Leukemia Developing Following Recent SARS-CoV-2 Infection

Author: Leclercq, Charlotte, Toutain, Fabienne, Baleydier, Frederic, L’Huillier, Arnaud G., Wagner, Noemie, Lironi, Céline, Calza, Anne-Marie, Ansari, Marc, and Blanchard-Rohner, Geraldine
Abstract: Coronavirus disease-2019 in children has been linked to various clinical presentation, from paucisymptomatic cutaneous eruptions, to multisystemic inflammatory syndrome. We report the case of an 8-year-old boy who presented with persistent fever and pancytopenia, associated to a skin rash. An extensive etiological workup showed a positive serology for severe acute respiratory syndrome coronavirus 2 and Epstein-Barr virus. A few weeks later, type B acute lymphocytic leukemia was diagnosed. This case underlines the polymorphic appearance of coronavirus disease-2019 and the need for critical appraisal.
Published: 2021
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23. Cancer risk in adolescents and young adults living with HIV in South Africa: a nationwide cohort study

Author: Ruffieux, Yann, Dhokotera, Tafadzwa, Muchengeti, Mazvita, Bartels, Lina, Olago, Victor, Bohlius, Julia, Singh, Elvira, Egger, Matthias, and Rohner, Eliane
Abstract: Literature on cancer in adolescents and young adults (AYA; aged 15–24 years) living with HIV is scarce. We studied cancer incidence in AYA living with HIV in South Africa between 2004 and 2014.
Published: 2021
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24. Characterization of Inflammatory and Fibrotic Encapsulation Responses of Implanted Materials with Bacterial Infection

Author: Rohner, Nathan A., Learn, Greg D., Wiggins, Michael J., Woofter, Ricky T., and von Recum, Horst A.
Abstract: Medical device infections are costly, while preclinical assessment of antimicrobial properties for new materials is time intensive and imperfect at capturing the interrelated aspects of infection response and wound resolution. Herein, we developed an in vivo model for quantification of inflammatory and biocompatibility responses in the presence of a sustained implant-associated infection. The antimicrobial effectiveness of commercially available polymer materials was compared to that of thermoplastic polyurethane (TPU) materials modified with putative antimicrobial strategies as example test materials. Materials were incubated with bioluminescent Escherichia coliprior to implantation in a dorsal subcutaneous pocket in rats with an additional intraluminal bolus of bacteria. Infection kinetics were monitored with bioluminescence, and inflammatory infiltrate and fibrous capsule thickness were determined from stained histological sections. Our model resulted in a persistent infection, sensitive to antimicrobial effects, as the materials modified with a putative antimicrobial surface were able to significantly reduce the level of infection in animals at day 4 postimplantation with efficacy similar to that of commercially available antimicrobial drug-eluting polymers (positive controls). At day 30 postimplantation, the antimicrobial surface modified TPU tubing was found to promote complete elimination of intraluminal bacteria in the absence of antibiotics. Differences were also measurable in acute inflammation, as Wright–Giemsa staining demonstrated reduced inflammatory cell infiltration at day 4 postimplantation for antimicrobial TPU materials. Additionally, antimicrobial materials exhibited reduced fibrous capsule thickness coinciding with infection resolution, as compared to unmodified TPU controls. The developed model can be utilized for testing antimicrobial polymers in the context of a prolonged infection while also revealing concurrent differences in the infiltrating immune cell profiles and fibrous capsule thickness, thus improving the relevance of preclinical medical device material testing.
Published: 2021
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25. Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019.

Author: Grazioli, Serge, Tavaglione, Fedora, Torriani, Giulia, Wagner, Noemie, Rohr, Marie, L'Huillier, Arnaud G, Leclercq, Charlotte, Perrin, Anne, Bordessoule, Alice, Beghetti, Maurice, Schmid, Jana Pachlopnik, Vavassori, Stefano, Perreau, Matthieu, Eberhardt, Christiane, Didierlaurent, Arnaud, Kaiser, Laurent, Eckerle, Isabella, Roux-Lombard, Pascale, and Blanchard-Rohner, Geraldine
Abstract: Recently, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) have been reported worldwide. Negative polymerase chain reaction (RT-PCR) testing associated with positive serology in most of the cases suggests a postinfectious syndrome. Because the pathophysiology of this syndrome is still poorly understood, extensive virological and immunological investigations are needed.
Published: 2021
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26. Rejecting the rejection of parental alienation: Comment on Mercer (2021)

Author: Bernet, William, Rohner, Ronald P., and Reay, Kathleen M.
Abstract: AbstractThis article is a response to comments by Mercer (2021), who criticized Bernet, Gregory, Rohner, and Reay (2020) regarding their research on parental alienation and the use of the Parental Acceptance-Rejection Questionnaire (PARQ). Here we respond to Mercer’s claims that the work of Bernet et al. is pseudoscience, that parental alienation theory involves false assumptions, that the extreme degree of psychological splitting observed by Bernet et al. is age-appropriate for adolescents, and that conclusions drawn by Bernet et al. are exaggerated and misstated.
Published: 2021
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27. The View From Europe: What’s New in European Arbitration?

Author: Rohner, Thomas, P. Ebert, Björn, Wilske, Stephan, Lindholm, Michelle, Beisteiner, Lisa, Horne, Lois, and Edworthy, Chloë
Published: 2021

28. Reply to: Shark mortality cannot be assessed by fishery overlap alone

Author: Queiroz, Nuno, Humphries, Nicolas E., Couto, Ana, Vedor, Marisa, da Costa, Ivo, Sequeira, Ana M. M., Mucientes, Gonzalo, Santos, António M., Abascal, Francisco J., Abercrombie, Debra L., Abrantes, Katya, Acuña-Marrero, David, Afonso, André S., Afonso, Pedro, Anders, Darrell, Araujo, Gonzalo, Arauz, Randall, Bach, Pascal, Barnett, Adam, Bernal, Diego, Berumen, Michael L., Lion, Sandra Bessudo, Bezerra, Natalia P. A., Blaison, Antonin V., Block, Barbara A., Bond, Mark E., Bonfil, Ramon, Bradford, Russell W., Braun, Camrin D., Brooks, Edward J., Brooks, Annabelle, Brown, Judith, Bruce, Barry D., Byrne, Michael E., Campana, Steven E., Carlisle, Aaron B., Chapman, Demian D., Chapple, Taylor K., Chisholm, John, Clarke, Christopher R., Clua, Eric G., Cochran, Jesse E. M., Crochelet, Estelle C., Dagorn, Laurent, Daly, Ryan, Cortés, Daniel Devia, Doyle, Thomas K., Drew, Michael, Duffy, Clinton A. J., Erikson, Thor, Espinoza, Eduardo, Ferreira, Luciana C., Ferretti, Francesco, Filmalter, John D., Fischer, G. Chris, Fitzpatrick, Richard, Fontes, Jorge, Forget, Fabien, Fowler, Mark, Francis, Malcolm P., Gallagher, Austin J., Gennari, Enrico, Goldsworthy, Simon D., Gollock, Matthew J., Green, Jonathan R., Gustafson, Johan A., Guttridge, Tristan L., Guzman, Hector M., Hammerschlag, Neil, Harman, Luke, Hazin, Fábio H. V., Heard, Matthew, Hearn, Alex R., Holdsworth, John C., Holmes, Bonnie J., Howey, Lucy A., Hoyos, Mauricio, Hueter, Robert E., Hussey, Nigel E., Huveneers, Charlie, Irion, Dylan T., Jacoby, David M. P., Jewell, Oliver J. D., Johnson, Ryan, Jordan, Lance K. B., Joyce, Warren, Keating Daly, Clare A., Ketchum, James T., Klimley, A. Peter, Kock, Alison A., Koen, Pieter, Ladino, Felipe, Lana, Fernanda O., Lea, James S. E., Llewellyn, Fiona, Lyon, Warrick S., MacDonnell, Anna, Macena, Bruno C. L., Marshall, Heather, McAllister, Jaime D., Meÿer, Michael A., Morris, John J., Nelson, Emily R., Papastamatiou, Yannis P., Peñaherrera-Palma, Cesar, Pierce, Simon J., Poisson, Francois, Quintero, Lina Maria, Richardson, Andrew J., Rogers, Paul J., Rohner, Christoph A., Rowat, David R. L., Samoilys, Melita, Semmens, Jayson M., Sheaves, Marcus, Shillinger, George, Shivji, Mahmood, Singh, Sarika, Skomal, Gregory B., Smale, Malcolm J., Snyders, Laurenne B., Soler, German, Soria, Marc, Stehfest, Kilian M., Thorrold, Simon R., Tolotti, Mariana T., Towner, Alison, Travassos, Paulo, Tyminski, John P., Vandeperre, Frederic, Vaudo, Jeremy J., Watanabe, Yuuki Y., Weber, Sam B., Wetherbee, Bradley M., White, Timothy D., Williams, Sean, Zárate, Patricia M., Harcourt, Robert, Hays, Graeme C., Meekan, Mark G., Thums, Michele, Irigoien, Xabier, Eguiluz, Victor M., Duarte, Carlos M., Sousa, Lara L., Simpson, Samantha J., Southall, Emily J., and Sims, David W.
Published: 2021
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29. Reply to: Caution over the use of ecological big data for conservation

Author: Queiroz, Nuno, Humphries, Nicolas E., Couto, Ana, Vedor, Marisa, da Costa, Ivo, Sequeira, Ana M. M., Mucientes, Gonzalo, Santos, António M., Abascal, Francisco J., Abercrombie, Debra L., Abrantes, Katya, Acuña-Marrero, David, Afonso, André S., Afonso, Pedro, Anders, Darrell, Araujo, Gonzalo, Arauz, Randall, Bach, Pascal, Barnett, Adam, Bernal, Diego, Berumen, Michael L., Lion, Sandra Bessudo, Bezerra, Natalia P. A., Blaison, Antonin V., Block, Barbara A., Bond, Mark E., Bonfil, Ramon, Braun, Camrin D., Brooks, Edward J., Brooks, Annabelle, Brown, Judith, Byrne, Michael E., Campana, Steven E., Carlisle, Aaron B., Chapman, Demian D., Chapple, Taylor K., Chisholm, John, Clarke, Christopher R., Clua, Eric G., Cochran, Jesse E. M., Crochelet, Estelle C., Dagorn, Laurent, Daly, Ryan, Cortés, Daniel Devia, Doyle, Thomas K., Drew, Michael, Duffy, Clinton A. J., Erikson, Thor, Espinoza, Eduardo, Ferreira, Luciana C., Ferretti, Francesco, Filmalter, John D., Fischer, G. Chris, Fitzpatrick, Richard, Fontes, Jorge, Forget, Fabien, Fowler, Mark, Francis, Malcolm P., Gallagher, Austin J., Gennari, Enrico, Goldsworthy, Simon D., Gollock, Matthew J., Green, Jonathan R., Gustafson, Johan A., Guttridge, Tristan L., Guzman, Hector M., Hammerschlag, Neil, Harman, Luke, Hazin, Fábio H. V., Heard, Matthew, Hearn, Alex R., Holdsworth, John C., Holmes, Bonnie J., Howey, Lucy A., Hoyos, Mauricio, Hueter, Robert E., Hussey, Nigel E., Huveneers, Charlie, Irion, Dylan T., Jacoby, David M. P., Jewell, Oliver J. D., Johnson, Ryan, Jordan, Lance K. B., Joyce, Warren, Keating Daly, Clare A., Ketchum, James T., Klimley, A. Peter, Kock, Alison A., Koen, Pieter, Ladino, Felipe, Lana, Fernanda O., Lea, James S. E., Llewellyn, Fiona, Lyon, Warrick S., MacDonnell, Anna, Macena, Bruno C. L., Marshall, Heather, McAllister, Jaime D., Meÿer, Michael A., Morris, John J., Nelson, Emily R., Papastamatiou, Yannis P., Peñaherrera-Palma, Cesar, Pierce, Simon J., Poisson, Francois, Quintero, Lina Maria, Richardson, Andrew J., Rogers, Paul J., Rohner, Christoph A., Rowat, David R. L., Samoilys, Melita, Semmens, Jayson M., Sheaves, Marcus, Shillinger, George, Shivji, Mahmood, Singh, Sarika, Skomal, Gregory B., Smale, Malcolm J., Snyders, Laurenne B., Soler, German, Soria, Marc, Stehfest, Kilian M., Thorrold, Simon R., Tolotti, Mariana T., Towner, Alison, Travassos, Paulo, Tyminski, John P., Vandeperre, Frederic, Vaudo, Jeremy J., Watanabe, Yuuki Y., Weber, Sam B., Wetherbee, Bradley M., White, Timothy D., Williams, Sean, Zárate, Patricia M., Harcourt, Robert, Hays, Graeme C., Meekan, Mark G., Thums, Michele, Irigoien, Xabier, Eguiluz, Victor M., Duarte, Carlos M., Sousa, Lara L., Simpson, Samantha J., Southall, Emily J., and Sims, David W.
Published: 2021
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30. PerFECT 2.0: A Web-Based Platform Designed to Facilitate and Support the Diagnosis of Patients with Idiopathic Pulmonary Fibrosis in Italy

Author: Vancheri, Carlo, Bengus, Monica, Bianchino, Laura, Cagnazzo, Maria G., Ghirardini, Alessandra, Lacedonia, Donato, Pasquali, Mercedes, Rea, Gaetano, Rohner, Sonja A., Sanduzzi, Alessandro, Torrisi, Sebastiano E., and Pesci, Alberto
Abstract: Introduction: Timely and accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is challenging, requiring specific tests including chest high-resolution computed tomography (HRCT), and limited by access to specialist centres with a multidisciplinary team (MDT). Here we describe PerFECT 2.0, an Italian web-based platform designed to create a network between tertiary centres with an MDT (hubs) and secondary centres (spokes), aiming to facilitate the diagnosis of IPF. Methods: PerFECT 2.0 went live on 1 November 2016. Spoke centres submit anonymised documentation (HRCT images, pathological samples, clinical data) for a second opinion on the potential diagnosis of IPF from a hub centre. HRCT images are quickly uploaded, with patient-identifying information automatically removed. The hub centre views documentation online (no downloads allowed), makes any further information requests, then returns their second opinion as free text. An e-learning area contains educational material and simulated training clinical cases. Metrics were collected for 2017–2019; a user survey was conducted from 30 June–31 July 2020. Results: Ten hub centres and 137 spoke centres have registered. The requests for a second opinion numbered 251 in 2017, 270 in 2018 and 265 in 2019 (overall mean 19.9 requests per month). The proportion of requests answered was 100.0% (251) in 2017, 100.0% (270) in 2018 and 97.7% (259) in 2019. The mean response time was 15.7 days. In the user survey, of nine hub responders and 19 spoke responders, 78% and 74%, respectively, reported that the platform is easy to use, and 100% and 89%, respectively, would recommend the platform to colleagues. Conclusion: The PerFECT 2.0 web-based platform has created a network that enables secondary centres to gain quick and easy access to a second opinion from a tertiary centre with an MDT through online evaluation of anonymised documentation, thereby facilitating and supporting the timely and accurate diagnosis of IPF.
Published: 2021
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31. Plasticity, symbionts and niche construction interact in shaping dung beetle development and evolution

Author: Rohner, Patrick T., Jones, Joshua A., and Moczek, Armin P.
Abstract: Developmental plasticity is an important product of evolutionary processes, allowing organisms to maintain high fitness in the face of environmental perturbations. Once evolved, plasticity also has the potential to influence subsequent evolutionary outcomes, for example, by shaping phenotypic variation visible to selection and facilitating the emergence of novel trait variants. Furthermore, organisms may not just respond to environmental conditions through plasticity but may also actively modify the abiotic and (sym)biotic environments to which they themselves respond, causing plasticity to interact in complex ways with niche construction. Here, we explore developmental mechanisms and evolutionary consequences of plasticity in horned dung beetles. First, we discuss how post-invasion evolution of plasticity in an introduced Onthophagus species facilitated rapid range expansion and concurrent local adaptation of life history and morphology to novel climatic conditions. Second, we discuss how, in addition to plastically responding to variation in nutritional conditions, dung beetles engage in behaviors that modify the environment that they themselves respond to during later development. We document that these environment-modifying behaviors mask heritable variation for life history traits within populations, thereby shielding genetic variants from selection. Such cryptic genetic variation may be released and become selectable when these behaviors are compromised. Together, this work documents the complex interactions between plasticity, symbionts and niche construction, and highlights the usefulness of an integrative Eco–Evo–Devo framework to study the varied mechanisms and consequences of plasticity in development and evolution.
Published: 2024
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32. Toward a Conception of Culture for Cross-Cultural Psychology.

Author: Rohner, Ronald P.
Abstract: Discusses conceptual differences between "culture,""social system," and "society." Suggests ways that a unique concept of culture can become meaningful in cross-cultural psychological research. (GC)
Published: 1984

33. Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups

Author: Rau, Tilman T., Bettschen, Eva, Büchi, Carol, Christe, Lucine, Rohner, Amanda, Müller, Michael D., Carlson, Joseph W., Imboden, Sara, and Zlobec, Inti
Abstract: Tumor budding is a robust prognostic parameter in several tumor entities but is rarely investigated in endometrial carcinoma. We applied the recently standardized counting method from the International Tumor Budding Consensus Conference for colorectal cancer (ITBCC) on a cohort of 255 endometrial carcinomas with known molecular profiles according to The Cancer Genome Atlas (TCGA) subgroups. Our investigation aims to clarify the potential prognostic role of tumor budding in endometrial carcinoma in contrast to other known prognostic factors, including molecular factors. In addition, the microcystic elongated and fragmented (MELF) pattern and tumor budding were compared with respect to their potential as markers for epithelial–mesenchymal transition (EMT). Tumor budding was found in n?=?67 (26.3%) tumors, with a very low mean of 0.7 buds per ×20 HE field. Tumor budding was significantly associated with depth of invasion, nodal status, lymphatic invasion (each p?
Published: 2021
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34. Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial

Author: Jeger, Raban V, Farah, Ahmed, Ohlow, Marc-Alexander, Mangner, Norman, Möbius-Winkler, Sven, Weilenmann, Daniel, Wöhrle, Jochen, Stachel, Georg, Markovic, Sinisa, Leibundgut, Gregor, Rickenbacher, Peter, Osswald, Stefan, Cattaneo, Marco, Gilgen, Nicole, Kaiser, Christoph, Scheller, Bruno, Ammann, Peter, Awad, Belal, Baumgartner, Margarete, Boehm, Michael, Bohl, Steffen, Bruch, Leonhard, Buckert, Dominik, Buser, Peter, Butter, Christian, Clever, Yvonne P., Cremers, Bodo, Cuculi, Florim, Dannberg, Gudrun, Erne, Paul, Ewen, Sebastian, Fahrni, Gregor, Franz, Marcus, Haager, Philipp, Harder-Allgoewer, Andrea, Hoffmann, Andreas, Höllriegel, Robert, Hölschermann, Frank, Jerichow, Timo, Joerg, Lucas, Kapos, Ioannis, Keweloh, Boris, Kherad, Behrouz, Kühne, Michael, Lauer, Bernward, Lenk, Karsten, Lenz, Corinna, Von Lewinski, Dirk, Linke, Axel, Luha, Olev, Maeder, Micha, Mahfoud, Felix, Mueller, Christian, Neuss, Michael, Niederl, Ella, Noutsias, Michel, Nuessli, Dominique, Oenal, Ismet, Otto, Sylvia, Paliskyte, Rima, Perl, Sabine, Pieske, Burkert, Plicht, Bjoern, Poerner, Tudor C, Richter, Stefan, Rickli, Hans, Riede, Florian, Roelli, Hans, Roettgen, Alexandra, Rohner, Franziska, Schirmer, Stephan, Schmidt, Albrecht, Schreiber, Matthias, Seidel, Mirko, Stephan, Frank-Peter, Sticherling, Christian, Struck, Berthold, Surber, Ralf, Tambor, Grit, Toggweiler, Stefan, Trachsel, Lukas, Twerenbold, Raphael, Wagner, Andreas, Wein, Bastian, Winkler, Sebastian, Winzer, Ephraim, Wolf, Alexander, Zellweger, Michael, Krackhardt, Florian, and Zweiker, Robert
Abstract: In the treatment of de-novo coronary small vessel disease, drug-coated balloons (DCBs) are non-inferior to drug-eluting stents (DESs) regarding clinical outcome up to 12 months, but data beyond 1 year is sparse. We aimed to test the long-term efficacy and safety of DCBs regarding clinical endpoints in an all-comer population undergoing percutaneous coronary intervention.
Published: 2020
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35. »Die Hand einer Farbigen« Theodor Storms Von Jenseit des Meeres im literatur- und diskursgeschichtlichen Kontext

Author: Rohner, Melanie
Published: 2020
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36. Programmable multistage drug delivery to lymph nodes

Author: Schudel, Alex, Chapman, Asheley Poole, Yau, Mei-Kwan, Higginson, Cody James, Francis, David Mark, Manspeaker, Margaret Patricia, Avecilla, Alexa Regina Chua, Rohner, Nathan Andrew, Finn, M. G., and Thomas, Susan Napier
Abstract: Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering cargo to specific cells in the lymph node cortex and paracortex is difficult. Here, we describe a delivery system to overcome lymphatic and intra-lymph node transport barriers by combining nanoparticles that are rapidly conveyed to draining lymph nodes after administration in peripheral tissues with programmable degradable linkers. This platform enables the controlled release of intra-lymph-mobile small-molecular cargo, which can reach vastly more immune cells throughout the lymph node than either the particles or free compounds alone. The release rate can be programmed, allowing access to different lymph node structures and therefore specific lymphocyte subpopulations. We are thus able to alter the subtypes of drugged lymph node cells to improve immunotherapeutic effects.
Published: 2020
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37. Stigmatization and knowledge of anorexia nervosa

Author: Varnado-Sullivan, Paula J., Parker, Christina C., and Rohner, Ashley
Abstract: Purpose: To further understand the stigma, attitudes towards, and recognition of Anorexia Nervosa (AN), the current study utilized both stigma and mental health literacy methodology. This study also included another psychological disorder, major depressive disorder (MDD) and a normal, lonely female (C) as comparison conditions. Methods: Male (291) and female (576) undergraduate students read a vignette describing one of the conditions. Participants then rated the vignettes on general personality characteristics, condition recognition, perceived seriousness and need for treatment. Results: Many of the participants could not correctly identify AN. However, both AN and MDD were stigmatized. Although AN was rated as being very driven and disciplined, there was recognition that treatment was warranted. Familiarity with the conditions did not impact ratings. Conclusions: Continued efforts to reduce the stigma of AN and subsequent treatment seeking are warranted. The normal, lonely condition also being rated somewhat negatively highlights the need to include comparison conditions in stigma studies. Level of evidence: Level II, comparative study.
Published: 2020
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38. Health-Related Quality of Life in Young Adults Following Pediatric Arterial Ischemic Stroke

Author: Rohner, Aline, Gutbrod, Klemens, Kohler, Barbara, Lidzba, Karen, Fischer, Urs, Goeggel-Simonetti, Barbara, Regenyi, Maria, Steinlin, Maja, and Bigi, Sandra
Abstract: Supplemental Digital Content is available in the text.
Published: 2020
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39. Effect of an asymmetric flow disturber on an ultrasonic flowmeter

Author: Papathanasiou, Panagiotis, Kissling, Beat, Kumar, Vivek, Rohner, Adrian, Berberig, Oliver, and Bezdek, Michal
Abstract: An ultrasonic flowmeter used in custody-transfer heat metering applications is subject to several test applications for approval. A flow disturbance test with an asymmetric swirl generator upstream of the device is performed to evaluate its accuracy with and without the swirl generator. This standard asymmetric swirl generator is designed to reproduce the behaviour of applications in the field, such as an out of plane 90° double bend. To assess the compliance of the already approved device (Endress+Hauser Prosonic Flow E Heat) for heat metering applications with the standard asymmetric swirl generator, extensive Computational Fluid Dynamics (CFD) simulations are performed. The steady and transient CFD simulations are carried out on a High-Performance Computer (HPC) for several volume flows. With the developed automated simulation method, a virtual calibration of the device takes place. The calibration curves for the cases of a straight pipe, and an asymmetric flow disturber mounted upstream of the flowmeter are attained from experiments and simulations. The agreement of experiments and simulations is discussed and physical insight for the behaviour of the flow disturber and the flowmeter is gained.
Published: 2020
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40. Timing of voiding cystourethrography after febrile urinary tract infection in children: a systematic review

Author: Mazzi, Sara, Rohner, Katharina, Hayes, Wesley, and Weitz, Marcus
Abstract: BackgroundDespite a trend towards early voiding cystourethrography (VCUG) after febrile urinary tract infection (fUTI) in children, clinical guidelines do not comment on the optimal timing and current practice varies considerably.ObjectiveTo assess whether the detection rate of vesicoureteric reflux (VUR) in children depends on the time period of VCUG procedure after onset of antibiotic therapy.MethodsMEDLINE, EMBASE and Cochrane Controlled Trials Register electronic databases were searched for eligible studies without language or time restriction (19 November 2018). Inclusion criteria were (1) patients <18 years of age; (2) VCUG performed in patients with fUTI after onset of antibiotic therapy either in the same patient population or in two or more different patient populations within one study at different time periods; and (3) with reported detection rate of VUR. The systematic review was carried out following the recommendations of the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.ResultsOf 4175 records, nine studies were included (number of patients, n=1745) for the main outcome prevalence of VUR by VCUG <8 days compared with VCUG ≥8 days after onset of antibiotic therapy. Pooled overall prevalence of VUR was not significantly different between the early and the late VCUG groups (risk ratio 0.98, 95% CI 0.81 to 1.19). Prevalence of VUR stratified by grade was not significantly different between the two groups.ConclusionEarly VCUG within 8 days after onset of antibiotic therapy does not affect the prevalence of VUR.Trial registration numberCRD42018117545
Published: 2020
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41. Activated Phosphoinositide 3 Kinase Delta Syndrome (APDS): A Primary Immunodeficiency Mimicking Lymphoma

Author: Baleydier, Frederic, Ranza, Emmanuelle, Schäppi, Michela, Rougemont, Anne-Laure, Merlini, Laura, Ansari, Marc, and Blanchard-Rohner, Geraldine
Abstract: Supplemental Digital Content is available in the text.Malignant or nonmalignant lymphoproliferative disorders together with repeated ear, nose, and throat infections should strongly motivate immunologic investigations. Indeed, we report a 7-year-old patient with a history of persistent abdominal symptoms along with recurrent ear, nose, and throat infections, who presented with intra-abdominal masses highly suggestive of a diagnostic of lymphoma, and who was diagnosed with activated-PI3K-delta syndrome, a recently described primary immunodeficiency prone to lymphoproliferation.
Published: 2019
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42. Feasibility of an inductive pedicle screw loosening detection concept using a pulse induction metal detector

Author: Rohner, R., Bauer, D.E., Hartmann, M., Götschi, T., and Farshad, M.
Published: 2024
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43. Assessing Fracture Force in Classic and Novel Vertebropexy Techniques under Simulated Flexion Loads

Author: Widmer, J., Schuler, A., Calek, A., Beretta-Piccoli, A., Wigger, O., Graf, R., Kiener, L., Rohner, R., Fasser, M., and Farshad, M.
Published: 2024
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44. Defect-Tolerant Plasmonic Elliptical Resonators for Long-Range Energy Transfer

Author: Antolinez, Felipe V., Winkler, Jan M., Rohner, Patrik, Kress, Stephan J. P., Keitel, Robert C., Kim, David K., Marqués-Gallego, Patricia, Cui, Jian, Rabouw, Freddy T., Poulikakos, Dimos, and Norris, David J.
Abstract: Energy transfer allows energy to be moved from one quantum emitter to another. If this process follows the Förster mechanism, efficient transfer requires the emitters to be extremely close (<10 nm). To increase the transfer range, nanophotonic structures have been explored for photon- or plasmon-mediated energy transfer. Here, we fabricate high-quality silver plasmonic resonators to examine long-distance plasmon-mediated energy transfer. Specifically, we design elliptical resonators that allow energy transfer between the foci, which are separated by up to 10 μm. The geometry of the ellipse guarantees that all plasmons emitted from one focus are collected and channeled through different paths to the other focus. Thus, energy can be transferred even if a micrometer-sized defect obstructs the direct path between the focal points. We characterize the spectral and spatial profiles of the resonator modes and show that these can be used to transfer energy between green- and red-emitting colloidal quantum dots printed with subwavelength accuracy using electrohydrodynamic nanodripping. Rate-equation modeling of the time-resolved fluorescence from the quantum dots further confirms the long-distance energy transfer.
Published: 2019
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45. Global spatial risk assessment of sharks under the footprint of fisheries

Author: Queiroz, Nuno, Humphries, Nicolas E., Couto, Ana, Vedor, Marisa, da Costa, Ivo, Sequeira, Ana M. M., Mucientes, Gonzalo, Santos, António M., Abascal, Francisco J., Abercrombie, Debra L., Abrantes, Katya, Acuña-Marrero, David, Afonso, André S., Afonso, Pedro, Anders, Darrell, Araujo, Gonzalo, Arauz, Randall, Bach, Pascal, Barnett, Adam, Bernal, Diego, Berumen, Michael L., Bessudo Lion, Sandra, Bezerra, Natalia P. A., Blaison, Antonin V., Block, Barbara A., Bond, Mark E., Bonfil, Ramón, Bradford, Russell W., Braun, Camrin D., Brooks, Edward J., Brooks, Annabelle, Brown, Judith, Bruce, Barry D., Byrne, Michael E., Campana, Steven E., Carlisle, Aaron B., Chapman, Demian D., Chapple, Taylor K., Chisholm, John, Clarke, Christopher R., Clua, Eric G., Cochran, Jesse E. M., Crochelet, Estelle C., Dagorn, Laurent, Daly, Ryan, Cortés, Daniel Devia, Doyle, Thomas K., Drew, Michael, Duffy, Clinton A. J., Erikson, Thor, Espinoza, Eduardo, Ferreira, Luciana C., Ferretti, Francesco, Filmalter, John D., Fischer, G. Chris, Fitzpatrick, Richard, Fontes, Jorge, Forget, Fabien, Fowler, Mark, Francis, Malcolm P., Gallagher, Austin J., Gennari, Enrico, Goldsworthy, Simon D., Gollock, Matthew J., Green, Jonathan R., Gustafson, Johan A., Guttridge, Tristan L., Guzman, Hector M., Hammerschlag, Neil, Harman, Luke, Hazin, Fábio H. V., Heard, Matthew, Hearn, Alex R., Holdsworth, John C., Holmes, Bonnie J., Howey, Lucy A., Hoyos, Mauricio, Hueter, Robert E., Hussey, Nigel E., Huveneers, Charlie, Irion, Dylan T., Jacoby, David M. P., Jewell, Oliver J. D., Johnson, Ryan, Jordan, Lance K. B., Jorgensen, Salvador J., Joyce, Warren, Keating Daly, Clare A., Ketchum, James T., Klimley, A. Peter, Kock, Alison A., Koen, Pieter, Ladino, Felipe, Lana, Fernanda O., Lea, James S. E., Llewellyn, Fiona, Lyon, Warrick S., MacDonnell, Anna, Macena, Bruno C. L., Marshall, Heather, McAllister, Jaime D., McAuley, Rory, Meÿer, Michael A., Morris, John J., Nelson, Emily R., Papastamatiou, Yannis P., Patterson, Toby A., Peñaherrera-Palma, Cesar, Pepperell, Julian G., Pierce, Simon J., Poisson, Francois, Quintero, Lina Maria, Richardson, Andrew J., Rogers, Paul J., Rohner, Christoph A., Rowat, David R. L., Samoilys, Melita, Semmens, Jayson M., Sheaves, Marcus, Shillinger, George, Shivji, Mahmood, Singh, Sarika, Skomal, Gregory B., Smale, Malcolm J., Snyders, Laurenne B., Soler, German, Soria, Marc, Stehfest, Kilian M., Stevens, John D., Thorrold, Simon R., Tolotti, Mariana T., Towner, Alison, Travassos, Paulo, Tyminski, John P., Vandeperre, Frederic, Vaudo, Jeremy J., Watanabe, Yuuki Y., Weber, Sam B., Wetherbee, Bradley M., White, Timothy D., Williams, Sean, Zárate, Patricia M., Harcourt, Robert, Hays, Graeme C., Meekan, Mark G., Thums, Michele, Irigoien, Xabier, Eguiluz, Victor M., Duarte, Carlos M., Sousa, Lara L., Simpson, Samantha J., Southall, Emily J., and Sims, David W.
Abstract: Effective ocean management and the conservation of highly migratory species depend on resolving the overlap between animal movements and distributions, and fishing effort. However, this information is lacking at a global scale. Here we show, using a big-data approach that combines satellite-tracked movements of pelagic sharks and global fishing fleets, that 24% of the mean monthly space used by sharks falls under the footprint of pelagic longline fisheries. Space-use hotspots of commercially valuable sharks and of internationally protected species had the highest overlap with longlines (up to 76% and 64%, respectively), and were also associated with significant increases in fishing effort. We conclude that pelagic sharks have limited spatial refuge from current levels of fishing effort in marine areas beyond national jurisdictions (the high seas). Our results demonstrate an urgent need for conservation and management measures at high-seas hotspots of shark space use, and highlight the potential of simultaneous satellite surveillance of megafauna and fishers as a tool for near-real-time, dynamic management.
Published: 2019
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46. Cyclodextrin Polymer Preserves Sirolimus Activity and Local Persistence for Antifibrotic Delivery over the Time Course of Wound Healing

Author: Rohner, Nathan A., Schomisch, Steve J., Marks, Jeffrey M., and von Recum, Horst A.
Abstract: Fibrosis and dysphagic stricture of the esophagus is a major unaddressed problem often accompanying endoscopic removal of esophageal cancers and precancerous lesions. While weekly injections of antiproliferative agents show potential for improved healing, repeated injections are unlikely clinically and may alternatively be replaced by creating an esophageal drug delivery system. Affinity-based polymers have previously shown success for continuous delivery of small molecules for weeks to months. Herein, we explored the potential of an affinity-based microparticle to provide long-term release of an antiproliferative drug, sirolimus. In molecular docking simulations and surface plasmon resonance experiments, sirolimus was found to have suitable affinity for beta-cyclodextrin, while dextran, as a low affinity control, was validated. Polymerized beta-cyclodextrin microparticles exhibited 30 consecutive days of delivery of sirolimus during in vitrorelease studies. In total, the polymerized beta-cyclodextrin microparticles released 36.9 mg of sirolimus per milligram of polymer after one month of incubation in vitro. Taking daily drug release aliquots and applying them to PT-K75 porcine mucosal fibroblasts, we observed that cyclodextrin microparticle delivery preserved bioactivity of sirolimus inhibiting proliferation by 27–67% and migration of fibroblasts by 28–100% of buffer treated controls in vitro. Testing for esophageal injection site losses, no significant loss was incurred under simulated saliva flow for 10 min, and 16.7% of fluorescently labeled polymerized cyclodextrin microparticle signal was retained at 28 days after submucosal injection in esophageal tissue ex vivoversus only 4% of the initial amount remaining for free dye molecules injected alone. By combining affinity-based drug delivery for continuous long-term release with a microparticle platform that is injectable yet remains localized in tissue interstitium, this combination platform demonstrates promise for preventing esophageal fibrosis and stricture.
Published: 2019
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47. Short-Term Clinical and Radiographical Outcome after Application of Anchored Intervertebral Spacers in Dogs with Disc-Associated Cervical Spondylomyelopathy

Author: Rohner, Deborah, Kowaleski, Michael P., Schwarz, Günter, and Forterre, Franck
Published: 2019
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48. Usefulness of a systematic approach at listing for vaccine prevention in solid organ transplant candidates

Author: Blanchard‐Rohner, Geraldine, Enriquez, Natalia, Lemaître, Barbara, Cadau, Gianna, Combescure, Christophe, Giostra, Emiliano, Hadaya, Karine, Meyer, Philippe, Gasche‐Soccal, Paola M., Berney, Thierry, Delden, Christian, and Siegrist, Claire‐Anne
Abstract: Solid organ transplant (SOT) candidates may not be immune against potentially vaccine‐preventable diseases because of insufficient immunizations and/or limited vaccine responses. We evaluated the impact on vaccine immunity at transplant of a systematic vaccinology workup at listing that included (1) pneumococcal with and without influenza immunization, (2) serology‐based vaccine recommendations against measles, varicella, hepatitis B virus, hepatitis A virus, and tetanus, and (3) the documentation of vaccines and serology tests in a national electronic immunization registry (www.myvaccines.ch). Among 219 SOT candidates assessed between January 2014 and November 2015, 54 patients were transplanted during the study. Between listing and transplant, catch‐up immunizations increased the patients’ immunity from 70% to 87% (hepatitis A virus, P= .008), from 22% to 41% (hepatitis B virus, P= .008), from 77% to 91% (tetanus, P= .03), and from 78% to 98% (Streptococcus pneumoniae, P= .002). Their immunity at transplant was significantly higher against S. pneumoniae(P= .006) and slightly higher against hepatitis A virus (P= .07), but not against hepatitis B virus, than that of 65 SOT recipients transplanted in 2013. This demonstrates the value of a systematic multimodal serology‐based approach of immunizations of SOT candidates at listing and the need for optimized strategies to increase their hepatitis B virus vaccine responses. The authors evaluate the impact of a systematic vaccinology workup, including pneumococcal ±influenza immunization at listing, serology‐based vaccine recommendations against other vaccine‐preventable diseases, and the documentation of vaccines and serologies in a national electronic immunization registry, in solid organ transplant candidates. Danziger‐Isakov and Kumar comment on page 315.
Published: 2019
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49. Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial

Author: Jeger, Raban V, Farah, Ahmed, Ohlow, Marc-Alexander, Mangner, Norman, Möbius-Winkler, Sven, Leibundgut, Gregor, Weilenmann, Daniel, Wöhrle, Jochen, Richter, Stefan, Schreiber, Matthias, Mahfoud, Felix, Linke, Axel, Stephan, Frank-Peter, Mueller, Christian, Rickenbacher, Peter, Coslovsky, Michael, Gilgen, Nicole, Osswald, Stefan, Kaiser, Christoph, Scheller, Bruno, Buser, Peter, Kühne, Michael, Zellweger, Michael, Sticherling, Christian, Wein, Bastian, Twerenbold, Raphael, Fahrni, Gregor, Plicht, Björn, Struck, Berthold, Önal, Ismet, Cremers, Bodo, Clever, Yvonne, Ewen, Sebastian, Schirmer, Stephan, Böhm, Michael, Wagner, Andreas, Lauer, Bernward, Stachel, Georg, Höllriegel, Robert, Winzer, Ephraim, Rickli, Hans, Ammann, Peter, Haager, Philipp, Trachsel, Lukas, Joerg, Lucas, Nüssli, Dominique, Roelli, Hans, Maeder, Micha, Rohner, Franziska, Markovic, Sinisa, Paliskyte, Rima, Buckert, Dominik, Awad, Belal, Erne, Paul, Jamshidi, Peiman, Cuculi, Florim, Kapos, Ioannis, Toggweiler, Stefan, Riede, Florian, Pörner, Tudor, Lenk, Karsten, Noutsias, Michel, Surber, Ralf, Dannberg, Gudrun, Franz, Markus, Otto, Sylvia, Zweiker, Robert, NIederl, Ella, Perl, Sabine, Pieske, Burkert, Schmidt, Albrecht, Luha, Olev, Von Lewinski, Dirk, Krackhardt, Florian, Kherad, Behrouz, Jerichow, Timo, Butter, Christian, Neuss, Michael, Tambor, Grit, Hölschermann, Frank, Bruch, Leonhard, Winkler, Sebastian, Lenz, Corinna, Seidel, Mirko, Keweloh, Boris, Röttgen, Alexandra, Bohl, Steffen, Wolf, Alexander, and Hoffmann, Andreas
Abstract: Drug-coated balloons (DCB) are a novel therapeutic strategy for small native coronary artery disease. However, their safety and efficacy is poorly defined in comparison with drug-eluting stents (DES).
Published: 2018
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50. Patients' Perceptions of Atrial Fibrillation, Stroke Risk, and Oral Anticoagulation Treatment: An International Survey

Author: Lane, Deirdre A., Meyerhoff, Juliane, Rohner, Ute, and Lip, Gregory Y. H.
Published: 2018
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