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The article discusses the age-specific immune response to La Crosse virus (LACV) infection in mice, highlighting differences between weanling and adult mice. Weanling mice showed early disease onset and higher levels of Th2 cytokines, while adult mice demonstrated resistance with increased Th1 cytokines and chemokines. The study emphasizes the importance of neutralizing antibodies and cytokine responses in protective immunity against LACV, suggesting further research into immune mechanisms in infection. [Extracted from the article]

This article discusses a study on orthobunyaviruses, a group of RNA viruses that can cause severe neurological disease in humans. The researchers developed a reverse genetics system using plasmid-based cDNA to study the genetic factors that drive neuropathogenesis. They compared wild type viruses with genetically modified viruses and found that the modified viruses maintained the replication and neuropathogenic phenotypes of the original viruses. This system provides a valuable tool for investigating the genetic determinants of orthobunyavirus neuropathogenesis. [Extracted from the article]

A recent report from Nationwide Children's Hospital in Columbus, Ohio discusses the findings of a study on La Crosse Virus (LACV) encephalitis in children. The study highlights the clinical manifestations and testing modalities for clinicians encountering this viral infection. It emphasizes the need for long-term neurobehavioral follow-up to better identify and support affected individuals. The research concludes that further investigation into host immune responses and therapeutic options is necessary. As climate change affects the distribution of mosquito-borne illnesses, there is a possibility of regional expansion of LACV endemicity. [Extracted from the article]

A recent study conducted by researchers at the University of Glasgow investigated the impact of Wolbachia symbionts on Bunyamwera virus (BUNV) infection in Aedes aegypti mosquitoes. Wolbachia, which is commonly used to control dengue virus transmission, was found to reduce BUNV infection in vitro but not in vivo. Instead, BUNV caused significant impacts on the density of Wolbachia strains in the mosquitoes. The study highlights the importance of understanding the complex interactions between arboviruses, mosquitoes, and Wolbachia in natural environments and the need to monitor Wolbachia prevalence at release sites. [Extracted from the article]

Oropouche virus could be linked to brain malformation and stillbirths, Brazilian health officials say.

A new report discusses research findings on the Orthobunyavirus, specifically the Brazoran virus. The Brazoran virus was first isolated from Culex mosquitoes in Texas in 2012, and this study reports its isolation from Culex erraticus mosquitoes in southern Florida in 2016. The study found that while Culex quinquefasciatus and Aedes aegypti mosquitoes were susceptible to infection, their vector competence for the Brazoran virus could not be demonstrated, suggesting they are unlikely vectors of the virus. This research was supported by the National Institutes of Health and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at the University of Tennessee has found that the region of eastern Tennessee and western North Carolina has a consistently high risk of pediatric La Crosse virus neuroinvasive disease (LACV-ND). The study investigated the geographic clustering and predictors of LACV-ND risk at the ZIP code level. The results showed that there were persistent high-risk and low-risk clusters of LACV-ND, with most cases consistently reported from a few high-risk clusters throughout the study period. The study also found that temperature and precipitation had positive but varying associations with disease risk. The findings suggest that targeted public health interventions should be implemented in high-risk areas to reduce the disease burden. Further research is needed to better understand the relationship between climate and LACV epidemiology. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the age-specific dynamics of neutralizing antibodies, cytokines, and chemokines in response to La Crosse virus (LACV) infection in mice. LACV is a primary cause of pediatric arboviral encephalitis in the United States, particularly affecting children aged 16 years or younger. The study reveals that weanling mice (3 weeks old) are more susceptible to LACV-induced disease compared to adult mice (6 weeks old). The research highlights age-specific variations in viral titers, neutralizing antibody titers, survivability, and cytokine and chemokine responses. Adult mice exhibit elevated levels of Th1 cytokines, while weanling mice show elevated levels of Th2 cytokines. The study emphasizes the need for further research into the immune responses to LACV infection. [Extracted from the article]

A study conducted by the Connecticut Agricultural Experiment Station provides new insights into the host-feeding behavior of mosquitoes in the Florida Everglades. The researchers collected blood-fed mosquitoes from the Everglades and an industrial site in Naples, FL, and identified the host species using PCR assays. The study found that different mosquito species fed on a variety of hosts, including mammals, birds, reptiles, and rodents. The findings contribute to a better understanding of the host and viral associations of mosquito species in southwestern Florida. [Extracted from the article]

A recent study conducted by researchers at the Institute Pasteur Dakar in Senegal has identified and characterized a strain of the Batai orthobunyavirus (BATV) that was previously misclassified as the Ilesha virus (ILEV). The study used genomic sequencing to confirm the presence of BATV in Senegal and revealed a close similarity between the Senegal strain and BATV strains from Uganda. This research provides the first evidence of BATV circulation in West Africa and highlights the importance of genomic approaches in virus classification. The study emphasizes the need for retrospective sequencing to reevaluate strains and identify potential public health threats. [Extracted from the article]

A recent study conducted by researchers at the University of South Carolina examined the presence of the La Crosse virus (LACV) in mosquito populations in the South Carolina Appalachian Mountains. The study found that while the three competent mosquito vectors for LACV were present in low abundance, none of the collected specimens tested positive for the virus. This suggests a low transmission risk for LACV in this region. However, further investigations are needed to understand the reasons for this endemicity variance within a relatively small geographic area. [Extracted from the article]

Bunyaviridae, California Encephalitis Virus, Encephalitis Viruses, Health and Medicine, La Crosse Virus, Orthobunyavirus, Mosquito-Borne Diseases, Public Health, RNA Viruses, Vertebrate Viruses Keywords: Bunyaviridae; California Encephalitis Virus; Encephalitis Viruses; Health and Medicine; La Crosse Virus; Mosquito-Borne Diseases; Orthobunyavirus; Public Health; RNA Viruses; Vertebrate Viruses EN Bunyaviridae California Encephalitis Virus Encephalitis Viruses Health and Medicine La Crosse Virus Mosquito-Borne Diseases Orthobunyavirus Public Health RNA Viruses Vertebrate Viruses 3882 3882 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on La Crosse virus are presented in a new report. [Extracted from the article]

This engineered human IgM constitutively expressed in a HEK-293 stable cell line can replace human-positive control sera in diagnostic serological techniques such as IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA). Keywords: Antibodies; Antineoplastics; Blood Proteins; Bunyaviridae; Engineering; Immunoglobulin Isotypes; Immunoglobulin M; Immunoglobulins; Immunology; Immunoproteins; Monoclonal Antibodies; Monoclonal Antibody; Orthobunyavirus; Proteins; RNA Viruses; Serum Globulins; U.S. Centers for Disease Control and Prevention EN Antibodies Antineoplastics Blood Proteins Bunyaviridae Engineering Immunoglobulin Isotypes Immunoglobulin M Immunoglobulins Immunology Immunoproteins Monoclonal Antibodies Monoclonal Antibody Orthobunyavirus Proteins RNA Viruses Serum Globulins U.S. Centers for Disease Control and Prevention 832 832 1 09/25/23 20230929 NES 230929 2023 OCT 1 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- New research on orthobunyavirus is the subject of a new report. [Extracted from the article]

Aedes albopictus, Bunyaviridae, California Encephalitis Virus, Encephalitis Viruses, La Crosse Virus, Mosquito-Borne Diseases, Mosquitoes, Orthobunyavirus, RNA Viruses, Vertebrate Viruses, Viral, Virology, Virus, Viruses, Mosquito Species Keywords: Aedes albopictus; Bunyaviridae; California Encephalitis Virus; Encephalitis Viruses; La Crosse Virus; Mosquito Species; Mosquito-Borne Diseases; Mosquitoes; Orthobunyavirus; RNA Viruses; Vertebrate Viruses; Viral; Virology; Virus; Viruses EN Aedes albopictus Bunyaviridae California Encephalitis Virus Encephalitis Viruses La Crosse Virus Mosquito Species Mosquito-Borne Diseases Mosquitoes Orthobunyavirus RNA Viruses Vertebrate Viruses Viral Virology Virus Viruses 777 777 1 08/14/23 20230815 NES 230815 2023 AUG 17 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on La Crosse virus are presented in a new report. [Extracted from the article]

A recent example is the Usutu virus, a flavivirus of the JEV complex responsible for human encephalitis, which has recently expanded in Europe (Ashraf et al., Viruses, 2015, 7, 219-38). Keywords: Arboviruses; Brain Diseases and Conditions; Bunyaviridae; Central Nervous System Diseases and Conditions; Central Nervous System Infections; Central Nervous System Viral Diseases and Conditions; Diagnostics and Screening; Drugs and Therapies; Encephalitis; Enzymes and Coenzymes; Epidemiology; Flavivirus; Genetics; Health and Medicine; Nucleocapsid; Orthobunyavirus; Patent Application; Peptides and Proteins; Polymerase; Polyproteins; RNA Viruses; Risk and Prevention; Therapeutics; Therapy; Vector-Borne Diseases and Conditions; Viral; Virions; Virology; Virus; Virus Diseases and Conditions; Viruses EN Arboviruses Brain Diseases and Conditions Bunyaviridae Central Nervous System Diseases and Conditions Central Nervous System Infections Central Nervous System Viral Diseases and Conditions Diagnostics and Screening Drugs and Therapies Encephalitis Enzymes and Coenzymes Epidemiology Flavivirus Genetics Health and Medicine Nucleocapsid Orthobunyavirus Patent Application Peptides and Proteins Polymerase Polyproteins RNA Viruses Risk and Prevention Therapeutics Therapy Vector-Borne Diseases and Conditions Viral Virions Virology Virus Virus Diseases and Conditions Viruses 2430 2430 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A patent application by the inventors CHRETIEN, Delphine (Saint Denis, FR); DUYCKAERTS, Charles (Saint Mande, FR); ELOIT, Marc (Paris, FR); PEROT, Philippe (Paris, FR); SEILHEAN, Danielle (Paris, FR), filed on May 7, 2020, was made available online on May 18, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. [Extracted from the article]

Keywords for this news article include: Rocky Mountain Laboratories, Genetics, RNA Viruses, Bunyaviridae, La Crosse Virus, Orthobunyavirus, Vertebrate Viruses, Health and Medicine, Encephalitis Viruses, Central Nervous System, Mosquito-Borne Diseases, California Encephalitis Virus. Keywords: Bunyaviridae; California Encephalitis Virus; Central Nervous System; Encephalitis Viruses; Genetics; Health and Medicine; La Crosse Virus; Mosquito-Borne Diseases; Orthobunyavirus; RNA Viruses; Vertebrate Viruses EN Bunyaviridae California Encephalitis Virus Central Nervous System Encephalitis Viruses Genetics Health and Medicine La Crosse Virus Mosquito-Borne Diseases Orthobunyavirus RNA Viruses Vertebrate Viruses 1576 1576 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in La Crosse virus. Bunyaviridae, California Encephalitis Virus, Central Nervous System, Encephalitis Viruses, Genetics, Health and Medicine, Mosquito-Borne Diseases, La Crosse Virus, RNA Viruses, Vertebrate Viruses, Orthobunyavirus. [Extracted from the article]

Keywords: Bunyamwera Virus; Bunyaviridae; Genetics; Orthobunyavirus; RNA Viruses; Risk and Prevention; Viral; Virology EN Bunyamwera Virus Bunyaviridae Genetics Orthobunyavirus RNA Viruses Risk and Prevention Viral Virology 1676 1676 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on Bunyamwera virus are presented in a new report. Bunyamwera Virus, Bunyaviridae, Genetics, Orthobunyavirus, RNA Viruses, Risk and Prevention, Viral, Virology. [Extracted from the article]