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South Africa faces the possibility of being grey listed. Wendy Murray and Chris Oliver look at how banks can face the identified challenges head-on There has been a lot of [...]

Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria for types of RTS (RTS1: CREBBP; RTS2: EP300), molecular investigations, long-term management of various particular physical and behavioural issues and care planning. The recommendations as presented here will need to be evaluated for improvements to allow for continued optimisation of diagnostics and care.

Dhis will be my final column in my role as the assistant administrator for NOAA Fisheries. It has been one of the greatest honors in my professional career to serve [...]

'These proposed modifications will affect about 2,500 lobster trap/pot vessels that will have to make changes to the way they fish.' --Chris Oliver, outgoing NMFS [...]

After more than a quarter-century of rapid growth, China's factory-to-the-world economy could now be set for a major slowdown, even as it tries to spend its way to strength, according [...]

The United States is recognized as a global leader in sustainable fisheries thanks to our fishermen, scientists, conservationists and many other partners, who work collaboratively to continuously expand and improve [...]

Back in May, Commerce Secretary Wilbur Ross announced the allocation of $300 million in fisheries I assistance funding in the Coronavirus Aid, Relief, and Economic Security Act, also called the [...]

In many fisheries, bycatch reduction is a priority for NOAA Fisheries, and a key component in managing and maintaining sustainable fisheries and supporting America's coastal communities. Recently, we announced $2.3 [...]

In my July column, I wrote about the president's Executive Order on Promoting American Seafood Competitiveness and Economic Growth. NOAA Fisheries has acted quickly to implement the executive order and [...]

OAA Fisheries and our many partners continue to build on the United States' successful fisheries management approach to help us meet the challenges of today and tomorrow. As reflected in [...]

As we are all well aware, your industry and our operations continue to be impacted by the ongoing coronavirus. While my staff and I have maintained an extremely high level [...]

Providing seafood to the country remains an essential function even in these extraordinary times. Adequately monitoring U.S. fisheries remains an important part of that process. However, in recognition of numerous [...]

The value of U.S. commercial fisheries landings remains strong and has a broad positive impact on the U.S. economy. NOAA Fisheries recently released Fisheries of the United States 2018, a [...]

NOAA Fisheries, in close coordination with the regional fishery management councils and state partners, is responsible for fostering healthy, productive and sustainable marine fisheries. Since 1996, NOAA Fisheries has reported [...]

NOAA Fisheries is committed to the sustainable management of our nation's fishery resources, including bluefin tuna. We domestically manage western Atlantic bluefin tuna based on recommendations adopted by the International [...]

On April 20, 2010, an explosion occurred on the Deepwater Horizon drilling platform in the Gulf of Mexico and took the lives of 11 workers. The explosion also resulted in [...]

As we sail into 2020, it is appropriate to look to the future and where NOAA Fisheries is heading. In November 2019 I attended the first-ever White House Ocean Science [...]

This is my last column of the calendar year, and I want to recount some of the biggest milestones from 2019. The first was our announcement regarding the continued high [...]

Talk about a headline--'West Coast Fisheries' Comeback of the Century.' What does a comeback have to do with fisheries? A lot, especially on the West Coast. In October, as part [...]

This month, I am highlighting three topics--the settlement with Carlos Rafael, the recent scoping meetings we held on North Atlantic right whales, and National Seafood Month. In settling the government's [...]

As stakeholders in the national effort to manage and maintain sustainable fisheries, I want you to know about NOAA Fisheries' new Strategic Plan. Released in July, the plan includes three [...]

This past June, Mother Nature reminded us she always has the final say. Here's what happened. As our Northeast Fisheries Science Center team was conducting the final leg of the [...]

Our agency leadership met recently with the regional fisheries management Council Coordination Committee in South Carolina. This is a regular meeting we have with the chairs, vice chairs, and executive [...]

The health and safety of our fisheries observers and at-sea monitors is a priority for the agency. They are our ears and eyes on the water in U.S. ocean fisheries [...]

The fishing industry has expressed concern about the effects of rapid wind energy development on coastal communities and sustainable fisheries, particularly in New England and the Mid-Atlantic. While wind can [...]

I know it seems like a subject that's over and done with now, but I do want to take this month's column to address how NMFS is getting back up [...]

Good news regarding landings, value and overall economic impact of the nation's marine fisheries was front and center recently when we released two flagship reports, Fisheries of the United States [...]

The Alaska pollock fishery is one of the largest and most valuable fisheries in the world. In 2016, commercial landings of pollock totaled more than 3.35 billion pounds and were [...]

Monitoring and measuring the impacts of changing ocean conditions on U.S. fisheries and protected resources and sharing that information with managers, researchers and the public is a top priority for [...]

Methods employed in genome-wide association studies are not feasible ways to explore genotype–phenotype associations in rare disorders due to limited statistical power. An alternative approach is to examine relationships among specific single nucleotide polymorphisms (SNPs), selected a priori, and behavioural characteristics. Here, we adopt this strategy to examine relationships between three SNPs (5-HTTLPR, MAOA, COMT) and specific clinically-relevant behaviours that are phenotypic of fragile X syndrome (FXS) but vary in severity and frequency across individuals. Sixty-four males with FXS participated in the current study. Data from standardised informant measures of challenging behaviour (defined as physical aggression, property destruction, stereotyped behaviour, and self-injury), autism symptomatology, attention-deficit-hyperactivity-disorder characteristics, repetitive behaviour and mood/interest and pleasure were compared between each SNP genotype. No association was observed between behavioural characteristics and either 5-HTTLPR (serotonin) or MAOA (monoamine oxidase) genotypes. However, compared to the COMT (dopamine) AG and GG genotypes, the AA genotype was associated with greater interest and pleasure in the environment, and with reduced risk for property destruction, stereotyped behaviour and compulsive behaviour. The results suggest that common genetic variation in the COMT genotype affecting dopamine levels in the brain may contribute to the variability of challenging and repetitive behaviours and interest and pleasure in this population. This study identifies a role for additional genetic risk in understanding the neural and genetic mechanisms contributing to phenotypic variability in neurodevelopmental disorders, and highlights the merit of investigating SNPs that are selected a priori on a theoretical basis in rare populations.

I experienced a bit of deja vu at the American Fisheries Society annual meeting this summer. There, I met a dozen or so graduate students from all over the United [...]

In July, limited operations got back underway in two high visibility sectors in the Northeast--sectors VII and IV. The interim rule that allowed operations to restart opened the door for [...]

Illegal, unregulated and unreported fishing is an issue that comes up frequently in this column. It has negative effects on fisheries, marine ecosystems, food security and coastal communities globally. It [...]

'Rebuilding stocks to fully utilize our fisheries is one way NOAA can reduce our nation's seafood deficit.' --Chris Oliver, NMFS [...]

Highly migratory species--tunas, sharks, swordfish and billfish--travel long distances and often cross domestic boundaries. NOAA Fisheries manages highly migratory species in waters of the U.S. Atlantic Ocean, Gulf of Mexico [...]

At NOAA Fisheries, summer is time for research cruises, surveys and other fisheries science related projects. Cooperative research, where fishermen, researchers and other stakeholders work together to collect fundamental information [...]

With summer on its way, I hope you will be enjoying the warmer weather and marine-related activities that come with it. With upticks in both recreational and commercial fishing, as [...]

The past year has been devastating for North Atlantic right whales--at least 18 whales have died in the United States and Canada, and the number of calves being born is [...]

This will be my first year attending the Seafood Expo North America trade show in Boston, and as the assistant administrator of NOAA Fisheries, I am looking forward to introducing [...]

In my last column, I pointed out that one of our top priorities for 2018 is maximizing fishing opportunities while ensuring the sustainability of fisheries and fishing communities. One of [...]

As part of our mission of science and stewardship, we also enforce regulations in order to safeguard our natural marine resources. Our special agents and enforcement officers have a big [...]

Sound science is the backbone of everything we do at NOAA Fisheries. This includes investing in and prioritizing technologies like electronic monitoring. Since 2006, we've provided more than $27 million [...]

Communicating this fact to the consumer is challenging. They are in a hurry, and making choices between seafood and a million other things for their families. That's why we created [...]

Every October, we celebrate seafood and U.S. fisheries with National Seafood Month. Our most recent statistics show U.S. commercial fishermen landed 9.7 billion pounds of seafood valued at $5.2 billion, [...]

Greetings, my name is Chris Oliver, and I have been serving as the head of NOAA Fisheries since June 19. I look forward to working with all of1 our partners, [...]

Full-service packet-based local exchange carriers supply small and medium-sized businesses with the network infrastructure to allow them to enter the new e-world. They give companies the means for advanced applications […]

Cornelia de Lange syndrome (CdLS) is an archetypical genetic syndrome that is characterized by intellectual disability, well-defined facial features, upper limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in any one of seven genes, all of which have a structural or regulatory function in the cohesin complex. Although recent advances in next-generation sequencing have improved molecular diagnostics, marked heterogeneity exists in clinical and molecular diagnostic approaches and care practices worldwide. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria, both for classic CdLS and non-classic CdLS phenotypes, molecular investigations, long-term management and care planning.

Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population; however, no meta-analysis has provided prevalence data within and between syndromes. In this systematic review and meta-analysis, we aimed to synthesise data from a wide range of papers to provide accurate estimates about ASD phenomenology in genetic and metabolic syndromes.