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Tsolis et al., reveal that the regulation of protein secretion in a Gram positive bacterial model is complex. Some of this regulation is transcriptional but a lot occurs post-transcriptionally and affects different exported proteins in different ways. Main Sec and chaperone machineries are not part of this regulation.

Im Zuge des Rohstoffwandels und einer nachhaltigen Entwicklung erschließt die chemische Industrie neue Rohstoffquellen für Chemikalien und Treibstoffe. Biobasierte Verfahren haben einen festen Platz im Portfolio der Unternehmen und angesichts von immer mehr Produkten auf Basis nachwachsender Rohstoffe fragen Forscher, wie die Industrie ethisch vertretbar mit Rohstoffen zu versorgen ist und wie sich petrochemische und biobasierte Raffineriekonzepte verknüpfen lassen. Das Beispiel Holz zeigt, wie viel Chemie ein nachwachsender Rohstoff erfordert und ermöglicht.

With the increasing use of metabolomics as a means to study a large number of different biological research questions, there is a need for a minimal set of reporting standards that allow the scientific community to evaluate, understand, repeat, compare and re-investigate metabolomics studies. Here we propose, a first draft of minimal requirements to effectively describe the biological context of metabolomics studies that involve microbial or in vitro biological subjects. This recommendation has been produced by the microbiology and in vitro biology working subgroup of the Metabolomics Standards Initiative in collaboration with the yeast systems biology network as part of a wider standardization initiative led by the Metabolomics Society. Microbial and in vitro biology metabolomics is defined by this sub-working group as studies with any cell or organism that require a defined external medium to facilitate growth and propagation. Both a minimal set and a best practice set of reporting standards for metabolomics experiments have been defined. The minimal set of reporting standards for microbial or in vitro biology metabolomics experiments includes those factors that are specificfor metabolomics experiments and that critically determine the outcome of the experiments. The best practice set of reporting standards contains both the factors that are specificfor metabolomics experiments and general aspectsthat critically determine the outcome of any microbial or in vitro biological experiment.