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Start Over Author "Ochmann, Carmen" Publication Type Magazines
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1. The Bispecific SDF1-GPVI Fusion Protein Preserves Myocardial Function After Transient Ischemia in Mice

Author

Ziegler, Melanie, Elvers, Margitta, Baumer, Yvonne, Leder, Christoph, Ochmann, Carmen, Schönberger, Tanja, Jürgens, Tobias, Geisler, Tobias, Schlosshauer, Burkhard, Lunov, Oleg, Engelhardt, Stefan, Simmet, Thomas, and Gawaz, Meinrad

Abstract

CXCR4-positive bone marrow cells (BMCs) are critically involved in cardiac repair mechanisms contributing to preserved cardiac function. Stromal cell–derived factor-1 (SDF-1) is the most prominent BMC homing factor known to augment BMC engraftment, which is a limiting step of stem cell–based therapy. After myocardial infarction, SDF-1 expression is rapidly upregulated and promotes myocardial repair.

Published
2012
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