33 results on '"O’Mahony, Michael"'
Search Results
2. Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (α/γ) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a double-blind, randomized, pioglitazone-comparative study
- Author
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Kendall, David M., Rubin, Cindy J., Mohideen, Pharis, Ledeine, Jean-Marie, Belder, Rene, Gross, Jorge, Norwood, Paul, O'Mahony, Michael, Sall, Kenneth, Sloan, Greg, Roberts, Anthony, Fiedorek, Fred T., and DeFronzo, Ralph A.
- Subjects
Type 2 diabetes -- Risk factors -- Diagnosis -- Drug therapy ,Hyperglycemia -- Risk factors -- Diagnosis -- Drug therapy ,Health ,Diagnosis ,Drug therapy ,Risk factors - Abstract
OBJECTIVE--We sought to evaluate the effects of muraglitazar, a dual (α/γ) peroxisome proliferator-activated receptor (PPAR) activator within the new glitazar class, on hyperglycemia and lipid abnormalities. RESEARCH DESIGN AND METHODS--A [...]
- Published
- 2006
3. Ertugliflozin and Slope of Chronic eGFR
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Cherney, David Z.I., Cosentino, Francesco, Dagogo-Jack, Samuel, McGuire, Darren K., Pratley, Richard, Frederich, Robert, Maldonado, Mario, Liu, Chih-Chin, Liu, Jie, Pong, Annpey, Cannon, Christopher P., Pozzi, Jose Maria, Maffei, Laura, Nardone, Lucrecia, Sessa, Horacio, Brasca, Daniela Garcia, Aizenberg, Diego, Baccaro, Claudia Emilce, Gelersztein, Elizabeth Silvana, Rosario, Fabian Calella Pedro, Leon de la Fuente, Ricardo, de Lapertosa, Silvia Gorban, Maldonado, Natacha, Cruciani, Adrian, Bartolacci, Ines, Hasbani, Eduardo, Frechtel, Gustavo, Papini, Nelson Rodriguez, Pereyra, Alejandro, Montana, Oscar, Zaidman, Cesar, Mansilla, Maria, Ayres, Bronte, Simpson, Richard, Glastras, Sarah, William, Maged, Davis, Timothy, Colquhoun, David, Proietto, Joseph, Roberts, Adam, Roberts, Anthony, Stuckey, Bronwyn, Wittert, Gary, Soldatos, Georgia, Vora, Parind, Kusljugic, Zumreta, Avdagic, Azra, Durak-Nalbantic, Azra, Ibrahimpasic, Kanita, Horozic, Bosanko, Spuzic, Muhamed, Soldat-Stankovic, Valentina, Stevanovic, Dragan, Koco, Damir, Jatic, Zaim, Terzic, Ibrahim, Potkonjak, Ljiljana Markovic, Prnjavorac, Besim, Radanovic, Aleksandar, Salihbasic, Muhamed, Dimitrov, Dimitar, Stoikov, Anastas, Damyanova, Velichka, Vasileva, Darina, Kirilov, Kiril, Lefterov, Ivailo, Lyubenova, Lyudmila, Raev, Dimitar, Tsanova, Veska, Mitkov, Mitko, Shumkova, Rositsa, Kichukov, Kostadin, Simeonova-Nikolova, Tatyana, Ekoe, Jean-Marie, Pandey, Shekhar A., Dumas, Richard, Woo, Vincent, Saunders, Kevin, Conway, James, Breger, Laurie, Constance, Christian, O'Mahony, Michael, Perron, Patrice, Garceau, Claude, Csanadi, Michael, Bourgeois, Ronald, Salter, Timothy, Frechette, Andre, Diaz, Ariel, Ransom, Thomas, Sanchez-Vallejo, Gregorio, Silva, Sandra Isabel Barrera, Mendoza, Jose Accini, Ortiz, Luis Garcia, Lozno, Hernan Yupanqui, de Salazar, Dora Molina, Arroyo, Julian Coronel, Orozco Linares, Luis Alejandro, Lenis Rendon, Claudia Patricia, Darko, Pocanic, Tusek, Srecko, Weiss, Sonja Slosic, Silvija, 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Ashwini, Al-Karadsheh, Amer, Masri, Bassem, Gorrela, Sushma, Al-Amin, Jessie Louise, Alani, Firas, Haffizulla, Jason, Hsieh, Ron, Hernandez, Luis Castillo, Turner, Merle, French, William, Jetty, Preetham, Sheikh-Ali, Mae, Leggett, Richard, Perlman, Richard, Goldstein, Gary, Osea, Edgardo A., Bartkowiak, Anthony James, Gimness, Michael Paul, Higgins, Alexander John, Khan, Sohail Mohyuddin, Rahimi, Ali R, Shah, Anil Vallabhdas, Lillo, Joseph Leonard, Hartman, Israel Alejandro, Whitney, Edwin J., Johnston, Janice G., Juarez, Mario R., Perley, Michael J., Kahn, Brian Howard, Amine, Maged A., Pace, Michael Anthony, Peters, Shirin Sabina, Hidalgo, Horacio Augusto, Krichmar, Perry, and Sinha, Rabi Ranjan
- Published
- 2021
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4. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
- Author
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Bhatt, Deepak L, Steg, Philippe Gabriel, Mehta, Shamir R, Leiter, Lawrence A, Simon, Tabassome, Fox, Kim, Held, Claes, Andersson, Marielle, Himmelmann, Anders, Ridderstråle, Wilhelm, Chen, Jersey, Song, Yang, Diaz, Rafael, Goto, Shinya, James, Stefan K, Ray, Kausik K, Parkhomenko, Alexander N, Kosiborod, Mikhail N, McGuire, Darren K, Harrington, Robert A, Santos, Vladimir, Jain, Ashit, Lendel, Irina, Russo, Michael, Haught, W H, Bouza, Manuel, Gogia, Harinder, Banerjee, Supratim, Kichura, George, Kantaros, Louis, Padron, Francisco, Passi, Rakesh, Stone, Jay, Pursley, Michael, D'Urso, Michael, Gardner, Timothy, Bennett, James, Nour, Khaled, Saini, Satinder, Zhang, Wenwu, Kumbhani, Dharam, Thomas, Dustin, Angiolillo, Dominick, Bertolet, Barry, Roman-Miranda, Amaury, Black, Robert, Manshadi, Ramin, Vaca, Carlos, Blanco, Antonio, Napoli, Mark, Brabham, David, Akyea-Djamson, Ayim, Desai, Pratik, Prasada, Sudhir, Khaira, Ajit, Forgosh, Leslie, Lieber, Ira, Umpierrez, Guillermo, Singal, Dinesh, Londono, Juan, Fraser, Neil, Ruiz, Jose, Vega, Damaris, Rodriguez, Lilia, Brown, Christopher, Syed, Faizullah, Aggarwala, Guarav, Eaves, William, Foster, Michael, Gupta, Dinesh, Avino, David, Asfour, Wail, Tonnessen, Glen, Zhao, Xue-Qiao, Singh, Narendra, Brockmyre, Andrew, Lepor, Norman, Shammas, Nicolas, Blick, David, Hearne, Steven, Prodafikas, John, Carell, Edgar, Izzo, Mark, Karim, Amin, Zakhary, Bosh, Atieh, Mahmoud, Leichter, Steven, Meadows, Charles, Hotchkiss, David, Abu-Fadel, Mazen, Wiseman, Alan, Bander, Jeffrey, Shah, Mahesh, Banerjee, Subhash, Ganim, Ricky, Sopko, Karen, Khan, Misal, Lloret, Ramon, Weirick, Troy, Mehta, Rajendra, Thadani, Udho, Bhargava, Anuj, Kosiborod, Mikhail, Moya, Jaynier, Staniloae, Cezar, Guerra, Yamirka D, Chhabra, Anil, Kosmicki, Douglas, Shaheen, Wassim, Mohammed, Akber, Bitters, J'Cinda, Pattanayak, Jan, Javier, Julian, Srivastava, Sunny, Phillips, Roland, Al-Amin, Jessie, Lillestol, Michael, Simpson, Patrick, Hazan, Lydie, Amin, Amit, Shah, Gopi, Korpas, Denes, Platt, Bruce, Dickert, Jim, Puente, Orlando, Hiotis, Louis, Doyle, Timothy, Rajan, Raj, Meholick, Alan, Gring, Christian, Hage-Korban, Elie, Feldman, Robert, Colfer, Harry, Butman, Samuel, Foster, Malcolm, Hart, Terence, Huling, Randall, Eshaghian, Shervin, Quintana, Ofsman, Cheung, Deanna, Handel, Franklin, Rodriguez, Mara, Suh, David, Gordon, Paul, Pressman, Gregg, Bauer, Michael, French, William, Barettella, Mark, Chatrathi, Sridhar, Suresh, Damodhar, Goldberg, Ronald, Huth, Mark, Younis, Liwa, Rahman, Aref, Mascolo, Richard, Welch, Michelle, Suneja, Randeep, Smith, Stephen, Shurmur, Scott, Agaiby, John, Jingo, Ahmad, Johnston, Janice, Beth, Mary, Vlastaris, Anthony, Kemp, Susan, Taheri, Hamid, Pereira, Edward, Deyoung, Michael, Hawa, Zafir, Smith, Ray, Galski, Thomas, Garas, Samer, Reddy, M, Sharma, Susheel, Hargrove, Joeseph, Treasure, Charles, Emerson, Ronald, Haddad, Tariq, Rohr, Kathryn, Levinson, Larry, Gaona, Raul, Uretsky, Barry, Maheshwari, Hiralal, Lee, Denny, Kinnaman, Stephanie, Singal, Robert, Geohas, Jeffrey, Gigliotti, Osvaldo, Raisinghani, Ajit, Khurana, Charanjit, Hella, Brent, Kelberman, Michael, Voyce, Steven, Singh, Sanjay, Lo, Eric, Singh, Pradeep, Goodfellow, Ross, Fischer, Stuart, Lorraine, Richard, Turner, Traci, Shanes, Jeffrey, Busch, Robert, Broker, Robert, Zaniewski, Michelle, Pounds, Kevin, Debs-Perez, Giselle, Ong, Stephen, Frandsen, Brad, Fullington, Douglas, Jaffrani, Naseem, Khan, Ahtaram, Lee, Marcus, Pouzar, Joe, Revtyak, George, Gonzalez, Julian, Nakhle, Samer, Murillo, Abel, Young, Douglas, Makam, Sashi, Syed, Mushtaq, Woolf, Kevin, Grena, Paul, Alfata, Sarab, Mahal, Sharan, Hoffman, David, Kizhakekuttu, Tinoy, Deering, Joseph, Bhavsar, Janak, Mikesell, Scott, Wilson, William, Wilson, Vance, El, Salah, Spinale, Francis, Kannarkat, Vinod, Rao, Sunder, Hanson, Lenita, Bertsch, John, Gonzalez-Ortiz, Elena, Severino, Norma, Willis, John, Schock, Joel, Bakhtari, Ladan, Gazmuri, Raul, Ansari, Saadat, Hall, Jason, Mehta, Arvind, Shealy, Neal, Zarich, Stuart, Singh, Deovrat, Vora, Kishor, Andrawis, Nabil, Molter, Darron, Maron, David, Cardona, Jose, D'Agostino, Ronald, Arshad, Tamjeed, Samaan, Rodney, Jones, David, Presser, Dale, Heath, John, Green, Sandy, Bittar, George, Henry, Sheldon, Korn, David, Schmedtje, John, Nadar, Venkatesh, Graham, Bruce, Labroo, Ajay, Clavijo, Leonardo, Roseman, Hal, Ledesma, Gilbert, Rosen, Robert, Dor, Isaac, Kirby, William, Sutton, Jennefer, Eder, Frank, Iteld, Bruce, Gomez-Cortes, Jose, Buchbinder, Maurice, Kasper, Joseph, Terrelonge, Antonio, Torres, Gustavo, Jagielo, Ted, Alvarez, Jose, Handelsman, Yehuda, Guillen, Mario, Richwine, Randall, Lewy-Alterbaum, Lorena, Corder, Clinton, Arvind, Moogali, Bolshoun, David, Mikhail, Magdy, Minton, Stephen, Alvarado, Odilon, Abbott, J, Cauthen, Brett, Welter, Ryan, Mintz, Randy, Cox, John, Quick, Annette, Weiss, Melvin, Dy, Johnny, Zebrack, James, Gandelman, Glenn, Hegde, Vinayak, Silver, Marc, DeGregorio, Michele, Lawson, William, Paa, Christopher, Bortnick, Anna, Krolick, Merrill, Sotolongo, Rodolfo, Cheirif, Jorge, Kumar, Priya, Nadar, Venkatesh, Jetty, Preetham, Patel, Ambar, Kruk, Mariusz, Kobielusz-Gembala, Iwona, Rewerska, Barbara, Madrzejewski, Adam, Milewski, Krzysztof, Cygler, Jerzy, Petryka-Mazurkiewicz, Joanna, Jastrzebski, Waldemar, Korecki, Janusz, Fil, Wojciech, Prokopczuk, Janusz, Bochenek, Anna, Wujkowski, Marek, Witek, Robert, Konczakowski, Piotr, Miekus, Pawel, Szczasny, Marcin, Musial, Wlodzimierz, Cymerman, Krzysztof, Lampart, Jacek, Mikosinski, Jacek, Szynal, Slawomir, Fares, Issa, Opolski, Grzegorz, Mazur, Stanislaw, Wozakowska-Kaplon, Beata, Bijata-Bronisz, Renata, Wierucki, Lukasz, Losa, Beata, Drelich, Grzegorz, Konieczny, Marek, Starczewski, Pawel, Pawlowicz, Lidia, Jesionowski, Pawel, Jurowiecki, Jaroslaw, Gniot, Jacek, Czyzycki, Mariusz, Stania, Karol, Kucharczyk-Bauman, Izabela, Busz-Papiez, Benita, Karczmarczyk, Agnieszka, Sudnik, Wanda, Koszek, Alina, Kolodziej, Piotr, Skwarna, Bartosz, Jaramillo, Nicolás, Jankowski, Maciej, Czochra, Wojciech, Kinasz, Leszek, Miklaszewicz, Beata, Stasinska, Teresa, Pluta, Wladyslaw, Basiak, Marcin, Rusicka, Teresa, Niedbal-Yahfouf, Izabela, Popenda, Grazyna, Korzeniak, Romuald, Mirek, Agnieszka, Mariankowski, Rafal, Wojnowski, Lukasz, Korol, Marek, Baszak, Jacek, Podolec, Piotr, Piesiewicz, Wojciech, Zurakowski, Aleksander, Luengas, Carlos, Skura, Marek, Pilecki, Piotr, Majchrzak, Piotr, Krzyzagórska, Ewa, Drozd, Marcin, Kaczmarek, Barbara, Sliwinska, Teresa, Zelazowska, Katarzyna, Sztembis, Rafal, Landa, Katarzyna, Matyszczak-Toniak, Lidia, Strojek, Krzysztof, Piepiorka, Marek, Malinowski, Robert, Górska, Maria, Stolarczyk-Sowa, Edyta, Romanowski, Leszek, Zinka, Elzbieta, Reszka, Zygfryd, Skierkowska, Joanna, Uzunow, Anna, Laskowska-Derlaga, Ewa, Puntus, Ekaterina, Kosmacheva, Elena D, Koziolova, Natalia, Pavlov, Prokhor, Supryadkina, Tatiana, Didenko, Yury, Kopylov, Philipp, Kazakov, Andrei, Aksentiev, Sergei, Vishneva, Elena, Repin, Alexey, Smolenskaya, Olga, Mantserova, Olga, Khrustalev, Oleg, Privalova, Elena, Konstantinov, Vladimir, Boldueva, Svetlana, Ezhov, Andrey, Chernyavsky, Alexander, Kamalov, Gadel, Galyavich, Albert, Zubeeva, Galina, Nechaeva, Galina, Shustov, Sergey, Dzhaiani, Nino, Treshkur, Tatiana, Osokina, Nataliya, Panov, Alexey, Shutemova, Elena, Makukhin, Valeriy, Kropotina, Tatiana, Tsyba, Larisa, Karpov, Yuri, Sizova, J M, Ballyuzek, Marina, Tarasov, Nikolay, Demchenko, Elena, Barbarash, Olga, Moiseev, Valentin, Markov, Valentin, Kuznetsov, Vadim, Viktorova, Inna, Sergienko, Igor, Ermoshkina, Lyudmila, Khasanov, Niyaz, Khlevchuk, Tatiana, Baglikov, Andrey, Shalaev, Sergey, Zonova, Elena, Reznik, Elena, Haisheva, Larisa, Morugova, Tatyana, Lomakin, Nikita, Vishnevsky, Alexander, Shvarts, Yuri, Magnitskaya, Olga, Mikhailusova, Marina, Pavlysh, Elena, Libov, Igor, Zateyschikova, Anna, Kostenko, Victor, Edin, Anton, Khovaeva, Yaroslava, Zakharov, Konstantin, Stryuk, Raisa, Khirmanov, Vladimir, Kanorskiy, Sergey, Yakushin, Sergey, Barabashkina, Anna, Li, Hongwei, Zhao, Qiang, Zhang, Jian, Ma, Jianhua, He, Yong, Luo, Ming, Zhang, Aidong, Zhang, Ningru, Chai, Yingru, Ma, Genshan, Wang, Hao, Liu, Zhigang, He, Lanjie, Song, Zhifang, Dong, Xiaolin, Tao, Liang, Li, Zhanquan, Su, Xi, Kong, Xiangqing, Niu, Heping, Ge, Junbo, Luo, Zhurong, Huang, Wenjun, Peng, Daoquan, Yuan, Zuyi, Milanova, Maria, Tenev, Doncho, Gogov, Antoni, Karageorgiev, Dimitar, Kolchev, Todor, Rusev, Nikolay, Georgieva, Nikolina, Kondov, Rumen, Rusinov, Veselin, Petrov, Ivo, Stanchev, Georgi, Konteva, Mariana, Dincheva, Adriana, Yaneva, Zdravka, Vatova, Ralitsa, Ilieva, Katya, Runev, Nikolai, Kolomanov, Borislav, Petrov, Ivan, Iliev, Nikolay, Tisheva, Snezhanka, Chompalova, Boryana, Tokmakova, Maria, Raev, Dimitar, Byanov, Kolyo, Markov, Dimitar, Mihov, Lenko, Mihov, Atanas, Milcheva, Nora, Minchev, Milen, Mollov, Mihail, Borisov, Borislav, Tihchev, Tihomir, Karakolev, Venelin, Dimov, Bojidar, Georgiev, Svetoslav, Smilov, Lachezar, Koo, Bon K, Ahn, Taehoon, Hong, Soon J, Yoon, Junghan, Oh, Seok K, Jeong, Myung H, Kim, Doo-Il, Chang, Kiyuk, Kim, Weon, Hahn, Joo-Yong, Cha, Kwang S, Lee, Jung-Hee, Choi, Si-Wan, Nam, Chang-Wook, Chae, In-Ho, Park, Yong H, Tahk, Seung-Jea, Shin, Won-Yong, Chae, Jei-Keon, Kim, Byung J, Bae, Jang-Whan, Park, Woo J, Rha, Seung W, Choi, Young J, Hwang, Jin-Yong, Park, Hun S, Baracioli, Luciano, Guimaraes, Fabio, Vasconcellos, Eduardo, Saraiva, José, Pereira, Adamastor, Santos, Queulla, Rossi, Paulo, Maia, Lilia, Madeira, Miguel, Pereira, Marcio, Botelho, Roberto, Reis, Gilmar, Eliaschewitz, Freddy, Borges, Joao, Nascimento, Carlos, Fortes, Jose A, de Souza, Weimar, Pimentel, Pedro, Hissa, Miguel, Franchetti, Marcos, Precoma, Dalton, Ortiz, Costantino, Hernandes, Mauro, Saporito, Wladmir, dos Santos, Fabio R, Kormann, Adrian, Neuenschwander, Fernando, Dutra, Oscar, Rassi, Nelson, Tanajura, Luiz, Souza, Juliana, Junior, Delcio S, Leaes, Paulo, Forte, Adriana, Bonansea, Teresa C, Marin, Jose, Machado, Bruno, Cerqueira, Maria J, Silva, Frederico, Michalaros, Yorghos, Manenti, Euler, Cercato, Cintia, Figueiredo, Estevao, Liu, Ming-En, Wang, Yi-Chih, Lee, Tsung-Ming, Fang, Chih, Wu, Yen-Wen, Ueng, Kwo-Chang, Sheu, Huey-Herng, Lai, Wen T, Hsieh, I-Chang, Chen, Zhih-Cherng, Lee, Mu-Jang, Chiang, Chern, Shyu, Kou-Gi, Hsia, Chien-Hsun, Mar, Guang-Yuan, Chan, Shih-Hung, Wu, Chih-Cheng, Tseng, Wei-Kung, Chang, Kuan-Cheng, Yeh, Hung-I, Wang, Ji-Hung, Hou, Charles, Sorokina, Inna, Dolzhenko, Maryna, Horoshko, Olha, Karpenko, Oleksandr, Rudenko, Leonid, Vakaliuk, Igor, Kulyk, Anna, Levchenko, Olena, Prokhorov, Oleksandr, Reshotko, Dmytro, Sorokivskyy, Mykhaylo, Velichko, Nataliia, Maslovskyi, Valentyn, Teliatnikova, Zinaida, Dotsenko, Sergiy, Krakhmalova, Olena, Kraiz, Igor, Zharinova, Viktoria, Bula, Larysa, Kaydashev, Igor, Molodtsov, Valeriy, Rasputina, Lesya, Pidlisna, Viktoriya, Lysunets, Olena, Kravchenko, Anatoliy, Glushko, Liubomyr, Khomazyuk, Tetyana, Svyshchenko, Yevgeniya, Parkhomenko, Oleksandr, Mankovsky, Boris, Abrahamovych, Orest, Yagensky, Andriy, Stanislavchuk, Mykola, Vasilyeva, Larisa, Sokolova, Liubov, Sychov, Oleg, Tseluyko, Vira, Kyrychenko, Igor, Rishko, Mykola, Furkalo, Sergiy, Gallo, Richard, Bertrand, Olivier, Mehta, Shamir, Constance, Christian, Sussex, Bruce, Zadra, Remo, Kouz, Simon, Chehayeb, Raja, Pandey, Amritanshu, Dion, Danielle, Bailey, Gordon, Hill, Laurie, Ramanathan, Krishnan, Dorsch, Micha, Nanji, Alykhan, Babapulle, Mohan, Montigny, Martine, Gosselin, Gilbert, Dehghani, Payam, Rupka, Dennis, Le May, Michel, Pichette, Francis, St-Maurice, Francois, Teefy, Patrick, Mansour, Samer, Kassam, Saleem, Cheung, Stephen, Siega, Anthony D, O'Keefe, Dennis, Sabbah, Eric, Bell, Alan, Chouinard, Guy, Wong, Brian, Miller, Mark, Gaudet, Daniel, Lachance, Pierre, Bata, Iqbal, Petrella, Robert, Gossard, Denis, Dumas, Richard, Ing, Douglas, Boyrazian, Hagop, Bessoudo, Ricardo, Huynh, Thao T, Hart, Randy, Belle-Isle, Jasmin, Shukla, Dinkar, Kelly, Allan, Mazza, Giuseppe, Cha, James, Henein, Sam, Frechette, Andre, Vizel, Saul, Liutkus, Joanne F, O'Mahony, Michael, Halperin, Frank, Kooy, Jacobus, Graham, John, Bailey, Allan, Wojcik, Ronald, Wilderman, Igor, Turi, Tibor, Motyovszki, Ákos, Merkely, Béla, Király, Csaba, Andrássy, Péter, Sárszegi, Zsolt, Fülöp, Tibor, Zilahi, Zsolt, Édes, István, Papp, Andras, Müller, Gábor, Czigány, Anna, Zólyomi, Szilárd, Korányi, László, Takács, János, Juhász, Ferenc, Benczur, Bela, Kancz, Sándor, Földi, András, Nagy, András C, Bakai, Judit, Greschik, István, Püski, László, Nagy, László, Kirschner, Róbert, Kuchar, Roman, Hajek, Petr, Busak, Ladislav, Michalik, Daniel, Matyasek, Ivo, Marusincova, Ivana, Kucera, Dusan, Jerabek, Ondrej, Honkova, Michaela, Dedek, Vratislav, Rihacek, Ivan, Kos, Pavel, Slaby, Josef, Machkova, Martina, Zidkova, Eva, Elbl, Lubomir, Grunfeldova, Hana, Carda, Jiri, Mrozek, Vladimir, Maly, Jiri, Milkovic, Richard, Malecha, Jan, Skalicka, Hana, Oral, Ivo, Krcova, Eva, Lisa, Libor, Belohlavek, Jan, Miklik, Roman, Cermak, Ondrej, Bednarova, Jana, Peroutka, Zdenek, Spinar, Jindrich, Wilke, Andreas, Appel, Karl-Friedrich, Taggeselle, Jens, Förster, Andreas, Toursarkissian, Nicole, Schmidt, Ekkehard, Bott, Jochen, Al-Zoebi, Ayham, Hennig, Dirk, Fischer, Sabine, Schön, Norbert, Sauter, Joachim, Simonis, Gregor, Nischik, Ruth, Rieker, Werner, Schenkenberger, Isabelle, Behnke, Thomas, Klausmann, Gerhard, Jeserich, Michael, Trenk, Dietmar, Weigmann, Ingo, Reuter, Hannes, Rummel, Reinhard, von Münchhausen, Candy, von Engelhardt, Charlotte, Horibe, Eishun, Shibasaki, Taro, Sato, Tomohiko, Kakuta, Tsunekazu, Michishita, Ichiro, Tan, Michinao, Ishiki, Ryoji, Aoyama, Takahiko, Higashiue, Shinichi, Niijima, Yawara, Idogaki, Akira, Hasegawa, Toru, Kiyosue, Arihiro, Tomobuchi, Yoshiaki, Kawamitsu, Katsunori, Kawasaki, Satsuki, Hata, Yoshiki, Fukui, Kazuki, Seki, Kozaburo, Takenaka, Takashi, Abe, Mitsuru, Utsu, Noriaki, Oono, Atsuyuki, Mitsuo, Kazuhisa, Sueyoshi, Atsushi, Hirohata, Atsushi, Tsujimoto, Mitsuru, Ueda, Osamu, Takase, Shinichi, Suzuki, Masahiro, Sakuragi, Satoru, Yamamoto, Fumi, Fujimoto, Noritaka, Kakinoki, Shigeo, Sugiura, Tatsushi, Sugino, Hiroshi, Nakamura, Toshihiro, Goto, Shinya, Kadokami, Toshiaki, Uehara, Hiroki, Ono, Masahiro, Yokoya, Koichi, Koike, Akihiro, Komatsu, Sei, Sonoda, Masahiro, Ueno, Hideki, Doi, Tomofumi, Takagi, Yuichiro, Fujimoto, Kazuteru, Eki, Yutaka, Okubo, Munenori, Sasaki, Kenichiro, van Eck, Martijn, Ronner, Eelko, The, Salem, van de Wal, Ruud, Nierop, Pieter, de Nooijer, Cornelis, The, Salem, The, Salem, Werner, Henri, Westendorp, Iris, van der Zwaan, Coen, Crijns, Hendrikus, Cornel, Jan H, Strikwerda, Sipke, Bos, Robert, de Melker, Edwin, Kuijper, Adrianus, Louwerenburg, Hans, Plomp, Jacobus, Dantzig, Jan-Melle, Prins, Francisco, van Kesteren, Henricus, Willems, Frank, Amoroso, Giovanni, Carnero, Gabriela, Duronto, Ernesto, Besada, Diego, Chacon, Carolina, Zangroniz, Pedro, Solis, Silvana, Liberman, Alberto, Sernia, Virginia, Alvarisqueta, Andres, Maffei, Laura, Vilamajo, Oscar G, García, Celso, Sicer, Maximiliano, Muntaner, Juan, Bordonava, Anselmo, Albisu, Juan, Zanini, Alejandra, Rista, Lucas, Hominal, Miguel, Estrada, José N, Prado, Aldo, Gosparini, Diego M, Schiavi, Beatriz, Castillo, Armando G, Ruíz, José G, Martinez, Guillermo R, López, Víctor G, Rosas, Enrique L, Lopez, Gabriel R, Cantu, Elias G, de los Ríos Ibarra, Manuel, Padilla, Francisco P, Carrasco, Jose P, Carrillo, Luis V, García, Joel D, Askar, Alfredo N, Salinas, Carlos A, Gamba, Marco A, Sanchez, Carlos G, Cantú, Arnulfo G, Sánchez, Raul V, Madrigal, Jaime C, Urbano, Rafael H, Romo, Andrés Í, González Juanatey, José R, Racugno, Paolo, Fillat, Angel C, de la Torre Hernández, José M, Peláez, Juan A, Cortada, Jorge B, Pavia, Pablo G, Navarro, Manuel J, Asenjo, Roberto M, Díaz, Francisco F, Peligero, Eduard B, Manterola, Fernando A, Ortiz, Antonio F, Mediavilla García, Juan D, Ortuño, Francisco M, Vera, Tomás R, González, Alfonso S, Viñas, Jaime A, Fernández Portales, Francisco J, Mayordomo, Petra S, Ojeda, Francisco B, Domínguez, Antonio R, González, Rosa S, Guerrero, Diego B, Ruiz Nodar, Juan M, Marimon, Xavier G, Margáez, José G, Aguilera, Roberto M, Díaz Fernández, José F, Zamorano Gómez, José L, González, Vicente B, del Blanco, Bruno G, Pérez, Ignacio P, Moreno, Mercé R, Ereño, Ainhoa R, García Lledó, José A, Prieto, Juan, Villablanca, Alex, Raffo, Carlos, Pincetti, Christian, Conejeros, Carlos, Roman, Oscar, Rodriguez, Manuel, Varleta, Paola, Goldberg, Cindy, Sandoval, Jorge, Arriagada, German, Leon, Lucio, Potthoff, Sergio, Cobos, Jorge, Figueroa, Christian, Makotoko, Ellen, Fourie, Nyda, Burgess, Lesley, Nortje, Hendrik, Theron, Rust, Pillai, Perumal, Ranjith, Naresh, Trokis, Julien, Pillay, Soobramoney, Reddy, Jeevren, Nunkoo, Theema, Kapp, Cornelia, Urbach, Dorothea, Distiller, Lawrence, Horak, Adrian, van Zyl, Louis, Coetzee, Kathleen, Punt, Zelda, Bayat, Junaid, Dawood, Saleem, Mitha, Ismail, Padayachee, Trevenesan, Hoosen, Farzana, Dalby, Anthony, Prabhavathi, Gowdaiah, Prakash, Mehta, Vimal, Chag, Milan, Gadkari, Milind, Ramamurthee, Kannaiyan, Das, Asit, Sawhney, Jitendra S, Banerjee, Suvro, Sathe, Prachee, Adhyapak, Srilakshmi, Nguyen, Tuan, Pham, Vinh, Do, Huan, Nguyen, Anh, Nguyen, Hien, Truong, Binh, Jamil-Copley, Shahnaz, Lang, Chim, Pell, Alastair, Zaman, Azfar, Storey, Robert, Swanson, Neil, Smith, Simon, Sharman, David, Braganza, Denise, Hammond, Peter, Moriarty, Andrew, Bain, Stephen, Pye, Maurice, Sharp, Andrew, Blagden, Mark, Randeva, Harpal, Myhill, Timothy, Viswanathan, Girish, Keeling, Philip, Clifford, Piers, Saxena, Manish, Lyons, Kristopher, McMurray, John, Jaafar, Feeroz, Murphy, Clare, Cartwright, Simon, Abouglila, Kamal, Antalik, Lubomir, Krajci, Peter, Urban, Miroslav, Fazekas, Frantisek, Pella, Daniel, Koleny, Daniel, Vykoukalova, Tatiana, Macek, Vladimir, Vinanska, Daniela, Jamriskova, Livia, Such, Slavomir, Fulop, Peter, Farsky, Stefan, Bugan, Viliam, Strbova, Jaroslava, Micko, Karol, Palka Jr, Juraj, Sivak, Vladimir, Kristensen, Dalby, Refsgaard, Jens, Holmvang, Lene, Dixen, Ulrik, Nielsen, Henrik, Egstrup, Kenneth, Jensen, Lisette O, Sykulski, Roman, Rasmussen, Ole, Andries, Alin, Luckow, Anders, Nielsen, Gitte, Sørensen, Torben, Wongvipaporn, Chaiyasith, Chamnarnphol, Noppadol, Srimahachota, Suphot, Sansanayudh, Nakarin, Kuanprasert, Srun, Tresukosol, Damras, Sookananchai, Bancha, Kanadasi, Mehmet, Ozcan, Turkay, Kucuk, Murathan, Ongen, Zeki, Okuyan, Ertugrul, Arat, Alev, Acikel, Sadik, Yalcin, Ahmet, Guray, Umit, Ceyhan, Ceyhun, Ozer, Necla, Arslan, Sakir, Angerås, Oskar, Johnston, Nina, Weiderman, Ann-Charlotte, Bandh, Stellan, Hansen, Ole, Larnefeldt, Hans, Kusiak, Dawid, Lindholm, Carl-Johan, Hedman, Anders, Erlinge, David, Curiac, Dan, Lundman, Pia, Zucconi-Mazzini, Roberto, Aladellie, Layth, Jensen, Jens, Verwerft, Jan, Vrolix, Mathias, Faes, Dirk, Striekwold, Harry, Sinnaeve, Peter, Timmermans, Patrick, Guedes, Antoine, Delforge, Marc, Nimmegeers, Jan, Stammen, Francis, Buysschaert, Ian, Hoffer, Etienne, Hollanders, Geert, Vervoort, Geert, Coussement, Patrick, de Maeseneire, Stefan, Janssens, Luc, Gravdal, Stein A, Risberg, Knut, Gullestad, Lars, Hofseth, Ola D, Nilsen, Dennis, Lappegård, Knut T, van den Heuvel, Christian, Gibbs, Charlotte, Khusrawi, Alamdar, Arora, Satish, Tomala, Tadeusz, Kjærnli, Thorbjørn, Berg-Johansen, Jan, Hagemeier, Robert, Skjelvan, Gunnar, Colquhoun, David, Amerena, John, Morbey, Claire, Hammett, Christopher, Dart, Anthony, Lehman, Ronald, Hamilton, Andrew, Worthley, Matthew, Purnell, Peter, Whelan, Alan, MacIsaac, Richard, Arya, Ktut, Linjawi, Sultan, Proietto, Joseph, Prasad, Lakshman, Rodriguez, Aldo, Godoy, Armando, Rodriguez, Victor, Berrospi, Percy, Chavez, Carlos, Negron, Sandra, Heredia, Javier, Medina, Felix, Manrique, Helard, Cabrera, Walter, Cordova, Fernando, Quinteros, Trinidad, Haro, Jaime M, Regalado, Susana, Guitton, Javier, Arbanil, Hugo, Pansieri, Michel, Decoulx, Eric, Goube, Pascal, de Labriolle, Axel, Labeque, Jean N, Range, Gregoire, Cottin, Yves, Montalescot, Gilles, Cayla, Guillaume, Danchin, Nicolas, Angoulvant, Denis, Ferrario, Emile, Elbaz, Meyer, Dubreuil, Olivier, Steg, Philippe G, Fontaine, Caroline, Sorbets, Emmanuel, Omer, Hafiz, Al-Saif, Shukri, Al-Faleh, Hussam, Al-Shehri, Abdullah, Alshehri, Halia, Bazari, Rasha, Hei, Pak, Ying, Man, Chan, Michael, Wong, Michelle, Ma, Ronald, Siu, Shing C, Tsang, Chiu C, Ferrario, Maurizio, Assanelli, Emilio, Senni, Michele, Piatti, Piermarco, Calabrò, Paolo, Urbinati, Stefano, Michisanti, Massimo, Varbella, Ferdinando, de Cosmo, Salvatore, Trevisan, Roberto, Bellotti, Sandro, Di Pasquale, Giuseppe, Bongo, Angelo S, Uguccioni, Massimo, Mannucci, Edoardo, Mauro, Ciro, Ragonese, Mauro, Fresco, Claudio, Turturo, Maurizio, Marcucci, Rossella, Lievano Triana, Manuel J, Arana, Camilo, Accini, Jose, Botero, Rodrigo, Muzyk-Osikowicz, Marlena, Dada, Fredy T, Vallejo, Gregorio S, Manzur, Fernando, Isaza, Daniel, Molina, Dora, Mesa, Juan G, Quintero, Alvaro, Nyman, Kai, Mäkelä, Jyrki, Strand, Jorma, Nieminen, Sakari, Taurio, Jyrki, Kuusela, Matti, Valle, Timo, Pietilä, Mikko, Kekki, Sakari, Strandberg, Timo, Klutstein, Marc, Greenberg, Gabriel, Rozenman, Yoseph, Chorin, Ehud, Roguin, Ariel, Lewis, Basil, Bashkin, Amir, Tan, Edgar, Prado, Jose P, Ferrolino, Arthur, Babilonia, Noe, Barbas, Benny, Matiga, Generoso, Coching, Raul M, Drexel, Heinz, Brath, Helmut, Schnack, Christoph, Hanusch, Ursula, Fließer-Görzer, Evelyn, Paulweber, Bernhard, Ebenbichler, Christoph, Prager, Rudolf, Huber, Kurt, Wolzt, Michael, Auer, Johann, Berger, Rudolf, Schernthaner, Gerit-Holger, Stanciulescu, Gabriela, Creteanu, Mihai, Spiridon, Marilena, Dobreanu, Viorica, Vinereanu, Dragos, Iosipescu, Laura C, Istratoaie, Octavian, Coman, Ioan, Militaru, Constantin, Cinteza, Mircea, Bhatt, Deepak L, Fox, Kim, Harrington, Robert A, Leiter, Lawrence A, Mehta, Shamir R, Simon, Tabassome, Andersson, Marielle, Himmelmann, Anders, Steg, Philippe G, Diaz, Rafael, Amerena, John, Huber, Kurt, Sinnaeve, Peter R, Nicolau, José C, Kerr Saraiva, José F, Petrov, Ivo, Leiter, Lawrence A, Mehta, Shamir R, Corbalán, Ramón, Ge, Junbo, Zhao, Qiang, Botero, Rodrigo, Widimský, Petr, Kristensen, Steen D, Hartikainen, Juha, Danchin, Nicolas, Darius, Harald, Tse, Hung F, Kiss, Robert G, Pais, Prem, Lev, Eli, de Luca, Leonardo, Goto, Shinya, Ramos López, Gabriel A, Cornel, Jan H, Kontny, Frederic, Medina, Felix, Babilonia, Noe A, Opolski, Grzegorz, Vinereanu, Dragos, Zateyshchikov, Dmitry A, Ruda, Mikhail, Elamin, Omer, Kovář, František, Dalby, Anthony J, Jeong, Myung H, Bueno, Héctor, James, Stefan K, Chiang, Chern-En, Tresukosol, Damras, Ongen, Zeki, Ray, Kausik K, Parkhomenko, Alexander, McGuire, Darren K, Kosiborod, Mikhail N, Nguyen, Tuan Q, Andersson, Marielle, Chen, Jersey, Himmelmann, Anders, Leonsson-Zachrisson, Maria, and Ridderstråle, Wilhelm
- Abstract
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
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- 2019
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5. A Case Study of Collaboration and Reputation in Social Web Search
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McNally, Kevin, O’Mahony, Michael P., Coyle, Maurice, Briggs, Peter, and Smyth, Barry
- Abstract
Although collaborative searching is not supported by mainstream search engines, recent research has highlighted the inherently collaborative nature of many Web search tasks. In this article, we describe HeyStaks, a collaborative Web search framework that is designed to complement mainstream search engines. At search time, HeyStaks learns from the search activities of other users and leverages this information to generate recommendations based on results that others have found relevant for similar searches. The key contribution of this article is to extend the HeyStaks social search model by considering the search expertise, or reputation, of HeyStaks users and using this information to enhance the result recommendation process. In particular, we propose a reputation model for HeyStaks users that utilise the implicit collaboration events that take place between users as recommendations are made and selected. We describe a live-user trial of HeyStaks that demonstrates the relevance of its core recommendations and the ability of the reputation model to further improve recommendation quality. Our findings indicate that incorporating reputation into the recommendation process further improves the relevance of HeyStaks recommendations by up to 40%.
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- 2011
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6. Are three-sample tasks less sensitive than two-sample tasks? Memory effects in the testing of taste discrimination
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Lau, Samantha, O’mahony, Michael, and Rousseau, Benoît
- Abstract
Abstract: In order to provide insights into why discrimination protocols with three stimuli sometimes tend to be less sensitive than protocols with two stimuli, two experiments were conducted. In these experiments, the relative effects of memory decay and memory interference were investigated. Both experiments involved purified water and/or solutions of low NaCl concentration. In Experiment 1, three protocols were compared: the traditional same-different test (Protocol 1), the same protocol with a rinse between the two samples (Protocol 2), and Protocol 2 with an added time delay between the first sample and the intermediate rinse (Protocol 3.) The decrease in measuredd’ values as time delay increased indicated that memory decay might be a factor for tests with three stimuli, such as the triangle method, rendering it less sensitive than tests with two stimuli, such as the same-different method. In Experiment 2, four protocols were compared: the traditional same-different test, the two-rinse same-different test, the triangle test, and what will be called duo same-different test. The experimental design allowed the individual consideration of memory decay and interference effects. From this last experiment, the substantial effect of memory interference was uncovered. Further experimentation will be necessary to estimate the exact relative effects of memory interference and memory decay.
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- 2004
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7. A COMPARISON OF CATEGORY AND LINE SCALES UNDER VARIOUS EXPERIMENTAL PROTOCOLS
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JEON, SEON‐YOUNG, O'MAHONY, MICHAEL, and KIM, KWANG‐OK
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Judges were required to rate the total intensity of NaCl solutions and the sweetness of orange flavored beverages using a variety of unstructured category and line scales. Discrimination errors were noted for each type of scale. No strong differences were observed in discrimination between category and line scales although a 20‐point category scale incurred fewer discrimination errors than 9‐point category and line scales. Allowing judges to retaste stimuli and review and modify their scores reduced discrimination errors.
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- 2004
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8. CONSUMERS REPORT PREFERENCES WHEN THEY SHOULD NOT: A CROSS‐CULTURAL STUDY
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MARCHISANO, CRISTINA, LIM, JUYUN, CHO, HYUNG SUK, SUH, DONG SOON, JEON, SEON YOUNG, KIM, KWANG OK, and O'MAHONY, MICHAEL
- Abstract
If a chi‐squared analysis were to be performed to determine whether preferences were significant in a paired preference test, the appropriate expected frequencies in the analysis would represent those that would occur should the consumers have no preference. One way of determining these ‘no preference’frequencies, for a particular test situation, would be to note the preference responses obtained when the stimuli were putatively identical. Over 2000 consumers were given paired preference tests in which the stimuli were putatively identical. Response conditions and consumer groups were varied and the proportions of preference and no preference responses were noted. In a preliminary experiment, further research was seen to be justified when for putatively identical stimuli, judges did not exclusively express lack of preference; many expressed a preference for one or other of the stimuli. Further experiments were conducted using a written response condition and putatively identical potato chips (potato crisps) as stimuli. Using a single ‘no preference’option, variation in the placement of this option at either first, second or third place on the response sheet had no significant effect on the response frequencies. The proportion of ‘no preference’responses was approximately 30% in all cases. A previously reported 40‐20‐40 distribution was not always confirmed. The experiment was repeated with Korean consumers; these had fewer ‘no preference’responses. Deriving preferences from hedonic scales, rather than having judges respond to preference options, increased the proportion of ‘no preference’responses, with American judges still having more than Korean judges. Yet there are logical objections to extracting preference data from hedonic scales. Increasing the number of ‘no preference’options to two or three, had the effect of increasing the number of ‘no preference’responses up to as much as approximately 60%. Extending the results to Koreans, using two ‘no preference’options, it was seen that only the judges in an anonymous response condition had significantly fewer ‘no preference’responses than Americans. The use of these response frequencies as expected frequencies in chi squared analyses was illustrated, after adjustments for counterbalancing.
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- 2003
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9. STRUCTURED AND UNSTRUCTURED 9‐POINT HEDONIC SCALES: A CROSS CULTURAL STUDY WITH AMERICAN, JAPANESE AND KOREAN CONSUMERS
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YAO, EMILY, LIM, JUYEON, TAMAKI, KAZUHIKO, ISHII, RIE, KIM, KWANG‐OK, and O'MAHONY, MICHAEL
- Abstract
The range of scores elicited by a structured, an unstructured and a ‘labels‐only’version of the 9‐point hedonic scale were compared using consumers from USA, Japan and Korea. It was found that the unstructured scale elicited a wider range of scores for American and Japanese consumers. After correction for hedonic ranges, it was found that Japanese had smaller ranges of scores on all three scales, although the effect was less pronounced for the unstructured scale. The Korean consumers were the exception. Their ranges were less than Americans but their ranges on the unstructured scale did not increase. The results were discussed in terms of the effects of inhibition of use of categories by the scale labels, effects of translation from the English, psychophysical style and order effects.
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- 2003
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10. SENSORY PROFILING WITH PROBABILISTIC MULTIDIMENSIONAL SCALING
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MacKAY, DAVID and O'MAHONY, MICHAEL
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Variability is a fundamental characteristic of sensory profile data. Ignoring the variability may result in biased solutions that cannot be improved by the collection of additional data. Probabilistic multidimensional scaling (PMDS) models provide a means of accounting for the variability inherent in sensory data by using distributions, instead of points, to portray sensory objects. For profile data with high levels of variability, the probabilistic model recovers latent structure parameters very well — traditional deterministic MDS models and principal components analyses (PCA) do not. Advantages of the PMDS models include their parsimony, testability and extensibility. Two particularly attractive PMDS attributes are their ability to relate consumers’ expressions of liking to product profiles and their ability to estimate a product's “ perceptual share” from liking and profile data. Used as a criterion with what‐if modeling, perceptual share estimates enable the evaluation of alternative product development strategies.
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- 2002
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11. MONITORING SCALING DRIFT FOR HEDONIC CATEGORY SCALES
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ISHII, RIE, EDELMAN, MARTIN J, and O'MAHONY, MICHAEL
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Judges on anti‐nausea medication, used hedonic scales to assess a set of foods and beverages on two occasions, initially on beginning a treatment with anti‐nausea medication and then four weeks later. To detect the possibility that changes in hedonic scores for the foods and beverages may be caused not by changes in liking but by ‘scaling drift’: changes in the use of the scale, control stimuli were also assessed. These control stimuli were sets of stimuli to be assessed for intensity and a set to be assessed for liking. These latter stimuli were a class of stimuli that were unlikely to be liked to a different extent on the two testing occasions. The lack of change in the control stimuli and the change in the hedonic scores for the foods and beverages suggested that the latter was due to changes in liking for the foods and beverages rather than ‘scaling drift’.
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- 2002
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12. EFFECTS OF FORGETTING ON PERFORMANCE ON VARIOUS INTENSITY SCALING PROTOCOLS: MAGNITUDE ESTIMATION AND LABELED MAGNITUDE SCALE (GREEN SCALE)
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KOO, TAE‐YOUNG, KIM, KWANG‐OK, and O'MAHONY, MICHAEL
- Abstract
Judges rated the intensity of NaCl solutions using magnitude estimation and the labeled magnitude scale. They performed under four response conditions that varied in reliance on memory: (1) verbal response, (2) written response with no retasting and the response sheet removed, (3) written response with a single response sheet which allowed past scores to be reviewed and amended but with no retasting, (4) the same as ‘3’ but with retasting. Discrimination errors tended to decrease from conditions ‘1’ through ‘4’ yet the major and significant effect was allowing judges to retaste stimuli. The effects of how forgetting lowered discrimination were discussed in the context of experimental design and the absolute versus relative cognitive models of scaling.
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- 2002
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13. It hurts so good: oral irritation by spices and carbonated drinks and the underlying neural mechanisms
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Carstens, E., Carstens, Mirela M. Iodi, Dessirier, Jean-Marc J.-M., O'Mahony, Michael M., Simons, Christopher T. C.T., Sudo, Makoto M., and Sudo, Satoko S.
- Abstract
This paper reviews neurophysiological and psychological studies of oral irritation elicited by chemicals in spicy foods and carbonated drinks. Oral irritant, thermal and textural sensations are conveyed to the brain by the trigeminal pathway, which is separate from the gustatory and olfactory systems. In humans, repetitive application of capsaicin, citric acid, or concentrated NaCl elicits oral irritation that grows in intensity across trials ("sensitization"). After a rest period, reapplication elicits less irritation ("self-desensitization"), but if given recurrently will eventually evoke a progressive rise in irritation ("stimulus-induced recovery"=SIR). In neurophysiological recordings from neurons in the trigeminal subnucleus caudalis (Vc), the first relay in the pathway for oral somatosensation, these irritants elicit a similar pattern of progressively increasing firing, followed after a rest by self-desensitization and SIR. In contrast, nicotine, menthol or mustard oil elicit irritation that decreases across trials ("desensitization"), a pattern also observed in Vc neuronal responses to these irritants. Carbonated water elicits an oral tingling sensation and excites Vc neurons largely through its conversion to carbonic acid. The good correspondence in temporal profiles for perception and neuronal activity supports a role for Vc neurons in the mediation of oral irritation. Finally, the development of preference for foods containing aversive chemicals is addressed. This may involve mere exposure, social reinforcement, the "thrill" of the strong sensation, or physiological reinforcement associated with satiety or release of endorphins by the painful stimulus.
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- 2002
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14. EFFECTS OF FORGETTING ON VARIOUS PROTOCOLS FOR CATEGORY AND LINE SCALES OF INTENSITY
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LEE, HAE‐JIN, KIM, KWANG‐OK, and O'MAHONY, MICHAEL
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Judges rated the intensity of NaCl solutions and orange drinks of varying sweetness using category scales and line scales. They performed under four response conditions that varied in reliance on memory: (1) verbal response (2) written response with no retasting and the response sheet removed (3) written response with a single response sheet which allowed past scores to be reviewed and amended but with no retasting (4) the same as ‘3’ but with retasting. Discrimination errors decreased from conditions ‘1’ through ‘4’ indicating how allowing judges to ‘refresh the memory’ improved discrimination. The cognitive processes involved in rating and consequences for scaling protocols and the experimental design for descriptive analysis are discussed in the light of these findings.
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- 2001
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15. INVESTIGATION OF THE DUAL‐PAIR METHOD AS A POSSIBLE ALTERNATIVE TO THE TRIANGLE AND SAME‐DIFFERENT TESTS
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ROUSSEAU, BENOÎT and O'MAHONY, MICHAEL
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Previous experiments have shown that the same‐different test, because of its more suitable cognitive strategy and lower memory requirements, is a more powerful and sensitive alternative to the triangle and duo‐trio tests. This project describes an experiment conducted in order to investigate ways to improve further the performance of the same‐different test. Three protocols were compared using orange flavored beverages and 24 judges: the same‐different method, the triangle test and the dual‐pair paradigm. The latter protocol could improve the same‐different's performance by preventing the spontaneous variations of the judges’τ criterion. While no significant differences were detected among the d’ values obtained with each procedure, a trend was observed for the same‐different and dual‐pair test to be slightly more sensitive (higher d’ values) than the triangle test. Since the same‐different test is statistically more powerful, it is a preferable choice over the triangle, duo‐trio and dual‐pair tests.
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- 2001
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16. HOW DO THE SIGNAL DETECTION INDICES REACT TO FREQUENCY CONTEXT BIAS FOR INTENSITY SCALING?
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LEE, HYE‐SEONG, KIM, KWANG‐OK, and O'MAHONY, MICHAEL
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Stimulus frequency context effects were noted for stimuli with positive, negative and no skew, using aqueous NaCl stimuli of different concentrations as a model system and orange juice stimuli with added amounts of sucrose as a beverage system. The hypothesis that analysis by signal detection Δm values, rather than individually rated intensity values, would result in the absence of the context effect, was not confirmed.
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- 2001
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17. Thurstonian models for variants of the method of tetrads
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Ennis, John M., Ennis, Daniel M., Yip, Dorene, and O'Mahony, Michael
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Variants of the method of tetrads are discussed and their psychometric functions are both derived and presented in table form. For the first variant, the Unspecified method, subject response is correct provided that the subject, when presented with two stimuli from one set and two stimuli from a second set, correctly segregates the four stimuli into their two appropriate groups. In the second variant, the Specified method, subject response is correct provided that the subject, when presented with two stimuli from one set and two stimuli from a second set, correctly discerns the two strongest stimuli. For the Unspecified method,
- Published
- 1998
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18. Serotonergic blockade in the treatment of the cancer anorexia-cachexia syndrome <FNR HREF="fn1"></FNR> <FN ID="fn1">Dr. Edelman has received research support from Glaxo Wellcome, Inc., Dr. Gandara received an honorarium and is a member of the advisory board for Glaxo Wellcome, Inc., M. Uhrich has stock ownership in Glaxo PLC, and Dr. Gietzen previously has received financial support for research as well as financial support for travel to a scientific meeting from the Glaxo Research Institute.</FN>
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Edelman, Martin J., Gandara, David R., Meyers, Frederick J., Ishii, Rie, O'Mahony, Michael, Uhrich, Margaret, Lauder, Ignacio, Houston, Joan, and Gietzen, Dorothy W.
- Abstract
Imbalanced amino acid diets in animals rapidly produce anorexia and weight loss. Blockade of type 3 serotonergic receptors (5HT
3 ) can ameliorate anorexia in this animal model. Imbalanced plasma amino acid levels also have been documented in both animal models and human patients with cancer cachexia. Therefore a trial of the 5HT3 receptor antagonist, ondansetron, was undertaken in the treatment of patients with cancer cachexia. Patients with metastatic cancer who were not undergoing chemotherapy or radiotherapy and who had lost >5% of their body weight were eligible. Baseline physical examination; weight; anthropometric studies; levels of retinol binding protein, albumin, and prealbumin; and skin testing for anergy were obtained. The ability to enjoy food was assessed utilizing a seven-point hedonic category scale for specific foods. Therapy was comprised of oral ondansetron, 8 mg twice a day. Twenty-seven patients were enrolled; all were evaluable for toxicity and 20 patients were evaluable for response. Toxicity of ondansetron was minimal. Patients demonstrated significant weight loss prior to disease entry (mean baseline weight of 76.9 kg vs. 72.1 kg; P < 0.000002). Patients continued to lose weight on study (Week 0: 72.5 kg vs. Week 4: 71.4 kg; P = 0.027); in addition, there was significant deterioration of midarm circumference and hand grip strength, all of which indicated worsening nutritional status. However, a significant improvement in food enjoyment was noted (P = 0.04). Although it apparently improved the ability of patients to enjoy food, the blockade of 5HT3 receptors failed to prevent weight loss in patients with cancer cachexia or alter laboratory parameters of protein nutrition. Cancer 1999;86:6848. © 1999 American Cancer Society.- Published
- 1999
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19. TASTE DISCRIMINATION BY THE 3‐AFC METHOD: TESTING SENSITIVITY PREDICTIONS REGARDING PARTICULAR TASTING SEQUENCES BASED ON THE SEQUENTIAL SENSITIVITY ANALYSIS MODEL
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DESSIRIER, JEAN‐MARC, SIEFFERMANN, JEAN‐MARC, and O'MAHONY, MICHAEL
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3‐AFC discrimination tests between‘threshold’concentration NaCl solutions and purified water stimuli were performed using a variety of interstimulus rinsing regimes to test predictions of test sensitivity based on the Sequential Sensitivity Analysis model. Superior performance on triads with NaCl as the‘odd’stimulus, over triads with water as the‘odd’stimulus, confirmed earlier research. It was possible, using SSA predictions, to find the right combination of rinses, to arrange for either set of triads to elicit strongly superior performance from judges. This manipulation was predicted by SSA but not by an unequal variance Thurstonian model. Failure of some SSA predictions highlighted the notion of stimulus enhancement by adaptation, leading to a modification of the model. Such manipulation of interstimulus rinses could form the basis for increasing or decreasing test sensitivity.
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- 1999
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20. SAME‐DIFFERENT DISCRIMINATION TESTS WITH INTERSTIMULUS DELAYS UP TO ONE DAY
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ALMEIDA, TEREZA C. AVANCINI DE, CUBERO, ELBA, and O'MAHONY, MICHAEL
- Abstract
There are many ways in which a laboratory difference test differs from ‘real life’discrimination of foods. One of these is the interval of time between tasting the two stimuli to be discriminated. To investigate this, Cubero et al. (1995) investigated interstimulus delays of up to 1 min. for the same‐different test, using a citrus flavored beverage as a medium. The present study extended this research by increasing the interstimulus delays up to 1 day. For judges unfamiliar with the stimuli, performance deteriorated as the time interval increased. For judges more familiar with the stimuli, performance deteriorated but not as much. The results were compatible with Cubero et al.'s hypothesis that different types of memory trace for the first (standard) stimulus were utilized for comparison with the second (comparison) stimulus.
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- 1999
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21. Evolution Towards Photonic Networks.
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Lagasse, Paul, Demeester, Piet, Ackaert, Ann, Van Caenegem, Bart, Van Parys, Wim, O'Mahony, Michael J., Stubkjaer, Kristian, and Benoit, Jacques
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- 1999
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22. How Many Tastes are there for Low Concentration ‘Sweet’ and ‘Sour’ Stimuli?—Threshold Implications
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O'Mahony, Michael, Hobson, Anita, Garvey, John, Davies, Mary, and Birt, Caroline
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Ascending series of solutions of sucrose, glucose, and citric acid were tasted and detection and recognition thresholds were noted; subjects were also required to determine the number of taste sensations that occurred and their sequence of occurrence. It was found that subjects varied in their reports of the number of taste changes and hence potential criteria for detection and recognition. Even among those subjects who reported the same number of criteria there was little consistency as to which were actually chosen for detection and recognition. Some subjects even used an intensity change rather than a quality change to signal a threshold. The criterion can thus be seen to be a potential variable in threshold measurement, and criterion-free measures of sensitivity are recommended. Taste quality descriptions were also studied and a high proportion of novel descriptions was noted; it was hypothesised that this was due to the fact that subjects were not primed with traditional descriptive terms during the instructions.
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- 1976
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23. How We Perceive Flavor
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O'MAHONY, MICHAEL A.P.
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- 1984
24. Do You Have An Umami Tooth
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O'MAHONY, MICHAEL and ISHII, RIE
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All of us in the Western hemisphere have been taught that there are four basic tastes— sweet, sour, salty, and bitter. If we look to the Orient, we see differences from our own common taste categories and more.
- Published
- 1985
25. HOW TO ESTIMATE AND USE THE VARIANCE OF d’ FROM DIFFERENCE TESTS
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BI, JIAN, ENNIS, DANIEL M., and O'MAHONY, MICHAEL
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d′ is an estimate of δ, a measure of the degree of sensory difference between two products, that can be obtained easily using tables, from the proportion of difference tests performed correctly. Tables of δ are available for the 2‐AFC, 3‐AFC, triangular and duo‐trio tests. Tables for calculating the variance of d′ for these tests are provided in this paper. They can be used for comparison of d's, especially for those obtained from different difference tests. A simple procedure is described here for computing values for the variance of d′. Having obtained the variance, confidence intervals for d′ can be obtained, tests of significance for d′ can be made as well as tests of whether two or more d's are significantly different. The formula and tables for the number of judgments required for the estimation of δ are given also in this paper.
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- 1997
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26. SENSORY DIFFERENCE TESTS: THURSTONIAN AND SSA PREDICTIONS FOR VANILLA FLAVORED YOGURTS
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ROUSSEAU, BENOÎT and O'MAHONY, MICHAEL
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The Thurstonian prediction that judges will get a higher proportion of correct 3‐AFC tests than triangle tests was confirmed using a yogurt system. As predicted, d′ values for the triangle and 3‐AFC tests corresponded. Sequential Sensitivity Analysis predictions for the sensitivity of various tasting sequences were confirmed for the 3‐AFC test but not the triangle test. Further predictions that the 2‐AFC is more sensitive than the 3‐AFC were confirmed. This increase in sensitivity more than offset the greater statistical power of the 3‐AFC. Difficulties of specifying the nature of the difference for the 2‐AFC and 3‐AFC tests were overcome using a warm‐up procedure.
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- 1997
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27. ELIMINATING ARTIFACTS IN THE STUDY OF SINGULARITY/MIXEDNESS OF TASTE STIMULI
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ROCHMAN, DANA, GUINARD, JEAN‐XAVIER, and O'MAHONY, MICHAEL
- Abstract
Taste stimuli with a single solute were not judged as tasting equally singular; this confirmed earlier results, except in this study the possibility of the results being caused by trigeminal effects was virtually eliminated. Binary mixtures were generally perceived as more mixed than single solute stimuli, indicating a degree of analytic mixing. However, a caffeine/KCl mixture was perceived as more singular tasting than some single solute stimuli, indicating a degree of synthetic mixing. A preliminary examination was made of the hypotheses that the perceived mixedness of a taste mixture might be determined by a summation of the mixedness of its components or alternatively by latency effects.
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- 1997
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28. A NEW APPROACH TO CATEGORY SCALES OF INTENSITY II: USE OF d’VALUES
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KIM, KWANG‐OK, ENNIS, DANIEL M., and O'MAHONY, MICHAEL
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Using a Rank‐Rating method, d’values were obtained for stimuli from a model system using 15‐point, 9‐point, 7‐point and 5‐point category scales. For an apple/grape juice system, d’values were compared for 9‐point and 7‐point scales. There was general agreement on d’values among the scales, except where stimuli had their scores ‘bunched’into one category: this tended to occur for the strongest and weakest stimuli for Rank‐Rating and for the scales with fewer points. Bunching altered distribution variances and distorted the calculated d’values. Further study gave d’values for the discrimination of confusable stimuli, using paired‐comparison and rating data, thus providing numerical measures of their relative sensitivity.
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- 1998
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29. A NEW APPROACH TO CATEGORY SCALES OF INTENSITY I: TRADITIONAL VERSUS RANK‐RATING
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KIM, KWANG‐OK and O'MAHONY, MICHAEL
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A traditional approach to intensity scaling, using ratings on a 9‐point category scale was compared to a method that combined elements of ranking called Rank‐Rating. The latter method forced judges to retaste stimuli whose tastes they had forgotten and accordingly reduced discrimination errors, thus increasing ability to discriminate.
- Published
- 1998
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30. POWER AND SENSITIVITY OF THE SAME‐DIFFERENT TEST: COMPARISON WITH TRIANGLE AND DUO‐TRIO METHODS
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ROUSSEAU, BENOÎT, MEYER, ALEXANDRA, and O'MAHONY, MICHAEL
- Abstract
Same‐different, duo‐trio and triangle discrimination methods were compared using vanilla flavored yogurt with and without added sugar as the medium. Two experiments were performed, one in controlled laboratory conditions and the other in conditions approximating more to consumer testing. A modification of the same‐different test had greater power than the duo‐trio of triangle tests. At higher sugar concentrations, d’values for the three methods were equivalent. Yet, at lower sugar concentrations, the same‐different d’tended to be higher. The results are discussed in terms of Sequential Sensitivity Analysis, memory effects and changes between β and criteria.
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- 1998
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31. Non-Linear Optical Transmission Systems.
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O'Mahony, Michael J.
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- 1993
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32. Oral Irritant Effects of Nicotine: Psychophysical Evidence for Decreased Sensation following Repeated Application of and Lack of Cross-Desensitization to Capsaicin a
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DESSIRIER, JEAN-MARC, O'MAHONY, MICHAEL, and CARSTENS, E.
- Abstract
When delivered to the oral mucosa, a variety of naturally occurring chemicals such as capsaicin from red chili peppers, piperine from black pepper, and nicotine from tobacco, cause a diffuse burning sensation often referred to as irritation. The burning sensation evoked by capsaicin increases when delivered repeatedly at 1 min intervals (sensitization), but then decreases markedly following a 10 min rest period (self-desensitization. It is also interesting that following desensitization by capsaicin, irritant sensations evoked by other chemicals are also reduced (cross-desensitization), suggesting that oral irritation from some agents may be mediated by a population of capsaicin-sensitive trigeminal polymodal nociceptors.
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- 1998
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33. Maintenance Treatment of Gastroesophageal Reflux Disease: An Evaluation of Continuous and On-Demand Therapy with Rabeprazole 20 mg
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G Morgan, David, FJ O’Mahony, Michael, F O’Mahony, William, Roy, Jean, Camacho, Fernando, Dinniwell, Julie, Horbay, GLA, A Husein-Bhabha, Farah, and the RAB-GRD-3002 Study Group, for
- Abstract
OBJECTIVE: To evaluate continuous therapy (COT) and on-demand therapy (ODT) with rabeprazole 20 mg for maintenance in uninvestigated gastroesophageal reflux disease (GERD).METHODS: This randomized, open-label study enrolled 331 GERD (heartburn-predominant) patients with a pre-existing proton pump inhibitor history of one month or longer, to an acute four-week trial with 20 mg rabeprazole daily for heartburn management. Patients who achieved satisfactory heartburn control during the acute phase (three days or less of heartburn, with no more than one episode rated as moderate, and heartburn rated satisfactorily or completely controlled with minimal rescue antacid use in the seven days preceding randomization) were randomly assigned to six months of rabeprazole 20 mg given as either daily COT or daily ODT, which was initiated upon symptom recurrence and stopped upon symptom resolution. Rescue antacid usage was permitted and tracked. Primary efficacy was measured as the proportion of heartburn-free days over six months.RESULTS: For the 268 patients, the mean percentage of heartburn-free days for the COT group and for the ODT group were 90.3%±14.8% and 64.8%±22.3%, respectively (P<0.0001). COT was associated with an increased number of medication intake days (154±40.2) versus ODT (68±46.1), with less heartburn episodes observed with COT versus ODT, respectively (n=7, n=26, P<0.0001). Ninety-two per cent of COT patients and 79% of ODT patients were either ‘satisfied’ or ‘very satisfied’ with treatment. The mean usage of antacids was low and similar in both groups. COT and ODT regimens were safe and well-tolerated, with a similar incidence of adverse events.CONCLUSION: Results based on symptom assessments favour COT with rabeprazole 20 mg for maintenance therapy in patients with uninvestigated GERD; however, both therapy types are safe and acceptable treatment options for selected patients.
- Published
- 2007
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