5 results on '"O'Hanlon, Simon"'
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2. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
- Author
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Murray, Christopher J L, Vos, Theo, Lozano, Rafael, Naghavi, Mohsen, Flaxman, Abraham D, Michaud, Catherine, Ezzati, Majid, Shibuya, Kenji, Salomon, Joshua A, Abdalla, Safa, Aboyans, Victor, Abraham, Jerry, Ackerman, Ilana, Aggarwal, Rakesh, Ahn, Stephanie Y, Ali, Mohammed K, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Bahalim, Adil N, Barker-Collo, Suzanne, Barrero, Lope H, Bartels, David H, Basáñez, Maria-Gloria, Baxter, Amanda, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bernabé, Eduardo, Bhalla, Kavi, Bhandari, Bishal, Bikbov, Boris, Abdulhak, Aref Bin, Birbeck, Gretchen, Black, James A, Blencowe, Hannah, Blore, Jed D, Blyth, Fiona, Bolliger, Ian, Bonaventure, Audrey, Boufous, Soufiane, Bourne, Rupert, Boussinesq, Michel, Braithwaite, Tasanee, Brayne, Carol, Bridgett, Lisa, Brooker, Simon, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Buckle, Geoffrey, Budke, Christine M, Burch, Michael, Burney, Peter, Burstein, Roy, Calabria, Bianca, Campbell, Benjamin, Canter, Charles E, Carabin, Hélène, Carapetis, Jonathan, Carmona, Loreto, Cella, Claudia, Charlson, Fiona, Chen, Honglei, Cheng, Andrew Tai-Ann, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahiya, Manu, Dahodwala, Nabila, Damsere-Derry, James, Danaei, Goodarz, Davis, Adrian, Leo, Diego De, Degenhardt, Louisa, Dellavalle, Robert, Delossantos, Allyne, Denenberg, Julie, Derrett, Sarah, Des Jarlais, Don C, Dharmaratne, Samath D, Dherani, Mukesh, Diaz-Torne, Cesar, Dolk, Helen, Dorsey, E Ray, Driscoll, Tim, Duber, Herbert, Ebel, Beth, Edmond, Karen, Elbaz, Alexis, Ali, Suad Eltahir, Erskine, Holly, Erwin, Patricia J, Espindola, Patricia, Ewoigbokhan, Stalin E, Farzadfar, Farshad, Feigin, Valery, Felson, David T, Ferrari, Alize, Ferri, Cleusa P, Fèvre, Eric M, Finucane, Mariel M, Flaxman, Seth, Flood, Louise, Foreman, Kyle, Forouzanfar, Mohammad H, Fowkes, Francis Gerry R, Fransen, Marlene, Freeman, Michael K, Gabbe, Belinda J, Gabriel, Sherine E, Gakidou, Emmanuela, Ganatra, Hammad A, Garcia, Bianca, Gaspari, Flavio, Gillum, Richard F, Gmel, Gerhard, Gonzalez-Medina, Diego, Gosselin, Richard, Grainger, Rebecca, Grant, Bridget, Groeger, Justina, Guillemin, Francis, Gunnell, David, Gupta, Ramyani, Haagsma, Juanita, Hagan, Holly, Halasa, Yara A, Hall, Wayne, Haring, Diana, Haro, Josep Maria, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Higashi, Hideki, Hill, Catherine, Hoen, Bruno, Hoffman, Howard, Hotez, Peter J, Hoy, Damian, Huang, John J, Ibeanusi, Sydney E, Jacobsen, Kathryn H, James, Spencer L, Jarvis, Deborah, Jasrasaria, Rashmi, Jayaraman, Sudha, Johns, Nicole, Jonas, Jost B, Karthikeyan, Ganesan, Kassebaum, Nicholas, Kawakami, Norito, Keren, Andre, Khoo, Jon-Paul, King, Charles H, Knowlton, Lisa Marie, Kobusingye, Olive, Koranteng, Adofo, Krishnamurthi, Rita, Laden, Francine, Lalloo, Ratilal, Laslett, Laura L, Lathlean, Tim, Leasher, Janet L, Lee, Yong Yi, Leigh, James, Levinson, Daphna, Lim, Stephen S, Limb, Elizabeth, Lin, John Kent, Lipnick, Michael, Lipshultz, Steven E, Liu, Wei, Loane, Maria, Ohno, Summer Lockett, Lyons, Ronan, Mabweijano, Jacqueline, MacIntyre, Michael F, Malekzadeh, Reza, Mallinger, Leslie, Manivannan, Sivabalan, Marcenes, Wagner, March, Lyn, Margolis, David J, Marks, Guy B, Marks, Robin, Matsumori, Akira, Matzopoulos, Richard, Mayosi, Bongani M, McAnulty, John H, McDermott, Mary M, McGill, Neil, McGrath, John, Medina-Mora, Maria Elena, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Merriman, Tony R, Meyer, Ana-Claire, Miglioli, Valeria, Miller, Matthew, Miller, Ted R, Mitchell, Philip B, Mock, Charles, Mocumbi, Ana Olga, Moffitt, Terrie E, Mokdad, Ali A, Monasta, Lorenzo, Montico, Marcella, Moradi-Lakeh, Maziar, Moran, Andrew, Morawska, Lidia, Mori, Rintaro, Murdoch, Michele E, Mwaniki, Michael K, Naidoo, Kovin, Nair, M Nathan, Naldi, Luigi, Narayan, K M Venkat, Nelson, Paul K, Nelson, Robert G, Nevitt, Michael C, Newton, Charles R, Nolte, Sandra, Norman, Paul, Norman, Rosana, O'Donnell, Martin, O'Hanlon, Simon, Olives, Casey, Omer, Saad B, Ortblad, Katrina, Osborne, Richard, Ozgediz, Doruk, Page, Andrew, Pahari, Bishnu, Pandian, Jeyaraj Durai, Rivero, Andrea Panozo, Patten, Scott B, Pearce, Neil, Padilla, Rogelio Perez, Perez-Ruiz, Fernando, Perico, Norberto, Pesudovs, Konrad, Phillips, David, Phillips, Michael R, Pierce, Kelsey, Pion, Sébastien, Polanczyk, Guilherme V, Polinder, Suzanne, Pope, C Arden, Popova, Svetlana, Porrini, Esteban, Pourmalek, Farshad, Prince, Martin, Pullan, Rachel L, Ramaiah, Kapa D, Ranganathan, Dharani, Razavi, Homie, Regan, Mathilda, Rehm, Jürgen T, Rein, David B, Remuzzi, Guiseppe, Richardson, Kathryn, Rivara, Frederick P, Roberts, Thomas, Robinson, Carolyn, De Leòn, Felipe Rodriguez, Ronfani, Luca, Room, Robin, Rosenfeld, Lisa C, Rushton, Lesley, Sacco, Ralph L, Saha, Sukanta, Sampson, Uchechukwu, Sanchez-Riera, Lidia, Sanman, Ella, Schwebel, David C, Scott, James Graham, Segui-Gomez, Maria, Shahraz, Saeid, Shepard, Donald S, Shin, Hwashin, Shivakoti, Rupak, Silberberg, Donald, Singh, David, Singh, Gitanjali M, Singh, Jasvinder A, Singleton, Jessica, Sleet, David A, Sliwa, Karen, Smith, Emma, Smith, Jennifer L, Stapelberg, Nicolas JC, Steer, Andrew, Steiner, Timothy, Stolk, Wilma A, Stovner, Lars Jacob, Sudfeld, Christopher, Syed, Sana, Tamburlini, Giorgio, Tavakkoli, Mohammad, Taylor, Hugh R, Taylor, Jennifer A, Taylor, William J, Thomas, Bernadette, Thomson, W Murray, Thurston, George D, Tleyjeh, Imad M, Tonelli, Marcello, Towbin, Jeffrey A, Truelsen, Thomas, Tsilimbaris, Miltiadis K, Ubeda, Clotilde, Undurraga, Eduardo A, van der Werf, Marieke J, van Os, Jim, Vavilala, Monica S, Venketasubramanian, N, Wang, Mengru, Wang, Wenzhi, Watt, Kerrianne, Weatherall, David J, Weinstock, Martin A, Weintraub, Robert, Weisskopf, Marc G, Weissman, Myrna M, White, Richard A, Whiteford, Harvey, Wiebe, Natasha, Wiersma, Steven T, Wilkinson, James D, Williams, Hywel C, Williams, Sean RM, Witt, Emma, Wolfe, Frederick, Woolf, Anthony D, Wulf, Sarah, Yeh, Pon-Hsiu, Zaidi, Anita KM, Zheng, Zhi-Jie, Zonies, David, and Lopez, Alan D
- Abstract
Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
- Published
- 2012
- Full Text
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3. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
- Author
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Vos, Theo, Flaxman, Abraham D, Naghavi, Mohsen, Lozano, Rafael, Michaud, Catherine, Ezzati, Majid, Shibuya, Kenji, Salomon, Joshua A, Abdalla, Safa, Aboyans, Victor, Abraham, Jerry, Ackerman, Ilana, Aggarwal, Rakesh, Ahn, Stephanie Y, Ali, Mohammed K, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Bahalim, Adil N, Barker-Collo, Suzanne, Barrero, Lope H, Bartels, David H, Basáñez, Maria-Gloria, Baxter, Amanda, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bernabé, Eduardo, Bhalla, Kavi, Bhandari, Bishal, Bikbov, Boris, Abdulhak, Aref Bin, Birbeck, Gretchen, Black, James A, Blencowe, Hannah, Blore, Jed D, Blyth, Fiona, Bolliger, Ian, Bonaventure, Audrey, Boufous, Soufiane, Bourne, Rupert, Boussinesq, Michel, Braithwaite, Tasanee, Brayne, Carol, Bridgett, Lisa, Brooker, Simon, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Buckle, Geoffrey, Budke, Christine M, Burch, Michael, Burney, Peter, Burstein, Roy, Calabria, Bianca, Campbell, Benjamin, Canter, Charles E, Carabin, Hélène, Carapetis, Jonathan, Carmona, Loreto, Cella, Claudia, Charlson, Fiona, Chen, Honglei, Cheng, Andrew Tai-Ann, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahiya, Manu, Dahodwala, Nabila, Damsere-Derry, James, Danaei, Goodarz, Davis, Adrian, De Leo, Diego, Degenhardt, Louisa, Dellavalle, Robert, Delossantos, Allyne, Denenberg, Julie, Derrett, Sarah, Des Jarlais, Don C, Dharmaratne, Samath D, Dherani, Mukesh, Diaz-Torne, Cesar, Dolk, Helen, Dorsey, E Ray, Driscoll, Tim, Duber, Herbert, Ebel, Beth, Edmond, Karen, Elbaz, Alexis, Ali, Suad Eltahir, Erskine, Holly, Erwin, Patricia J, Espindola, Patricia, Ewoigbokhan, Stalin E, Farzadfar, Farshad, Feigin, Valery, Felson, David T, Ferrari, Alize, Ferri, Cleusa P, Fèvre, Eric M, Finucane, Mariel M, Flaxman, Seth, Flood, Louise, Foreman, Kyle, Forouzanfar, Mohammad H, Fowkes, Francis Gerry R, Franklin, Richard, Fransen, Marlene, Freeman, Michael K, Gabbe, Belinda J, Gabriel, Sherine E, Gakidou, Emmanuela, Ganatra, Hammad A, Garcia, Bianca, Gaspari, Flavio, Gillum, Richard F, Gmel, Gerhard, Gosselin, Richard, Grainger, Rebecca, Groeger, Justina, Guillemin, Francis, Gunnell, David, Gupta, Ramyani, Haagsma, Juanita, Hagan, Holly, Halasa, Yara A, Hall, Wayne, Haring, Diana, Haro, Josep Maria, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Higashi, Hideki, Hill, Catherine, Hoen, Bruno, Hoffman, Howard, Hotez, Peter J, Hoy, Damian, Huang, John J, Ibeanusi, Sydney E, Jacobsen, Kathryn H, James, Spencer L, Jarvis, Deborah, Jasrasaria, Rashmi, Jayaraman, Sudha, Johns, Nicole, Jonas, Jost B, Karthikeyan, Ganesan, Kassebaum, Nicholas, Kawakami, Norito, Keren, Andre, Khoo, Jon-Paul, King, Charles H, Knowlton, Lisa Marie, Kobusingye, Olive, Koranteng, Adofo, Krishnamurthi, Rita, Lalloo, Ratilal, Laslett, Laura L, Lathlean, Tim, Leasher, Janet L, Lee, Yong Yi, Leigh, James, Lim, Stephen S, Limb, Elizabeth, Lin, John Kent, Lipnick, Michael, Lipshultz, Steven E, Liu, Wei, Loane, Maria, Ohno, Summer Lockett, Lyons, Ronan, Ma, Jixiang, Mabweijano, Jacqueline, MacIntyre, Michael F, Malekzadeh, Reza, Mallinger, Leslie, Manivannan, Sivabalan, Marcenes, Wagner, March, Lyn, Margolis, David J, Marks, Guy B, Marks, Robin, Matsumori, Akira, Matzopoulos, Richard, Mayosi, Bongani M, McAnulty, John H, McDermott, Mary M, McGill, Neil, McGrath, John, Medina-Mora, Maria Elena, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Merriman, Tony R, Meyer, Ana-Claire, Miglioli, Valeria, Miller, Matthew, Miller, Ted R, Mitchell, Philip B, Mocumbi, Ana Olga, Moffitt, Terrie E, Mokdad, Ali A, Monasta, Lorenzo, Montico, Marcella, Moradi-Lakeh, Maziar, Moran, Andrew, Morawska, Lidia, Mori, Rintaro, Murdoch, Michele E, Mwaniki, Michael K, Naidoo, Kovin, Nair, M Nathan, Naldi, Luigi, Narayan, KM Venkat, Nelson, Paul K, Nelson, Robert G, Nevitt, Michael C, Newton, Charles R, Nolte, Sandra, Norman, Paul, Norman, Rosana, O'Donnell, Martin, O'Hanlon, Simon, Olives, Casey, Omer, Saad B, Ortblad, Katrina, Osborne, Richard, Ozgediz, Doruk, Page, Andrew, Pahari, Bishnu, Pandian, Jeyaraj Durai, Rivero, Andrea Panozo, Patten, Scott B, Pearce, Neil, Padilla, Rogelio Perez, Perez-Ruiz, Fernando, Perico, Norberto, Pesudovs, Konrad, Phillips, David, Phillips, Michael R, Pierce, Kelsey, Pion, Sébastien, Polanczyk, Guilherme V, Polinder, Suzanne, Pope, C Arden, Popova, Svetlana, Porrini, Esteban, Pourmalek, Farshad, Prince, Martin, Pullan, Rachel L, Ramaiah, Kapa D, Ranganathan, Dharani, Razavi, Homie, Regan, Mathilda, Rehm, Jürgen T, Rein, David B, Remuzzi, Guiseppe, Richardson, Kathryn, Rivara, Frederick P, Roberts, Thomas, Robinson, Carolyn, De Leòn, Felipe Rodriguez, Ronfani, Luca, Room, Robin, Rosenfeld, Lisa C, Rushton, Lesley, Sacco, Ralph L, Saha, Sukanta, Sampson, Uchechukwu, Sanchez-Riera, Lidia, Sanman, Ella, Schwebel, David C, Scott, James Graham, Segui-Gomez, Maria, Shahraz, Saeid, Shepard, Donald S, Shin, Hwashin, Shivakoti, Rupak, Silberberg, Donald, Singh, David, Singh, Gitanjali M, Singh, Jasvinder A, Singleton, Jessica, Sleet, David A, Sliwa, Karen, Smith, Emma, Smith, Jennifer L, Stapelberg, Nicolas JC, Steer, Andrew, Steiner, Timothy, Stolk, Wilma A, Stovner, Lars Jacob, Sudfeld, Christopher, Syed, Sana, Tamburlini, Giorgio, Tavakkoli, Mohammad, Taylor, Hugh R, Taylor, Jennifer A, Taylor, William J, Thomas, Bernadette, Thomson, W Murray, Thurston, George D, Tleyjeh, Imad M, Tonelli, Marcello, Towbin, Jeffrey A, Truelsen, Thomas, Tsilimbaris, Miltiadis K, Ubeda, Clotilde, Undurraga, Eduardo A, van der Werf, Marieke J, van Os, Jim, Vavilala, Monica S, Venketasubramanian, N, Wang, Mengru, Wang, Wenzhi, Watt, Kerrianne, Weatherall, David J, Weinstock, Martin A, Weintraub, Robert, Weisskopf, Marc G, Weissman, Myrna M, White, Richard A, Whiteford, Harvey, Wiersma, Steven T, Wilkinson, James D, Williams, Hywel C, Williams, Sean RM, Witt, Emma, Wolfe, Frederick, Woolf, Anthony D, Wulf, Sarah, Yeh, Pon-Hsiu, Zaidi, Anita KM, Zheng, Zhi-Jie, Zonies, David, Lopez, Alan D, and Murray, Christopher JL
- Abstract
Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).
- Published
- 2012
- Full Text
- View/download PDF
4. Evaluation of Molecular Typing Methods in Characterizing a European Collection of Epidemic Methicillin-Resistant Staphylococcus aureusStrains: the HARMONY Collection
- Author
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Cookson, Barry D., Robinson, D. Ashley, Monk, Alastair B., Murchan, Stephen, Deplano, Ariane, de Ryck, Rafae¨l, Struelens, Marc J., Scheel, Christina, Fussing, Vivian, Salmenlinna, Saara, Vuopio-Varkila, Jaana, Cuny, Christina, Witte, Wolfgang, Tassios, Panayotis T., Legakis, Nikolas J., van Leeuwen, Willem, van Belkum, Alex, Vindel, Anna, Garaizar, Javier, Haeggman, Sara, Olsson-Liljequist, Barbro, Ransjo, Ulrika, Muller-Premru, Manica, Hryniewicz, Waleria, Rossney, Angela, O'Connell, Brian, Short, Benjamin D., Thomas, Jonathan, O'Hanlon, Simon, and Enright, Mark C.
- Abstract
ABSTRACTWe analyzed a representative sample of methicillin-resistant Staphylococcus aureus(MRSA) from 11 European countries (referred to as the HARMONY collection) using three molecular typing methods used within the HARMONY group to examine their usefulness for large, multicenter MRSA surveillance networks that use these different laboratory methodologies. MRSA isolates were collected based on their prevalence in each center and their genetic diversity, assessed by pulsed-field gel electrophoresis (PFGE). PFGE groupings (=3 bands difference between patterns) were compared to those made by sequencing of the variable repeats in the protein A gene spaand clonal designations based on multilocus sequence typing (MLST), combined with PCR analysis of the staphylococcal chromosome cassette containing the mecgenes involved in methicillin resistance (SCCmec). A high level of discrimination was achieved using each of the three methodologies, with discriminatory indices between 89.5% and 91.9% with overlapping 95% confidence intervals. There was also a high level of concordance of groupings made using each method. MLST/SCCmectyping distinguished 10 groups containing at least two isolates, and these correspond to the majority of nosocomial MRSA clones described in the literature. PFGE and spatyping resolved 34 and 31 subtypes, respectively, within these 10 MRSA clones, with each subtype differing only slightly from the most common pattern using each method. The HARMONY group has found that the methods used in this study differ in their availability and affordability to European centers involved in MRSA surveillance. Here, we demonstrate that the integration of such technologies is achievable, although common protocols (such as we have developed for PFGE) may also be important, as is the use of centralized Internet sites to facilitate data analysis. PFGE and spa-typing data from analysis of MRSA isolates from the many centers that have access to the relevant equipment can be compared to reference patterns/sequences, and clonal designations can be made. In the majority of cases, these will correspond to those made by the (more expensive) method of choice—MLST/SCCmectyping—and these alternative methods can therefore be used as frontline typing systems for multicenter surveillance of MRSA.
- Published
- 2007
- Full Text
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5. In vitro activity of a novel compound, the metal ion chelating agent AQ+, against clinical isolates of Staphylococcus aureus
- Author
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Short, Benjamin R. D., Vargas, Miguel A., Thomas, Jonathan C., O'Hanlon, Simon, and Enright, Mark C.
- Abstract
Objectives: To determine the efficacy of a novel antimicrobial compound, AQ+, against a genetically heterogeneous collection comprising 213 Staphylococcus aureus isolates from global sources. AQ+ is an aqueous preparation containing 0.5% 8-hydroxyquinoline.Methods: MICs were found for all the isolates tested using the BSAC microdilution method. Time–kill studies were performed according to NCCLS guidelines. Transmission electron microscopy (TEM) was used to view the ultrastructural effects of AQ+.Results: AQ+ was shown to strongly inhibit the growth of all isolates with a median MIC of 0.25% at a pH optimum of 9.2. Lowering the pH to 7.5 gave an ∼4-fold reduction in efficacy and at pH 5.5 there was an ∼8-fold reduction in efficacy. Methicillin-resistant S. aureus (MRSA) as well as vancomycin-intermediate S. aureus were shown to be as equally susceptible to AQ+ as methicillin-susceptible S. aureus. Time–kill curves for AQ+ were similar to those for gentamicin. TEM showed that AQ+ actively disrupts the cell wall of S. aureus leading to cell lysis.Conclusions: These results suggest that AQ+ has strong antimicrobial activity and may be useful in preparations to reduce nasal and skin carriage of MRSA.
- Published
- 2006
- Full Text
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