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Interest in local foods, especially locally grown fruit, is increasing. High tunnel vegetable growers are strategically poised to meet this demand by growing specialty melons (Cucumis melo). Although specialty melons are commonly grown in high tunnels in other parts of the world, it is an uncommon practice in the midwestern United States. The objectives of this study were to evaluate 10 specialty melon cultivars for high tunnel production and measure fruit yield and internal quality. Fruit of the cultivar Eden's Gem yielded the greatest number of marketable fruits per plant; however, these melons are small and have a loose cavity. Fruit of the cultivars Honey Orange and Divergent yielded the largest marketable fruit per plant with tighter cavities; however, the cavities were large. All cultivars had good to excellent internal quality in terms of sugar content. The production of specialty melons in the high tunnel was successful, resulting in the production of melons with good to excellent internal quality, and several yielded three to four marketable fruit per plant. Implementing a strong pest management plan for cucumber beetle (Diabrotica undecimpunctata howardi) and powdery mildew (Erysiphe cichoracearum, Sphaerotheca fuliginea) is recommended to prevent yield loss, especially in locations such as the Midwest, where cucumber beetles often vector bacterial wilt (Erwinia tracheiphila). [ABSTRACT FROM AUTHOR]

Bacterial wilt of cucurbits, caused by Erwinia tracheiphila, is spread by spotted (Diabrotica undeimpunctata howardi) and striped (Acalymma vittatum) cucumber beetles and results in major losses for US cucurbit (Cucurbitaceae spp.) growers. Organic growers of muskmelon (Cucumis melo) lack reliable control measures against bacterial wilt. During previous field trials in Iowa, USA, a system called mesotunnels, which are 3.5-ft-tall barriers covered with a nylon mesh insect netting, resulted in a higher marketable yield of organic 'Athena' muskmelon than low tunnels or noncovered plots. However, satisfactory pollination and weed control are challenging in mesotunnels because the netting covers the crop for most or all of the growing season, and economic feasibility of these systems has not been determined. Consequently, two field trials conducted in Iowa from2020 to 2022 evaluated strategies to ensure pollination under mesotunnels in commercial-scale plots, assess effectiveness of teff (Eragrostis tef ) as a living mulch for weed control in mesotunnel systems, and compare the profitability of the treatment options for organic 'Athena' muskmelon. The treatments used during the pollination trial were as follows: full season, in which mesotunnels remained sealed all season and bumble bees (Bombus impatiens) were added at the start of bloom for pollination; open ends, wherein both ends of the tunnels were opened at the start of bloom then reclosed 2 weeks later; and on-off-on, in which nets were removed at the start of bloom and then reinstalled 2 weeks later. The full-season treatment had significantly higher marketable yield than the other treatments in two of three trial years. Plants with the full season and open ends treatments had a bacterial wilt incidence <2.5% across all three years and similar numbers of cucumber beetles, whereas plants with the on-off-on treatment had an average bacterial wilt incidence of 11.0% and significantly more cucumber beetles. The open ends treatment had fewer bee visits to 'Athena' muskmelon flowers than the other treatments. In the 2-year (2021-22) weed management trial, treatments applied to the furrow between plastic-mulched rows were as follows: landscape fabric; teff seeded at 4 lb/acre and mowed 3 weeks after seeding; teff seeded at 4 lb/acre and not mowed; a control with bare ground where weeds were mowed 3 weeks after transplanting; and a bare ground control with no mowing. The landscape fabric and mowed teff treatments had statistically similar marketable yield, and mowing appeared tominimize yield losses compared with nonmowed treatments. The landscape fabric had no weeds, followed by mowed teff, mowed bare ground, and nonmowed teff. Nonmowed bare ground had the highest weed biomass. The partial budget and costefficiency ratio analysis indicated that the full-season treatment was the most costefficient pollination option for mesotunnel systems. An economic analysis of the weed management strategies showed that using teff as a living mulch in the furrows between organic 'Athena' muskmelon rows, coupled with timely mowing to suppress its growth, can generate revenue comparable to that of landscape fabric. Our findings suggest that organic 'Athena' muskmelon growers in Iowa may gain the greatest yield and soil quality benefits when mesotunnels are kept closed for the entire season, bumble bees are used for pollination, and teff (mowed 3 weeks after seeding) is used to control weeds in the furrows. Further trials integrating these pollination and weed management strategies would help validate a comprehensive approach to organic 'Athena' muskmelon production under mesotunnels. [ABSTRACT FROM AUTHOR]

This systematic review was designed to compare the outcomes of the two braces against each other classified by the Graf method. The databases sources included PubMed, Embase, and Google Scholar. The keywords included “DDH Tubingen versus Pavlik” and Tubingen and Pavlik separately. Included papers provided specific data regarding success and failure rate, avascular necrosis (AVN), duration, and age of intervention. The excluded studies discussed surgeries, diagnosis and mechanism, and ones that weren't in English. Total of 20 papers were included, resulting in 1243 Tubingen and 420 Pavlik samples. It was seen that the Tubingen splint had a statistically significant greater success rate and lower failure rate for Graf 2, D, and 3 hips, while both braces were not very successful for Graf 4 at success rates less than 60 %. Tubingen also had a lower incidence of AVN. Both braces shared similar ages of intervention, duration, and time per day. Both braces are very comparable to each other, each having better success rates for lower Graf grades, which points to the importance of bracing earlier to improve the success rates. The Tubingen splint had a higher success rate, lower failure rate, and lower AVN rate compared to the Pavlik harness. This points to the Tubingen splint potentially being the preferred option for bracing in infants.

Meditation practices increase attention, memory, and self-awareness. The neuroscientific study of meditation has helped gain useful insights into the functional changes in the brain. In this study, we have assessed the performance of meditators with different years of practice while performing an engaging task rather than studying the meditation practice itself. This task helps assess many neural processes simultaneously and represents task performance in presence of multiple audio-visual distractors as in a real-life scenario. The long-term practice of meditation could bring neuroplastic changes in the way cognitive processing is carried out. It could be conscious and effortful in short-term practitioners and relatively unconscious and effortless in long-term practitioners. Our goal is to understand if it is possible to differentiate between long-term and short-term meditators solely based on their cognitive processing. A group of proficient Rajayoga meditators from the Brahma Kumaris were recruited based on their meditation experience—Long-Term Practitioners (n= 12, mean 13,596 h) and Short-Term Practitioners (n= 10, mean 1095 h). A task-based functional Magnetic Resonance Imaging was acquired while the subjects performed the task. Functional Connectivity Analysis was performed to derive the correlation measures to be used as features for classification. Five supervised Machine Learning algorithms Logistic Regression, Support Vector Machine, Decision Tree, Random Forest, and Gradient Boosted Tree were used for classification. Among all the classifiers Gradient Boosted Tree performed the best with an accuracy of 77% when all the four Functional Connectivity Metrics were used. Connectivity in visual areas, cerebellum, left rostral prefrontal cortex, and middle frontal gyrus was found to be higher in long-term meditators. Such a classification demonstrates that long-term meditation practice brings about neuroplastic changes that influence cognitive processing.

. Organic growers of cucurbit (Cucurbitaceae) crops in the midwestern United States have difficulty managing bacterial wilt—a fatal disease with a pathogen (Erwinia tracheiphila) that is transmitted by striped and spotted cucumber beetles (Acalymma vittatum and Diabrotica undecimpunctata howardi, respectively). Registered organic insecticides lack effectiveness, and host plant resistance is rare in commercial cultivars of many cucurbit crops. Row covers are widely used as barriers to minimize pest access, but the spunbonded polypropylene fabric covering traditional low tunnels must be removed at bloom to prevent overheating and facilitate pollination, thereby exposing the crop for the rest of the season. “Mesotunnels”—nylon mesh fabric covering 3.5-ft-high hoops-provide more space than low tunnels and mitigate overheating. In field experiments at Iowa State University (Ames, IA, USA) during 2016-18, two variations of mesotunnels-full-season tunnels [with purchased bumble bees (Bombus impatiens) added for pollination] and part-season tunnels (with covers removed for 2 weeks during bloom to provide pollinator access)-were compared with low tunnels and a noncovered treatment for organic ‘Athena’ muskmelon (Cucumis melo) production. Based on scouting results, full-season mesotunnels required no insecticides and part-season mesotunnels averaged 0.6 spray per season compared with 1.0 and 5.0 sprays per season for the low-tunnel and noncovered treatments, respectively. Incidence of pest and disease damage was zero for the full-season mesotunnels, 5% to 22% for the part-season mesotunnels, and 37% to 70% for both of the other treatments. Marketable yield for the full-season mesotunnel treatment exceeded the noncovered treatment significantly each year, and mean marketable yields were greater numerically than for the other treatments. Both mesotunnel treatments had a marketable yield that averaged more than twice that of the noncovered treatment in each year. Economic analysis (partial budget and cost-efficiency ratio) indicated that mesotunnels were likely to be more profitable in Iowa, USA, than either the low-tunnel or noncovered systems, but also that the year-to-year differential among treatments in profitability could be substantial. Additional experiments are needed to evaluate the efficacy of these integrated pest management practices and their profitability at spatial scales representative of commercial farms. [ABSTRACT FROM AUTHOR]

Few people who look like Ajay Nair lead colleges. Less than 17 percent of campus chief executives are non-white. Asians and Asian Americans make up just 2 percent of them, [...]

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced fibrosis1,2. Here we interrogated functions of hepatic stellate cells (HSCs), the main source of liver fibroblasts3, during hepatocarcinogenesis. Genetic depletion, activation or inhibition of HSCs in mouse models of HCC revealed their overall tumour-promoting role. HSCs were enriched in the preneoplastic environment, where they closely interacted with hepatocytes and modulated hepatocarcinogenesis by regulating hepatocyte proliferation and death. Analyses of mouse and human HSC subpopulations by single-cell RNA sequencing together with genetic ablation of subpopulation-enriched mediators revealed dual functions of HSCs in hepatocarcinogenesis. Hepatocyte growth factor, enriched in quiescent and cytokine-producing HSCs, protected against hepatocyte death and HCC development. By contrast, type I collagen, enriched in activated myofibroblastic HSCs, promoted proliferation and tumour development through increased stiffness and TAZ activation in pretumoural hepatocytes and through activation of discoidin domain receptor 1 in established tumours. An increased HSC imbalance between cytokine-producing HSCs and myofibroblastic HSCs during liver disease progression was associated with increased HCC risk in patients. In summary, the dynamic shift in HSC subpopulations and their mediators during chronic liver disease is associated with a switch from HCC protection to HCC promotion.

Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver1. Cancer-associated fibroblasts, the extracellular matrix and type I collagen (Col I) support2,3or restrain the progression of PDAC and may impede blood supply and nutrient availability4. The dichotomous role of the stroma in PDAC, and the mechanisms through which it influences patient survival and enables desmoplastic cancers to escape nutrient limitation, remain poorly understood. Here we show that matrix-metalloprotease-cleaved Col I (cCol I) and intact Col I (iCol I) exert opposing effects on PDAC bioenergetics, macropinocytosis, tumour growth and metastasis. Whereas cCol I activates discoidin domain receptor 1 (DDR1)–NF-κB–p62–NRF2 signalling to promote the growth of PDAC, iCol I triggers the degradation of DDR1 and restrains the growth of PDAC. Patients whose tumours are enriched for iCol I and express low levels of DDR1 and NRF2 have improved median survival compared to those whose tumours have high levels of cCol I, DDR1 and NRF2. Inhibition of the DDR1-stimulated expression of NF-κB or mitochondrial biogenesis blocks tumorigenesis in wild-type mice, but not in mice that express MMP-resistant Col I. The diverse effects of the tumour stroma on the growth and metastasis of PDAC and on the survival of patients are mediated through the Col I–DDR1–NF-κB–NRF2 mitochondrial biogenesis pathway, and targeting components of this pathway could provide therapeutic opportunities.

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2 infection1,2, but the host response at the lung tissue level is poorly understood. Here we performed single-nucleus RNA sequencing of about 116,000 nuclei from the lungs of nineteen individuals who died of COVID-19 and underwent rapid autopsy and seven control individuals. Integrated analyses identified substantial alterations in cellular composition, transcriptional cell states, and cell-to-cell interactions, thereby providing insight into the biology of lethal COVID-19. The lungs from individuals with COVID-19 were highly inflamed, with dense infiltration of aberrantly activated monocyte-derived macrophages and alveolar macrophages, but had impaired T cell responses. Monocyte/macrophage-derived interleukin-1β and epithelial cell-derived interleukin-6 were unique features of SARS-CoV-2 infection compared to other viral and bacterial causes of pneumonia. Alveolar type 2 cells adopted an inflammation-associated transient progenitor cell state and failed to undergo full transition into alveolar type 1 cells, resulting in impaired lung regeneration. Furthermore, we identified expansion of recently described CTHRC1+pathological fibroblasts3contributing to rapidly ensuing pulmonary fibrosis in COVID-19. Inference of protein activity and ligand–receptor interactions identified putative drug targets to disrupt deleterious circuits. This atlas enables the dissection of lethal COVID-19, may inform our understanding of long-term complications of COVID-19 survivors, and provides an important resource for therapeutic development.

ABSTRACTNow-a-days public transit in our country has a significant usage of bridges and tunnels. Maintaining the safety of such structures becomes the need of the hour. Cracking can invite sudden failures of concrete structures. Within recent years, there has been an increase in the use of image processing techniques as Non-Destructive Testing (NDT) method to detect defects and anomalies in such structures. Hence, this work presents an efficient image processing model for identifying and quantifying the cracks in common structures using two algorithms. The first algorithm uses pattern classification method to classify the identified specimens as crack or not. This pattern classification algorithm is tested and evaluated with the test specimens of structures having induced cracks. The second algorithm called morphological processing uses an efficient thresholding strategy to improve the detection accuracy of the cracks. Here the aim is to detect even the faintest of cracks and magnify them. Thus, any one of the algorithms can be adopted depending on the application. The developed algorithms have been tested in real field at the final stage and achieved a detection accuracy of nearly 96.37%and all the obtained images have been stored digitally on a web server.

ABSTRACTIntroductionSchizophrenia has a prevalence of approximately 1% in the general population, with 15.2 per 100,000 persons affected. Iloperidone is a second-generation antipsychotic drug approved for the treatment of schizophrenia in adults. It acts primarily by D2/5HT2a receptor antagonism, with greater affinity for the 5HT2a receptor than for the D2 receptor.Areas coveredThis article discusses iloperidone and aims to provide useful information for clinicians to determine which circumstances would best suit the use of iloperidone to treat schizophrenic patients. In this review, the authors briefly discuss schizophrenia and its treatment, before they discuss properties of iloperidone, its indications, approval process, and adverse effects. Finally, the authors review the specific strengths and weaknesses of the medication.Expert opinionIloperidone would be an attractive option in patients who are particularly prone to EPS, or who are showing prominent negative symptoms, as well as cognitive deficits. Its availability only in an oral formulation makes it a better option for patients with good medication adherence, and though it could be useful in patients prone to weight gain or hepatic dysfunction on other second generation antipsychotics, it should be used with caution in patients prone to side effects related to alpha adrenergic blockade.

Conventional polysomnographic recordings reflect brain dynamics associated with sleep architecture. We hypothesized that noninvasive tools like transcranial alternating current stimulation (tACS) and acoustic stimulation (for generating event related potentials [ERPs]) would help to predict sleep stability and provide a window to actively assess brain activity during sleep. Twelve healthy male volunteers participated in the multiple whole‐night polysomnography (PSG) recording protocol. Acoustic tones (100 msec duration) were presented throughout night to evaluate ERP during sleep. Furthermore, 30 sec tACS were presented during nonrapid eye movement (NREM) and rapid eye movement (REM) sleep on subsequent two nights without disturbing the subject's sleep. For ERP analysis, event‐locked artifact‐free epochs from each sleep stage were averaged separately. For tACS analysis, 30 sec prestimulus and poststimulus artifact‐free EEG epochs were subjected to bootstrapping‐based comparison of power spectral values. Acoustic stimulation generated sleep stage‐dependent ERP components (N350, N550, and P900) in all participants. The tACS stimulation during NREM sleep (0.75 Hz) increased parietal delta power but decreased frontocentral theta and increased frontal gamma power when delivered during REM sleep (40Hz). These interventions provide details on sleep stability as larger N550‐P900 ERP‐complex correlated with lower NREM disruptions (Spearman's rho= −0.553; p= 0.049; n= 10) and tACS‐related theta power perturbation with higher REM disruptions (Spearman's rho= 0.734; p= 0.030; n= 7). Noninvasive brain stimulation approaches such as sleep ERP and sleep tACS are reliable tools to evaluate sleep stability during NREM and REM sleep, respectively, but more large‐sample studies are warranted.

Desalination within Australia is not widely practiced, but a persistent, long-term drought is driving government authorities to investigate alternative water sources in order to alleviate the demand on existing supplies. [...]

Current drought conditions throughout Australia have forced a change in thinking on urban water issues and have highlighted the many challenges in providing a balance between supply and demand in [...]

Biochar, a carbon-rich material derived from the pyrolysis of organic matter, exhibits beneficial chemical and physical properties when added to a soilless medium. Research on the use of biochar to improve plant productivity and growth has increased over the past decade, and has focused on using biochar as an alternative to sphagnum peatmoss. However, little work has been done to determine whether biochar can be used to partially replace commercially available sphagnum peatmoss-based greenhouse medium in vegetable transplant production. This study investigated the potential for supplementing a greenhouse growing medium with biochar for 'Paladin' pepper (Capsicum annuum) transplant production. Biochar was added to a soilless mix at rates of 0%, 20%, 40%, 60%, or 80% (by weight). Pepper seedlings were grown for 56 days in 50-, 72-, or 98-cell transplant trays at each of the five levels of biochar concentration. Germination increased in the 50- and 72- cell trays with 20%, 40%, and 60% biochar; however, biochar had no effect on germination in tire 98-cell tray. Seedling height and dry weight decreased as biochar concentration and cell number increased. Seedling stem diameter also decreased with increasing cell number and biochar concentration. Leaf SP AD readings (indirect measurement of chlorophyll) decreased with increasing biochar rate. Medium pH increased with increasing biochar application rates. Higher rates of biochar (60% and 80%) increased pH well beyond 7.0 and negatively affected transplant growth. Overall results indicate positive effect of biochar in sphagnum peatmoss-based growing mix on seedling growth characteristics; although higher biochar concentrations could negatively affect seedling growth. Biochar can successfully replace up to 40% of sphagnum peatmoss-based growing medium and serve as a sustainable alternative medium in vegetable transplant production. [ABSTRACT FROM AUTHOR]

Cover crops can be used as a sustainable weed management tool in crop production systems. Cover crops have the ability to suppress weeds, reduce soil erosion, increase soil organic matter, and improve soil physical, chemical, and biological properties. In the north-central region of the United States, including Iowa, much cover crop research has been conducted in row crop systems, mainly with com (Zea mays) and soybean (Glycine max) where cover crops are planted at die end of the growing season in September or October. There is litde information available on the use of cover crops in vegetable cropping systems, particularly on the use of summer cover crops for fall vegetable production. The choice of the cover crop will significantly impact the entire fall vegetable production enterprise. Vegetable growers need information to identify the right cover crop for a particular slot in the cropping system and to understand how cover crops would affect weed suppression, soil properties, and successive vegetable crop yield. The time interval between cover crop termination and vegetable planting critically affects the growth and successive yield of the vegetable crop. This study investigated how shortduration summer cover crops impact weed suppression, soil properties, and 'Adriana' lettuce (Lactuca sativa) yield. The study also examined appropriate planting times of lettuce transplants after soil incorporation of cover crops. The experimental design was a randomized complete block split-plot design with four replications. Whole plots consisted of cover crop treatments: 'Mancan' buckwheat (Fagopyrum escnlentum), 'Iron & Clay' cowpea/southempea (Vigna unguiculata), black oats (Avena stnjjosa), 'Grazex II' sorghum-sudangrass (Sorghum bicolor ssp. drummondii), and a control (no-cover crop) where weeds were left to grow unchecked. The subplot treatment consisted of two lettuce transplanting times: planted immediately or 8 days after cover crop soil incorporation. Fall-planted butterhead lettuce was used. Data were collected on cover crop biomass, weed biomass, soil nutrient concentration, lettuce growth, and yield. All cover crops significantly reduced weed biomass during the fallow period as compared with the control treatment. Highest degree of weed suppression (90% as compared with the no-cover crop control treatment) was provided by buckwheat. Southempea, a legume, increased soil nitrogen (N) concentration and contributed to higher lettuce yield and improved quality'. Southempea also enhanced lettuce growth and led to an earlier harvest than other treatments. Sorghum-sudangrass showed evidence of detrimental effects to the marketable lettuce crop. This was not due to N immobilization but presumably due to alleopathic properties. There is no clear pattern within any cover crop treatment that lettuce planting time following cover crop termination affects plant growth; however, planting early or soon after cover crop incorporation ensures more growing degree days and daylight, thus leading to timely harvest of a higher quality product. This study demonstrates that cover crops can successfully be integrated into vegetable cropping systems; however, cover crop selection is critical. [ABSTRACT FROM AUTHOR]

Over the past few years, foodborne disease outbreaks linked to enteric pathogens present on cantaloupe and watermelon surfaces have raised concerns in the melon industry. This research evaluated the effectiveness of commercially available produce sanitizers against selected foodborne pathogens, both in cell suspensions and on the outer rind surface of melons. The sanitizers (65 and 200 ppm of chlorine, 5 and 35% hydrogen peroxide, 5 and 50 ppm of liquid chlorine dioxide, various hydrogen peroxide–acid combinations, 0.78 and 2.5% organic acids, and 300 ppm of quaternary ammonium) were tested against Escherichia coliO157:H7, Listeria monocytogenes, Salmonella, and non-O157 Shiga toxin–producing E. coli(O26, O45, O103, O111, O121, and O145). The cell suspension study revealed the ability of all tested sanitizers to reduce all selected pathogens by 0.6 to 9.6 log CFU/ml in vitro. In the melon study, significant differences in pathogen reduction were observed between sanitizers but not between melon types. The most effective sanitizers were quaternary ammonium and hydrogen peroxide–acid combinations, with 1.0- to 2.2-log CFU/g and 1.3- to 2.8-log CFU/g reductions, respectively, for all pathogens. The other sanitizers were less effective in killing the pathogens, with reductions ranging from 0.0 to 2.8 log CFU/g depending on pathogen and sanitizer. This study provides guidance to the melon industry on the best produce sanitizers for use in implementing a broad-spectrum pathogen intervention strategy.

The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. We report the high quality draft genome sequences of Bombus terrestrisand Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis melliferaand other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.

Thermal energy storage (TES) using phase change materials (PCM) has been widely investigated for various applications from very low to very high temperatures due to its flexible operating temperature range, high energy storage density, and long-life cycle at a reasonable cost. The use of PCM in building components and hot water production can reduce the building energy demand, indoor temperature fluctuation, and better demand-side management by utilising available renewable energy and off-peak electricity. This paper presents a state-of-the-art review of the application of PCM domestic thermal heating. The classifications of TES systems, advantages of PCM over other TES systems, and the methods to overcome shortcomings of PCM are discussed in brief. Then the various novel techniques employed in underfloor heating, wall heating, PCM integration in domestic hot water tanks, and developing latent heat thermal energy storage units are extensively reviewed and the major findings of the research works reviewed are tabulated. Based on the extensive review conducted, the important factors to be considered for selecting a suitable PCM for these applications are summarised, and the commercially available PCM for the above applications are listed with their major thermo-physical properties and supplier details in the appendix.

Increasing interest in using cover crops and reduced tillage to build soil health has created a demand for strategies to implement rolled cover crop systems. In northern areas of the United States, cool soil temperature in rolled cover crop systems can create a challenge when growing warm season vegetable crops. The use of rowcovers could mitigate the issue and facilitate adoption of rolled cover crop systems for both conventional and organic growers. This study investigated muskmelon (Cucumis mclo) in two production systems, strip tillage (ST) into rolled cereal rye (Secale cercale) or conventional tillage with black plastic mulch (plasticulture), with or without the use of spunbonded polypropylene rowcovers. The trial was conducted in two fields, one in organic management and die other in conventional management. In general, ST led to cooler, moister soils than plasticulture, but rowcovers rarely affected soil temperature. Rowcovers increased mean and maximum daily air temperature by up to 4.2 and 11.7 °C, respectively, and decreased average daily light intensity by 33% to 37%. Rowcovers sometimes increased fruit size, but rarely affected marketable yield. Overall, ST reduced marketable yield compared with plasticulture by 6732 to 9900 lb/acre; however, ST with rowcovers often produced similar vegetative growth compared with plasticulture without rowcovers. Given the slow vining growth habit of muskmelon and the late planting inherent in a rolled cereal rye system, achieving high muskmelon yields, especially early yields, may be difficult. [ABSTRACT FROM AUTHOR]

Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth factor and transforming growth factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death and fibrosis in the liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may link epithelial cell death to fibrogenesis in the injured liver. DAMP receptor screening identified purinergic receptor P2Y14 among several candidates as highly enriched in hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver. Conversely, P2Y14 ligands uridine 5′-diphosphate (UDP)–glucose and UDP-galactose were enriched in hepatocytes and were released upon different modes of cell death. Accordingly, ligand-receptor interaction analysis that combined proteomic and single-cell RNA sequencing data revealed P2Y14 ligands and P2Y14 receptor as a link between dying cells and HSCs, respectively. Treatment with P2Y14 ligands or coculture with dying hepatocytes promoted HSC activation in a P2Y14-dependent manner. P2Y14 ligands activated extracellular signal–regulated kinase (ERK) and Yes-associated protein (YAP) signaling in HSCs, resulting in ERK-dependent HSC activation. Global and HSC-selective P2Y14 deficiency attenuated liver fibrosis in multiple mouse models of liver injury. Functional expression of P2Y14 was confirmed in healthy and diseased human liver and human HSCs. In conclusion, P2Y14 ligands and their receptor constitute a profibrogenic DAMP pathway that directly links cell death to fibrogenesis.

Stewartias (Stewartia spp.) are prized for their camellia (Camellia japonica)-like flowers, intense fall color, and exfoliating bark. In spite of having outstanding ornamental value and features, these plants are not readily available for landscaping in the horticulture trade. The primary reason stated is the difficulty of its mass propagation and production. In the last two decades, considerable research has been conducted on various aspects of stewartia propagation such as seed germination, cutting type, light, rooting medium, rooting hormone, cold acclimation, and tissue culture. In this article, we discuss factors that directly influence propagation of stewartia and we highlight results of published studies to propagate stewartia. The evidence indicates success in adventitious rooting of cuttings but at the same time recognizes the continuing challenge associated with overwinter survival. Sexual propagation has also been studied, but its commercial application is limited. To date, there is lack of concrete information on why stewartia remains under-represented in our landscapes. It stall remains unclear if it is the lack of consumer demand or existing propagation difficulties that is the cause of Under utilization of stewartia. Given the information from most published studies, we suggest further research on the aspect of overwinter survival in addition to a survey of the nursery and greenhouse industry to accurately determine the cause behind the absence of stewartia in horticultural trade. [ABSTRACT FROM AUTHOR]