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The article deals with the ban on public consumption of cannabis at the Hessentag. The Administrative Court of Kassel has ruled that a general order prohibiting cannabis consumption at public events is lawful. The court justifies this by stating that a violation of the consumption ban under the Cannabis Consumption Act is imminent and that the protection of children and adolescents from the consequences of cannabis consumption is an objective of the legislator. The applicant argues that the ban violates the Basic Law and the principle of equal treatment, but the court decides that the general order is justified in order to achieve the goal of health and youth protection. It is determined that cannabis, alcohol, and nicotine are not comparable and can therefore be treated differently. [Extracted from the article]

2024 AUG 26 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

2024 AUG 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 AUG 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Life Science. According to news reporting from […]

The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to cytisinicline for the treatment of nicotine e-cigarette or vaping dependence. Cytisinicline is a plant-based alkaloid that is believed [...]

2024 JUL 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

REGULARS / REALITY CHECK COMMENT Nicotine pouches are a danger to public health, but especially for kids Just because there's no tobacco, doesn't mean nicotine pouches are risk-free by DR [...]

Cabbacis, a U.S. federally-licensed tobacco product manufacturer and plant biotech company focused on harm reduction products, reported that it has licensed a flue-cured, low-nicotine tobacco line from North Carolina State [...]

2024 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on endocrinology is the subject of a new report. According to news [...]

Retailers engaging in the sale of ZYN nicotine pouches to minors are being hit with warning letters by the Food and Drug Administration (FDA). The Agency is cracking down on [...]

Zyn, a discreet and addictive nicotine product, is gaining popularity among teens as an alternative to traditional cigarettes and e-cigarettes. Similar to Juul, Zyn does not contain tobacco and is delivered through a small pouch placed under the lip. While Zyn's manufacturer has filed the necessary applications with the FDA, the agency has not yet made a decision on its regulation. Concerns have been raised about Zyn's appeal to young people, its viral marketing tactics, and the potential health risks associated with long-term use. However, research suggests that nicotine pouches like Zyn may be safer than cigarettes and traditional chewing tobacco, although they still pose risks to oral health and cardiovascular health. [Extracted from the article]

Curried Red Lentils with Kabocha Squash This flavorful curry is warming and comforting without being spicy. The ingredient list looks long because you are combining your own curry seasonings. Makes [...]

Nicotine pouches are finding an audience with people who view them as a healthier alternative to other products. Five men with prior nicotine or tobacco use habits told BI they [...]

Byline: Matt Stieb As with many trends in conservative circles, you can trace the cultish popularity of Zyn to (https://nymag.com/intelligencer/article/michael-wolff-fox-news-rupert-murdoch-tucker-carlson-book-excerpt.html) Tucker Carlson. The former Fox News host has been praising [...]

2024 JAN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

Although the addictive qualities of nicotine are well known, the damaging health effects of smoking are usually attributed to more-obvious toxins such as polycyclic aromatic hydrocarbons (PAHs), cadmium and the sticky brown tar left inside the lungs. "It is hard to sort out because most nicotine exposure data comes from cigarette smoking", says Neal Benowitz, a physician and nicotine researcher at the University of California, San Francisco. "We've underplayed the role that nicotine has in the health effects of tobacco products." A 2009 study of long-term nicotine replacement therapy - specifically, a nicotine gum - found no effect on cancer risk5, although nicotine exposure from gum is lower than would be expected from vaping or snus. [Extracted from the article]

2023 NOV 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Life Science. According to news reporting from [...]

The measures have changed since 2020, so the 2022 National Survey on Drug Use and Health (NSDUH) can't be compared to previous years before then. Still, the survey, released last week by the Substance Abuse and Mental Health Services Administration (SAMHSA), provides some useful information about how people living in the United States report their experience with substance use and treatment (the survey also includes mental health measures, as it has for years). [ABSTRACT FROM AUTHOR]

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2023 SEP 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Opioids. According to news reporting from Seattle, [...]

The article presents the discussion on electronic cigarettes and commercial nicotine vaping. Topics include imposition of non-tobacco flavor banning on e-cigarettes and vaping products; eliminating flavored nicotine e-liquids not preventing further cases of lung disease containing nicotine liquids, defective batteries, and heating coils; and nicotine exposure causing brain damage.

The article presents the discussion on Food and Drug Administration (FDA) responsible for regulating the manufacture, marketing, distribution, and sales of tobacco products. Topics include e-cigarette being a battery-operated device containing nicotine, flavorings, and other chemicals when heated creating inhalable aerosol; and providing assistance to manufacturers intending to market products deriving from tobacco based on the products.

The article presents the discussion on health risks of e-cigarettes. Topics include e-cigarette use conferring lower risk of addiction comparing with combustible tobacco cigarettes; elevating the cardiovascular disease risk in people with preexisting cardiovascular diseases; and e-cigarette use increasing airborne concentrations of particulate matter and increasing the levels of nicotine.

A recent study commissioned by The Ohio State University Comprehensive Cancer Center has found that oral nicotine pouches, a type of tobacco product, are becoming increasingly popular among teens and young adults. These pouches, which contain flavored powder with nicotine, are easy to use and conceal, making them appealing to young users. The study suggests that these pouches could serve as a gateway to future tobacco addiction. The researchers recommend stricter regulation, such as removing flavorings and increasing prices, to discourage youth experimentation and reduce the risk of nicotine addiction. Parents are advised to be aware of what is in their teenagers' backpacks and to talk to them about the dangers of these products. [Extracted from the article]

The article highlights a study which examines how voluntary ethanol exposure and social isolation during adolescence influence ethanol and nicotine use in adulthood. Topics include the effects of adolescent isolation on ethanol intake, changes in adult substance use patterns, and the impact on nicotine consumption, revealing no significant long-term risk increase from adolescent ethanol exposure alone.

A recent study conducted at Virginia Commonwealth University examined the consumption and preference for nicotine in male and female mice of various Diversity Outbred (DO) founder strains. The study found that the strain 129S1/SvlmJ consumed the highest amount of nicotine, while the A/J strain consumed the lowest. The researchers also discovered that nicotine consumption patterns are heritable and influenced by genotype. These findings may contribute to future studies that identify genetic factors related to nicotine consumption. The study was supported by the National Institute on Drug Abuse and the School of Medicine at Virginia Commonwealth University. [Extracted from the article]

A recent study conducted by the University of Washington School of Medicine has found a potential association between the long-term use of benzodiazepines (BZDs) for anxiety disorders and an increased risk of mood and substance use disorders. The study analyzed a large cohort of patients with anxiety disorders and compared those who were exposed to BZDs with a control group. The results showed that the BZD-exposed group had significantly higher risks of being diagnosed with depressive disorders, bipolar disorders, and various substance use disorders. These findings highlight the need for further research and caution when prescribing BZDs for anxiety disorders. [Extracted from the article]

A recent study conducted by researchers from the University of Amsterdam explores the association between tobacco smoking and neurometabolite levels in the anterior cingulate cortex (ACC) of first-episode psychosis (FEP) patients. The study found that there were no significant differences in ACC glutamate levels between smoking and non-smoking FEP patients. However, smoking patients did show lower total choline (tCh) levels compared to non-smoking patients. The researchers suggest that the observed alterations in tCh levels may be a result of exposure to the neurotoxic effects of smoking. [Extracted from the article]

The article focuses on a clinical trial assessing the effects of nicotine form, concentration, and flavor on e-cigarette use among young adults. Topics include the comparison between salt-based and freebase nicotine, the impact of nicotine concentration and flavor on subjective effects and vaping behavior, and the potential implications for e-cigarette addiction and abuse.

A recent systematic review and meta-analysis conducted by researchers at the University of Queensland in Brisbane, Australia explored the relationship between cannabis and nicotine use. The study found that there is a positive association between baseline nicotine use and the initiation of cannabis use, as well as a positive association between baseline cannabis use and the initiation of nicotine use. However, there were no significant associations between baseline cannabis use and subsequent nicotine use among youths. The researchers concluded that while the evidence for the association between cannabis and tobacco use is mixed, a majority of studies have found a relationship between the two. [Extracted from the article]

The article reports that Minnesota teenagers who use e-cigarettes are experiencing increased nicotine dependence, with many showing persistent cravings and multiple attempts to quit. Topics discussed include the rising rates of nicotine dependence among youth, its impact on mental health and learning, and the positive effects of recent public health measures that have led to a decline in youth vaping rates.

The article reports that some tobacco companies are substituting nicotine in e-cigarettes with chemicals that mimic nicotine's effects but may evade regulation. Topics include the use of nicotine analogs in vaping products, discrepancies between labeled and actual chemical contents, and the potential health risks of these unregulated substances.

A study published in Health & Medicine Week highlights discrepancies between labeled and measured concentrations of nicotine analogues in e-cigarettes and e-cigarette liquids marketed as nicotine replacements. These discrepancies may lead to uncertainty about user exposure and pose challenges for assessing product risk from a clinical and regulatory standpoint. The study raises concerns about the unknown health risks associated with nicotine analogue-containing products, especially as e-cigarettes are increasingly considered for smoking cessation. Further research is needed to understand the acute and chronic inhalation hazards and addictive potential of these products. [Extracted from the article]

The article highlights patent application no. 20240252020 for "Cardiac p16 Expression Following Vape Exposure with Nicotine Shows Sex-Specific Induction in Males but not Females," filed by researchers on August 19, 2024. It also discusses the differential effects of nicotine and non-nicotine vape aerosols on cardiac function, the sex-specific induction of p16 in males, and the associated collagen deposition in cardiac tissue.

A recent study explored the cognitive processes involved in decision-making among regular and non-regular cannabis users. The researchers used a two-alternative forced choice task to assess value-based decision-making (VBDM) in relation to cannabis-related and unrelated images. The results showed that regular cannabis users valued cannabis more than non-regular users, but there were no significant differences in their valuation of cannabis-unrelated alternatives. This study provides a proof-of-concept for the use of computational models in cannabis research. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

The article reviews recent advancements in managing nicotine dependence among individuals with psychiatric disorders. Topics discussed include the current treatment methods for nicotine dependence, such as pharmacotherapy and harm reduction strategies, the challenges in including psychiatric patients in clinical trials, and the Polish Psychiatric Association's updated recommendations for treating nicotine dependence in this population.

The article from Mersey Care NHS Foundation Trust outlines a study on nicotine management for mental health patients. Topics include the assessment of nicotine replacement management against trust guidelines, the prevalence of smoking among patients with mental health conditions, and the support provided to patients to manage or quit smoking during their rehabilitation.

The article from the Medical University of Warsaw provides new insights into the management of nicotine dependence in patients with psychiatric disorders. Topics include the higher prevalence of smoking and nicotine dependence among individuals with psychiatric conditions compared to the general population, the impact of nicotine on psychiatric disorders and treatments, and the effectiveness of combining pharmacotherapy with psychotherapeutic interventions for achieving smoking cessation.

A recent pilot study conducted by researchers at Riga Stradins University in Latvia explored the effects of nicotine pouches and e-cigarettes on oral microbes. The study found that the presence of periodontopathogenic bacteria in the saliva of nicotine pouch and e-cigarette users could potentially alter the oral microbiome and lead to periodontal diseases. However, further quantitative investigation is needed to fully understand the impact. The study used polymerase chain reaction to identify periodontal bacteria in saliva samples from users of nicotine pouches, e-cigarettes, conventional cigarettes, and a control group of non-tobacco users. [Extracted from the article]

A recent report from the U.S. Food and Drug Administration (FDA) highlights the characteristics of aerosols produced by nicotine salt-based e-liquids. These e-liquids are popular in the electronic nicotine delivery system (ENDS) market in the United States. The study found that the chemical and physical properties of aerosols produced by nicotine salt e-liquids differ from those produced by freebase nicotine e-liquids. The presence of carboxylic acids in the nicotine salt e-liquids impacted aerosol output, nicotine delivery, and the yields of harmful and potentially harmful constituents (HPHCs). The findings suggest that interchanging carboxylic acids in ENDS products may have downstream effects. [Extracted from the article]

A recent study conducted at Tanta University in Egypt examined the effect of nicotine on different implant platform designs in patients with mandibular implant-assisted overdentures. The study found that platform-switched dental implants were more effective in controlling marginal bone loss around the implants in smoker patients. The research concluded that these implants are the preferred choice for smokers undergoing implant therapy. The study provides valuable insights for dentists and patients considering implant-assisted overdentures. [Extracted from the article]

A recent study conducted by researchers at the University of Central Florida examined the associations between smoking, alcohol consumption, and mental health issues among Chinese older adults. The study found that among males, former alcohol users had higher odds of reporting depression, while current alcohol users did not. Current and former smoking statuses were positively associated with depression, and only current smoking status was positively associated with loss of interest. Among females, former alcohol consumption was positively associated with loneliness, and current alcohol consumption was positively associated with depression. The researchers suggest that health practitioners should consider the long-term effects of smoking and alcohol consumption on the mental health of Chinese older adults. [Extracted from the article]

New research conducted by the University of Ioannina in Greece aims to develop a method for determining nicotine and cotinine levels in urine samples using gas chromatography-mass spectrometry (GC-MS). The study focuses on the effects of passive smoking, which is believed to have risks comparable to active smoking and is considered dangerous for children and a potential cause of asthma. The method developed in this study was validated and found to be rapid, sensitive, accurate, and simple, making it suitable for analyzing a large number of samples on a daily basis. The research provides a valuable tool for confirming passive smoking in children and is the first method applied to the analysis of such samples belonging to nonsmokers of young age. [Extracted from the article]

A recent study found that the use of nicotine pouches among U.S. adults is low, despite a significant increase in sales of these products. Nicotine pouches are a new tobacco product that contains nicotine, flavorings, and other additives. While they are perceived as a potential aid for adults trying to quit smoking, concerns have been raised about their appeal to youth. The study, conducted by the Keck School of Medicine of USC and the University of Nebraska Medical Center, found that only 2.9% of adults had ever used nicotine pouches, with the majority of users also currently smoking cigarettes. The study raises questions about who is using these products and why. The researchers suggest that the sales of nicotine pouches may be diverted to adolescents, who were not included in the survey. The study also highlights the need for further research on the potential health risks and benefits of nicotine pouches. [Extracted from the article]

A systematic review conducted by researchers from ABF Analytisch-Biologisches Forschungslabor GmbH explores the potential of new nicotine and tobacco products, such as electronic cigarettes (ECs), heated tobacco products, and nicotine pouches, as alternatives to combustible cigarettes. The review found that while there are contradictory outcomes in studies on the cessation efficacy of ECs, a comprehensive Cochrane review concluded with high certainty on their effectiveness. The researchers identified weaknesses in common study designs, such as the lack of compliance measures and the absence of a defined motivation for participants to quit. They recommend that future studies consider these recommendations to determine the abuse liability and cessation efficacy of these products more robustly, with a particular focus on low- and middle-income countries. [Extracted from the article]

"People smoke for the nicotine but die from the tar." Michael Russell, a psychiatrist who was an early proponent of nicotine's role in cigarette addiction and developed smoking‐cessation therapies. Born on March 9, 1932, in Cape Town, South Africa, he died of a heart attack on July 16, 2009, in Cape Town. [ABSTRACT FROM AUTHOR]

A preprint abstract from biorxiv.org discusses the role of glucocorticoid receptors (GRs) and nicotinic acetylcholine receptors (nAChRs) in the rewarding effects of nicotine. The study used the intracranial self-stimulation (ICSS) procedure in male and female rats to investigate the effects of the GR antagonist mifepristone and the nAChR antagonist mecamylamine on nicotine's reward-enhancing effects. The results showed that nicotine lowered brain reward thresholds and decreased response latencies in both male and female rats, indicating its stimulant properties. The study suggests that the rewarding effects of nicotine are mediated through nAChR activation, while GR activation does not contribute to the acute rewarding effects of nicotine. [Extracted from the article]