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1. Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosisGrowth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests

Author

Ardizzoni, E., Ariza, E., Mulengwa, D., Mpala, Q., de La Tour, R., Maphalala, G., Varaine, F., Kerschberger, B., Graulus, P., Page, A. L., Niemann, S., Dreyer, V., Van Deun, A., Decroo, T., Rigouts, L., and de Jong, B. C.

Abstract

Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring the rpoBmutation, common in southern Africa. In addition, Xpert MTB/RIF does not distinguish between viable and dead Mycobacterium tuberculosis(MTB).

Published
2021
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