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Purpose: The purpose of this research is to provide an effective contribution to contrast the spread of Covid19. Therefore, the authors aimed to model a new strategy (technologies and processes), using the principles made available by Industry 4.0. Method: The strategy consists in an IoT thermoscanner (developed by the authors, strategically placed throughout the settlement), and an innovative method of disinfection (achieved by redesigning the sanitization processes, using UV-C rays and gaseous Ozone produced by IoT machines, again conceptualized and developed by the authors, being capable of reproducing the Chapman Cycle and its associated benefits). This method was discussed in the article "Sanitizing of Confined Spaces Using Gaseous Ozone Produced by 4.0 Machines," which was presented at the WCE 2021 IAENG Congress (Best Paper Award of the 2021 International Conference of Systems Biology and Bioengineering). Result: The results consist in: 1. an absolute disinfection system based on a reversible cycle Oxygen-Ozone-Oxygen, with quick re-habitability of the treated rooms, at a minimum treatment costs, without expensive and harmful chemicals or moist water vapor (incompatible by nature with paper and electronics); 2. a 4.0 device for quick detection of fever; 3. clear processes for disease spread prevention. Conclusion: The target contribution was widely achieved, providing machinery, processes and procedures. The authors aim now to extend the solution proposed to any other type virus, bacteria, or pathogen agent introduced by subjects who, despite being unaware of acting as vectors, develop infection along their stay in hotels, offices or any other public place.

Polymorphonuclear leukocyte infiltration and activation into colonic mucosa are believed to play a pivotal role in mediating tissue damage in human ulcerative colitis (UC). Ligands of human CXC chemokine receptor 1 and 2 (CXCR1/R2) are chemoattractants of PMN, and high levels were found in the mucosa of UC patients. To investigate the pathophysiological role played by CXCR2 in experimental UC, we induced chronic experimental colitis in WT and CXCR2−/−mice by two consecutive cycles of 4% dextran sulfate sodium administration in drinking water. In wild‐type (WT) mice, the chronic relapsing of DSS‐induced colitis was characterized by clinical signs and histopathological findings that closely resemble human disease. CXCR2−/−mice failed to show PMN infiltration into the mucosa and, consistently with a key role of PMN in mediating tissue damage in UC, showed limited signs of mucosal damage and reduced clinical symptoms. Our data demonstrate that CXCR2 plays a key pathophysiological role in experimental UC, suggesting that CXCR2 activation may represent a relevant pharmacological target for the design of novel pharmacological treatments in human UC.