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101 results on '"Morris, Tim P."'

1. MOSAIC on the ELT: front-end and instrument AITV planification

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., El Hadi, K., Chapuis, D., Prieto, E., Martin, L., Floriot, J., Dohlen, K., Challita, Z., Rodrigues, M., Larrieu, M., Dupieux, M., Castilho, B., Lewis, I., Dejonghe, J., Araujo, R., Thurneysen, M., Perez, A., Morris, Tim, Bharmal, A. N., Hottier, C., Janssen, A., Mohamed, M., Ducret, F., Puech, M., Pello, R., Dalton, G., Garcia Vargas, M., Lynn, J., and Sanchez-Janssen, R.

Published
2024
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2. Speaking Stata: The joy of sets: Graphical alternatives to Euler and Venn diagrams

Author

Cox, Nicholas J. and Morris, Tim P.

Abstract

Membership of overlapping or intersecting sets may be recorded in a bundle of (0, 1) indicator variables. Annotated Euler or Venn diagrams may be used to show graphically the frequencies of subsets so defined, but beyond just a few sets such diagrams can be hard to draw and use effectively. This column presents two new commands for graphical alternatives: upsetplotand vennbar. Each command produces a bar chart by default, but there is scope to recast to different graphical forms. The differences between the new commands reflect the divide in Stata between twowaycommands and other graphcommands. They also provide some flexibility in graph design to match tastes and circumstances. The discussion includes many historical details and references.

Published
2024
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4. A glossary for social-to-biological research

Author

Robertson, Tony, Benzeval, Michaela, Betzer, Martin, Booker, Cara, Castagné, Raphaële, Delpierre, Cyrille, Gallagher, Iain, Kelly-Irving, Michelle, McCrory, Cathal, Morris, Tim, Narimatsu, Ethan, and Paval, Robert

Published
2024
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5. Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial

Author

Patterson, Tiffany, Perkins, Gavin D, Perkins, Alexander, Clayton, Tim, Evans, Richard, Dodd, Matthew, Robertson, Steven, Wilson, Karen, Mellett-Smith, Adam, Fothergill, Rachael T, McCrone, Paul, Dalby, Miles, MacCarthy, Philip, Firoozi, Sam, Malik, Iqbal, Rakhit, Roby, Jain, Ajay, Nolan, Jerry P, Redwood, Simon R, Perera, Divaka, Clapp, Brian, Prendergast, Bernard, Pavlidis, Antonis, Wragg, Andrew, Byrne, Jonathan, Stephens, Nigel, Rosser, Gareth, Wood, Darryl, Bell, Robert, Kurbaan, Arvinder, Ozkor, Muhiddin, Lampard, Anthony, Papadopoulos, Desiree, Hughes, Johanna, Pendolino, Valentina, Shaw, Joanna, Bannister, Clara, Long, Amy, Kearney, Justin, Palti, Gabriel, Ritches-Price, Joanne, Whitbread, Mark, Adamson, Dawn, Blows, Lucy, Brown, Martin, Lane, Garth, Connor, Michael, Muir, Keith, Chamberlain, Douglas, Morris, Tim, Kwok, Matthew, Knight, Megan, Jerome, Lauren, Nijjer, Sukhjinder, Das, Rita, Sidney, Therese, Bogle, Richard, Roberts, Patrick, Webb, Ian, Spencer, Oliver, Petzer, Edward, Khan, Masood, Marciniak, Maciej, De Belder, Mark, Stables, Rod, Curzen, Nick, and Mamas, Mamas

Abstract

The International Liaison Committee on Resuscitation has called for a randomised trial of delivery to a cardiac arrest centre. We aimed to assess whether expedited delivery to a cardiac arrest centre compared with current standard of care following resuscitated cardiac arrest reduces deaths.

Published
2023
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6. Polygenic Prediction of Education and Its Role in the Intergenerational Transmission of Education: Cohort Changes Among Finnish Men and Women Born in 1925–1989

Author

Lahtinen, Hannu, Korhonen, Kaarina, Martikainen, Pekka, and Morris, Tim

Abstract

Major changes in the educational distribution of the population and in institutions over the past century have affected the societal barriers to educational attainment. These changes can possibly result in stronger genetic associations. Using genetically informed, population-representative Finnish surveys linked to administrative registers, we investigated the polygenic associations and intergenerational transmission of education for those born between 1925 and 1989. First, we found that a polygenic index (PGI) designed to capture genetic predisposition to education strongly increased the predictiveness of educational attainment in pre-1950s cohorts, particularly among women. When decomposing the total contribution of PGI across different educational transitions, the transition between the basic and academic secondary tracks was the most important. This transition accounted for 60–80% of the total PGI–education association among most cohorts. The transition between academic secondary and higher tertiary levels increased its contribution across cohorts. Second, for cohorts born between 1955 and 1984, we observed that one eighth of the association between parental and one's own education is explained by the PGI. There was also an increase in the intergenerational correlation of education among these cohorts, which was partly explained by an increasing association between family education of origin and the PGI.

Published
2023
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7. Computational methods for predicting human behaviour in smart environments

Author

Dunne, Rob, Matthews, Oludamilare, Vega, Julio, Harper, Simon, and Morris, Tim

Abstract

This systematic literature review presents the computational methods of human behaviour prediction research from Pentland and Liu’s seminal 1999 paper on human behaviour prediction to the latest research to date. The PRISMA framework for systematic reviews was used as the review methodology to structure this information aggregation. This review provides a high-level summary of the field with key areas identified for new research. The results show that there are frequently used datasets for training predictive models: MavHome, MavLab, LIARA, CASAS, PlaceLab, and REDD. Accuracies in the range of 43.9% to 100% for predictions of varying complexity. Common data structures for modelling behavioural data: Vectors, tables, trees, Markov models, and graphs. Algorithms that fall into three distinct categories: Machine Learning (NN, RL, LSTM), Probabilistic Graphical Models (namely Bayesian and Markov variants), and Statistical and Trend Analysis (ARIMA, Prophet). Additionally, we document other notably useful algorithms that fall outside of these three main categories including Jaro-Winkler and Levenshtein distances. Opportunities identified for further research include the use of audio as the data source for behaviour prediction methods, and applying times-series prediction machine learning algorithms (RNN, LSTM) to the smart home problem space.

Published
2023
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8. artcat: Sample-size calculation for an ordered categorical outcome

Author

White, Ian R., Marley-Zagar, Ella, Morris, Tim P., Parmar, Mahesh K. B., Royston, Patrick, and Babiker, Abdel G.

Abstract

We describe a new command, artcat, that calculates sample size or power for a randomized controlled trial or similar experiment with an ordered categorical outcome, where analysis is by the proportional-odds model. artcatimplements the method of Whitehead (1993, Statistics in Medicine12: 2257–2271). We also propose and implement a new method that 1) allows the user to specify a treatment effect that does not obey the proportional-odds assumption, 2) offers greater accuracy for large treatment effects, and 3) allows for noninferiority trials. We illustrate the command and explore the value of an ordered categorical outcome over a binary outcome in various settings. We show by simulation that the methods perform well and that the new method is more accurate than Whitehead’s method.

Published
2023
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9. Height, social position and coronary heart disease incidence: the contribution of genetic and environmental factors

Author

Silventoinen, Karri, Lahtinen, Hannu, Davey Smith, George, Morris, Tim T, and Martikainen, Pekka

Abstract

BackgroundThe associations between height, socioeconomic position (SEP) and coronary heart disease (CHD) incidence are well established, but the contribution of genetic factors to these associations is still poorly understood. We used a polygenic score (PGS) for height to shed light on these associations.MethodsFinnish population-based health surveys in 1992–2011 (response rates 65–93%) were linked to population registers providing information on SEP and CHD incidence up to 2019. The participants (N=29 996; 54% women) were aged 25–75 at baseline, and there were 1767 CHD incident cases (32% in women) during 472 973 person years of follow-up. PGS-height was calculated based on 33 938 single-nucleotide polymorphisms, and residual height was defined as the residual of height after adjusting for PGS-height in a linear regression model. HRs of CHD incidence were calculated using Cox regression.ResultsPGS-height and residual height showed clear gradients for education, social class and income, with a larger association for residual height. Residual height also showed larger associations with CHD incidence (HRs per 1 SD 0.94 in men and 0.87 in women) than PGS-height (HRs per 1 SD 0.99 and 0.97, respectively). Only a small proportion of the associations between SEP and CHD incidence was statistically explained by the height indicators (6% or less).ConclusionsResidual height associations with SEP and CHD incidence were larger than for PGS-height. This supports the role of material and social living conditions in childhood as contributing factors to the association of height with both SEP and CHD risk.

Published
2023
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14. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Author

Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared V., Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret I., Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njølstad, Pål Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hägg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Øyvind, Willer, Cristen J., Åsvold, Bjørn Olav, Koellinger, Philipp D., Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Benjamin, Daniel J., Turley, Patrick, Evans, David M., Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, and Davies, Neil M.

Abstract

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.

Published
2022
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15. A semantic blocks model for human activity prediction in smart environments using time-windowed contextual data

Author

Dunne, Rob, Morris, Tim, and Harper, Simon

Abstract

Complex human activity prediction is a difficult problem for computer science. Simple behaviours can be mapped to sequence prediction algorithms with good results; however, real-world examples of activity are generally stochastic and much more computationally difficult to infer. One method for solving this problem is to utilise contextual data—clues surrounding the actual activity—to decipher what is about to happen next; in much the same way humans do. In this paper, we present the semantic blocks model (SBM), a method for using contextual data to infer the next activity in a smart home environment by augmenting the inference with contextual data, but also segmenting it into time-windowed sections of activity—or semantic blocks. Our proof-of-concept produces 74.55% accuracy on the CASAS smart home dataset, an increase on the comparable CRAFFT algorithm which produces 66.91% on the same dataset. We detail how our experimental prototype works using intersecting contextual data, and explore opportunities for further work by the research community.

Published
2022
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16. MOSAIC at the ELT: a unique instrument for the largest ground-based telescope

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Pelló, Roser, Puech, Mathieu, Prieto, Éric, Rodrigues, Myriam, Sanchez-Janssen, Rubén, Dalton, Gavin B., Ducret, Franck, El Hadi, Kacem, García-Vargas, María L., Lynn, Jeff, Bharmal, Nazim A., Chapuis, Diane, Dupieux, Michel, Hottier, Clément, Larrieu, Marie, Martin, Laurent, Mohamed, Meghna, Morris, Tim, Pérez, Ana, Seifert, Walter, Xu, Wenli, Morris, Simon, Kaper, Lex, Gallego, Jesús, Afonso, Jose, Barbuy, Beatriz, Contini, Thierry, Finoguenov, Alexis, Kassin, Susan, Miller, Christopher, Ostlin, Göran, Pentericci, Laura, Schaerer, Daniel, Steinmetz, Matthias, Ziegler, Bodo, Araujo, Ricardo, Brynnel, Joar, Castilho, Bruno, Conselice, Christopher J., Cvetojevic, Nick, Davison, Christopher, Dejonghe, Julien, Dessauges-Zavadsky, Mirka, Dohlen, Kjetil, Ferreira, Décio, Gil de Paz, Armando, Gonçalves, Thiago S., Guinouard, Isabelle, Hayes, Matthew J., Ives, Derek, Janssen, Annemieke, Kehrig, Carol, Kelz, Andreas, Krajnović, Davor, Lanotte, Audrey A., Laporte, Nicolas, Laporte, Philippe, Larsen, Soren, Lemasle, Bertran, Lewis, Ian, Li, Jiang-Tao, Pancino, Elena, Pieri, Matthew M., Surace, Christian, Thurneysen, Markus, Vergani, Susanna, Wildi, François, Álvarez Moreno, Fernando, Artan, Raziye, Beaulieu, Mathilde, Besada, Eva, Bik, Arjan, Bond, Charlotte, Bouri, Mohamed, Boy, Jérémie, Bramall, David, Brands, Sarah, Braulio, Antonio, Butterley, Tim, Cabello, Cristina, Calero de Ory, Marina, Calvo, Rocio, Castillo Morales, Africa, Challita, Zalpha, Chittik, Stephen, Curto Maldonado, Andrés, De Frontat, Fátima, Dijkstra, Elfi, Elswijk, Eddy, Fasola, Gilles, Feiz, Carmen, Fialho, Fabio, Floriot, Johan, Franzetti, Paolo, Fumana, Marco, Gabarra, Luis, Garcia, Lia, Gargiulo, Adriana, Gaudemard, Julien, Giannone, Domenico, Gill, Polly, Gomez-Gutierrez, Alicia, Gouvret, Carole, Guenther, Alan, Harvey, Douglas, Ibáñez Mengual, José Miguel, Iglesias, Jorge, Ivanisenko, Yevgeniy, Kunst, Peter, Kwast, Sander, Leschinski, Kieran, Licausi, Gianluca, Ligori, Sebastiano, López Orozco, Juan Antonio, Lowe, Adam, Macintosh, Mike, Magan, Héctor, Maldonado, Manuel, Marquart, Thomas, Martins, Lucimara, Melara, Marisole, Melinder, Jens, Molema, Jeannet, Montgomery, David, Morales, María, Najarro, Francisco, Nardetto, Nicolas, Navarro, Ramon, Ottomani, Antoine, Pamplona, Tony, Pannetier, Cyril, Parr-Burman, Phil, Pascual, Sergio, Peñataro, María, Pérez Grande, Isabel, Peterzon, Jan Rinze, Piqueras, Javier, Piskunov, Nicolai, Rodriguez Cardoso, Ramon, Rodriguez Venzal, Sergio, Romp, Rick, Rostami, Hossein, Royer, Frédéric, Sablowski, Daniel, Sanchez, Ainhoa, Sánchez Blanco, Ernesto, Schalling, Ellen, Schmoll, Jurgen, Schwartz, Noah, Stephan, Jay, Taburet, Sylvestre, Terrett, David, Torralbo, Ignacio, Tromp, Niels, Veredas, Gerardo, Yang, Yanbin, York, Alec, and Zeilinger, Werner

Published
2024
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17. HARMONI at ELT: project status and instrument overview

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Thatte, Niranjan A., Melotte, Dave, Neichel, Benoit, Le Mignant, David, Rees, Phil, Clarke, Fraser, Ferraro-Wood, Vanessa, Gonzalez, Oscar, Jones, Maia, Álvarez Urueña, Alonso, Argelaguet Vilaseca, Heribert, Arribas Mocoroa, Santiago, Caballero, José Antonio, Carracedo Carballal, Gonzalo José, Estrada Piqueras, Alberto, Ferro, Irene, García García, Miriam, Lamperti, Isabella, Pereira Santaella, Miguel, Perna, Michele, Piqueras Lopez, Javier, Bouché, Nicolas, Boudon, Didier, Daguise, Eric, Domenis, Nicola, Fensch, Jérémy, Olivier Flasseur, Olivier, Giroud, Rémi, Guibert, Matthieu, Jarno, Aurelien, Jeanneau, Alexandre, Krogager, Jens-Kristian, Langlois, Maud, Laurent, Florence, Loupias, Magali, Migniau, Jean-Emmanuel, Nguyen, Dieu, Piqueras, Laure, Remillieux, Alban, Richard, Johan, Pecontal, Arlette, Bardou, Lisa, Barr, David, Cetre, Sylvain, Dimoudi, Sofia, Dubbeldam, Marc, Dunn, Andrew, Gadotti, Dimitri, Guy, Joss, King, David, McLeod, Anna, Morris, Simon, Morris, Tim, O'Brien, Kieran, Ronson, Emily, Smith, Russell, Staykov, Lazar, Swinbank, Mark, Accardo, Matteo, Alvarez Mendez, Domingo, Fuerte Rodriguez, Pablo Alberto, George, Elizabeth, Ives, Derek, Mehrgan, Leander, Mueller, Eric, Reyes, Javier, Conzelmann, Ralf, Gutierrez Cheetham, Pablo, Alonso Sanchez, Angel, Battaglia, Giuseppina, Cagigas, Miguel, Castro-Almazán, Julio A., Chulani, Haresh, Delgado-García, Graciela, Fernandez Izquierdo, Patricia, Esparza-Arredondo, Donaji, García-Lorenzo, Begoña, Hernández González, Alberto, Hernández Suárez, Elvio, Licandro, Javier, Joven, Enrique, López López, Roberto, Lujan Gonzalez, Alejandro Antonio, Martín Hernando, Yolanda, Martín-Navarro, Ignacio, Mediavilla, Evencio, Menéndez Mendoza, Saúl, Montoya Martínez, Luz Maria, Peñate Castro, José, Murgas, Felipe, Pallé, Enric, Pérez, Álvaro, Rasilla, Jose Luis, Rebolo, Rafael, Rodríguez, Horacio, Rodríguez Ramos, Luis Fernando, Sánchez Béjar, Victor, Shahbaz, Tariq, Vega Moreno, Afrodisio, Viera, Teodora, Bonnefoy, Mickaël, Bret, Tony, Carlotti, Alexis, Correia, Jean-Jacques, Curaba, Stéphane, Delboulbé, Alain, Guieu, Sylvain, Hours, Adrien, Hubert, Zoltan, Jocou, Laurent, Magnard, Yves, Michaud, Laurence, Moulin, Thibaut, Pancher, Fabrice, Rabou, Patrick, Rochat, Sylvain, Stadler, Eric, Contini, Thierry, Larrieu, Marie, Mamessier, Sébastien, Boebion, Olivier, Fantei-Caujolle, Yan, Lecron, Daniel, Amram, Philippe, Blanchard, Patrick, Bon, William, Bonnefoi, Anne, Bozier, Alexandre, Ceria, William, Challita, Zalpha, Charles, Yannick, Choquet, Elodie, Costille, Anne, Delsanti, Audrey, Dohlen, Kjetil, Ducret, Franck, El Hadi, Kacem, Foulon, Benjamin, Gimenez, Jean-Luc, Groussin, Olivier, Jaquet, Marc, Renault, Edgard, Rouquette, Paul, Sanchez, Patrice, Vigan, Arthur, Zavagno, Annie, Fétick, Romain, Fusco, Thierry, Héritier, Cedric, Sauvage, Jean-Francois, Vedrenne, Nicolas, Aksoy, Demet, Caldwell, Martin, Fitzpatrick, Ann, Geddert, Carl, Hiscock, Peter, Johnson, Emma, Nalagatla, Murali, Saraff, Louise, Shreeves, Joe, Tildesley, Matthew, Wells, Mark, Aretos, Anastasios, Barrett, Lee, Black, Martin, Bond, Charlotte, Brierley, Saskia, Bryson, Ian, Calderhead, Amelia, Campbell, Kenny, Carruthers, James, Chapman, Lee, Cochrane, William, Gillespie, Rory, Harman, Joel, Harvey, Douglas, Harvey, Eamonn, Johnson, Bethany, Louth, Tom, MacIntosh, Mike, MacIver, Anna, Miller, Chris, Montgomery, David, Murali, Meenu, Murray, John, O'Malley, Norman, Sanchez-Janssen, Ruben, Schwartz, Noah, Smith, Patrick, Strachan, Jonathan, Todd, Stephen, Wasley, Dawn, Wilson, Sandi, Zhou, Junyi, Bell, Eric, Gnedin, Oleg, Gultekin, Kayhan, Mateo, Mario, Meyer, Michael, Birkby, Jayne, Boland, Liam, Cappellari, Michele, Castillo Dominguez, Edgar, Gooding, David, Grisdale, Kearn, Hidalgo, Andrea, Kariuki, James, Lewis, Ian, McCall, Kieran, Meyer, R. Elliot, Muslimov, Eduard, Lowe, Adam, Ozer, Zeynep, Paszynska, Sophie, Rigopoulou, Dimitra, Tecza, Matthias, and York, Alec

Published
2024
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18. Global tip-tilt and high-order aberration correction with plenoptic wavefront sensors in closed-loop AO systems

Author

Zhang, Zhentao, Morris, Tim, Bharmal, Nazim, and Liang, Yonghui

Abstract

The plenoptic wavefront sensor (PlWFS) has been proposed as being suitable for operating on extended objects in adaptive optics (AO) systems. We propose a new self-referencing method that uses the cell image of PlWFS as a correlation reference and enables the simultaneous measurement of high-order aberrations and tilt. Simulations have been performed for different operating conditions to verify the feasibility of the proposed method. These show that using the cell image results in better AO performance compared to existing reference generation techniques and allows stable wavefront tilt control with a small residual variance.

Published
2021

19. Multi-core fibre-fed integral-field unit (MCIFU): overview and first-light

Author

Schreiber, Laura, Schmidt, Dirk, Vernet, Elise, Haffert, Sebastiaan Y., Harris, Robert J., Zanutta, Alessio, Pike, Fraser A., Bianco, Andrea, Redaelli, Edoardo, Benoît, Aurélien, MacLachlan, David G., Ross, Calum A., Gris-Sánchez, Itandehui, Trappen, Mareike D., Xu, Yilin, Blaicher, Matthias, Maier, Pascal, Riva, Giulio, Sinquin, Baptiste, Kulcsár, Caroline, Bharmal, Nazim Ali, Gendron, Eric, Staykov, Lazar, Morris, Tim J., Barboza, Santiago, Muench, Norbert, Bardour, Lisa, Prengère, Léonard, Raynaud, Henri-François, Hottinger, Philipp, Anagnos, Theodoros, Osborn, James, Koos, Christian, Thompson, Robert R., Birks, Tim A., Snellen, Ignas A. G., Keller, Christoph U., Close, Laird, and Males, Jared R.

Published
2020
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26. Product assurance for instrumental projects in research laboratory: galaxies, etoiles, physique, instrumentation (GEPI)

Author

Angeli, George Z., Dierickx, Philippe, De Frondat Laadim, Fatima, Jagourel, Pascal, Frotin, Mickael, Hammer, François, Rodrigues, Myriam, Puech, Mathieu, Guinouard, Isabelle, Chemla, Fanny, Yang, Yanbin, Fitzsimons, Ewan, Parr-Burman, Phil, Morris, Tim, Dubbeldam, Marc, Close, Madeline, Middleton, Kevin, Rousset, Gerard, Kelz, Andreas, Janssen, Annemieke, Pragt, Johan, Navarro, Ramon, Larrieu, Marie, El Hadi, Kacem, Dohlen, Kjetil, Dalton, Gavin, and Lewis, Ian

Published
2018
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29. The E-ELT first light spectrograph HARMONI: capabilities and modes

Author

Evans, Christopher J., Simard, Luc, Takami, Hideki, Thatte, Niranjan A., Clarke, Fraser, Bryson, Ian, Shnetler, Hermine, Tecza, Matthias, Fusco, Thierry, Bacon, Roland M., Richard, Johan, Mediavilla, Evencio, Neichel, Benoît, Arribas, Santiago, Garcia-Lorenzo, Begoña, Evans, Christopher J., Remillieux, Alban, El Madi, Kacem, Herreros, Jose Miguel, Melotte, Dave, O'Brien, Kieran, Tosh, Ian A., Vernet, Joël, Hammersley, Peter, Ives, Derek J., Finger, Gert, Houghton, Ryan, Rigopoulou, Dimitra, Lynn, James D., Allen, Jamie R., Zieleniewski, Simon D., Kendrew, Sarah, Ferraro-Wood, Vanessa, Pécontal-Rousset, Arlette, Kosmalski, Johan, Laurent, Florence, Loupias, Magali, Piqueras, Laure, Renault, Edgar, Blaizot, Jeremy, Daguisé, Eric, Migniau, Jean-Emmanuel, Jarno, Aurélien, Born, Andy, Gallie, Angus M., Montgomery, David M., Henry, David, Schwartz, Noah, Taylor, William, Zins, Gérard, Rodríguez-Ramos, Luis Fernando, Cagigas, Miguel, Battaglia, Giuseppina, Rebolo López, Refael, Hernández Suárez, Elvio, Gigante-Ripoll, José Vicente, Piqueras López, Javier, Villa Martin, Montserrat, Correia, Carlos, Pascal, Sandrine, Blanco, Leonardo, Vola, Pascal, Epinat, Benoit, Peroux, Celine, Vigan, Arthur, Dohlen, Kjetil, Sauvage, Jean-Francois, Lee, Martin, Carlotti, Alexis, Verinaud, Christophe, Morris, Tim, Myers, Richard, Reeves, Andrew, Swinbank, Mark, Calcines, Ariadna, and Larrieu, Marrie

Published
2016
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33. Reference-based Sensitivity Analysis via Multiple Imputation for Longitudinal Trials with Protocol Deviation

Author

Cro, Suzie, Morris, Tim P., Kenward, Michael G., and Carpenter, James R.

Abstract

Randomized controlled trials provide essential evidence for the evaluation of new and existing medical treatments. Unfortunately, the statistical analysis is often complicated by the occurrence of protocol deviations, which mean we cannot always measure the intended outcomes for individuals who deviate, resulting in a missing-data problem. In such settings, however one approaches the analysis, an untestable assumption about the distribution of the unobserved data must be made. To understand how far the results depend on these assumptions, the primary analysis should be supplemented by a range of sensitivity analyses, which explore how the conclusions vary over a range of different credible assumptions for the missing data. In this article, we describe a new command, mimix, that can be used to perform reference-based sensitivity analyses for randomized controlled trials with longitudinal quantitative outcome data, using the approach proposed by Carpenter, Roger, and Kenward (2013, Journal of Biopharmaceutical Statistics23: 1352–1371). Under this approach, we make qualitative assumptions about how individuals’ missing outcomes relate to those observed in relevant groups in the trial, based on plausible clinical scenarios. Statistical analysis then proceeds using the method of multiple imputation.

Published
2016
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34. Quantifying the Uptake of user-written Commands over Time

Author

Choodari-Oskooei, Babak and Morris, Tim P.

Abstract

A major factor in the uptake of new statistical methods is the availability of user-friendly software implementations. One attractive feature of Stata is that users can write their own commands and release them to other users via Statistical Software Components at Boston College. Authors of statistical programs do not always get adequate credit, because programs are rarely cited properly. There is no obvious measure of a program's impact, but researchers are under increasing pressure to demonstrate the impact of their work to funders. In addition to encouraging proper citation of software, the number of downloads of a user-written package can be regarded as a measure of impact over time. In this article, we explain how such information can be accessed for any month from July 2007 and summarized using the new ssccountcommand.

Published
2016
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35. Multiple Imputation of Covariates by Substantive-model Compatible Fully Conditional Specification

Author

Bartlett, Jonathan W. and Morris, Tim P.

Abstract

Multiple imputation is a practical, principled approach to handling missing data. When used to impute missing values in covariates of regression models, imputation models may be misspecified if they are not compatible with the substantive model of interest for the outcome. In this article, we introduce the smcfcscommand, which imputes covariates by substantive-model compatible fully conditional specification. This modifies the popular fully conditional specification or chained-equations approach to multiple imputation by imputing each covariate compatibly with a user-specified substantive model. We compare the smcfcscommand with standard fully conditional specification imputation using mi impute chainedin a simulation study and illustrative analysis of data from a study investigating time to tumor recurrence in breast cancer.

Published
2015
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36. HARMONI at ELT: overview of the capabilities and expected performance of the ELT's first light, adaptive optics assisted integral field spectrograph.

Author

Evans, Christopher J., Bryant, Julia J., Motohara, Kentaro, Thatte, Niranjan A., Melotte, Dave, Neichel, Benoit, Le Mignant, David, Bryson, Ian, Clarke, Fraser, Ferraro-Wood, Vanessa, Fusco, Thierry, Gonzalez, Oscar, Schnetler, Hermine, Tecza, Matthias, Wilson, Sandi, Álvarez Urueña, Alonso, Vilaseca, Heribert A., Arribas, Santiago, Carracedo Carballale, Gonzalo José, Crespo, Alejandro, Estrada Piqueras, Alberto, García García, Miriam, Martínez Martín, Cecilai, Pereira Santaella, Miguel, Perna, Michele, Piqueras Lopez, Javier, Bouché, Niolas, Boudon, Didier, Daguise, Eric, Disseau, Karen, Fensch, Jérémy J., Girardot, Adrien, Guibert, Matthieu, Jarno, Aurélien, Jeanneau, Alexandre, Krogager, Jens-Kristian, Laurent, Florence, Loupias, Magali, Migniau, Jean-Emmanuel, Piqueras, Laure, Remillieux, Alban, Richard, Johan, Pecontal, Arlette, Bardou, Lisa F., Barr, David, Cetre, Sylvain, Deshmukh, Rishi, Dimoudi, Sofia, Dubbledam, Marc, Dunn, Andrew, Gadotti, Dimitri, Guy, Joss J., King, David, Little, David J., McLeod, Anna, Morris, Simon, Morris, Tim, O'Brien, Kieran S., Ronson, Emily, Smith, Russell, Staykov, Lazar, Swinbank, Mark, Townson, Matthew, Accardo, Matteo, Alvarez Mendez, Domingo, George, Elizabeth, Hopgood, Joshua, Ives, Derek, Mehrgan, Leander, Mueller, Eric, Reyes, Javier, Conzelmann, Ralf, Gutierrez Cheetham, Pablo, Alonso-Sánchez, Ángel, Battaglia, Giuseppina, Cagigas, Miguel, Chulani, Haresh, Delgado García, Graciela, Fernandez Izquierdo, Patricia, Fragoso López, Ana Belén, García-Lorenzo, Begoña, Hernández González, Alberto, Hernandez Suarez, Elvio, Herreros Linares, Jose Miguel, Joven, Enrique, López López, Roberto, Lujan Gonzalez, Alejandro Antonio, Martín Hernando, Yolanda, Mediavilla, Evencio, Menéndez Mendoza, Saúl, Montoya Martínez, Luz Maria, Peñate Castro, José, Pérez, Álvaro, Rasilla, Jose Luis, Rebolo, Rafael, Rodríguez Ramos, Luis Fernando, Vega-Moreno, Afrodisio, Viera, Teodora, Zanon Dametto, Natacha, Carlotti, Alexis, Correia, Jean-Jacques, Curaba, Stéphane, Delboulbe, Alain, Guieu, Sylvain, Hours, Adrien, Hubert, Zoltan, Jocou, Laurent, Magnard, Yves, Moulin, Thibaut, Pancher, Fabrice, Rabou, Patrick, Stadler, Eric, Vérove, Maxime, Contini, Thierry, Larrieu, Marie, Boebion, Olivier, Fantei-Caujolle, Yan, Lecron, Daniel, Rousseau, Sylvain, Amram, Philippe, Beltramo-Martin, Olivier, Bon, William, Bonnefoi, Anne, Ceria, William, Challita, Zalpha, Charles, Yannick, Choquet, Elodie, Correia, Carlos, Costille, Anne, Dohlen, Kjetil, Ducret, Franck, El Hadi, Kacem, Gach, Jean-Luc, Gimenez, Jean-Luc, Groussin, Olivier, Jaquet, Marc, Jouve, Pierre, Madec, Fabrice, Pedreros, Felipe, Renault, Edgard, Sanchez, Patrice, Vigan, Arthur, Vola, Pascal, Zavago, Annie, Fetick, Romain, Lim, Caroline, Petit, Cyril, Sauvage, Jean-Francois, Védrenne, Nicolas, Bagci, Fehim Taha, Caldwell, Martin E., Elliott, Ellis, Hiscock, Peter, Johnson, Emma, Nalagatla, Murali, Seitis, Aristea, Wells, Mark, Black, Martin, Bond, Charlotte, Brierley, Saskia, Campbell, Kenny, Campbell, Neil, Carruthers, James, Cochrane, William, Evans, Chris, Harman, Joel, Humphreys, William, Louth, Thomas, Miller, Chris, Montgomery, David, Murali, Meenu, Murray, John, O'Malley, Norman, Sanchez-Janssen, Ruben, Schwartz, Noah, Smith, Patrick, Strachan, Jonathan, Todd, Stephen, Watt, Stuart, Wells, Martyn, Yaqoob, Asim, Bell, Eric, Gnedin, Oleg O., Gultekin, Kayhan, Mateo, Mario, Meyer, Michael, Ahmad, Munadi, Birkby, Jayne, Booth, Michael, Cappellari, Michele, Castillo Dominguez, Edgar, Chao Ortiz, Jorge, Gooding, David, Grisdale, Kearn, Hidalgo, Andrea, Hogan, Laurence, Kariuki, James, Lewis, Ian, Lowe, Adam, Ozer, Zeynep, Routledge, Laurence, Rigopoulou, Dimitra, and York, Alec

Published
2022
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37. HARMONI- the Extremely Large Telescope first light integral field spectrograph: a novel control architecture to integrate the science instrument control system with that of adaptive optics

Author

Angeli, George Z., Dierickx, Philippe, Schnetler, Hermine, Bond, Charlotte, Chulani, Haresh, Clarke, Fraser, Costille, Anne, Delgado Garcia, Graciela, Delgado, Jose Miguel, Dimoudi, Sofia, Dunn, Andrew, George, Elizabeth, Estrada Piqueras, Alberto, Guieu, Sylvain, Joven, Enrique, Larrieu, Marie, Martin Hernando, Yolanda, Martinez Martin, Cecilia, Menendez-Mendoza, Saul, Miller, Chris, Morris, Tim, Pecontal, Arlette, Piqueras Lopez, Javier, Rodriguez Ramos, Luis Fernando, Stegmeier, Jörg, Townson, Matthew, Viera, Teodora, Fusco, Thierry, Le Mignant, David, Neichel, Benoît, Melotte, Dave, Tecza, Matthias, and Thatte, Niranjan

Published
2022
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38. CANARY phase B: on-sky open-loop tomographic LGS AO results

Author

Marchetti, Enrico, Close, Laird M., Véran, Jean-Pierre, Morris, Tim, Gendron, Eric, Basden, Alastair, Martin, Olivier, Osborn, James, Henry, David, Hubert, Zoltan, Sivo, Gaetano, Gratadour, Damien, Chemla, Fanny, Sevin, Arnaud, Cohen, Matthieu, Younger, Eddy, Vidal, Fabrice, Wilson, Richard, Butterley, Tim, Bitenc, Urban, Reeves, Andrew, Bharmal, Nazim, Raynaud, Henri-François, Kulcsar, Caroline, Conan, Jean-Marc, Huet, Jean-Michel, Perret, Denis, Dickson, Colin, Atkinson, David, Bailie, Tom, Longmore, Andy, Todd, Stephen, Talbot, Gordon, Morris, Simon, Rousset, Gérard, and Myers, Richard

Published
2014
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44. PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement

Author

Khan, Anjum Bashir, Barrington, Sally Fiona, Mikhaeel, Nabegh George, Hunt, Alesia Abigael, Cameron, Laura, Morris, Tim, and Carr, Robert

Abstract

We investigated whether positron emission tomography combined with computed tomography (PET-CT) identifies clinically important bone marrow involvement by diffuse large B-cell lymphoma (DLBCL) with sufficient accuracy to replace routine staging bone marrow biopsy. All patients from a single centre diagnosed as DLBCL since 2005 had data extracted from staging PET-CT, marrow biopsy, and treatment records. Of 130 patients, 35 (27%) were judged to have marrow involvement; 33 were identified by PET-CT compared with 14 by marrow histology. PET identified all clinically important marrow lymphoma, while biopsy did not upstage any patient. Sensitivity and specificity were 94% and 100% for PET-CT and 40% and 100% for marrow biopsy. As a secondary aim, we compared the prognosis of marrow involvement, as detected by PET-CT or biopsy. Cases with marrow deposits identified by PET-CT but not biopsy had progression-free survival (PFS) and overall survival similar to stage IV disease without involved marrow. Positive biopsy conferred significantly inferior PFS (P = .003); these cases frequently had other markers of poor-risk disease. These data confirm that in experienced hands PET-CT has a high level of accuracy for identifying marrow disease in DLBCL, and provide new insight into the nature and clinical significance of marrow involvement.

Published
2013
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45. PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement

Author

Khan, Anjum Bashir, Barrington, Sally Fiona, Mikhaeel, Nabegh George, Hunt, Alesia Abigael, Cameron, Laura, Morris, Tim, and Carr, Robert

Abstract

We investigated whether positron emission tomography combined with computed tomography (PET-CT) identifies clinically important bone marrow involvement by diffuse large B-cell lymphoma (DLBCL) with sufficient accuracy to replace routine staging bone marrow biopsy. All patients from a single centre diagnosed as DLBCL since 2005 had data extracted from staging PET-CT, marrow biopsy, and treatment records. Of 130 patients, 35 (27%) were judged to have marrow involvement; 33 were identified by PET-CT compared with 14 by marrow histology. PET identified all clinically important marrow lymphoma, while biopsy did not upstage any patient. Sensitivity and specificity were 94% and 100% for PET-CT and 40% and 100% for marrow biopsy. As a secondary aim, we compared the prognosis of marrow involvement, as detected by PET-CT or biopsy. Cases with marrow deposits identified by PET-CT but not biopsy had progression-free survival (PFS) and overall survival similar to stage IV disease without involved marrow. Positive biopsy conferred significantly inferior PFS (P= .003); these cases frequently had other markers of poor-risk disease. These data confirm that in experienced hands PET-CT has a high level of accuracy for identifying marrow disease in DLBCL, and provide new insight into the nature and clinical significance of marrow involvement.

Published
2013
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46. FOCUS Cayo Evo 2.0.

Author

MORRIS, TIM

Abstract

The article evaluates the FOCUS Cayo Evo 2.0 bicycle from Derby Cycle Werke Gmbh.

Published
2012

47. Viner Mitus 0.5.

Author

MORRIS, TIM

Abstract

The article evaluates the Viner Mitus 0.5 bike from Viner. INSETS: SPECIFICATIONS;SUMMING UP.

Published
2012

48. NeilPryde Alize.

Author

MORRIS, TIM

Abstract

The article evaluates the Alize bicycle from Neil Pryde Ltd.

Published
2011

49. Scott Speedster S20.

Author

Morris, Tim

Abstract

The article evaluates the Scott Speedster S20 bike from Scott Sports SA.

Published
2011

50. Hiker Racing 3000.

Author

Morris, Tim

Abstract

The article evaluates the Hiker Racing 3000 bicycle from Lombardo Bikes.

Published
2011

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