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3. Laser ion acceleration for hadron therapy

Author

Bulanov, S V, Wilkens, J J, Esirkepov, T Zh, Korn, G, Kraft, G, Kraft, S D, Molls, M, and Khoroshkov, V S

Abstract

The paper examines the prospects of using laser plasma as a source of high-energy ions for the purpose of hadron beam therapy -- an approach which is based on both theory and experimental results (ions are routinely observed to be accelerated in the interaction of high-power laser radiation with matter). Compared to therapy accelerators like synchrotrons and cyclotrons, laser technology is advantageous in that it is more compact and is simpler in delivering ions from the accelerator to the treatment room. Special target designs allow radiation therapy requirements for ion beam quality to be satisfied.

Published
2014

4. Clinical, Molecular- and Cytogenetic Analysis of a Case of Severe Radio- Sensitivity

Author

Greulich-Bode, K.M., Zimmermann, F., Muller, W.-U., Pakisch, B., Molls, M., and Wurschmidt, F.

Abstract

In radiotherapy the normal tissue reaction is often a limiting factor for radiation treatment. Still there is no screening method, which predicts normal tissue reaction on radiotherapy, especially in comparison to tumor tissue, and therefore allows tailoring of the radiation dose to each patient. Here, we present a case of severe radiation-related side effects. We applied classical cytogenetic techniques (Giemsa-banding and staining of centromeric regions), the comet assay as well as multicolor fluorescence in situ hybridization on peripheral blood lymphocytes of this patient in order to determine the radio-sensitivity on the DNA level and to correlate these findings with the clinical outcome. Our investigations revealed abnormalities on chromosome 9, deficiencies in the DNA-repair capacity after radiation exposure and a high number of radiation induced chromosomal aberrations. A detected high amount of residual damage two or three hours after radiation exposure and repair as well as the high number of chromosomal aberrations (ChAs) suggests a correlation between repair capacity and radiation induced ChAs. We concluded that the detected abnormalities might serve as a genetic basis for the radio-sensitive phenotype of this patient. Taken together this report strengthens the idea that intensive DNA genomic analysis of individual patients can serve as the basis for more favourable treatment of cancer patients.

Published
2012

5. DEGRO 2004

Author

Wendt, Thomas, Gademann, G., Pambor, C., Grießbach, I., Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U., Zamboglou, N., Eich, H., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F., Ring, J., Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S., Gutwein, S., Schulz-Ertner, D., Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S., Schreiber, F., Rustgi, A., McKenna, W., Bernhard, E., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R., Dudas, J., Hess, C., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P., Blumstein, N., Gottfried, H.-W., Schneider, E., Reske, S., Röttinger, E., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R., Mintz, G., Kotani, J.-I., Shah, V., Canos, D., Weissman, N., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M., Frank, A., Trappe, A., Lumenta, C., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M., Ludwig, C., Körholz, J., Grötz, K., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B., Schmid, R., Stratakis, D., Huber, R., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Eck, A., Bundschuh, O., Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S., Glashörster, M., Weining, C., Hentschel, B., Sauer, O., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
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6. Indikationen zur neoadjuvanten Therapie beim Rektumkarzinom

Author

Zimmermann, F. and Molls, M.

Abstract

Zusammenfassung Prä- wie postoperative adjuvante Therapien haben beim lokal fortgeschrittenen, prognostisch resektablen Rektumkarzinom (R0-Resektion) die Ergebnisse verbessert. Grundsätzlich gilt in diesen Stadien des Rektumkarzinoms (T3/4 N0 M0; jedes T-Stadium N+M0) immer noch der interdisziplinäre Konsens der Deutschen Krebsgesellschaft, der sich für die postoperative adjuvante Radiochemotherapie ausspricht. Nach zahlreichen klinischen Studien mit guten Resultaten wird international mittlerweile die präoperative adjuvante Therapie bevorzugt. Sie scheint bei vergleichsweise höherer Compliance der Patienten auch besser toleriert zu werden. Die alleinige hypofraktionierte präoperative Radiotherapie über 3–4 Felder, der in kürzester Zeit die Operation folgt, stellt beim primär resektablen T3-Tumor eine Therapieoption dar. Ein zusätzlicher Nutzen kann von einer konventionell fraktionierten simultanen Radiochemotherapie (Einzeldosis im Bereich von 2 Gy, Gesamtdosis über 40 Gy, Chemotherapie basiert auf 5-FU), der die Operation erst nach mehreren Wochen folgt, erwartet werden. Dringend zu empfehlen ist eine präoperative Therapie bei T4-Tumoren, bei denen der Chirurg von einer R1- oder R2-Resektion ausgehen muss. Die Wahrung der Kontinenz kann bei Einhaltung der erforderlichen chirurgischen Radikalität (Ziel: R0-Resektion!) in Einzelfällen ein weiteres Ziel der multimodalen Therapie sein.

Published
2003
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7. Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review

Author

Nieder, C., Licht, T., Andratschke, N., Peschel, C., and Molls, M.

Abstract

In the absence of evidence from randomised trials, radiation treatment of diffuse large-cell lymphoma of B-cell type represents an area of controversy with considerable differences in patterns of practice. The present literature survey aims at clarification of the role of radiotherapy in combined modality settings by identification of dose–response relationships, predictive factors for local control, and potential pitfalls in the interpretation of retrospective studies. Radiotherapy might increase local control in initially involved areas and is usually delivered to these sites (involved-field treatment). Combined modality treatment is currently recommended for patients in stage I or II if they are not treated in the context of prospective studies. Whether involved-field consolidation radiotherapy after systemic treatment in patients with bulky, stage III–IV lymphomas should be routinely recommended is presently unclear. Definition of bulky disease is arbitrary and varied between 6 and 10cm, reflecting a considerable difference in the number of clonogenic tumour cells.Several retrospective and one prospective randomised study suggest improved disease-free and overall survival by radiotherapy in advanced stages. The 5-year local control by radiotherapy was 93–98%. Currently, we recommend the following minimum doses for involved-field radiotherapy derived from this literature survey. Lymphomas with initial size <3.5 cm (possibly <6 cm) can be treated with 30 or 30.6Gy when a complete remission (CR) has been achieved by chemotherapy. The next group might be sufficiently controlled by 36Gy, but it remains unclear whether the cut-off should be 6cm or higher. Forty Gy appears to control tumours in the range of 7–10cm. Most likely, 45Gy does not have to be exceeded for larger lesions. Data on those with less than CR are contradictory. Judging the amount of viable tumour in these patients is problematic, but crucial to determine the intensity of further treatment. The value of positron emission tomography is still under investigation. Because the difference between doses of 30 and 40Gy might actually make a difference for the long-term toxicity of radiotherapy in some of the normal tissues and organs at risk (salivary glands, orbital structures, lung, heart, etc.), it appears prudent to resolve the open questions in prospective trials with careful documentation of side effects.

Published
2003
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8. Stereotaktische Strahlentherapie am adaptierten Linearbeschleuniger bei Patienten mit Hirnmetastasen

Author

Grosu, A. L., Feldmann, H. J., Stärk, S., Pinsker, M., Nieder, C., Kneschaurek, P., Lumenta, C., and Molls, M.

Abstract

Zusammenfassung: Ziel der Studie war es, die klinischen Ergebnisse nach stereotaktischer Strahlentherapie (Radiochirurgie und stereotaktischer fraktionierter Strahlentherapie) am adaptierten Linearbeschleuniger bei Patienten mit Hirnmetastasen zu evaluieren. Dabei wurden folgende Parameter untersucht: Tumorkontrolle, Überlebenszeit und Nebenwirkungen. Die Vor- und Nachteile dieser Behandlungstechnik im Vergleich zu traditionellen Behandlungsmethoden (Operation und Ganzschädelbestrahlung) wurden auf der Basis der Literaturdaten und der eigenen Erfahrung analysiert. Nach Behandlung von 80 Läsionen, mit einer medianen Nachbeobachtungszeit von 13 Monaten, kommt die Studie zu folgendem Ergebnis: Die stereotaktische Strahlentherapie am Linearbeschleuniger stellt eine wichtige Therapieoption in der Behandlung der Hirnmetastasen dar. Gegenüber alleiniger Ganzschädelbestrahlung erreicht die stereotaktische Strahlentherapie eine deutlich höhere Tumorkontrolle bei einem niedrigen Nebenwirkungsrisiko. Die stereotaktische Strahlentherapie hat gegenüber der Operation den Vorteil einer kürzeren Behandlungszeit und einer niedrigeren Morbidität und Mortalität.

Published
2001
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9. A new Class of Drugs for BNCT? Borylated derivatives of ferrocenium compounds in animal experiments

Author

Weissfloch, L., Wagner, M., Probst, T., Senekowitsch-Schmidtke, R., Tempel, K., and Molls, M.

Abstract

A new class of drugs, borylated derivatives of ferrocenium compounds, which show a comparatively facile synthesis is investigated on their boron neutron capture accumulation. Investigations focused on the fast and effective testing of 12 ferrocene derivatives with tetracoordinated boron atoms, which should accumulate in rodent tumors. The macroscopic studies on time-dependent boron distributions and boron concentrations in mice were carried out by inductively coupled plasma-atomic emission spectrometry, inductively coupled plasma-mass spectrometry, and quantitative neutron capture radiography. The determination of boron concentrations after injection of 2bshowed high boron contents in spleen, liver, kidneys, less in lung and muscle, and poor in integral blood, blood plasma, tumor, and brain. It is interesting to note that 2bpenetrates the blood-brain barrier which may be advantageous in the treatment of astrocytomas and glioblastomas.

Published
2001
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11. A comparison of treatment results for recurrent malignant gliomas

Author

Nieder, C., Grosu, A. L., and Molls, M.

Abstract

Retreatment of malignant gliomas may be performed with palliative intent after careful consideration of the risks and benefits, and with special regards to iatrogenic neurotoxicity and quality of life (QOL). This review compares studies of several retreatment strategies (published between 1987 and 2000) based on the quality of their evidence. Depending on both established prognostic factors and previous treatment, individually tailored retreatment strategies are possible. In all studies that included a multivariate analysis of prognostic factors, performance status was the most important. So far, predictive factors for response, which might facilitate patient selection, have not been unequivocally defined. In terms of QOL, single-agent chemotherapy (temozolomide, nitrosoureas, platinum and taxane derivatives) may offer a better therapeutic ratio than polychemotherapy. For glioblastoma multiforme, progression-free survival and QOL were more favourable after temozolomide than procarbazine (level 1 evidence). The survival of patients after various radiotherapy techniques is broadly similar. However, considerable toxicity is associated with radiosurgery or brachytherapy. Fractionated stereotactic radiotherapy plus radio-sensitizing cytostatic agents has shown promising initial results in small groups of selected patients and awaits further evaluation. Level 2 evidence derived from non-randomized studies does not suggest a substantial prolongation of survival by re-resection as compared with chemotherapy or radiotherapy alone. Level 1 evidence derived from a randomized trial suggests that application of BCNU polymers significantly improves the outcome after re-resection. However, most studies reported median survival in the range of only 25–35 weeks, thereby emphasizing the need for the development and clinical evaluation of new innovative treatment approaches. Copyright 2000 Harcourt Publishers Ltd

Published
2000
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16. Problems associated with CT-guided catheter insertions

Author

Feldmann, H. J., Hoederath, A., Molls, M., and Sack, H.

Abstract

From October 1987 to August 1991 a total of 141 closed-tip catheters were inserted into deep-seated or half-deep-seated tumours in 95 treatment areas. Most of the catheters (n = 79) were implanted in the pelvic region. In 139 punctures no clinical evidence of bleeding was seen. A transient blood loss was evident in only two patients. In addition, no nerve injury was observed. The problems with 141 implanted catheters were evaluated. Nineteen catheters (13%) were lost during the treatment series. In five displacement of the catheters was verified by repeat CT scans during the whole treatment. Eight catheters had to be removed due to infection. In two patients with advanced disease who were receiving a combination of chemotherapy and hyperthermia a strong inflammatory response was evident. Another patient developed an acute pancreatitis after catheter insertion. No metastasis in the invasive tracks has been seen in the follow-up period. In conclusion the insertion of closed-tip catheters by CT guidance is a sure and well-tolerated method. There were a few problems only with the implanted catheters throughout the whole treatment series.

Published
1993
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18. Micronucleus Formation in Preimplanted Mouse Embryos Cultured In Vitro after Irradiation with X-rays and Neutrons

Author

Molls, M., Streffer, C., and Zamboglou, N.

Abstract

Preimplanted mouse embryos cultured in vitro were irradiated with X-rays and neutrons in the late G2-phase of the 2-cell stage. Both radiation qualities induced micronuclei at very low doses. The kinetics of micronucleus formation during the first and second cell cycles after X-irradiation depended on the radiation dose and on the extent of the division delay. New micronuclei appeared to be formed even after the third and later post-irradiation mitoses. The shape of the various dose-effect curves and the mechanism of micronucleus formation by the two radiation qualities are discussed.

Published
1981
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19. The Effects of Lead and X-rays, Alone or in Combination, on Blastocyst Formation and Cell Kinetics of Preimplantation Mouse Embryos in Vitro

Author

Molls, M., Pon, A., Streffer, C., Van Beuningen, D., and Zamboglou, N.

Abstract

Two-cell embryos in late G2-phase (cytofluorometrically determined) at 32 hours post-conception were treated in vitro with PbCl2 (0·1 or 1·0 μg per ml). An additional group was X-irradiated 1 hour later (0·94 Gy) with or without lead treatment. Lead alone impaired formation and hatching of blastocysts. The combined treatment increased this deleterious effect on preimplantation development but synergism was not observed. Cell proliferation was disturbed by lead alone but to a higher degree by lead plus X-rays. A pronounced reduction of cell number per embryo was found during the period after reaching the morula stage although the labelling index increased. Apparently cell death occurred. Unlabelled S-phase cell nuclei (comparison between autoradiographic results and cytofluorometric DNA-determinations on the same isolated cell nuclei) and cell nuclei with a hyperploid (0·1 μg PbCl2 + 0·94 Gy) or hypoploid (1·0 μg PcCl2 + 0·94 Gy) DNA-content may have contributed to this cell loss. Labelling of cell nuclei which according to their DNA-content were not in S-phase was only observed when 0·1 μg PbCl2 alone or in combination with X-rays was used. This effect may be due to unscheduled DNA-repair synthesis or to the induction of chromosome aberrations (acentric fragments or non-disjunction).

Published
1983
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20. Dreidimensionale Bestrahlungsplanung bei Hirntumoren

Author

Grosu, A., Feldmann, H., Albrecht, C., Kneschaurek, P., Wehrmann, R., Groß, M., Zimmermann, F., and Molls, M.

Abstract

Zusammenfassung: Ziel: In der Behandlung der Hirntumoren hat sich die Bestrahlung als wichtige Komponente der Behandlungs-strategie etabliert. Ziel dieser Studie ist, die technischen Vorteile der 3D-Technik im Vergleich zur konventionellen Bestrahlungsplanung zu analysieren und die klinischen Ergebnisse der 3D-Bestrahlungsplanung und konformalen Strahlentherapie bei 43 Patienten mit Hirngliomen darzustellen. Patienten und Methode: Von Januar 1994 bis Dezember 1995 wurden 43 Patienten mit malignen Hirngliomen (WHO Grad III und IV) nach einer 3D-Planung bestrahlt: Gesamtdosis 60 Gy, Einzeldosis 2 Gy, 5mal/Woche. Die mediane Überlebenszeit wurde unter Berücksichtigung der bekannten prognostischen Parameter: Histologie, Karnofsky-Index, Alter und Resektionsstatus analysiert. Bei zehn Patienten wurde eine 3D-Bestrahlungs-planung mit einem 2D-Modell verglichen; der Anteil von Hirngewebe im 95%-Isodosenbereich, die Nebenwirkungswahrscheinlichkeit (Normal Tissue Complication Probability [NTCP]) nach den mathematischen Modellen von Lyman und Kutcher wurden im Vergleich analysiert. Ergebnisse: Die mediane Überlebenszeit lag bei der gesamten Patientengruppe bei 14 Monaten. Tumorhistologie, Alter, Karnofsky-Index und Resektionsstatus waren wichtige Prognosefaktoren. Mit der 3D-Planung konnte im Vergleich zur konventionellen Bestrahlung 15 bis 20% mehr gesundes Gewebe im Hochdosisbereich geschont werden. Mit der Standardtechnik lag die NTCP bei 0,1% bis 26% und mit der 3D-Bestrahlungstechnik bei 0,03% bis 13%. Die NTCP stieg mit dem Tumorvolumen an. Schlußfolgerungen: Im Hinblick auf die Tumorkontrolle haben die 3D-Planung und konformale Strahlentherapie mit konventioneller Fraktionierung und Dosierung keinen Vorteil ergeben. Der große Vorteil der 3D-Technik besteht jedoch darin, daß das gesunde Gewebe besser geschont werden kann. Sie bietet damit grundsätzlich die Möglichkeit zur Dosiseskalation im Tumor, ohne das Risiko von Spätkomplikationen wesentlich zu erhöhen. Der Versuch, mathematische Modelle zur Berechnung der Wahrscheinlichkeit von Komplikationen in die Therapieplanung zu integrieren, könnte in die Behandlungsstrategien neue Dimensionen bringen.

Published
1998
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21. The Influence of G2 Progression on X-ray Sensitivity of Two-cell Mouse Embryos

Author

Molls, M. and Streffer, C.

Abstract

Naturally synchronous, two-cell mouse embryos were X-irradiated in vitro. In experiment 1, irradiation was either in the early or in the late G2 phase, which lasts about 14 hours. In experiment 2, irradiation of all the embryos was in late G2 but embryos with different intervals between irradiation and the first mitosis after irradiation were separated and investigated independently. After 2 Gy the time interval between irradiation in late G2 and the first mitosis post-irradiation was on the average about 9 hours; after irradiation in the early G2 phase about 13·5 hours. Development (hatching of blastocysts) and cell proliferation (cell number per embryo at the stage of the hatched blastocyst) was most impaired and the frequency of micronuclei (determined in four- or eight-cell embryos) was highest in the case of a short interval between irradiation in G2 and the first mitosis post-irradiation. It is concluded that a longer interval allows a longer period of DNA repair. The results also demonstrate a positive correlation between the extent of chromosomal damage (micronuclei) and the extent of cell death as well as the impairment of the development of the whole biological system.

Published
1984
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22. Abstracts

Author

Derlon, J. M., Petit-taboué, M. C., Dauphin, F., Courtheoux, P., Chapon, F., Creissard, P., Darcel, F., Houtteville, J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn, U., Fröhlich, T., Becker, G., Krone, A., Schlief, R., Schürmann, J., Jachimczak, P., Hofmann, E., Roggendorf, W., Roosen, K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank, G. S., Patterson, J., Hadley, D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone, A., Becker, G., Woydt, M., Roggendorf, W., Hofmann, E., Bogdahn, U., Roosen, K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci, M., Pantano, P., Maleci, A., Pierallini, S., Di Stefano, D., Bozzao, L., Cantore, G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado, D., Rodrigues, M., Salgado, L., Fonseca, A. T., Vieira, M. R., Bravo Marques, J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt, M., Krone, A., Tonn, J. C., Becker, G., Neumann, U., Roggendorf, W., Roosen, K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen, N., Chopra, R. K., Mikkelsen, T., Rosenblum, S. D., Yan, P. S., Knight, R., Windham, J., Rosenblum, M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin, C., Charrier, J., Fayet, G., Sagan, C., Cuillioere, P., Ricolleau, G., Martin, S., Menegalli-Bogeelli, D., Lajat, Y., Resche, F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati, M., Roselli, R., Iacoangeli, M., Pompucci, A., Rossi, G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser, A., Ortler, M., Seiwald, M., Kostron, H., Rajan, B., Ross, G., Lim, C., Ashlcy, S., Goode, D., Traish, D., Brada, M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor, A., Ebmeier, K. P., Jarvis, G., Lander, F., Cull, A., Sellar, R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein, J. J., Goldberg, W. J., Roelcke, U., Von Ammon, K., Hausmann, O., Radu, E. W., Kaech, D., Leenders, K. L., Fitzek, M. M., Aronen, J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra, U. M. U., Sipos, L., Slouik, F., Boiardi, A., Salmaggi, A., Pozzi, A., Farinotti, L., Fariselli, L., Silvani, A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. V., Thomas, R., Brazil, L., O'Connor, A. M., Ashley, S., Brada, M., Salvati, Maurizio, Cervoni, Luigi, Puzzilli, Fabrizio, Cervoni, Luigi, Salvati, Maurizio, Raguso, Michele, Cruickshank, G. S., Duckworth, R., Rumpling, R., Rottuci, M., Fariselli, L., Boiardi, A., Broggi, G., Plrint, N. G., Sabattini, E., Manetto, V., Gambacorta, H., Poggi, S., Pileri, S., Ferracini, R., Grant, R., Plev, D. V., Hopf, N. J., Knosp, E., Bohl, J., Perncczky, A., Kiss, R., Salmon, I., Catnby, I., Dewitte, O., Brotchi, J., Pasteels, J. L., Camby, I., Salmon, I., Darro, F., Danguy, A., Brotchi, J., Pasteels, J. L., Kiss, R., Kiu, M. C., Lai, G. M., Yang, T. S., Ng, K. T., Chen, J. S., Chang, C. N., Leung, W. M., Ho, Y. S., Rychter, M. Deblec, Klimek, A., Liberski, P. P., Karpinaka, A., Krauseneck, P., Schöffel, V., Müller, B., Kreth, F. W., Faist, M., Warnke, P. C., Ostertag, C. B., Nielen, K. M. B. v., Visscr, M. C., Lebrun, C., Lonjon, M., Desjardin, T., Michiels, J. F., Chanalet, Sa. Lagrange J. L., Roche, J. L., Chatel, M., Mastronardi, L., Puzzilli, F., Osman, Farah J., Lunardi, P., Matsutani, M., Ushio, Y., Takakura, K., Menten, Johan, Hamers, Han, Ribot, Jacques, Dom, René, Tcepen, Hans, Müller, B., Weidner, N., Krauseneck, P., Naujocks, G., van Roost, D., Wiestler, O. D., Kuncz, A., Nieder, C., Setzel-Sesterhein, M., Niewald, M., Schnabel, I., O'Neill, K. S., Kitchen, N. D., Wilkins, P. R., Marsh, H. T., Pierce, E., Doshi, R., Deane, R., Previtali, S., Quattrini, A., Nemni, R., Ducati, A., Wrabetz, L., Canal, N., Punt, C. J. A., Stamatakis, L., Giroux, B., Rutten, E., Quigley, Matthew R., Beth Sargent, P. A. -C., Flores, Nicholas, Simon, Sheryl, Maroon, Joseph C., Quigley, Matthew R., Beth Sargent, P. A. -C., Flores, Nicholas, Maroon, Joseph C., Rocca, A. A., Gervasoni, C., Castagna, A., Picozzi, P., Giugni, E., Rocca, A. A., Tonnarelli, G. P., Ducati, A., Mangili, F., Truci, G., Canal, N., Giovanelli, M., Roelcke, U., Von Ammon, K., Radu, E. W., Leenders, K. L., Sachsenheimer, W., Bimmler, T., Seiwald, M., Eiter, H. Rhomberg W., Ortler, M., Obwegesser, A., Kostron, H., Steilen, H., Henn, W., Moringlane, J. R., Kolles, H., Feiden, W., Zang, K. D., Sleudel, W. I., Steinbrecher, Andreas, Schabet, Martin, Heb, Clemens, Bamberg, Michael, Dichgans, Johannes, Stragliotto, G., Delattre, J. Y., Poisson, M., Zampieri, P., Brandes, A., Rigon, A., Tosatto, L., D'Amanzo, P., Menicucci, N., Rotilio, A., Mingrino, S., Steudel, W. I., Feld, R., Henn, W., Zang, K. D., Maire, J. Ph., Caudry, M., Guerin, J., Celerier, D., Salem, N., Demeaux, H., Fahregat, J. F., Kusak, M. E., Bucno, A., Albisua, J., Jerez, P., Sarasa, J. L., Garefa, R., de Campos, J. M., Kusak, M. E., de Campos, J. M., Bueno, A., García-Delgado, R., Sarasa, J. L., García-Sola, R., Lantsov, A. A., Shustova, T. I., Lcnartz, D., Wellenreuther, R., von Deirnling, A., Köning, W., Menzel, J., Scarpa, S., Manna, A., Reale, M. G., Oppido, P. A., Carapella, C. M., Frati, L., Valery, C. A., Ichen, M., Foncin, J. P., Soubrane, C., Khayat, D., Philippon, J., Vaz, R., Cruz, C., Weis, S., Protopapa, D., März, R., Winkler, P. A., Reulen, H. J., Bise, K., Beuls, E., Berg, J., Deinsberger, W., Böker, D. K., Samii, M., Caudry, M., Darrouzet, V., Guérin, J., Trouette, R., Causse, N., Bébéar, J. P., Parker, F., Vallee, J. N., Carlier, R., Zerah, M., Lacroix-Jousselin, C., Piepmeier, Joseph M., Kveton, John, Czibulka, Agnes, Tigliev, G. S., Chernov, M. P., Maslova, L. N., Valdueza, José M., Jänisch, Werner, Bock, Alexander, Harms, Lutz, Bessell, E. M., Graus, F., Punt, J., Firth, J., Hope, T., Koriech, Osama, Al Deeb, Saleh, Al Moutaery, Khalaf, Yaqub, B., Silvani, A., Salmaggi, A., Pozzi, A., Franzini, A., Boiardi, A., Goldbrunner, R., Warmuth-Metz, M., Paulus, W., Tonn, J. -Ch., Roosen, K., Strik, I. I., Müller, B., Markert, C., Pflughaupt, K. -W., Krauseneck, P., O'Neill, B. P., Dinapoli, R. P., Voges, J., Sturm, V., Deuß, U., Traud, C., Treuer, H., Lehrke, R., Kim, D. G., Müller, R. P., Alexandrov, Yu. S., Moutaery, K., Aabed, M., Koreich, O., Ross, G. M., Rajan, B., Traish, D., Ashley, S., Ford, D., Brada, M., Schmeets, I. L. O., Jager, J. J., Pannebakker, M. A. G., de Jong, J. M. A., van Lindert, E., Knosp, E., Kitz, K., Blond, S., Dubois, F., Assaker, R., Baranzelli, M. C., Sleiman, M., Pruvo, J. P., Coche-Dequeant, B., Matsutani, M., Takakura, K., Sano, K., PetriČ-Grabnar, G., Jereb, B., Župančič, N., Koršič, M., Rainov, N. G., Burkert, W., Ushio, Yukitaka, Kochi, Masato, Itoyama, Youichi, de Campos, J. M., Kusak, M. E., Sarasa, J. L., García, R., Bueno, A., Ferrando, L., Hoang-Xuan, K., Sanson, M., Merel, P., Delattre, J. Y., Poisson, M., Delattre, O., Thomas, G., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Thomas, G., Haritz, D., Obersen, B., Grochulla, F., Gabel, D., Haselsberger, K., Radner, H., Pendl, G., Brada, M., Laing, R. W., Warrington, A. P., Nowak, P. J. C. M., Kolkman-Deurloo, I. K. K., Visser, A. G., Berge, Hv. d., Niël, C. G. J. H., Levendag, P. C., Bergström, P., Hariz, M., Löfroth, P. -O., Bergenheim, T., Henriksson, R., Blond, S., Assaker, R., Cortet-rudelli, C., Dewailly, D., Coche-dequeant, B., Castelain, B., Dinapoli, R., Shaw, E., Coffey, R., Earle, J., Foote, R., Schomberg, P., Gorman, D., Girard, N., Courel, M. N., Delpech, B., Haselsberger, K., Friehs, G. M., Schröttner, O., Pendl, G., Pötter, R., hawliczek, R., Sperveslage, P., Prott, F. J., Wachter, S., Dieckmann, K., Würker, M., Herholz, K., Pietrzyk, U., Voges, J., Treuer, H., Sturm, V., Bauer, B., Heiss, W. -D., Jund, R., Zimmermann, F., Feldmann, H. J., Gross, M. W., Kneschaurek, P., Molls, M., Lederman, G., Lowry, J., Wertheim, S., Voulsinas, L., Fine, M., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voutsinas, I., Qian, G., Rashid, H., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voulsinas, L., Qian, G., Rashid, H., Moutaery, K., Aabed, M., Koreich, O., Scerrati, M., Montemaggi, P., Iacoangeli, M., Pompucci, A., Roselli, R., Trignani, R., Rossi, G. F., Shin, K., Mechtler, L., West, C., Grand, W., Shin, K., Sibata, C., West, C., Mechtler, L., Grand, W., Thomas, R., Guerrero, D., James, N., Ashley, S., Gregor, A., Brada, M., Voges, J., Sturm, V., Bramer, R., Pahlke, H., Lehrke, R., Treuer, H., Banik, N., Kim, D. G., Hövels, M., Bernsen, H. J. J. A., Rijken, P. F. J. W., Van der Sanden, B. P. J., Hagemeier, N. E. M., Van der Kogel, A. J., Koehler, P. J., Verbiest, H., Jager, J., Vecht, Ch. J., Ross, G. M., McIlwrath, A., Brown, R., Mottolesb, C., Pierre'Kahn, A., Croux, M., Roche, J. 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F., Wesseling, P., Thijssen, H. O. M., Wolff, J. E. A., Boos, J., Krähling, K. H., Gressner-Brocks, V., Jürgens, H., Schlegel, J., Scherthan, H., Arens, N., Stumm, Gabi, Kiessling, Marika, Merzak, A., Koochekpour, S., Pilkington, G. J., Reifenberger, G., Reifenberger, J., Liu, L., James, C. D., Wechsler, W., Collins, V. P., Fabel-Schulte, Klaus, Jachimczak, Plotr, Heßdörfer, Birgitt, Baur, Inge, Schlingensiepen, Karl -Hermann, Brysch, Wolgang, Bogdahn, Ulrich, Blesch, A., Bosserhoff, A. K., Apfel, R., Lottspeich, F., Jachimczak, P., Büttner, R., Bogdahn, U., Cece, R., Barajon, I., Tazzari, S., Cavaletti, G., Torri-Tarelli, L., Tredici, G., Hecht, B., Turc-Carel, C., Atllas, R., Chatel, M., Gaudray, P., Gioanni, J., Hecht, F., Balledux, Jeroen, Rothbart, David, Criscuolo, Gregory R., de Campos, J. M., Kusak, M. E., Rey, J. A., Bello, M. J., Sarasa, J. L., Dubois, F., Blond, S., Parent, M., Assaker, R., Gosselin, P., Christiaens, J. L., Feld, R., Moringlane, J. R., Steudel, W. I., Schaudies, J. R., Janka, M., Tonn, J. C., Fischer, U., Meese, E., Roosen, K., Remmelink, M., Salmon, I., Cras, P., Pasteels, J. L., Brotchi, J., Kiss, R., Bensadoun, R. J., Frenay, M., Formento, J. L., Milano, G., Lagrange, J. L., Grellier, P., Lee, J. -Y., Ernestus, R. -I., Riese, H. -H., Cervós-Navarro, J., Reutter, W., Lippitz, B., Scheitinger, C., Scholz, M., Weis, J., Gilsbach, J. M., Füzesi, L., Koochekpour, S., Merzak, A., Pilkington, G. J., Sanson, M., Li, Y. J., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Hamelin, R., Van de Kelft, Erik, Dams, Erna, Martin, Jean -Jacques, Willems, Patrick, Lehrke, R., Voges, J., Treuer, H., Erdmann, J., Müller, R. P., Sturm, V., Wurm, R. E., Warrington, A. P., Laing, R. W., Sardell, S., Hines, F., Graham, J. D., Brada, M., Ushio, Yukitaka, Kuratsu, Jun -ichi, Kochi, Masato, Kitz, K., Aichholzer, M., Rössler, K., Alesch, F., Ertl, A., Sorensen, P. S., Helweg-Larsen, S., Mourldsen, H., Hansen, H. H., El Sharoum, S. Y., Berfelo, M. W., Theunissen, P. H. M. H., Jager, J. J., de Jong, J. M. A., Fedorcsák, I., Nyáry, I., Osztie, É., Horvath, Á., Kontra, G., Frenay, M., Burgoni-chuzel, J., Paquis, P., Lagrange, J. L., Helweg-Larsen, S., Hansen, SW., Sørensen, PS., Salmon, I., Kiss, R., Krauseneck, P., Müller, B., Morche, M., Tonn, J. C., Lagerwaard, F. J., Levendag, P. C., Eijkenboom, W. M. H., Schmilz, P. I. M., Lentzsch, S., Weber, F., Franke, J., Dörken, B., Lunardi, P., Schettini, G., Osman, Farah J., Qasho, R., Mocellini, C., Ruda, R., Soffietti, R., Garabello, D., Sales, S., De Lucchi, R., Vasario, E., Schiffer, D., Muracciole, X., Régis, J., Manera, L., Peragut, J. C., Juin, P., Sedan, R., Nieder, C., Niewald, M., Walter, K., Schnabel, K., Nieder, C., Niewald, N., Nestle, U., Schnabel, K., Berberich, W., Oschmann, P., Theißen, R. D., Reuner, K. H., Kaps, M., Dorndorf, W., Martin, K. K., Akinwunmi, J., Rooprai, H. K., Kennedy, A., Linke, A., Ognjenovic, N., Pilkington, G. J., Svadovsky, A. I., Peresedov, V. V., Bulakov, A. A., Butyalko, M. Y., Zhirnova, I. G., Labunsky, D. A., Gnazdizky, V. V., Gannushkina, I. V., Taphoorn, M. J. B., Potman, R., Barkhof, F., Weerts, J. G., Karim, A. B. M. F., Heimans, J. J., van de Pol, M., van Aalst, V. C., Wilmink, J. T., Twijnstra, A., van der Sande, J. J., Boogerd, W., Kröger, R., Jäger, A., Wismeth, C., Dekant, A., Brysch, W., Schlingensiepen, K. H., Jachimczak, P., Bogdahn, U., Pirolte, B., Cool, V., Gérard, C., Levivier, M., Dargent, J. L., Goldman, S., Brotchi, J., Hildebrand, J., Velu, T., Herrlinger, U., Schabet, M., Ohneseit, P., Buchholz, R., Zhu, Jianhong, Reszka, Regina, Weber, Friedrich, Walther, Wolfgang, Zhang, L. I., Brock, Mario, Roosen, N., Rock, J. P., Zeng, H., Feng, J., Fenstermacher, J. D., Rosenblum, M. L., Siegal, T., Gabizon, A., Beljanski, M., Crochet, S., Bergenheim, A. T., Zackrisson, B., Elfverson, J., Bergström, P., Henriksson, R., Butti, G., Baetta, R., Magrassi, L., De Renzis, M. R., Soma, M. R., Davegna, C., Pezzotta, S., Paoletti, R., Fumagalli, R., Infuso, L., Sankar, A. A., Darling, J. L., Thomas, D. G. T., Defer, G. -L., Brugières, P., Gray, F., Chomienne, C., Poirier, J., Degos, L., Degos, J. D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk, P., Troost, D., Leenstra, S., Das, P. K., Bosch, D. A., Kostron, H., Hochleitner, B. W., Obwegeser, A., Ortler, M., Seiwald, M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman, Farah J., Lunardi, P., Puzzilli, F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen, N., Rock, J. P., Feng, J., Zeng, H., Ho, K. L., Fenstermacher, J. D., Rosenblum, M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. H., Myers, C. E., Reed, E., Schabet, M., Herrlinger, U., Buchholz, R., Shoshan, Y., Siegal, T., Siegal, T., Shezen, E., Siegal, Tz., Stockhammer, G., Rosenblum, M., Samid, D., Lieberman, F., Terzis, A. J. A., Bjerkvig, R., Laerum, O. D., Arnold, H., Thibault, A., Samid, D., Figg, W. D., Myers, C. E., Reed, E., Thomas, R., Flux, G., Chittenden, S., Doshi, P., Brazil, L., Thomas, D. G. T., Bignor, D., Zalutsky, M., Brada, M., Tjuvajev, Juri, Kaplitt, Michael, Desai, Revathi, Bradley, M. S., Bettie, B. S., Gansbacher, Bernd, Blasberg, Ronald, Haugland, H. K., Saraste, J., Rooseni, K., Laerum, O. D., Vincent, A. J. P. E., Avezaat, C. J. J., Bout, A., Noteboom, J. L., Vecht, C. h., Valerio, D., Hoogerbrugge, P. M., Weber, F., Reszka, R., Zhu, J., Walther, W., List, J., Schulz, W., Wolbers, J. G., Sterenborg, I. I. J. C. M., Kamphorst, W., van Gemert, M. J. C., van Alplien, H. A. M., Salander, P., Bergenheim, T., Henriksson, R., Grant, R., Brazil, L., Thomas, R., Guerrero, D., Laing, R., Ashley, S., Brada, M., Schmidt, B., Bauer, B., Grau, G., Bohnstedt, T., Frydrych, A., Franz, K., Lorenz, R., Brandes, A., Amanzo, P. D'., Zampieri, P., Rigon, A., Scelzi, E., Rotilio, A., Berti, F., Paccagnella, A., Fiorentino, M. V., Müller, B., Krauseneck, P., van Deventer, P. L., Dellemijn, P. L. I., van den Bent, M. J., Vecht, Ch. J., Kansen, P. J., Tredici, G., Petruccioli, N. G., Cavaletti, G., Cavalletti, E., Kiburg, B., Müller, L. J., Moorer-van Delft, C. M., Heimans, J. J., Boer, H. H., Pace, A., Bove, L., Pietrangeli, A., Innocenti, P., Aloe, A., Nardi, M., Jandolo, B., Kellie, S. J., De Graaf, S. S. N., Bloemhof, H., Roebuck, D., Dalla, Pozza L., Uges, D. D. R., Johnston, I., Besser, M., Chaseling, R. A., Koeppen, S., Gründemann, S., Lossos, A., Siegal, T., Nitschke, M., Vieregge, P., Reusche, E., Rob, P., Kömpf, D., Postma, T. J., Vermorken, J. B., Heimans, J. J., Rampling, R. P., Dunlop, D. J., Steward, M. S., Campbell, S. M., Roy, S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch, E., Zifko, U., Drlicek, M., Liszka, U., Grisold, W., Zifko, U., Fazeny, B., Dittrich, Ch., Wondrusch, E., Grisold, W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt, P. A. E., Manley, G., Posner, J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro, C., Ortale, D., Martinez, R., Lambre, J., Cagnolati, S., Vinai, C., Salmaggi, A., Nemni, R., Silvani, A., Forno, M. G., Luksch, R., Confalonieri, P., Boiardi, A., Nitschke, M., Scholz, J., Vieregge, P., Kömpf, D., Hochberg, F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel, Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
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23. Locally advanced rectal cancer: Resection and intraoperative radiotherapy using the flab method combined with preoperative or postoperative radiochemotherapy

Author

Huber, F. T., Stepan, R., Zimmermann, F., Fink, U., Molls, M., and Siewert, J. R.

Abstract

PURPOSE: Surgery often fails to achieve local control in advanced rectal cancer. Additional measures are necessary to prevent local recurrence. The aim of this study was to evaluate intraoperative radiation therapy (IORT) (flab technique) combined with preoperative or postoperative radiochemotherapy. PATIENTS/METHODS: IORT is performed using a flexible flab containing hollow plastic tubes that are connected to a multichannel afterloading device with a 370 Gbq-192-Ir source. Patients receive an intraoperative dose of 15 Gy. Target volumes were measured in a cadaver experiment. From 1989 to 1993, 38 patients were included in this study. Nineteen patients were staged as T3 tumors by preoperative endosonography (Group I) and 19 as T4 tumors (Group II). Patients in Group I underwent resection (abdominoperineal resection (APR), 16; anterior resection, 3) and IORT, followed by postoperative radiochemotherapy (50 Gy/5-fluorouracil), whereas patients in Group II received preoperative radiochemotherapy (40 Gy/5-fluorouracil) followed by resection (APR, 18; anterior resection, 1) and IORT. Mean follow-up was 25.5 months. RESULTS: Operative radicality in Group I was R0 (13), R1 (3), and R2 (3), and in Group II it was R0 (14), R1 (3), R2 (2). R2 resections were attributable to preoperative undetected distant metastases. Perioperative mortality was 0 percent in Group I and 10.5 percent (n=2) in Group II. Postoperative morbidity was 53 percent (n=10) in Group I and 84 percent (n=16) in Group II with delayed sacral wound healing being the predominant problem. Stenosis of the ureter occurred in two patients (Group II). Late or persistent therapy-related complications were seen in two patients in Group I and in six patients in Group II. Local recurrence developed in three patients in Group I (15.8 percent) and in two patients in Group II (10.5 percent). Survival data do not reach statistical significance between the two groups because of small numbers but show a favorable trend for the preoperative radiochemotherapy group. When compared with a matched historical control group of patients receiving resection only, adjuvant/neoadjuvant radiotherapy with resection/IORT improves survival significantly. CONCLUSION: The flab method is a simple but especially practical technique for IORT in the pelvis. Adjuvant/neoadjuvant therapy combined with resection/IORT is associated with high morbidity but acceptable mortality. Preliminary survival data are encouraging and call for a controlled prospective randomized trial.

Published
1996
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28. Clinical Evidence for Correlation of Insufficient Tissue Oxygen Supply (Hypoxia) and Tumor-Associated Proteolysis in Squamous Cell Carcinoma of the Head and Neck

Author

Stadler, P., Feldmann, H.J., Creighton, C., Zeilhoffer, H.-F., Zimmermann, V., Schmitt, M., and Molls, M.

Abstract

Hypoxic tumors of patients with squamous cell carcinoma of the head and neck show a consistent trend towards poor treatment outcome. We now report that tumor hypoxia in these patients is correlated with elevated antigen content of the tumor-associated serine protease uPA (urokinase-type plasminogen activator), a marker of tumor cell invasion and metastasis.

Published
2000
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32. Laser ion acceleration for hadron therapy

Author

Bulanov, S V, Wilkens, J J, Esirkepov, T Zh, Korn, G, Kraft, G, Kraft, S D, Molls, M, and Khoroshkov, V S

Abstract

The paper examines the prospects of using laser plasma as a source of high-energy ions for the purpose of hadron beam therapy — an approach which is based on both theory and experimental results (ions are routinely observed to be accelerated in the interaction of high-power laser radiation with matter). Compared to therapy accelerators like synchrotrons and cyclotrons, laser technology is advantageous in that it is more compact and is simpler in delivering ions from the accelerator to the treatment room. Special target designs allow radiation therapy requirements for ion beam quality to be satisfied.

Published
2014
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35. Comparison of the results of the BSD-2000 pre-treatment planning system with phantom measurements

Author

Baumhoer, W., Adler, S., Feldmann, H., and Molls, M.

Abstract

Abstract: A comparison of the results of the pretreatment planning software for the BSD-2000 hyperthermia system and measurements in an anthropomorphic phantom is shown. The planning system gives information of the locations of regions with relative high and low temperature values. The conversion into absolute temperatures is associated with failures which can not be neglected in clinical practice.

Published
1992
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41. 202 IORT in primary rectal cancer: Experimental and clinical results

Author

Molls, M., Stepan, R., Huber, F.T., Zimmermann, F.B., Kneschaurek, P., Lukas, P., Fink, U., and Siewert, J.R.

Abstract

For IORT we use a flexible flab which is placed into the sacral cavity. The flab contains plastic tubes. A 370 GBq-192-Ir-source is inserted in one tube after the other and stepwise retracted. IORT was experimentally performed in the pelvis ofa female dead body. The measured doses were identical with the 3 D-calculated dose distribution in the target volume and region of critical organs (e.g. ureter). In a phase II trial 40 patients with locally advanced primary rectal cancer were treated with pre- orpostoperative radiochemotherapy (pre: 2×21.1Gy/day, 40Gy; post: 1×21.8Gy, 50.4Gy; Cht: 5 FU, continuous infusion or bolus). Overall survival data suggest a benefit of IORT combined with preop RT. Major side effect is a prolonged wound healing and local infection.

Published
1995
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44. 841 Oxygenation status in primary squamous cell carcinomas of head and neck

Author

Feldmann, H.J., Saumweber, D.M., Auberger, Th., Arno, W., and Molls, M.

Abstract

45 patients with primary head and neck tumors were investigated pretherapeutically. In 30 patients the tumors were located at the floor of the mouth, the tongue or the tonsil. In these cases pO2measurements were performed in general anesthesia during endoscopic procedure. In 15 patients large neck nodes (N2/N3) were investigated pretherapeutically and during split course radiochemotherapy. In general, the median pO2distribution ranged between 2.4 and 46.6mmHg and showed marked tumor to tumor heterogeneity. The follow up investigations during split course radiochemotherapy (n=15) showed a significant increase of the median pO2after the pause. The observed changes of tumor oxygenation during therapy will be discussed in detail with regard to their clinical relevance.

Published
1995
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