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Cobalt(III) complexes of the type [Co(en)2(chel)]X.nH2O where en = ethylenediamine, chel = phthalato = C6H4CO2)2-2, maleato = (O2CCH = CHCO2)2-, succinato = (O2CCH2CH2CO2)2-, homophthalato = (O2CC6H4(CH2)CO2)2-, citraconato = (O2CC(CH3) = CHCO2)2-, itaconato = (CH2 = C(CO2)CH2CO2)2-, X = NO-3, Br-, (O2CC6H4CO2H)-, (O2CHC = CHCO2H)-, (O2C(CH2)2CO2H)-, (O2CC6H4(CH2)CO2H)-, (O2CHC = C(CH2)-CO2H)-, and (O2C-CH2-C(= CH2)-CO2H)-, [Co(en)2(malonato)]X.2H2O (where malonato = (O2CCH2CO2)2-, X = Cl-, Br-, and NO-3) and [Co(en)2CO3]Cl.2H2O have been investigated for their bacterial activity against Escherichia coli B growing on EMB agar and in minimal glucose media both in lag and log phases. Among the most active are where chel = phthalato and homophthalato. The effects are distinct from those known for compounds of Pt, e.g., cis-[Pt(NH3)2Cl2] and rhodium, e.g., trans-[Rh(C5H5N)4,Cl2].6H2O. Antagonisms are reported.

Summary The activities of the diethylenetriaminemonoacetatocobalt(III) complexes, [Co(en)(DTMA)]I2, [CoX2(DTMA)] and [CoCO3(DTMA)]·H2O (DTMA=diethylenetriaminemonoacetato or formally 3-amino-3, 6-diazaoctanato; en=ethylenediamine, X=Cl-, NO2-, NCS-) were studied onEscherichia coli B growing in a minimal glucose medium in both lag- and log-phases. Activities decrease in the order: [Co(NCS)2(DTMA)]> [Co(NO2)2(DTMA)]>[Co(en)(DTMA)]I2>[CoCl2(DTMA)] >[CoCO3(DTMA)]·H2O. The antagonistic activities of the complexes were also studied.

Summary Cobalt(III) complexes of the typetrans-[Co(AA)2(ox)] (where AA = aminoacidato, gly = glycinato, sar = sarcosinato, DL-ala = DL-alaninato, L-ala = L-alaninato; ox = oxalate); [Co(L-val)2CO3] and DL-[Co(en)2sar]I2 where L-val = L-valinato, en = ethylenediamine) have been investigated for their bacterial activity againstEscherichia coli B using well-cultured techniques on EMB agar and in minimal glucose media. The activities decrease in the order:trans-(N)(+)K[Co(sar)2(ox)] >trans-(N)(+)K[Co(L-ala)2(ox)] >trans-(N)(-)K[Co (gly)2(ox)] >trans-(N)(+)K[Co(DL-ala)2(ox)] >trans-(N)(+)K[Co(gly)2(ox)] >trans(+)K[Co(DL-ala)2(ox)] >trans-K[Co(L-val)2CO3].

Summary The growth of strains ofE. coli is inhibited in the early stages by several complex anions of cobalt(III). All of these contain chelating (chel) dicarboxylate ligands (propane-1, 3-dioate, ethane-1, 2-dioate, or carbonate)e.g. K3[Co(mal)3]3H2O where mal denotes the dianion of propane-1, 3-dioic acid, but most of them also contain unidentate pyridines,e.g. K[Co(chel)2(Rpy)2]nH2O. Among the most active arecis- andtrans-K[Co(mal)2(py)2] hydrates. The effects are distinct from those known for compounds of platinum,e.g. cis-[Pt(NH3)2Cl2] and rhodium,e.g. trans-[Rh(C5H5N)4Cl2]Cl·6H2O.

Summary Cobalt(III) complexes of the type [Co(en)2Chel]X [en=ethlenediamine; Chel=(ox)=oxalato anion, X=Cl-, Br- and I-; Chel=CO32-, X=Cl-, Br-, I- and NO3-] and (±)K[Co(edta)]·2H2O (edta=ethylenediaminetetracetato anion) have been investigated for their bacterial activity againstEscherichia coli B using well-cultured techniques on EMB plates and in minimal glucose media.

Summary The activities of the nicotine complexes of rhodium(III)-[RhCl3(nicH+)3](PF6)3 andtrans-[RhCl2(nic)4](PF6) (nicH+=monoprotonated S-nicotine, nic=unprotonated S-nicotine)—were studied onEscherichia coli B growing in a minimal glucose medium in both lag- and log-phases.