The Upper Río Lerma valley, Estado de México, is a high-altitude (2575 m a.s.l.) basin floored by Quaternary alluvial, lacustrine and pyroclastic deposits. Two pits were dug in the swampy bed of the recently drained L. Chiconahuapan. Ten 14C dates have been obtained from these profiles, which consist of diatomaceous organic lake muds and peats with intercalated tephras. The oldest unit is the Upper Toluca Pumice (Tripartite Ash), dated 11 580±70 yr BP. Analyses of sediment chemistry, loss-onignition, mineral-magnetic variations and subfossil diatom assemblages provide evidence of environmental changes since this date. Alkaline ponds or freshwater lakes developed during the intervals 9000–6000, 6000–5500, 3600–1400 and 800–0 yr BP, and acidic marshes or bogs during the intervening dry episodes. An important phase of accelerated erosion, beginning around 3100 yr BP and culminating around 1400–700 yr BP, appears to have been associated with human disturbance of the basin soils.