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138 results on '"Merrick, I"'

4. Histologic changes associated with false-negative sentinel lymph nodes after preoperative chemotherapy in patients with confirmed lymph node-positive breast cancer before treatment

Author

Brown, Alexandra S., Hunt, Kelly K., Shen, Jeannie, Huo, Lei, Babiera, Gildy V., Ross, Merrick I., Meric-Bernstam, Funda, Feig, Barry W., Kuerer, Henry M., Boughey, C., Ching, Christine D., and Gilcrease, Michael Z.

Subjects
False negative results -- Research, Neoadjuvant therapy -- Research, Breast cancer -- Care and treatment, Breast cancer -- Patient outcomes, Breast cancer -- Research, Lymph nodes -- Biopsy, Lymph nodes -- Research, Health
Published
2010

6. Should all patients with melanoma between 1 and 2 mm Breslow thickness undergo sentinel lymph node biopsy?

Author

Mays, Michael P., Martin, Robert C.G., Burton, Alison, Ginter, Brooke, Edwards, Michael J., Reintgen, Douglas S., Ross, Merrick I., Urist, Marshall M., Stromberg, Arnold J., McMasters, Kelly M., and Scoggins, Charles R.

Subjects
Melanoma -- Diagnosis, Melanoma -- Development and progression, Melanoma -- Research, Prognosis -- Research, Lymph nodes -- Biopsy, Lymph nodes -- Analysis, Health
Published
2010

7. A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma

Author

Beasley, Georgia M., McMahon, Nicole, Sanders, Gretchen, Augustine, Christina K., Selim, Maria A., Peterson, Bercedis, Norris, Robin, Peters, William P., Ross, Merrick I., and Tyler, Douglas S.

Subjects
Vasopressin -- Dosage and administration, Vasopressin -- Research, Infusion therapy -- Methods, Infusion therapy -- Patient outcomes, Infusion therapy -- Research, Melanoma -- Care and treatment, Melanoma -- Patient outcomes, Melanoma -- Research, Health
Published
2009

8. Lymph node ratio predicts disease-specific survival in melanoma patients

Author

Xing, Yan, Badgwell, Brian D., Ross, Merrick I., Gershenwald, Jeffrey E., Lee, Jeffrey E., Mansfield, Paul F., Lucci, Anthony, and Cormier, Janice N.

Subjects
Melanoma -- Diagnosis, Melanoma -- Patient outcomes, Melanoma -- Research, Lymphatic metastasis -- Diagnosis, Lymphatic metastasis -- Research, Cancer patients -- Prognosis, Cancer patients -- Research, Lymph nodes -- Biopsy, Lymph nodes -- Usage, Lymph nodes -- Research, Health
Published
2009

9. A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer

Author

Krishnamurthy, Savitri, Meric-Bernstam, Funda, Lucci, Anthony, Hwang, Rosa F., Kuerer, Henry M., Babiera, Gildy, Ames, Fredrick C., Feig, Barry W., Ross, Merrick I., Singletary, Eva, Hunt, Kelly K., and Bedrosian, Isabelle

Subjects
Breast cancer -- Diagnosis, Breast cancer -- Research, Cytodiagnosis -- Methods, Cytodiagnosis -- Comparative analysis, Frozen tissue sections -- Analysis, Lymph nodes -- Biopsy, Lymph nodes -- Analysis, Health
Published
2009

10. Neoadjuvant relatlimab and nivolumab in resectable melanoma

Author

Amaria, Rodabe N., Postow, Michael, Burton, Elizabeth M., Tetzlaff, Michael T., Ross, Merrick I., Torres-Cabala, Carlos, Glitza, Isabella C., Duan, Fei, Milton, Denái R., Busam, Klaus, Simpson, Lauren, McQuade, Jennifer L., Wong, Michael K., Gershenwald, Jeffrey E., Lee, Jeffrey E., Goepfert, Ryan P., Keung, Emily Z., Fisher, Sarah B., Betof-Warner, Allison, Shoushtari, Alexander N., Callahan, Margaret, Coit, Daniel, Bartlett, Edmund K., Bello, Danielle, Momtaz, Parisa, Nicholas, Courtney, Gu, Aidi, Zhang, Xuejun, Korivi, Brinda Rao, Patnana, Madhavi, Patel, Sapna P., Diab, Adi, Lucci, Anthony, Prieto, Victor G., Davies, Michael A., Allison, James P., Sharma, Padmanee, Wargo, Jennifer A., Ariyan, Charlotte, and Tawbi, Hussein A.

Abstract

Relatlimab and nivolumab combination immunotherapy improves progression-free survival over nivolumab monotherapy in patients with unresectable advanced melanoma1. We investigated this regimen in patients with resectable clinical stage III or oligometastatic stage IV melanoma (NCT02519322). Patients received two neoadjuvant doses (nivolumab 480 mg and relatlimab 160 mg intravenously every 4 weeks) followed by surgery, and then ten doses of adjuvant combination therapy. The primary end point was pathologic complete response (pCR) rate2. The combination resulted in 57% pCR rate and 70% overall pathologic response rate among 30 patients treated. The radiographic response rate using Response Evaluation Criteria in Solid Tumors 1.1 was 57%. No grade 3–4 immune-related adverse events were observed in the neoadjuvant setting. The 1- and 2-year recurrence-free survival rate was 100% and 92% for patients with any pathologic response, compared to 88% and 55% for patients who did not have a pathologic response (P= 0.005). Increased immune cell infiltration at baseline, and decrease in M2 macrophages during treatment, were associated with pathologic response. Our results indicate that neoadjuvant relatlimab and nivolumab induces a high pCR rate. Safety during neoadjuvant therapy is favourable compared to other combination immunotherapy regimens. These data, in combination with the results of the RELATIVITY-047 trial1, provide further confirmation of the efficacy and safety of this new immunotherapy regimen.

Published
2022
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11. How many sentinel lymph nodes are enough during sentinel lymph node dissection for breast cancer?

Author

Yi, Min, Meric-Bernstam, Funda, Ross, Merrick I., Akins, Jeri S., Hwang, Rosa F., Lucci, Anthony, Kuerer, Henry M., Babiera, Gildy V., Gilcrease, Michael Z., and Hunt, Kelly K.

Subjects
Breast cancer -- Care and treatment, Breast cancer -- Complications and side effects, Breast cancer -- Research, Lymphatic metastasis -- Diagnosis, Lymphatic metastasis -- Research, Lymph nodes -- Surgery, Lymph nodes -- Research, Health
Published
2008

13. Prospective assessment of the reliability, validity, and sensitivity to change of the functional assessment of cancer therapy-melanoma questionnaire

Author

Cormier, Janice M., Ross, Merrick I., Gershenwald, Jeffrey E., Lee, Jeffrey E., Mansfield, Paul F., Camacho, Luis H., Kim, Kevin, Webster, Kimberly, Cella, David, and Palmer, J. Lynn

Subjects
Melanoma -- Care and treatment, Melanoma -- Patient outcomes, Quality of life -- Health aspects, Quality of life -- Research, Outcome and process assessment (Health Care) -- Research, Health
Published
2008

14. Adjuvant high-dose interferon for cutaneous melanoma is most beneficial for patients with early stage III disease

Author

Anaya, Daniel A., Xing, Yan, Feng, Lei, Huang, Xuelin, Camacho, Luis H., Ross, Merrick I., Gershenwald, Jeffrey E., Lee, Jeffrey E., Mansfield, Paul F., and Cormier, Janice N.

Subjects
Interferon -- Dosage and administration, Interferon -- Research, Melanoma -- Care and treatment, Skin cancer -- Care and treatment, Cancer -- Adjuvant treatment, Cancer -- Research, Health
Published
2008

15. Decision analysis to assess the efficacy of routine sentinel lymphadenectomy in patients undergoing prophylactic mastectomy

Author

Boughey, Judy C., Cormier, Janice N., Xing, Yan, Hunt, Kelly K., Meric-Bernstam, Funda, Babiera, Gildy V., Ross, Merrick I., Kuerer, Henry M., Singletary, Sonja E., and Bedrosian, Isabelle

Subjects
Mastectomy -- Patient outcomes, Mastectomy -- Research, Breast cancer -- Diagnosis, Lymph nodes -- Surgery, Lymph nodes -- Methods, Lymph nodes -- Research, Health
Published
2007

16. Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival

Author

Williams, Stephanie A., Ehlers, Richard A. II, Hunt, Kelly K., Yi, Min, Kuerer, Henry M., Singletary, S. Eva, Ross, Merrick I., Feig, Barry W., Symmans, W. Fraser, and Meric-Bernstam, Funda

Subjects
Metastasis -- Research, Metastasis -- Patient outcomes, Metastasis -- Physiological aspects, Breast cancer -- Care and treatment, Breast cancer -- Research, Breast cancer -- Patient outcomes, Breast cancer -- Development and progression, Mastectomy -- Patient outcomes, Mastectomy -- Research, Breast -- Biopsy, Breast -- Research, Health
Published
2007

18. Feasibility and accuracy of sentinel lymph node biopsy after preoperative chemotherapy in breast cancer patients with documented axillary metastases

Author

Shen, Jeannie, Gilcrease, Michael Z., Babiera, Gildy V., Ross, Merrick I., Meric-Bernstam, Funda, Feig, Barry W., Kuerer, Henry M., Francis, Ashleigh, Ames, Frederick C., and Hunt, Kelly K.

Subjects
Breast cancer -- Diagnosis, Breast cancer -- Patient outcomes, Metastasis -- Analysis, Chemotherapy -- Research, Preoperative care -- Research, Lymph nodes -- Biopsy, Lymph nodes -- Analysis, Cancer -- Chemotherapy, Cancer -- Research, Health
Published
2007

19. Accuracy of lymphatic mapping and sentinel lymph node biopsy after previous wide local excision in patients with primary melanoma

Author

Gannon, Christopher J., Rousseau, Dennis L., Jr., Ross, Merrick I., Johnson, Marcella M., Lee, Jeffrey E., Mansfield, Paul F., Cormier, Janice N., Prieto, Victor G., and Gershenwald, Jeffrey E.

Subjects
Melanoma -- Research, Melanoma -- Physiological aspects, Melanoma -- Care and treatment, Lymph nodes -- Biopsy, Lymph nodes -- Usage, Health
Published
2006

21. Ethnic differences among patients with cutaneous melanoma

Author

Cormier, Janice N., Xing, Yan, Ding, Meichun, Lee, Jeffrey E., Mansfield, Paul F., Gershenwald, Jeffrey E., Ross, Merrick I., and Du, Xianglin L.

Subjects
Melanoma -- Demographic aspects, Melanoma -- Risk factors, Melanoma -- Research, Ethnicity -- Health aspects, Ethnicity -- Research, Risk factors (Health) -- Demographic aspects, Health
Published
2006

22. Metastatic melanoma to lymph nodes in patients with unknown primary sites

Author

Cormier, Janice N., Xing, Yan, Feng, Lei, Huang, Xuelin, Davidson, Latunya, Gershenwald, Jeffrey E., Lee, Jeffrey E., Mansfield, Paul F., and Ross, Merrick I.

Subjects
Melanoma -- Patient outcomes, Lymphatic metastasis -- Patient outcomes, Cancer patients -- Prognosis, Health
Published
2006

24. Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast carcinoma recurrence and contralateral breast carcinoma development in patients with ductal carcinoma in situ treated with breast conserving therapy

Author

Adepoju, Linda J., Symmans, W. Fraser, Babiera, Gildy V., Singletary, S. Eva, Arun, Banu, Sneige, Nour, Pusztai, Lajos, Buccholz, Thomas A., Sahin, Aysegul, Hunt, Kelly K., Meric-Bernstam, Funda, Ross, Merrick I., Ames, Frederick C., and Kuerer, Henry M.

Subjects
Breast cancer -- Risk factors, Carcinoma in situ -- Complications and side effects, Mastectomy -- Research, Tamoxifen -- Research, Cancer -- Relapse, Cancer -- Risk factors, Health
Published
2006

25. In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis

Author

Wang, Li-E, Xiong, Ping, Strom, Sara S., Goldberg, Leonard H., Lee, Jeffrey E., Ross, Merrick I., Mansfield, Paul F., Gershenwald, Jeffrey E., Prieto, Victor G., Cormier, Janice N., Duvic, Madeleine, Clayman, Gary L., Weber, Randal S., Lippman, Scott M., Amos, Christopher I., Spitz, Margaret R., and Wei, Qingyi

Subjects
Health
Abstract

Background: Mutagen sensitivity, measured as mutagen-induced chromatid breaks per cell in primary lymphocytes in vitro, has been used to study susceptibility to various epithelial cancers. Patients with xeroderma pigmentosum are highly sensitive to ultraviolet (UV) light due to inherited defects in DNA repair and have a 1000-fold higher risk of UV-induced skin cancer than the general population. However, an association between UV-induced chromosomal aberrations and risk of skin cancer in the general population has not been established. Methods: We assessed in vitro UVB-induced chromatid breaks in a hospital-based case-control study. The study included 469 patients with skin cancer (231 with nonmelanoma skin cancer [NMSC] and 238 with cutaneous malignant melanoma [CMM]) and 329 cancer-free control subjects. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: Compared with the frequency of UVB-induced chromatid breaks per cell in control subjects (mean = 0.28 breaks per cell, 95% CI = 0.27 to 0.30), that in NMSC patients (basal cell carcinoma [BCC], n = 143, mean = 0.36 breaks per cell, 95% CI = 0.33 to 0.39 and squamous cell carcinoma [SCC], n = 88, mean = 0.35 breaks per cell, 95% CI = 0.32 to 0.38) was higher (P = .001 and P

Published
2005

26. Is incisional biopsy of melanoma harmful?

Author

Martin, Robert C.G., II, Scoggins, Charles R., Ross, Merrick I., Reintgen, Douglas S., Noyes, R. Dirk, Edwards, Michael J., and McMasters, Kelly M.

Subjects
Melanoma -- Diagnosis, Biopsy -- Methods, Biopsy -- Complications and side effects, Metastasis -- Risk factors, Health
Published
2005

28. Incidence of anaphylactoid reactions to isosulfan blue dye during breast carcinoma lymphatic mapping in patients treated with preoperative prophylaxis

Author

Raut, Chandrajit P., Hunt, Kelly H., Akins, Jeri S., Daley, M. Denise, Ross, Merrick I., Singletary, S. Eva, Marshall, Gailen D., Jr., Meric-Bernstam, Funda, Babiera, Gildy, Feig, Barry W., Ames, Frederick C., and Kuerer, Henry M.

Subjects
Lymph nodes -- Research, Breast cancer -- Research, Anaphylaxis -- Research, Health
Published
2005

29. Predictors of systemic recurrence and disease-specific survival after ipsilateral breast tumor recurrence

Author

Shen, Jeannie, Hunt, Kelly K., Mirza, Nadeem Q., Buchholz, Thomas A., Babiera, Gildy V., Kuerer, Henry M., Bedrosian, Isabelle, Ross, Merrick I., Ames, Frederick C., Feig, Barry W., Singletary, S. Eva, Cristofanilli, Massimo, and Meric-Bernstam, Funda

Subjects
Breast cancer -- Patient outcomes, Breast cancer -- Development and progression, Diseases -- Relapse, Diseases -- Risk factors, Health
Published
2005

30. Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry

Author

Chagpar, Anees, Middleton, Lavinia P., Sahin, Aysegul A., Meric-Bernstam, Funda, Kuerer, Henry M., Feig, Barry W., Ross, Merrick I., Ames, Frederick C., Singletary, S. Eva, Buchholz, Thomas A., Valero, Vincente, and Hunt, Kelly K.

Subjects
Immunohistochemistry -- Usage, Lymph nodes -- Care and treatment, Breast cancer -- Care and treatment, Metastasis -- Diagnosis, Metastasis -- Care and treatment, Health
Published
2005

31. Lower and central tumor location correlates with lymphoscintigraphy drainage to the internal mammary lymph nodes in breast carcinoma

Author

Shahar, Karen H., Buchholz, Thomas A., Delpassand, Ebrahim, Sahin, Aysegul A., Ross, Merrick I., Ames, Fredrick C., Kuerer, Henry M., Feig, Barry W., Meric-Bernstam, Funda, Babiera, Gildy V., Singletary, S. Eva, Akins, Jeri S., Mirza, Nadeem Q., and Hunt, Kelly K.

Subjects
Lymphatic metastasis -- Risk factors, Breast cancer -- Prognosis, Breast tumors -- Observations, Health
Published
2005

32. Breast conservation after neoadjuvant chemotherapy: A prognostic index for clinical decision-making

Author

Chen, Allen M., Meric-Bernstam, Funda, Hunt, Kelly K., Thames, Howard D., Outlaw, Elesyia D., Strom, Eric A., McNeese, Marsha D., Kuerer, Henry M., Ross, Merrick I., Singletary, S. Eva, Ames, Fredrick C., Feig, Barry W., Sahin, Aysegul A., Perkins, George H., Babiera, Gildy, Hortobagyi, Gabriel N., and Buchholz, Thomas A.

Subjects
Prognosis -- Methods, Prognosis -- Practice, Prognosis -- Patient outcomes, Breast cancer -- Research, Breast cancer -- Patient outcomes, Breast cancer -- Development and progression, Breast cancer -- Diagnosis, Cancer invasiveness -- Research, Diseases -- Relapse, Diseases -- Research, Chemotherapy, Health
Published
2005

33. The effect of ethnicity on immediate reconstruction rates after mastectomy for breast cancer

Author

Tseng, Jennifer F., Kronowitz, Steven J., Sun, Charlotte C., Perry, Allison C., Hunt, Kelly K., Babiera, Gildy V., Newman, Lisa A., Singletary, S. Eva, Mirza, Nadeem Q., Ames, Frederick C., Meric-Bernstam, Funda, Ross, Merrick I., Feig, Barry W., Robb, Geoffrey L., and Kuerer, Henry M.

Subjects
Mastectomy -- Case studies, Ethnicity -- Case studies, Mammaplasty -- Case studies, Health
Published
2004

35. An evidence-based staging systems for cutaneous melanoma

Author

Balch, charles M, Soong, Seng-Jaw, Atkins, Micheal B, Buzaid, Antonio C, Casinelli Natale, Coit, Daniel G., Fleming. Irvin D, Gershenwald, Jeffrey E, Houghton, Alan, Jr, Kirkwood, John M., McMasters Kelly M., Mihm, Martin F., Morton, Donald L, Reintgen, Douglas S., Ross, Merrick I., Sober, Arthur, Thompson, John A., and Thompson, John F.

Subjects
Melanoma -- Care and treatment, Melanoma -- Research, Tumor staging -- Research, Health
Abstract

A major collaborative study of predicting melanoma outcome was conducted specifically for the cutaneous melanoma project. This was the largest prognostic factor analysis of prospectively followed melanoma patients ever conducted.

Published
2004

36. Biochemotherapy in patients with metastatic anorectal mucosal melanoma

Author

Kim, Kevin B., Sanguino, Angela M., Hodges, Cynthia, Papadopoulos, Nicholas E., Eton, Omar, Camacho, Luis H., Broemeling, Lyle D., Johnson, Marcella M., Ballo, Matthew T., Ross, Merrick I., Gershenwald, Jeffrey E., Lee, Jeffrey E., Mansfield, Paul F., Prieto, Victor Y., and Bedikian, Agop Y.

Subjects
Chemotherapy -- Drug therapy, Chemotherapy -- Observations, Anal cancer -- Care and treatment, Anal cancer -- Case studies, Cancer -- Chemotherapy, Cancer -- Drug therapy, Cancer -- Observations, Health
Published
2004

39. Conjunctival melanoma with a positive sentinel lymph node

Author

Esmaeli, Bita, Reifler, David Tex, Prieto, Mich Victor G., Ahmadi, M. Amir, Hidaji, Lilllie, Delpassand, Ebrahim, and Ross, Merrick I.

Subjects
Melanoma -- Care and treatment, Melanoma -- Case studies, Lymph nodes -- Research, Health
Published
2003

41. Adjuvant irradiation for cervical lymph node metastases from melanoma

Author

Ballo, Matthew T., Bonnen, Mark D., Garden, Adam S., Myers, Jeffrey N., Gershenwald, Jeffrey E., Zagars, Gunar K., Schechter, Naomi R., Morrison, William H., Ross, Merrick I., and Ang, K. Kian

Subjects
Lymphatic metastasis -- Care and treatment, Lymphatic metastasis -- Patient outcomes, Melanoma -- Care and treatment, Melanoma -- Complications, Melanoma -- Patient outcomes, Head and neck cancer -- Care and treatment, Head and neck cancer -- Complications, Head and neck cancer -- Patient outcomes, Health
Published
2003

42. Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma

Author

Wei, Qingyi, Lee, Jeffrey E., Gershenwald, Jeffrey E., Ross, Merrick I., Mansfield, Paul F., Strom, Sarah S., Wang, Li-E, Guo, Zhaozheng, Qiao, Yawei, Amos, Christopher I., Spitz, Margaret R., and Duvic, Madeleine

Subjects
DNA damage -- Care and treatment, Melanoma -- Risk factors, Health
Abstract

Background: The mechanism underlying the role of UV light exposure from sunlight in the etiology of cutaneous malignant melanoma (CMM) is unclear. Patients with xeroderma pigmentosum, a disease characterized by severe sensitivity to UV radiation and a defect in nucleotide excision repair, have a high incidence of CMM, which suggests that DNA repair capacity (DRC) plays a role in sunlight-induced CMM in the general population as well. Methods: We conducted a hospital-based case--control study of DRC and CMM among 312 non-Hispanic white CMM patients who had no prior chemotherapy or radiation therapy, and 324 cancer-free control subjects who were frequency-matched to case patients on age, sex, and ethnicity. Information on demographic variables, risk factors, and tumor characteristics was obtained from questionnaires and medical records. We used the host-cell reactivation assay to measure the DRC in study subjects' lymphocytes. All statistical tests were two sided. Results: Case patients had a 19% lower mean ([+ or -] standard deviation [SD]) DRC (8.5 [+ or -] 3.4%) than control subjects (10.5 [+ or -] 5.1%), a statistically significant difference (P

Published
2003

43. Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy

Author

Meric, Funda, Mirza, Nadeem Q., Vlastos, Georges, Buchholz, Thomas A., Kuerer, Henry M., Babiera, Gildy V., Singletary, S. Eva, Ross, Merrick I., Ames, Frederick C., Feig, Barry W., Krishnamurthy, Savitri, Perkins, George H., McNeese, Marsha D., Strom, Eric A., Valero, Vicente, and Hunt, Kelly K.

Subjects
Breast cancer -- Patient outcomes, Breast cancer -- Care and treatment, Breast cancer -- Prognosis, Cancer patients -- Care and treatment, Cancer patients -- Prognosis, Health
Published
2003

44. Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

Author

Vellano, Christopher P., White, Michael G., Andrews, Miles C., Chelvanambi, Manoj, Witt, Russell G., Daniele, Joseph R., Titus, Mark, McQuade, Jennifer L., Conforti, Fabio, Burton, Elizabeth M., Lastrapes, Matthew J., Ologun, Gabriel, Cogdill, Alexandria P., Morad, Golnaz, Prieto, Peter, Lazar, Alexander J., Chu, Yanshuo, Han, Guangchun, Khan, M. A. Wadud, Helmink, Beth, Davies, Michael A., Amaria, Rodabe N., Kovacs, Jeffrey J., Woodman, Scott E., Patel, Sapna, Hwu, Patrick, Peoples, Michael, Lee, Jeffrey E., Cooper, Zachary A., Zhu, Haifeng, Gao, Guang, Banerjee, Hiya, Lau, Mike, Gershenwald, Jeffrey E., Lucci, Anthony, Keung, Emily Z., Ross, Merrick I., Pala, Laura, Pagan, Eleonora, Segura, Rossana Lazcano, Liu, Qian, Borthwick, Mikayla S., Lau, Eric, Yates, Melinda S., Westin, Shannon N., Wani, Khalida, Tetzlaff, Michael T., Haydu, Lauren E., Mahendra, Mikhila, Ma, XiaoYan, Logothetis, Christopher, Kulstad, Zachary, Johnson, Sarah, Hudgens, Courtney W., Feng, Ningping, Federico, Lorenzo, Long, Georgina V., Futreal, P. Andrew, Arur, Swathi, Tawbi, Hussein A., Moran, Amy E., Wang, Linghua, Heffernan, Timothy P., Marszalek, Joseph R., and Wargo, Jennifer A.

Abstract

Treatment with therapy targeting BRAF and MEK (BRAF/MEK) has revolutionized care in melanoma and other cancers; however, therapeutic resistance is common and innovative treatment strategies are needed1,2. Here we studied a group of patients with melanoma who were treated with neoadjuvant BRAF/MEK-targeted therapy (NCT02231775, n= 51) and observed significantly higher rates of major pathological response (MPR; ≤10% viable tumour at resection) and improved recurrence-free survival (RFS) in female versus male patients (MPR, 66% versus 14%, P= 0.001; RFS, 64% versus 32% at 2 years, P= 0.021). The findings were validated in several additional cohorts2–4of patients with unresectable metastatic melanoma who were treated with BRAF- and/or MEK-targeted therapy (n= 664 patients in total), demonstrating improved progression-free survival and overall survival in female versus male patients in several of these studies. Studies in preclinical models demonstrated significantly impaired anti-tumour activity in male versus female mice after BRAF/MEK-targeted therapy (P= 0.006), with significantly higher expression of the androgen receptor in tumours of male and female BRAF/MEK-treated mice versus the control (P= 0.0006 and P= 0.0025). Pharmacological inhibition of androgen receptor signalling improved responses to BRAF/MEK-targeted therapy in male and female mice (P= 0.018 and P= 0.003), whereas induction of androgen receptor signalling (through testosterone administration) was associated with a significantly impaired response to BRAF/MEK-targeted therapy in male and female patients (P= 0.021 and P< 0.0001). Together, these results have important implications for therapy.

Published
2022
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46. Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences

Author

Huang, Eugene, Buchholz, Thomas A., Meric, Funda, Krishnamurthy, Savitri, Mirza, Nadeem Q., Ames, Frederick C., Feig, Barry W., Kuerer, Henry M., Ross, Merrick I., Singletary, S. Eva, McNeese, Marsha D., Strom, Eric A., and Hunt, Kelly K.

Subjects
Breast cancer -- Physiological aspects, Oncology, Experimental -- Reports, Histology -- Usage, Cancer -- Relapse, Health
Published
2002

49. Breast cancer on the world wide web: cross sectional survey of quality of information and popularity of websites. (Papers)

Author

Meric, Funda, Bernstam, Elmer V., Mirza, Nadeem Q., Hunt, Kelly K., Ames, Frederick C., Ross, Merrick I., Kuerer, Henry M., Pollock, Raphael E., Musen, Mark A., and Singletary, S Eva

Subjects
Information services industry, Web sites, Information services, Breast cancer, Health, Company Web site/Web page, Information services industry
Abstract

Introduction Recent surveys show that 40-54% of patients access medical information via the internet and that this information affects their choice of treatment. (1-5) Although the quality of medical information [...]

Published
2002

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