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p-Hydroxycinnamic diester is very common in fruits and beverages. Furthermore, it belongs to the family of cinnamic acids. It is a chemical compound present in carnauba leaf powder, and it has promising pharmacological properties against non-transmissible chronic diseases. Then, the objective of this work was characterizing the chemical composition of p-hydroxycinnamic diester obtained from carnauba leaf powder, as thoroughly evaluate its antioxidant profile and to analyze its effect in diabetic mice induced by high-fat diet. Male C57BL/6J mice were induced by 60 days by a high-fat diet and treated for 30 days with p-hydroxycinnamic diester (200 e 400 mg/Kg) and metformin (200 mg/Kg). p-Hydroxycinnamic diester presented chemical structure consistent with the cinnamic acid derivatives reported in scientific literature. Furthermore, p-hydroxycinnamic diester exhibited excellent in vivoand in vitroantioxidant activity, and it also decreased glycemia, MDA, reactive oxygen species in liver tissue, body mass, water consumption of animals. p-Hydroxycinnamic diester had satisfactory results, and this product could be useful for diabetes treatment.