Search

At the first interim analysis of the phase 3 ENGOT-cx11/GOG-3047/KEYNOTE-A18 study, the addition of pembrolizumab to chemoradiotherapy provided a statistically significant and clinically meaningful improvement in progression-free survival in patients with locally advanced cervical cancer. We report the overall survival results from the second interim analysis of this study.

Estimar la carga de COVID-19 aguda en Córdoba, uno de los departamentos (estados) más afectados de Colombia, a través de la estimación de años de vida ajustados por discapacidad (AVISAS).

Bagrada hilarisBurmeister (Hemiptera: Pentatomidae) is a pest of Palearctic origin. Its presence in the United States was first reported in 2008 and in Mexico in 2014; it affects brassica crops. There are practically no reports of natural enemies of B. hilarisin America. Entomopathogenic fungi are strong candidates for microbial control of this pest. Evaluating the susceptibility of this pest to fungi that are native to the region where they will be used is a sensible first step to finding candidate biological control agents. The aim of our research was to select potential microbial agents to control B. hilaris. Eleven isolates of Beauveria bassiana, Beauveria pseudobassiana, Metarhizium anisopliae, and Isaria fumosoroseawere evaluated to determine the susceptibility of B. hilaris. Isolates of B. bassianacaused the highest mortality due to infection (100%) compared with the other isolates. The I. fumosoroseaisolate caused the lowest percent mortality (56%). The two B. bassianaisolates Bb88 and AP3 were more virulent than M. anisopliaeisolate Ma129. The sex of the insect had no effect on infection levels achieved by B. bassianaisolates Bb88 and AP3. The results of our study contribute valuable information for the development of fungal species with potential to manage B. hilarispopulations. Field studies are the next step in order to develop these isolates as biological control agents of B. hilaris.

Pembrolizumab has shown efficacy in persistent, recurrent, or metastatic cervical cancer. The effect of chemoradiotherapy might be enhanced by immunotherapy. In this phase 3 trial, we assessed the efficacy and safety of adding pembrolizumab to chemoradiotherapy in locally advanced cervical cancer.

Influenza is considered a leading public health problem because its large economic burden of disease worldwide, especially in low-and middle-income countries, such as Colombia.

Access to combination antiretroviral therapy (ART) is expanding in Latin America (Mexico, Central America, and South America) and the Caribbean. We assessed the incidence of and factors associated with regimen failure and regimen change of initial ART in this region.