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Your search keyword '"Mehrdad Rajaei"' showing total 7 results
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7 results on '"Mehrdad Rajaei"'

1. New Heart Failure Findings from University of Houston Described (Akap12 Upregulation Associates With Pde8a To Accelerate Cardiac Dysfunction).

Subjects
HEART failure, HEART diseases, BETA adrenoceptors, MEMBRANE proteins, ADRENERGIC receptors, ADENOSINES, CYCLIC-AMP-dependent protein kinase
Abstract

A recent study conducted by researchers at the University of Houston explores the role of AKAP12 (A kinase anchoring protein 12) in heart failure. The study found that AKAP12 upregulation is associated with accelerated cardiac dysfunction through the AKAP12-PDE8 axis. The researchers used various methods, including live cell imaging and mouse models, to investigate the effects of AKAP12 on cardiac function. The findings suggest that AKAP12 may be a potential target for pharmacological interventions in heart failure. [Extracted from the article]

Published
2024

2. Discovery of key target for precision pharmacology makes ideal candidate to treat heart failure.

Subjects
HEART failure, PHARMACOLOGY, CONGESTIVE heart failure, HEART diseases, CARDIAC contraction
Abstract

Researchers at the University of Houston College of Pharmacy have discovered that increased levels of a protein called AKAP12 in the heart can accelerate cardiac dysfunction. The researchers found that increased activity of AKAP12 reduces the contractility of cardiac myocytes, the cells responsible for heart contraction. This reduced contractility can be reversed by inhibiting an enzyme called PDE8A, which is located near AKAP12. The researchers suggest that AKAP12 could be a potential target for precision pharmacology in the treatment of heart failure, a condition that affects over 6 million adults in the United States. [Extracted from the article]

Published
2024

3. New Heart Failure Findings from University of Houston Described (Akap12 Upregulation Associates With Pde8a To Accelerate Cardiac Dysfunction)

Subjects
Medical research -- Reports, Medicine, Experimental -- Reports, Cyclic adenylic acid -- Research -- Reports, Proteins -- Reports -- Research, Heart -- Reports -- Research, Physical fitness -- Research -- Reports, Heart failure -- Research, Health, University of Houston -- Reports
Abstract

2024 JUN 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Heart Disorders and Diseases - Heart Failure is the [...]

Published
2024

4. New Neuroblastomas Research from University of Houston Outlined (Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action)

Subjects
Tumor proteins -- Research, Antineoplastic agents -- Research, Cancer -- Care and treatment, Neuroblastoma -- Research, Physical fitness -- Research -- Reports, Antimitotic agents -- Research, Health, University of Houston -- Reports
Abstract

2020 DEC 26 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on neuroblastomas are discussed in a new report. According to [...]

Published
2020

5. Data on Brain Cancer Published by Researchers at Texas Tech University Health Sciences Center (Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action)

Subjects
Physical fitness -- Research -- Reports, Tumor proteins -- Genetic aspects -- Research, Cancer research -- Reports -- Genetic aspects, Brain research -- Research -- Genetic aspects -- Reports, Brain cancer -- Genetic aspects -- Research, Health
Abstract

2020 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on brain cancer are discussed in a new report. According [...]

Published
2020

6. Study Data from University of Houston Provide New Insights into Cancer (Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy)

Subjects
Physical fitness -- Research, Tumor proteins -- Research, Cancer, Cancer research, Antineoplastic agents -- Research, Obesity, Anopheles, Medical research, Tumors, Editors, Health, University of Houston
Abstract

2020 MAY 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on cancer. According to news reporting from the [...]

Published
2020

7. University of Fudan Researchers Add New Findings in the Area of Liver Cancer (A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance)

Subjects
Cancer treatment -- Reports, Physical fitness -- Reports, Cancer genetics -- Genetic aspects -- Drug therapy -- Reports, Tumor proteins -- Genetic aspects -- Drug therapy -- Reports, Cancer -- Genetic aspects -- Drug therapy -- Reports, Hepatocellular carcinoma -- Genetic aspects -- Drug therapy -- Reports, Cancer research -- Reports, Sorafenib -- Reports, Cancer metastasis -- Genetic aspects -- Drug therapy -- Reports, Mortality, Anopheles, Carcinoma, Tumors, Obesity, Liver cancer, Editors, Health
Abstract

2019 DEC 21 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on liver cancer. According to news reporting originating [...]

Published
2019

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