275 results on '"Mazoyer A"'
Search Results
2. A deep reinforcement learning approach to wavefront control for exoplanet imaging
- Author
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Gutierrez, Yann, Mazoyer, Johan, Herscovici-Schiller, Olivier, Mugnier, Laurent M., Abeloos, Baptiste, and Laginja, Iva
- Published
- 2024
- Full Text
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3. Revisiting the Borde-Traub focal plane wavefront estimation technique for exoplanet direct imaging
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Potier, Axel, Riggs, A. J. Eldorado, Ruane, Garreth, Poon, Phillip K., Noyes, Matthew R., Allan, Greg W., Walter, Alexander, Mejia Prada, Camilo, Galicher, Raphaël, Mazoyer, Johan, and Baudoz, Pierre
- Published
- 2024
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4. The Nancy Grace Roman Space Telescope coronagraph community participation program
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Savransky, Dmitry, Bailey, Vanessa P., Wolff, Schuyler G., Millar-Blanchaer, Maxwell A., Wang, Jason, Altinier, Lisa, Anche, Ramya, Baudoz, Pierre, Biller, Beth, Blunt, Sarah, Brandner, Wolfgang, Brinjikji, Marah, Carrión-González, Oscar, Chavez, Amanda, Choquet, Elodie, Doelman, David, Girard, Julien H., Greenbaum, Alexandra Z., Hasler, Samantha N., Hom, Justin, Ingalls, James G., Kane, Stephen R., Kasdin, N. Jeremy, Krause, Oliver, Kuzuhara, Masayuki, Lau, Alexis, Li, Zhexing, Livingston, John, Lowrance, Patrick J., Ludwick, Kevin, Macintosh, Bruce, Mamajek, Eric, Marley, Mark, Mazoyer, Johan, Mennesson, Bertrand, Mizuki, Toshiyuki, Moran, Sarah E., Murakami, Naoshi, Nishikawa, Jun, Noel, Malachi, Pueyo, Laurent, Hildebrandt Rafels, Sergi, Rhodes, Jason, Robinson, Tyler, De Rosa, Robert J., Samland, Matthias, Schragal, Nicholas, Schreiber, Jürgen, Sobeck, Jennifer, Stapelfeldt, Karl, Tamura, Motohide, Uyajma, Taichi, Vigan, Arthur, Woodland, Michele, Ygouf, Marie, Yoneta, Kenta, Zellem, Robert T., and Zimmerman, Neil T.
- Published
- 2024
- Full Text
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5. Upgrading SPHERE with the second stage AO system SAXO+: non-common path aberrations estimation and correction
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Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Mazoyer, Johan, Goulas, Charles, Vidal, Fabrice, Bernardino Dinis, Isaac, Milli, Julien, Tallon, Michel, Galicher, Raphaël, Absil, Olivier, Bechet, Clémentine, Boccaletti, Anthony, Ferreira, Florian, Langlois, Maud, Martinez, Patrice, Mugnier, Laurent, N'diaye, Mamadou, Orban de Xivry, Gilles, Potier, Axel, Tallon-Bosc, Isabelle, and Vigan, Arthur
- Published
- 2024
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6. Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation
- Author
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Ge, Ruiyang, Yu, Yuetong, Qi, Yi Xuan, Fan, Yu-nan, Chen, Shiyu, Gao, Chuntong, Haas, Shalaila S, New, Faye, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Buckner, Randy, Caseras, Xavier, Crivello, Fabrice, Crone, Eveline A, Erk, Susanne, Fisher, Simon E, Franke, Barbara, Glahn, David C, Dannlowski, Udo, Grotegerd, Dominik, Gruber, Oliver, Hulshoff Pol, Hilleke E, Schumann, Gunter, Tamnes, Christian K, Walter, Henrik, Wierenga, Lara M, Jahanshad, Neda, Thompson, Paul M, Frangou, Sophia, Agartz, Ingrid, Asherson, Philip, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Baumeister, Sarah, Bertolino, Alessandro, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Buitelaar, Jan K, Cannon, Dara M, Cervenka, Simon, Conrod, Patricia J, Crespo-Facorro, Benedicto, Davey, Christopher G, de Haan, Lieuwe, de Zubicaray, Greig I, Di Giorgio, Annabella, Frodl, Thomas, Gruner, Patricia, Gur, Raquel E, Gur, Ruben C, Harrison, Ben J, Hatton, Sean N, Hickie, Ian, Howells, Fleur M, Huyser, Chaim, Jernigan, Terry L, Jiang, Jiyang, Joska, John A, Kahn, René S, Kalnin, Andrew J, Kochan, Nicole A, Koops, Sanne, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S, Lochner, Christine, Martin, Nicholas G, Mazoyer, Bernard, McDonald, Brenna C, McDonald, Colm, McMahon, Katie L, Medland, Sarah, Modabbernia, Amirhossein, Mwangi, Benson, Nakao, Tomohiro, Nyberg, Lars, Piras, Fabrizio, Portella, Maria J, Qiu, Jiang, Roffman, Joshua L, Sachdev, Perminder S, Sanford, Nicole, Satterthwaite, Theodore D, Saykin, Andrew J, Sellgren, Carl M, Sim, Kang, Smoller, Jordan W, Soares, Jair C, Sommer, Iris E, Spalletta, Gianfranco, Stein, Dan J, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, van 't Ent, Dennis, van den Heuvel, Odile A, van Erp, Theo GM, van Haren, Neeltje EM, Vecchio, Daniela, Veltman, Dick J, Wang, Yang, Weber, Bernd, Wei, Dongtao, Wen, Wei, Westlye, Lars T, Williams, Steven CR, Wright, Margaret J, Wu, Mon-Ju, and Yu, Kevin
- Abstract
The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to date. We aimed to identify the optimal approach for normative modelling of brain morphometric data through systematic empirical benchmarking, by quantifying the accuracy of different algorithms and identifying parameters that optimised model performance. We developed this framework with regional morphometric data from 37 407 healthy individuals (53% female and 47% male; aged 3–90 years) from 87 datasets from Europe, Australia, the USA, South Africa, and east Asia following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The multivariate fractional polynomial regression (MFPR) emerged as the preferred algorithm, optimised with non-linear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3000 study participants. This model can inform about the biological and behavioural implications of deviations from typical age-related neuroanatomical changes and support future study designs. The model and scripts described here are freely available through CentileBrain.
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- 2024
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7. Integrated photonic-based coronagraphic systems for future space telescopes
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Ruane, Garreth J., Desai, Niyati, König, Lorenzo, Por, Emiel, Juanola-Parramon, Roser, Belikov, Ruslan, Laginja, Iva, Guyon, Olivier, Pueyo, Laurent, Fogarty, Kevin, Absil, Olivier, Altinier, Lisa, Baudoz, Pierre, Bidot, Alexis, Bonse, Markus Johannes, Bott, Kimberly, Brandl, Bernhard, Carlotti, Alexis, Casewell, Sarah L., Choquet, Elodie, Cowan, Nicolas B., Doelman, David, Fowler, J., Gebhard, Timothy D., Gutierrez, Yann, Haffert, Sebastiaan Y., Herscovici-Schiller, Olivier, Hours, Adrien, Kenworthy, Matthew, Kleisioti, Elina, Krasteva, Mariya, Landman, Rico, Leboulleux, Lucie, Mazoyer, Johan, Millar-Blanchaer, Maxwell A., Mouillet, David, N'Diaye, Mamadou, Snik, Frans, van Dam, Dirk, van Gorkom, Kyle, van Kooten, Maaike, and Vaughan, Sophia R.
- Published
- 2023
- Full Text
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8. Visible extreme adaptive optics on extremely large telescopes: towards detecting oxygen in Proxima Centauri b and analogs
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Ruane, Garreth J., Fowler, J., Haffert, Sebastiaan Y., van Kooten, Maaike A. M., Landman, Rico, Bidot, Alexis, Hours, Adrien, N'Diaye, Mamadou, Absil, Olivier, Altinier, Lisa, Baudoz, Pierre, Belikov, Ruslan, Bonse, Markus Johannes, Bott, Kimberly, Brandl, Bernhard, Carlotti, Alexis, Casewell, Sarah L., Choquet, Elodie, Cowan, Nicolas B., Desai, Niyati, Doelman, David, Fogarty, Kevin, Gebhard, Timothy D., Gutierrez, Yann, Guyon, Olivier, Herscovici-Schiller, Olivier, Juanola-Parramon, Roser, Kenworthy, Matthew, Kleisioti, Elina, König, Lorenzo, Krasteva, Mariya, Laginja, Iva, Leboulleux, Lucie, Mazoyer, Johan, Millar-Blanchaer, Maxwell A., Mouillet, David, Por, Emiel, Pueyo, Laurent, Snik, Frans, van Dam, Dirk, van Gorkom, Kyle, and Vaughan, Sophia R.
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- 2023
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9. Anabolisants : « Poisons Mortels »
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Aknouche, Frederic, Gheddar, Laurie, Maruejouls, Christophe, Trebuchet, Claire, Fargeot, Kévin, Korkmazyigit, Fatima, Thion, Laureen, Mazoyer, Cedric, Teston, Kati, and Kintz, Pascal
- Abstract
Démontrer la responsabilité des anabolisants dans la mort d’un garde du corps retrouvé décédé dans son lit sans aucune lésion traumatique, en présence de plusieurs boites de stéroïdes anabolisants.
- Published
- 2024
- Full Text
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10. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
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Duperron, Marie-Gabrielle, Knol, Maria J., Le Grand, Quentin, Evans, Tavia E., Mishra, Aniket, Tsuchida, Ami, Roshchupkin, Gennady, Konuma, Takahiro, Trégouët, David-Alexandre, Romero, Jose Rafael, Frenzel, Stefan, Luciano, Michelle, Hofer, Edith, Bourgey, Mathieu, Dueker, Nicole D., Delgado, Pilar, Hilal, Saima, Tankard, Rick M., Dubost, Florian, Shin, Jean, Saba, Yasaman, Armstrong, Nicola J., Bordes, Constance, Bastin, Mark E., Beiser, Alexa, Brodaty, Henry, Bülow, Robin, Carrera, Caty, Chen, Christopher, Cheng, Ching-Yu, Deary, Ian J., Gampawar, Piyush G., Himali, Jayandra J., Jiang, Jiyang, Kawaguchi, Takahisa, Li, Shuo, Macalli, Melissa, Marquis, Pascale, Morris, Zoe, Muñoz Maniega, Susana, Miyamoto, Susumu, Okawa, Masakazu, Paradise, Matthew, Parva, Pedram, Rundek, Tatjana, Sargurupremraj, Muralidharan, Schilling, Sabrina, Setoh, Kazuya, Soukarieh, Omar, Tabara, Yasuharu, Teumer, Alexander, Thalamuthu, Anbupalam, Trollor, Julian N., Valdés Hernández, Maria C., Vernooij, Meike W., Völker, Uwe, Wittfeld, Katharina, Wong, Tien Yin, Wright, Margaret J., Zhang, Junyi, Zhao, Wanting, Zhu, Yi-Cheng, Schmidt, Helena, Sachdev, Perminder S., Wen, Wei, Yoshida, Kazumichi, Joutel, Anne, Satizabal, Claudia L., Sacco, Ralph L., Bourque, Guillaume, Lathrop, Mark, Paus, Tomas, Fernandez-Cadenas, Israel, Yang, Qiong, Mazoyer, Bernard, Boutinaud, Philippe, Okada, Yukinori, Grabe, Hans J., Mather, Karen A., Schmidt, Reinhold, Joliot, Marc, Ikram, M. Arfan, Matsuda, Fumihiko, Tzourio, Christophe, Wardlaw, Joanna M., Seshadri, Sudha, Adams, Hieab H. H., and Debette, Stéphanie
- Abstract
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter. These were associated with white matter PVS already in young adults (N= 1,748; 22.1 ± 2.3 yr) and were enriched in early-onset leukodystrophy genes and genes expressed in fetal brain endothelial cells, suggesting early-life mechanisms. In total, 53% of white matter PVS risk loci showed nominally significant associations (27% after multiple-testing correction) in a Japanese population-based cohort (N= 2,862; 68.3 ± 5.3 yr). Mendelian randomization supported causal associations of high blood pressure with basal ganglia and hippocampal PVS, and of basal ganglia PVS and hippocampal PVS with stroke, accounting for blood pressure. Our findings provide insight into the biology of PVS and cerebral small vessel disease, pointing to pathways involving extracellular matrix, membrane transport and developmental processes, and the potential for genetically informed prioritization of drug targets.
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- 2023
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11. Un nouveau variant d’épissage intronique profond de CYP11B1 est le plus fréquent chez les patients caucasiens atteints de déficits en 11β-hydroxylase : données fonctionnelles, cliniques et hormonales dans 36 familles
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Janot, C., Mallet, D., Brac-De-La-Perrière, A., Bertherat, J., Brioude, F., Cartault, A., Daval-Cote, M., Espiard, S., Houang, M., Lefebvre, H., Martinerie, L., Mayer, A., Mazoyer, H., Pienkowski, C., Ribault, V., Morel, Y., Plotton, I., and Roucher-Boulez, F.
- Abstract
Le déficit en 11β-hydroxylase (11OHD) est due à des mutations du gène CYP11B1. L’augmentation pathognomonique de 11-desoxycortisol plasmatique confirme le diagnostic. Pourtant, des mutations de CYP11B1 ne sont pas toujours retrouvées dans notre cohorte. Cette étude rétrospective décrit et confirme le caractère pathogène d’un variant d’épissage inédit, et étudie la corrélation phénotype-génotype.
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- 2024
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12. Upgrading the high contrast imaging facility SPHERE: science drivers and instrument choices
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Evans, Christopher J., Bryant, Julia J., Motohara, Kentaro, Boccaletti, A., Chauvin, G., Wildi, F., Milli, J., Stadler, E., Diolaiti, E., Gratton, R., Vidal, F., Loupias, M., Langlois, M., Cantalloube, F., N’Diaye, M., Gratadour, D., Ferreira, F., Tallon, M., Mazoyer, J., Segransan, D., Mouillet, D., Beuzit, J.-L., Bonnefoy, M., Galicher, R., Vigan, A., Snellen, I., Feldt, M., Desidera, S., Rousseau, S., Baruffolo, A., Goulas, C., Baudoz, P., Bechet, C., Benisty, M., Bianco, A., Carry, B., Cascone, E., Charnay, B., Choquet, E., Christiaens, V., Cortecchia, F., Di Capprio, V., De Rosa, A., Desgrange, C., D'Orazi, V., Douté, S., Frangiamore, M., Gendron, E., Ginski, C., Huby, E., Keller, C., Kulcsár, C., Landman, R., Lagarde, S., Lagadec, E., Lagrange, A.-M., Lombini, M., Kasper, M., Ménard, F., Magnard, Y., Malaguti, G., Maurel, D., Mesa, D., Morgante, G., Pantin, E., Pichon, T., Potier, A., Rabou, P., Rochat, S., Terenzi, l., Thiébaut, E., Tallon-Bosc, I., Raynaud, H.-F, Rouan, D., Sevin, A., Schiavone, F., Schrieber, L., and Zanutta, A.
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- 2022
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13. Coagulation disorders in patients with venous malformation of the limbs and trunk: a case series of 118 patients
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Mazoyer, Elisabeth, Enjolras, Odile, Bisdorff, Annouk, Perdu, Jerome, Wassef, Michel, and Drouet, Ludovic
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Blood clotting disorders -- Development and progression ,Blood clotting disorders -- Physiological aspects ,Blood clotting disorders -- Reports ,Arteriovenous malformations -- Development and progression ,Arteriovenous malformations -- Physiological aspects ,Arteriovenous malformations -- Reports ,Health - Published
- 2008
14. Allergies alimentaires dans le syndrome de Netherton : analyse rétrospective longitudinale d’une cohorte de 43 patients
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Mazoyer, H., Bellon, N., Bataille, P., Bonigen, J., Hadj-Rabia, S., Lezmi, G., and Bodemer, C.
- Abstract
Le syndrome de Netherton (SN) prédispose à l’atopie et aux allergies en particulier alimentaires (AA). Cette étude vise à décrire et analyser l’histoire naturelle des AA dans le SN et à identifier les facteurs de risque d’anaphylaxie.
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- 2024
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15. Toxidermie lichénoïde à l’osimertinib avec positivité des patch-tests cutanés
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Marcombes, C., Bel Hareth, K., Mazoyer, H., Solinas, S., Oro, S., and Assier, H.
- Abstract
Des toxidermies lichénoïdes ont été rapportées avec les immunothérapies ou inhibiteurs de tyrosine kinase (ITK). La rentabilité des tests allergologiques avec ces nouveaux médicaments du cancer est peu rapportée. Nous décrivons le premier cas de patch-test positif à l’osimertinib (Tagrisso®) chez une patiente ayant une toxidermie lichénoïde.
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- 2024
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16. Exoplanet imaging data challenge, phase II: comparison of algorithms in terms of characterization capabilities
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Jackson, Kathryn J., Schmidt, Dirk, Vernet, Elise, Cantalloube, F., Christiaens, V., Cantero, C., Cioppa, A., Nasedkin, E., Absil, O., Delorme, P., Wang, J.-J., Bonse, J. M., Daglayan, H., Dahlqvist, C.-H., Guyot, N., Juillard, S., Mazoyer, J., Samland, M., Sabalbal, M., Ruffio, J.-B., and Van Droogenbroeck, M.
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- 2024
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17. Upgrading SPHERE with the second stage AO system SAXO+: exploration of the parameter space with end-to-end numerical simulations
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Jackson, Kathryn J., Schmidt, Dirk, Vernet, Elise, Goulas, Charles, Galicher, Raphaël, Vidal, Fabrice, Mazoyer, Johan, Ferreira, Florian, Sevin, Arnaud, Boccaletti, Anthony, Gendron, Eric, Béchet, Clémentine, Tallon, Michel, Tallon, Isabelle, Langlois, Maud, Loupias, Magali, Thiébaut, Eric, Kulcsár, Caroline, Raynaud, Henri-François, Galland, Nicolas, Schreiber, Laura, Diolaiti, Emiliano, Bernardino Dinis, Isaac, Wildi, François, Chauvin, Gaël, Milli, Julien, Mouillet, David, Feldt, Markus, Kasper, Markus, Lelouarn, Miska, and Gratton, Raffaele
- Published
- 2024
- Full Text
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18. The Roman coronagraph community participation program: data reduction and simulations
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Millar-Blanchaer, Maxwell Andrew, Wang, Jason, Bogat, Ellis, Schreiber, Jürgen, Ygouf, Marie, Ludwick, Kevin J., Greenbaum, Alexandra Z., Bailey, Vanessa, Hildebrandt Rafels, Sergi, Savransky, Dmitry, Samland, Matthias, Altinier, Lisa, Anche, Ramya, Biller, Beth, Chavez, Amanda, Choquet, Elodie, Girard, Julien H., Hom, Justin, Ingalls, James G., Kasdin, N. Jeremy, Krause, Oliver, Livingston, John, Mazoyer, Johan, Pueyo, Laurent, Uyama, Taichi, Zellem, Robert T., and Zimmerman, Neil T.
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- 2024
- Full Text
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19. Brain charts for the human lifespan
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Bethlehem, R. A. I., Seidlitz, J., White, S. R., Vogel, J. W., Anderson, K. M., Adamson, C., Adler, S., Alexopoulos, G. S., Anagnostou, E., Areces-Gonzalez, A., Astle, D. E., Auyeung, B., Ayub, M., Bae, J., Ball, G., Baron-Cohen, S., Beare, R., Bedford, S. A., Benegal, V., Beyer, F., Blangero, J., Blesa Cábez, M., Boardman, J. P., Borzage, M., Bosch-Bayard, J. F., Bourke, N., Calhoun, V. D., Chakravarty, M. M., Chen, C., Chertavian, C., Chetelat, G., Chong, Y. S., Cole, J. H., Corvin, A., Costantino, M., Courchesne, E., Crivello, F., Cropley, V. L., Crosbie, J., Crossley, N., Delarue, M., Delorme, R., Desrivieres, S., Devenyi, G. A., Di Biase, M. A., Dolan, R., Donald, K. A., Donohoe, G., Dunlop, K., Edwards, A. D., Elison, J. T., Ellis, C. T., Elman, J. A., Eyler, L., Fair, D. A., Feczko, E., Fletcher, P. C., Fonagy, P., Franz, C. E., Galan-Garcia, L., Gholipour, A., Giedd, J., Gilmore, J. H., Glahn, D. C., Goodyer, I. M., Grant, P. E., Groenewold, N. A., Gunning, F. M., Gur, R. E., Gur, R. C., Hammill, C. F., Hansson, O., Hedden, T., Heinz, A., Henson, R. N., Heuer, K., Hoare, J., Holla, B., Holmes, A. J., Holt, R., Huang, H., Im, K., Ipser, J., Jack, C. R., Jackowski, A. P., Jia, T., Johnson, K. A., Jones, P. B., Jones, D. T., Kahn, R. S., Karlsson, H., Karlsson, L., Kawashima, R., Kelley, E. A., Kern, S., Kim, K. W., Kitzbichler, M. G., Kremen, W. S., Lalonde, F., Landeau, B., Lee, S., Lerch, J., Lewis, J. D., Li, J., Liao, W., Liston, C., Lombardo, M. V., Lv, J., Lynch, C., Mallard, T. T., Marcelis, M., Markello, R. D., Mathias, S. R., Mazoyer, B., McGuire, P., Meaney, M. J., Mechelli, A., Medic, N., Misic, B., Morgan, S. E., Mothersill, D., Nigg, J., Ong, M. Q. W., Ortinau, C., Ossenkoppele, R., Ouyang, M., Palaniyappan, L., Paly, L., Pan, P. M., Pantelis, C., Park, M. M., Paus, T., Pausova, Z., Paz-Linares, D., Pichet Binette, A., Pierce, K., Qian, X., Qiu, J., Qiu, A., Raznahan, A., Rittman, T., Rodrigue, A., Rollins, C. K., Romero-Garcia, R., Ronan, L., Rosenberg, M. D., Rowitch, D. H., Salum, G. A., Satterthwaite, T. D., Schaare, H. L., Schachar, R. J., Schultz, A. P., Schumann, G., Schöll, M., Sharp, D., Shinohara, R. T., Skoog, I., Smyser, C. D., Sperling, R. A., Stein, D. J., Stolicyn, A., Suckling, J., Sullivan, G., Taki, Y., Thyreau, B., Toro, R., Traut, N., Tsvetanov, K. A., Turk-Browne, N. B., Tuulari, J. J., Tzourio, C., Vachon-Presseau, É., Valdes-Sosa, M. J., Valdes-Sosa, P. A., Valk, S. L., van Amelsvoort, T., Vandekar, S. N., Vasung, L., Victoria, L. W., Villeneuve, S., Villringer, A., Vértes, P. E., Wagstyl, K., Wang, Y. S., Warfield, S. K., Warrier, V., Westman, E., Westwater, M. L., Whalley, H. C., Witte, A. V., Yang, N., Yeo, B., Yun, H., Zalesky, A., Zar, H. J., Zettergren, A., Zhou, J. H., Ziauddeen, H., Zugman, A., Zuo, X. N., Bullmore, E. T., and Alexander-Bloch, A. F.
- Abstract
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
- Published
- 2022
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20. Prevalence of insulin resistance syndrome in Southwestern France and its relationship with inflammatory and hemostatic markers. (Epidemiology/Health Services/Psychosocial Research)
- Author
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Marques-Vidal, Pedro, Mazoyer, Elizabeth, Bongard, Vanina, Gourdy, Pierre, Ruidavets, Jean-Bernard, Drouet, Ludovic, and Ferrieres, Jean
- Subjects
France -- Health aspects ,Diabetes -- Research ,Insulin resistance -- Health aspects ,Health ,Health aspects - Abstract
OBJECTIVE -- To assess the prevalence and relationships of insulin resistance syndrome (IRS) with inflammatory and hemostatic markers in a representative sample of the population of Southwestern France aged 35-64 [...]
- Published
- 2002
21. Genetic effects on planum temporaleasymmetry and their limited relevance to neurodevelopmental disorders, intelligence or educational attainment
- Author
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Carrion-Castillo, Amaia, Pepe, Antonietta, Kong, Xiang-Zhen, Fisher, Simon E., Mazoyer, Bernard, Tzourio-Mazoyer, Nathalie, Crivello, Fabrice, and Francks, Clyde
- Abstract
Previous studies have suggested that altered asymmetry of the planum temporale(PT) is associated with neurodevelopmental disorders, including dyslexia, schizophrenia, and autism. Shared genetic factors have been suggested to link PT asymmetry to these disorders. In a dataset of unrelated subjects from the general population (UK Biobank, N = 18,057), we found that PT volume asymmetry had a significant heritability of roughly 14%. In genome-wide association analysis, two loci were significantly associated with PT asymmetry, including a coding polymorphism within the gene ITIH5that is predicted to affect the protein's function and to be deleterious (rs41298373, p = 2.01 × 10–15), and a locus that affects the expression of the genes BOKand DTYMK(rs7420166, p = 7.54 × 10-10). DTYMKshowed left-right asymmetry of mRNA expression in post mortem PT tissue. Cortex-wide mapping of these SNP effects revealed influences on asymmetry that went somewhat beyond the PT. Using publicly available genome-wide association statistics from large-scale studies, we saw no significant genetic correlations of PT asymmetry with autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia, educational attainment or intelligence. Of the top two individual loci associated with PT asymmetry, rs41298373 showed a tentative association with intelligence (unadjusted p = .025), while the locus at BOK/DTYMKshowed tentative association with educational attainment (unadjusted Ps < .05). These findings provide novel insights into the genetic contributions to human brain asymmetry, but do not support a substantial polygenic association of PT asymmetry with cognitive variation and mental disorders, as far as can be discerned with current sample sizes.
- Published
- 2020
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22. Fish Intake and MRI Burden of Cerebrovascular Disease in Older Adults
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Thomas, Aline, Crivello, Fabrice, Mazoyer, Bernard, Debette, Stephanie, Tzourio, Christophe, and Samieri, Cecilia
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- 2021
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23. Pretreatment staging evaluation in small cell lung carcinoma: a new approach to medical decision making
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Chauvin, Franck, Trillet, Veronique, Court-Fortune, Isabelle, Velay, Brigitte, Mazoyer, Gisele, Girodet, Bruno, Gormand, Frederic, Rebattu, Paul, and Cordier, Jean Francois
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Lung cancer, Small cell -- Diagnosis ,Tumor staging -- Usage ,Health ,Diagnosis ,Usage - Abstract
The real need for extensive staging at the time of diagnosis is discussed in regard to small cell lung carcinoma. We performed a decisional retrospective analysis on a series of [...]
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- 1992
24. Regional cerebral blood flow in childhood autism: a SPECT study
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Zilbovicius, Monica, Garreau, Bernard, Tzourio, Nathalie, Mazoyer, Bernard, Bruck, Bernadette, Martinot, Jean-Luc, Raynaud, Claude, Samson, Yves, Syrota, Andre, and Lelord, Gilbert
- Subjects
Autistic children -- Physiological aspects ,Health ,Psychology and mental health - Abstract
The authors investigated a possible cortical brain dysfunction associated with infantile autism. Method: They measured regional cerebral blood flow with single photon emission computed tomography (SPECT) and xenon-133 in 21 children with primary autism (according to DSM-III-R criteria). Five cortical brain areas including frontal, temporal, and sensory association cortices were examined in order to test the recent hypothesis of cerebral dysfunction in primary autism. Anatomical references for each subject were obtained with computerized tomography or magnetic resonance imaging and were used to delimit the regions of interest for SPECT analysis. Results: When the results from the group with primary autism were compared with an age-matched group of nonautistic children with slight to moderate language disorders (N=14), no cortical regional abnormalities were found. Conclusions: It appears that there is no regional cortical dysfunction in primary autism; however, in light of methodological limitations, one cannot exclude the possibility of more localized or subcortical brain dysfunctions in autism. (Am J Psychiatry 1992; 149:924-930)
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- 1992
25. Genetic variants for head size share genes and pathways with cancer
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Knol, Maria J., Poot, Raymond A., Evans, Tavia E., Satizabal, Claudia L., Mishra, Aniket, Sargurupremraj, Muralidharan, van der Auwera, Sandra, Duperron, Marie-Gabrielle, Jian, Xueqiu, Hostettler, Isabel C., van Dam-Nolen, Dianne H.K., Lamballais, Sander, Pawlak, Mikolaj A., Lewis, Cora E., Carrion-Castillo, Amaia, van Erp, Theo G.M., Reinbold, Céline S., Shin, Jean, Scholz, Markus, Håberg, Asta K., Kämpe, Anders, Li, Gloria H.Y., Avinun, Reut, Atkins, Joshua R., Hsu, Fang-Chi, Amod, Alyssa R., Lam, Max, Tsuchida, Ami, Teunissen, Mariël W.A., Aygün, Nil, Patel, Yash, Liang, Dan, Beiser, Alexa S., Beyer, Frauke, Bis, Joshua C., Bos, Daniel, Bryan, R. Nick, Bülow, Robin, Caspers, Svenja, Catheline, Gwenaëlle, Cecil, Charlotte A.M., Dalvie, Shareefa, Dartigues, Jean-François, DeCarli, Charles, Enlund-Cerullo, Maria, Ford, Judith M., Franke, Barbara, Freedman, Barry I., Friedrich, Nele, Green, Melissa J., Haworth, Simon, Helmer, Catherine, Hoffmann, Per, Homuth, Georg, Ikram, M. Kamran, Jack, Clifford R., Jahanshad, Neda, Jockwitz, Christiane, Kamatani, Yoichiro, Knodt, Annchen R., Li, Shuo, Lim, Keane, Longstreth, W.T., Macciardi, Fabio, Amouyel, Philippe, Arfanakis, Konstantinos, Aribisala, Benjamin S., Bastin, Mark E., Chauhan, Ganesh, Chen, Christopher, Cheng, Ching-Yu, de Jager, Philip L., Deary, Ian J., Fleischman, Debra A., Gottesman, Rebecca F., Gudnason, Vilmundur, Hilal, Saima, Hofer, Edith, Janowitz, Deborah, Jukema, J. Wouter, Liewald, David C.M., Lopez, Lorna M., Lopez, Oscar, Luciano, Michelle, Martinez, Oliver, Niessen, Wiro J., Nyquist, Paul, Rotter, Jerome I., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Helena, Tiemeier, Henning, Trompet, Stella, van der Grond, Jeroen, Völzke, Henry, Wardlaw, Joanna M., Yanek, Lisa, Yang, Jingyun, Agartz, Ingrid, Alhusaini, Saud, Almasy, Laura, Ames, David, Amunts, Katrin, Andreassen, Ole A., Armstrong, Nicola, Bernard, Manon, Blangero, John, Blanken, Laura M.E., Boks, Marco P., Boomsma, Dorret I., Brickman, Adam M., Brodaty, Henry, Buckner, Randy L., Buitelaar, Jan K., Cannon, Dara M., Carr, Vaughan J., Catts, Stanley V., Chakravarty, M. Mallar, Chen, Qiang, Ching, Christopher R.K., Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Davies, Gareth E., de Geus, Eco J.C., de Zubicaray, Greig I., den Braber, Anouk, Desrivières, Sylvane, Dillman, Allissa, Djurovic, Srdjan, Drevets, Wayne C., Duggirala, Ravi, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fedko, Iryna O., Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana M., Ge, Tian, Giddaluru, Sudheer, Glahn, David C., Goldman, Aaron L., Green, Robert C., Greven, Corina U., Grimm, Oliver, Hansell, Narelle K., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Henskens, Frans, Hibar, Derrek P., Ho, Beng-Choon, Hoekstra, Pieter J., Holmes, Avram J., Hoogman, Martine, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Jablensky, Assen, Jenkinson, Mark, Jia, Tianye, Jöckel, Karl-Heinz, Jönsson, Erik G., Kim, Sungeun, Klein, Marieke, Kochunov, Peter, Kwok, John B., Lawrie, Stephen M., Le Hellard, Stephanie, Lemaître, Hervé, Loughland, Carmel, Marquand, Andre F., Martin, Nicholas G., Martinot, Jean-Luc, Matarin, Mar, Mathalon, Daniel H., Mather, Karen A., Mattay, Venkata S., McDonald, Colm, McMahon, Francis J., McMahon, Katie L., E, Rebekah, McWhirter, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Michie, Patricia T., Milaneschi, Yuri, Morris, Derek W., Mowry, Bryan, Nho, Kwangsik, Nichols, Thomas E., Nöthen, Markus N., Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Pantelis, Christos, Pappa, Irene, Penninx, Brenda, Pike, G. Bruce, Rasser, Paul E., Rentería, Miguel E., Reppermund, Simone, Rietschel, Marcella, Risacher, Shannon L., Romanczuk-Seiferth, Nina, Rose, Emma Jane, Sachdev, Perminder S., Sämann, Philipp G., Saykin, Andrew J., Schall, Ulrich, Schofield, Peter R., Schramm, Sara, Schumann, Gunter, Scott, Rodney, Shen, Li, Sisodiya, Sanjay M., Soininen, Hilkka, Sprooten, Emma, Srikanth, Velandai, Steen, Vidar M., Strike, Lachlan T., Thalamuthu, Anbupalam, Toga, Arthur W., Tooney, Paul, Tordesillas-Gutiérrez, Diana, Turner, Jessica A., Valdés Hernández, Maria del C., van der Meer, Dennis, Van der Wee, Nic J.A., Van Haren, Neeltje E.M., van 't Ent, Dennis, Veltman, Dick J., Walter, Henrik, Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Westman, Eric, Winkler, Anderson M., Woldehawariat, Girma, Wright, Margaret J., Wu, Jingqin, Mäkitie, Outi, Mazoyer, Bernard, Medland, Sarah E., Miyamoto, Susumu, Moebus, Susanne, Mosley, Thomas H., Muetzel, Ryan, Mühleisen, Thomas W., Nagata, Manabu, Nakahara, Soichiro, Palmer, Nicholette D., Pausova, Zdenka, Preda, Adrian, Quidé, Yann, Reay, William R., Roshchupkin, Gennady V., Schmidt, Reinhold, Schreiner, Pamela J., Setoh, Kazuya, Shapland, Chin Yang, Sidney, Stephen, St Pourcain, Beate, Stein, Jason L., Tabara, Yasuharu, Teumer, Alexander, Uhlmann, Anne, van der Lugt, Aad, Vernooij, Meike W., Werring, David J., Windham, B. Gwen, Witte, A. Veronica, Wittfeld, Katharina, Yang, Qiong, Yoshida, Kazumichi, Brunner, Han G., Le Grand, Quentin, Sim, Kang, Stein, Dan J., Bowden, Donald W., Cairns, Murray J., Hariri, Ahmad R., Cheung, Ching-Lung, Andersson, Sture, Villringer, Arno, Paus, Tomas, Cichon, Sven, Calhoun, Vince D., Crivello, Fabrice, Launer, Lenore J., White, Tonya, Koudstaal, Peter J., Houlden, Henry, Fornage, Myriam, Matsuda, Fumihiko, Grabe, Hans J., Ikram, M. Arfan, Debette, Stéphanie, Thompson, Paul M., Seshadri, Sudha, and Adams, Hieab H.H.
- Abstract
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.
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- 2024
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26. Repérage de la maladie d’Alzheimer dans les populations diverses : intérêt d’un rappel à 20min au test de mémoire du TNI-93
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Palisson, Juliette, Garcin, Béatrice, Benrahmoune, Kenza, Morzyglod, Sara, Joly, Charlotte, Mazoyer, Julie, Maillet, Didier, Belin, Catherine, and Narme, Pauline
- Abstract
Le TNI-93 est un test de repérage des troubles neurocognitifs majeurs dans une population multiculturelle/de faible niveau socio-éducatif [1], ayant une pertinence dans le diagnostic de patients avec biomarqueurs amyloïdes positifs [2].
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- 2024
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27. Intérêt des séquences T1 injectées en écho de spin chez les patients suspects d’astrocytopathie : à propos de deux cas
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Lapostolle, Arnaud, Ba, Stéphane Tran, Mazoyer, Julie, Garcin, Béatrice, De Liège, Astrid, Mongin, Marie, and Degos, Bertrand
- Abstract
L’imagerie cérébrale par résonance magnétique peut mettre en évidence des lésions inflammatoires cérébrales en cas d’encéphalite et orienter vers une étiologie, selon la topographie et l’aspect de ces lésions.
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- 2024
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28. Left prefrontal glucose hypometabolism in the depressed state: a confirmation
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Martinot, Jean-Luc, Hardy, Patrick, Feline, Andre, Huret, Jean-Damiem, Mazoyer, Bernard, Attar-Levy, Dominique, Pappata, Sabina, and Syrota, Andre
- Subjects
Antidepressants, Tricyclic -- Physiological aspects ,Depression, Mental -- Drug therapy ,Brain -- Physiological aspects ,Glucose metabolism -- Measurement ,Cerebral hemispheres -- Measurement ,Brain research -- Psychological aspects ,Glucose metabolism -- Psychological aspects ,Health ,Psychology and mental health - Abstract
Previous studies of depressed patients have found a reduction of glucose metabolism (hypometabolism) in the left dorsal anterolateral prefrontal cortex area of the brain. After successful treatment of these patients, relative metabolic rate increased on the left, but no change occurred on the right side. Other findings have also indicated reduced metabolic activity in the frontal portion of the brain and in the whole brain of depressed subjects. To replicate these results, 10 severely depressed subjects were examined before and after tricyclic antidepressant treatment, using positron emission tomography (PET scanning) and fluorodeoxyglucose tests; measurements of regional cerebral metabolism of glucose in the brain were obtained. The 10 experimental subjects consisted of seven patients diagnosed with bipolar disorder and three with unipolar depressive disorder; 10 normal control subjects of comparable age were also evaluated. The results confirmed the previous findings of left-right prefrontal asymmetry in the brain, which was detected in the depressed patients before successful treatment, but not afterwards. This suggests the efficacy of tricyclic antidepressants in reducing asymmetry. In addition, depressed patients had significant frontal and whole-cortex hypometabolism when compared with the normal controls. This was observed before treatment and persisted after treatment, even if clinical improvements in the patient were noted. These results suggest that this feature of hypometabolism in depressed individuals may not be state-dependent. Implications of these data are discussed and additional research is recommended to further investigate these brain abnormalities in depressed patients. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1990
29. Coagulation Characterization of Prothrombin 20209C > T Variant: About 27 New Cases
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Jourdi, Georges, Lobies, Sophie, Kosmider, Olivier, Duchemin, Jérôme, Audureau, Etienne, Conard, Jacqueline, Mazoyer, Elisabeth, Horellou, Marie-Hélène, Gouin-Thibault, Isabelle, Flaujac, Claire, and Fontenay, Michaëla
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- 2021
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30. Weak mineralization despite strong processing of dissolved organic matter in Eastern Arctic tundra ponds
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Laurion, Isabelle, Massicotte, Philippe, Mazoyer, Flora, Negandhi, Karita, and Mladenov, Natalie
- Abstract
Permafrost thawing mobilizes large quantities of organic carbon that was sequestered in Arctic regions over the last glacial cycle. Processes involved in the oxidation of this carbon need to be further assessed to estimate the fraction to be released into the atmosphere. Shallow tundra ponds are sites of active carbon turnover on the landscape and significant sources of greenhouse gases. Dissolved organic matter (DOM) leached from thawing peat into these ponds is exposed to sunlight, with the potential to accelerate its mineralization directly into CO2or through the production of more labile molecules. We tested the catalytic effect of sunlight on DOM mineralization in tundra ponds formed on organic‐rich polygonal landscapes originating from syngenetic permafrost, including a pond exposed to active permafrost erosion. Microbial decay rates, measured as the loss of chromophoric DOM, were similar to photodecay rates (1%–3% d−1). Groups of fluorescing molecules were formed through microbial transformation or lost through photolysis at differing rates among studied ponds, with the erosive trough pond presenting a unique response suggesting the involvement of soil microbes. Despite the stimulation of microbial growth under sunlight and the dynamic response of DOM optical properties, the loss of dissolved organic carbon was not significant under any treatment. This suggests that microbial and photochemical mineralization of DOM was slow and potentially substrate‐limited during the dry period when ponds were sampled. The static nature of tundra ponds, with their long water retention time, may thus constrain hot moments when water moves and transports carbon on the landscape.
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- 2021
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31. Towards high throughput and low-order aberration robustness for vortex coronagraphs with central obstructions
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Lystrup, Makenzie, Perrin, Marshall D., Fogarty, Kevin, Mawet, Dimitri, Mazoyer, Johan, Sirbu, Dan, Ruane, Garreth, and Pueyo, Laurent
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- 2020
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32. Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension
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Omura, Junichi, Habbout, Karima, Shimauchi, Tsukasa, Wu, Wen-Hui, Breuils-Bonnet, Sandra, Tremblay, Eve, Martineau, Sandra, Nadeau, Valérie, Gagnon, Kassandra, Mazoyer, Florence, Perron, Jean, Potus, Francois, Lin, Jian-Hui, Zafar, Hamza, Kiely, David G., Lawrie, Allan, Archer, Stephen L., Paulin, Roxane, Provencher, Steeve, Boucherat, Olivier, and Bonnet, Sébastien
- Abstract
Supplemental Digital Content is available in the text.
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- 2020
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33. Descente fatale après consommation de 3-méthylmethcathinone (3-MMC) : à propos d’un cas
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Aknouche, Frederic, Maruejouls, Christophe, Kernalleguen, Angeline, Teston, Kati, Mazoyer, Cédric, Gasnot, Wilfrid, Pellegrino, Fanny, Arbouche, Nadia, Gheddar, Laurie, Ameline, Alice, and Kintz, Pascal
- Abstract
L’usage de cathinones est un phénomène récent lié à l’émergence de nouvelles substances psychoactives. Certains groupes de la population peuvent être davantage exposés comme, par exemple, les hommes qui ont des activités sexuelles avec d’autres hommes sous l’influence de substances psychoactives. Cette pratique porte le nom de « chemsex ». Les auteurs rapportent une observation originale qui a conduit au décès de façon indirecte d’un consommateur. Le matin à 10h30, une dispute éclate au sein d’un couple homosexuel. L’un d’eux pourrait être consommateur de stupéfiants. Il aurait consommé des cathinones plusieurs fois en deux jours. Afin d’éviter une phase de descente désagréable, il voulait consommer à nouveau des drogues, mais son conjoint s’y est opposé. À 20h35, l’individu est découvert pendu sur son lieu de travail. À l’autopsie, les observations sont compatibles avec un mécanisme de pendaison. Une expertise toxicologique de référence est ordonnée, qui a mis en évidence de la 3-méthylmethcathinone (3-MMC) dans les prélèvements, selon les concentrations suivantes : sang fémoral (49ng/mL), sang cardiaque (53ng/mL), urines (310ng/mL), contenu gastrique (74ng/mL) et bile (205ng/mL). Une analyse en GC-MS a été indispensable afin de différencier la 3-MMC et la 4-MMC (méphédrone). L’analyse des poils pubiens a donné les résultats suivants : 12pg/mg de MDMA, 4pg/mg de 3-MMC et 28pg/mg de buphédrone. L’analyse d’une fiole retrouvée au domicile de la victime a mis en évidence de la buphédrone. Enfin, sur les vêtements que portait la victime (tee-shirt et sous-vêtement), il a été retrouvé de la 3-MMC ainsi que des traces de MDMA, de MDA et de buphédrone, démontrant un usage correspondant à la période où ils ont été portés. Toutes les concentrations de 3-MMC sont probablement sous-estimées, du fait de l’instabilité chimique bien connue de cette molécule. Le suicide semble correspondre au phénomène de descente difficile, après consommation répétée de stimulants. Les circonstances apparaissent comme superposables aux rares cas décrits dans la littérature, avec une prévalence importante de la pendaison.
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- 2020
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34. Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities
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Armstrong, Nicola J., Mather, Karen A., Sargurupremraj, Muralidharan, Knol, Maria J., Malik, Rainer, Satizabal, Claudia L., Yanek, Lisa R., Wen, Wei, Gudnason, Vilmundur G., Dueker, Nicole D., Elliott, Lloyd T., Hofer, Edith, Bis, Joshua, Jahanshad, Neda, Li, Shuo, Logue, Mark A., Luciano, Michelle, Scholz, Markus, Smith, Albert V., Trompet, Stella, Vojinovic, Dina, Xia, Rui, Alfaro-Almagro, Fidel, Ames, David, Amin, Najaf, Amouyel, Philippe, Beiser, Alexa S., Brodaty, Henry, Deary, Ian J., Fennema-Notestine, Christine, Gampawar, Piyush G., Gottesman, Rebecca, Griffanti, Ludovica, Jack, Clifford R., Jenkinson, Mark, Jiang, Jiyang, Kral, Brian G., Kwok, John B., Lampe, Leonie, C.M. Liewald, David, Maillard, Pauline, Marchini, Jonathan, Bastin, Mark E., Mazoyer, Bernard, Pirpamer, Lukas, Rafael Romero, José, Roshchupkin, Gennady V., Schofield, Peter R., Schroeter, Matthias L., Stott, David J., Thalamuthu, Anbupalam, Trollor, Julian, Tzourio, Christophe, van der Grond, Jeroen, Vernooij, Meike W., Witte, Veronica A., Wright, Margaret J., Yang, Qiong, Morris, Zoe, Siggurdsson, Siggi, Psaty, Bruce, Villringer, Arno, Schmidt, Helena, Haberg, Asta K., van Duijn, Cornelia M., Jukema, J. Wouter, Dichgans, Martin, Sacco, Ralph L., Wright, Clinton B., Kremen, William S., Becker, Lewis C., Thompson, Paul M., Mosley, Thomas H., Wardlaw, Joanna M., Ikram, M. Arfan, Adams, Hieab H.H., Seshadri, Sudha, Sachdev, Perminder S., Smith, Stephen M., Launer, Lenore, Longstreth, William, DeCarli, Charles, Schmidt, Reinhold, Fornage, Myriam, Debette, Stephanie, and Nyquist, Paul A.
- Abstract
Supplemental Digital Content is available in the text.
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- 2020
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35. Association Between Cerebral Small Vessel Disease With Antidepressant Use and Depression
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Tully, Phillip J., Alpérovitch, Annick, Soumaré, Aicha, Mazoyer, Bernard, Debette, Stephanie, and Tzourio, Christophe
- Abstract
Supplemental Digital Content is available in the text.
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- 2020
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36. Atypical brain aging and its association with working memory performance in major depressive disorder
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Ho, Natalie C.W., Bethlehem, Richard AI., Seidlitz, Jakob, Nogovitsyn, Nikita, Metzak, Paul, Ballester, Pedro L., Hassel, Stefanie, Rotzinger, Susan, Poppenk, Jordan, Lam, Raymond W., Taylor, Valerie H., Milev, Roumen, Adamson, Chris, Adler, Sophie, Alexander-Bloch, Aaron F., Anagnostou, Evdokia, Anderson, Kevin M., Areces-Gonzalez, Ariosky, Astle, Duncan E., Auyeung, Bonnie, Ayub, Muhammad, Bae, Jong Bin, Ball, Gareth, Baron-Cohen, Simon, Beare, Richard, Bedford, Saashi A., Benegal, Vivek, Bethlehem, Richard A.I., Beyer, Frauke, Blangero, John, Blesa Cábez, Manuel, Boardman, James P., Borzage, Matthew, Bosch-Bayard, Jorge F., Bourke, Niall, Bullmore, Edward T., Calhoun, Vince D., Chakravarty, Mallar M., Chen, Christina, Chertavian, Casey, Chetelat, Gaël, Chong, Yap S., Corvin, Aiden, Costantino, Manuela, Courchesne, Eric, Crivello, Fabrice, Cropley, Vanessa L., Crosbie, Jennifer, Crossley, Nicolas, Delarue, Marion, Delorme, Richard, Desrivieres, Sylvane, Devenyi, Gabriel, Di Biase, Maria A., Dolan, Ray, Donald, Kirsten A., Donohoe, Gary, Dorfschmidt, Lena, Dunlop, Katharine, Edwards, Anthony D., Elison, Jed T., Ellis, Cameron T., Elman, Jeremy A., Eyler, Lisa, Fair, Damien A., Fletcher, Paul C., Fonagy, Peter, Franz, Carol E., Galan-Garcia, Lidice, Gholipour, Ali, Giedd, Jay, Gilmore, John H., Glahn, David C., Goodyer, Ian M., Grant, P.E., Groenewold, Nynke A., Gudapati, Shreya, Gunning, Faith M., Gur, Raquel E., Gur, Ruben C., Hammill, Christopher F., Hansson, Oskar, Hedden, Trey, Heinz, Andreas, Henson, Richard N., Heuer, Katja, Hoare, Jacqueline, Holla, Bharath, Holmes, Avram J., Huang, Hao, Ipser, Jonathan, Jack, Clifford R., Jackowski, Andrea P., Jia, Tianye, Jones, David T., Jones, Peter B., Kahn, Rene S., Karlsson, Hasse, Karlsson, Linnea, Kawashima, Ryuta, Kelley, Elizabeth A., Kern, Silke, Kim, Ki-Woong, Kitzbichler, Manfred G., Kremen, William S., Lalonde, François, Landeau, Brigitte, Lerch, Jason, Lewis, John D., Li, Jiao, Liao, Wei, Liston, Conor, Lombardo, Michael V., Lv, Jinglei, Mallard, Travis T., Marcelis, Machteld, Mathias, Samuel R., Mazoyer, Bernard, McGuire, Philip, Meaney, Michael J., Mechelli, Andrea, Misic, Bratislav, Morgan, Sarah E., Mothersill, David, Ortinau, Cynthia, Ossenkoppele, Rik, Ouyang, Minhui, Palaniyappan, Lena, Paly, Leo, Pan, Pedro M., Pantelis, Christos, Park, Min Tae M., Paus, Tomas, Pausova, Zdenka, Paz-Linares, Deirel, Pichet Binette, Alexa, Pierce, Karen, Qian, Xing, Qiu, Anqi, Raznahan, Armin, Rittman, Timothy, Rodrigue, Amanda, Rollins, Caitlin K., Romero-Garcia, Rafael, Ronan, Lisa, Rosenberg, Monica D., Rowitch, David H., Salum, Giovanni A., Satterthwaite, Theodore D., Schaare, H. Lina, Schabdach, Jenna, Schachar, Russell J., Schöll, Michael, Schultz, Aaron P., Seidlitz, Jakob, Sharp, David, Shinohara, Russell T., Skoog, Ingmar, Smyser, Christopher D., Sperling, Reisa A., Stein, Dan J., Stolicyn, Aleks, Suckling, John, Sullivan, Gemma, Thyreau, Benjamin, Toro, Roberto, Traut, Nicolas, Tsvetanov, Kamen A., Turk-Browne, Nicholas B., Tuulari, Jetro J., Tzourio, Christophe, Vachon-Presseau, Étienne, Valdes-Sosa, Mitchell J., Valdes-Sosa, Pedro A., Valk, Sofie L., van Amelsvoort, Therese, Vandekar, Simon N., Vasung, Lana, Vértes, Petra E., Victoria, Lindsay W., Villeneuve, Sylvia, Villringer, Arno, Vogel, Jacob W., Wagstyl, Konrad, Wang, Yin-Shan S., Warfield, Simon K., Warrier, Varun, Westman, Eric, Westwater, Margaret L., Whalley, Heather C., White, Simon R., Witte, A. Veronica, Yang, Ning, Yeo, B.T. Thomas, Yun, Hyuk Jin, Zalesky, Andrew, Zar, Heather J., Zettergren, Anna, Zhou, Juan H., Ziauddeen, Hisham, Zimmerman, Dabriel, Zugman, Andre, Zuo, Xi-Nian N., Bullmore, Edward T., Alexander-Bloch, Aaron F., Frey, Benicio N., Harkness, Kate L., Addington, Jean, Kennedy, Sidney H., and Dunlop, Katharine
- Abstract
Patients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to aging. Yet, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool quantifying normative neurodevelopmental trajectories.
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- 2024
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- View/download PDF
37. Multi-factorial modulation of hemispheric specialization and plasticity for language in healthy and pathological conditions: A review
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Tzourio-Mazoyer, Nathalie, Perrone-Bertolotti, Marcela, Jobard, Gael, Mazoyer, Bernard, and Baciu, Monica
- Abstract
This review synthesizes anatomo-functional variability of language hemispheric representation and specialization (hemispheric specialization for language, HSL) as well as its modulation by several variables (demographic, anatomical, developmental, genetic, clinical, and psycholinguistic) in physiological and pathological conditions. The left hemisphere (LH) dominance for language, observed in approximately 90% of healthy individuals and in 70% of patients, is grounded by intra-hemispheric connections mediated by associative bundles such as the arcuate fasciculusand inter-hemispheric transcallosal connections mediated by the corpus callosumthat connects homotopic regions of the left and right hemispheres (RH). In typical brains, inter-hemispheric inhibition, exerted from the LH to the RH, permits the LH to maintain language dominance. In pathological conditions, inter- and intra-hemispheric inhibition is decreased, inducing modifications on the degree of HSL and of language networks. HSL evaluation is classically performed in clinical practice with the Wada test and electro-cortical stimulation, gold standardmethods. The advent of functional neuroimaging has allowed a more detailed assessment of the language networks and their lateralization, consistent with the results provided by the gold standardmethods. In the first part, we describe anatomo-functional support for HSL in healthy conditions, its developmental course, its relationship with cognitive skills, and the various modulatory factors acting on HSL. The second section is devoted to the assessment of HSL in patients with focal and drug-resistant epilepsy (FDRE). FDRE is considered a neurological model associated with patterns of language plasticity, both before and after surgery: FDRE patients show significant modification of language networks induced by changes mediated by transcallosal connections (explaining inter-hemispheric patterns of language reorganization) or collateral connections (explaining intra-hemispheric patterns of language reorganization). Finally, we propose several predictive and explicative models of language organization and reorganization.
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- 2017
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38. Étude prospective comparative de deux enseignements par le jeu (Neurospeed et jeu du chapeau neurologique) de la sémiologie neurologique pour les étudiants en médecine
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Mazoyer, Julie, Zeidan, Sinéad, Baltaze, Solenne, Garcin, Béatrice, Josse, Laure, and Degos, Bertrand
- Abstract
La neurologie est considérée comme difficile à apprendre. Le jeu du chapeau neurologique et le Neurospeed sont deux jeux qui ont chacun fait preuve de leur efficacité comme méthode d’enseignement.
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- 2023
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39. Genetic architecture of subcortical brain structures in 38,851 individuals
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Satizabal, Claudia L., Adams, Hieab H. H., Hibar, Derrek P., White, Charles C., Knol, Maria J., Stein, Jason L., Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V., Smith, Albert V., Bis, Joshua C., Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J., Yang, Jingyun, Yanek, Lisa R., Lee, Tom V., Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D., Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E., Kim, Sungeun, Hoehn, David, Armstrong, Nicola J., Chen, Qiang, Holmes, Avram J., den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K., Jones, Hannah J., Pike, G. Bruce, Stein, Dan J., Stevens, Allison, Bralten, Janita, Vernooij, Meike W., Harris, Tamara B., Filippi, Irina, Witte, A. Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H., Becker, James T., Doan, Nhat Trung, Hagenaars, Saskia P., Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M., Ames, David, Goldman, Aaron L., Lee, Phil H., Boomsma, Dorret I., Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M., Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M., Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E., Shin, Jean, Ipser, Jonathan C., Vinke, Louis N., Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K., Aribisala, Benjamin S., Schmidt, Helena, Strike, Lachlan T., Cheng, Ching-Yu, Risacher, Shannon L., Pütz, Benno, Fleischman, Debra A., Assareh, Amelia A., Mattay, Venkata S., Buckner, Randy L., Mecocci, Patrizia, Dale, Anders M., Cichon, Sven, Boks, Marco P., Matarin, Mar, Penninx, Brenda W. J. H., Calhoun, Vince D., Chakravarty, M. Mallar, Marquand, Andre F., Macare, Christine, Kharabian Masouleh, Shahrzad, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I., Schork, Andrew J., Liewald, David C. M., de Zubicaray, Greig I., Wong, Tien Yin, Shen, Li, Sämann, Philipp G., Brodaty, Henry, Roffman, Joshua L., de Geus, Eco J. C., Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R., Cavalleri, Gianpiero L., van der Wee, Nic J. A., McIntosh, Andrew M., Gollub, Randy L., Bulayeva, Kazima B., Bernard, Manon, Richards, Jennifer S., Himali, Jayandra J., Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T., Valdés Hernández, Maria C., Hansell, Narelle K., van Erp, Theo G. M., Wolf, Christiane, Kwok, John B. J., Vellas, Bruno, Heinz, Andreas, Olde Loohuis, Loes M., Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R. K., Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M., Bastin, Mark E., Montgomery, Grant W., Foroud, Tatiana M., Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D., van Donkelaar, Marjolein M. J., Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Hulshoff Pol, Hilleke E., Lin, Honghuang, Jack, Clifford R., Schofield, Peter R., Mühleisen, Thomas W., Maillard, Pauline, Potkin, Steven G., Wen, Wei, Fletcher, Evan, Toga, Arthur W., Gruber, Oliver, Huentelman, Matthew, Davey Smith, George, Launer, Lenore J., Nyberg, Lars, Jönsson, Erik G., Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N., Uitterlinden, André G., Weinberger, Daniel R., Steen, Vidar M., Fedko, Iryna O., Groenewold, Nynke A., Niessen, Wiro J., Toro, Roberto, Tzourio, Christophe, Longstreth, William T., Ikram, M. Kamran, Smoller, Jordan W., van Tol, Marie-Jose, Sussmann, Jessika E., Paus, Tomas, Lemaître, Hervé, Schroeter, Matthias L., Mazoyer, Bernard, Andreassen, Ole A., Holsboer, Florian, Depondt, Chantal, Veltman, Dick J., Turner, Jessica A., Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J., McMahon, Katie L., Müller-Myhsok, Bertram, Brouwer, Rachel M., Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H., Cheung, Joshua W., Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P., Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G., Kanai, Ryota, Westman, Eric, Kahn, René S., Sisodiya, Sanjay M., White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G., Völzke, Henry, Wright, Margaret J., van ‘t Ent, Dennis, Nöthen, Markus M., Ophoff, Roel A., Buitelaar, Jan K., Fernández, Guillén, Sachdev, Perminder S., Rietschel, Marcella, van Haren, Neeltje E. M., Fisher, Simon E., Beiser, Alexa S., Francks, Clyde, Saykin, Andrew J., Mather, Karen A., Romanczuk-Seiferth, Nina, Hartman, Catharina A., DeStefano, Anita L., Heslenfeld, Dirk J., Weiner, Michael W., Walter, Henrik, Hoekstra, Pieter J., Nyquist, Paul A., Franke, Barbara, Bennett, David A., Grabe, Hans J., Johnson, Andrew D., Chen, Christopher, van Duijn, Cornelia M., Lopez, Oscar L., Fornage, Myriam, Wardlaw, Joanna M., Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L., Villringer, Arno, Debette, Stéphanie, Gudnason, Vilmundur, Medland, Sarah E., Shulman, Joshua M., Thompson, Paul M., Seshadri, Sudha, and Ikram, M. Arfan
- Abstract
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophilaorthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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- 2019
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40. A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development
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Eising, Else, Carrion-Castillo, Amaia, Vino, Arianna, Strand, Edythe, Jakielski, Kathy, Scerri, Thomas, Hildebrand, Michael, Webster, Richard, Ma, Alan, Mazoyer, Bernard, Francks, Clyde, Bahlo, Melanie, Scheffer, Ingrid, Morgan, Angela, Shriberg, Lawrence, and Fisher, Simon
- Abstract
Genetic investigations of people with impaired development of spoken language provide windows into key aspects of human biology. Over 15 years after FOXP2was identified, most speech and language impairments remain unexplained at the molecular level. We sequenced whole genomes of nineteen unrelated individuals diagnosed with childhood apraxia of speech, a rare disorder enriched for causative mutations of large effect. Where DNA was available from unaffected parents, we discovered de novo mutations, implicating genes, including CHD3, SETD1Aand WDR5. In other probands, we identified novel loss-of-function variants affecting KAT6A, SETBP1, ZFHX4, TNRC6Band MKL2, regulatory genes with links to neurodevelopment. Several of the new candidates interact with each other or with known speech-related genes. Moreover, they show significant clustering within a single co-expression module of genes highly expressed during early human brain development. This study highlights gene regulatory pathways in the developing brain that may contribute to acquisition of proficient speech.
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- 2019
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41. New insights into minor splicing—a transcriptomic analysis of cells derived from TALS patients
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Cologne, Audric, Benoit-Pilven, Clara, Besson, Alicia, Putoux, Audrey, Campan-Fournier, Amandine, Bober, Michael B., De Die-Smulders, Christine E.M., Paulussen, Aimee D.C., Pinson, Lucile, Toutain, Annick, Roifman, Chaim M., Leutenegger, Anne-Louise, Mazoyer, Sylvie, Edery, Patrick, and Lacroix, Vincent
- Abstract
Minor intron splicing plays a central role in human embryonic development and survival. Indeed, biallelic mutations in RNU4ATAC, transcribed into the minor spliceosomal U4atac snRNA, are responsible for three rare autosomal recessive multimalformation disorders named Taybi–Linder (TALS/MOPD1), Roifman (RFMN), and Lowry–Wood (LWS) syndromes, which associate numerous overlapping signs of varying severity. Although RNA-seq experiments have been conducted on a few RFMN patient cells, none have been performed in TALS, and more generally no in-depth transcriptomic analysis of the ∼700 human genes containing a minor (U12-type) intron had been published as yet. We thus sequenced RNA from cells derived from five skin, three amniotic fluid, and one blood biosamples obtained from seven unrelated TALS cases and from age- and sex-matched controls. This allowed us to describe for the first time the mRNA expression and splicing profile of genes containing U12-type introns, in the context of a functional minor spliceosome. Concerning RNU4ATAC-mutated patients, we show that as expected, they display distinct U12-type intron splicing profiles compared to controls, but that rather unexpectedly mRNA expression levels are mostly unchanged. Furthermore, although U12-type intron missplicing concerns most of the expressed U12 genes, the level of U12-type intron retention is surprisingly low in fibroblasts and amniocytes, and much more pronounced in blood cells. Interestingly, we found several occurrences of introns that can be spliced using either U2, U12, or a combination of both types of splice site consensus sequences, with a shift towards splicing using preferentially U2 sites in TALS patients’ cells compared to controls.
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- 2019
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42. Review of high-contrast imaging systems for current and future ground-based and space-based telescopes III: technology opportunities and pathways
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Navarro, Ramón, Geyl, Roland, Snik, Frans, Absil, Olivier, Baudoz, Pierre, Beaulieu, Mathilde, Bendek, Eduardo, Cady, Eric, Carlomagno, Brunella, Carlotti, Alexis, Cvetojevic, Nick, Doelman, David, Fogarty, Kevin, Galicher, Raphaël, Guyon, Olivier, Haffert, Sebastiaan, Huby, Elsa, Jewell, Jeffrey, Jovanovic, Nemanja, Keller, Christoph, Kenworthy, Matthew A., Knight, Justin, Kuhn, Jonas, Mazoyer, Johan, Miller, Kelsey, N'Diaye, Mamadou, Norris, Barnaby, Por, Emiel, Pueyo, Laurent, Riggs, A. J. Eldorado, Ruane, Garreth, Sirbu, Dan, Wallace, J. Kent, Wilby, Michael, and Ygouf, Marie
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- 2018
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43. Fluctuation analysis on mutation models with birth-date dependence.
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Mazoyer, Adrien
- Subjects
- *
POISSON distribution , *NUMERICAL analysis , *MATHEMATICAL models , *ALGORITHMS , *GENETIC mutation - Abstract
The classic Luria–Delbrück model can be interpreted as a Poisson compound (number of mutations) of exponential mixtures (developing time of mutant clones) of geometric distributions (size of a clone in a given time). This “three-ingredients” approach is generalized in this paper to the case where the split instant distributions of cells are not i.i.d. : the lifetime of each cell is assumed to depend on its birth date. This model takes also into account cell deaths and non-exponentially distributed lifetimes. Previous results on the convergence of the distribution of mutant counts are recovered. The particular case where the instantaneous division rates of normal and mutant cells are proportional is studied. The classic Luria–Delbrück and Haldane models are recovered. Probability computations and simulation algorithms are provided. Robust estimation methods developed for the classic mutation models are adapted to the new model: their properties of consistency and asymptotic normality remain true; their asymptotic variances are computed. Finally, the estimation biases induced by considering classic mutation models instead of an inhomogeneous model are studied with simulation experiments. [ABSTRACT FROM AUTHOR]
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- 2018
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44. Review of high-contrast imaging systems for current and future ground-based and space-based telescopes: Part II. Common path wavefront sensing/control and coherent differential imaging
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Close, Laird M., Schreiber, Laura, Schmidt, Dirk, Jovanovic, Nemanja, Absil, Olivier, Baudoz, Pierre, Beaulieu, Mathilde, Bottom, Michael, Cady, Eric, Carlomagno, Brunella, Carlotti, Alexis, Doelman, David, Fogarty, Kevin, Galicher, Raphaël, Guyon, Olivier, Haffert, Sebastiaan, Huby, Elsa, Jewell, Jeffrey, Keller, Christoph, Kenworthy, Matthew A., Knight, Justin, Kühn, Jonas, Miller, Kelsey, Mazoyer, Johan, N'Diaye, Mamadou, Por, Emiel, Pueyo, Laurent, Riggs, A. J. E., Ruane, Garreth, Sirbu, Dan, Snik, Frans, Wallace, J. K., Wilby, Michael, and Ygouf, Marie
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- 2018
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45. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38for White Matter Hyperintensities on Brain Magnetic Resonance Imaging
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Jian, Xueqiu, Satizabal, Claudia L., Smith, Albert V., Wittfeld, Katharina, Bis, Joshua C., Smith, Jennifer A., Hsu, Fang-Chi, Nho, Kwangsik, Hofer, Edith, Hagenaars, Saskia P., Nyquist, Paul A., Mishra, Aniket, Adams, Hieab H.H., Li, Shuo, Teumer, Alexander, Zhao, Wei, Freedman, Barry I., Saba, Yasaman, Yanek, Lisa R., Chauhan, Ganesh, van Buchem, Mark A., Cushman, Mary, Royle, Natalie A., Bryan, R. Nick, Niessen, Wiro J., Windham, Beverly G., DeStefano, Anita L., Habes, Mohamad, Heckbert, Susan R., Palmer, Nicholette D., Lewis, Cora E., Eiriksdottir, Gudny, Maillard, Pauline, Mathias, Rasika A., Homuth, Georg, Valdés-Hernández, Maria del C., Divers, Jasmin, Beiser, Alexa S., Langner, Sönke, Rice, Kenneth M., Bastin, Mark E., Yang, Qiong, Maldjian, Joseph A., Starr, John M., Sidney, Stephen, Risacher, Shannon L., Uitterlinden, André G., Gudnason, Vilmundur G., Nauck, Matthias, Rotter, Jerome I., Schreiner, Pamela J., Boerwinkle, Eric, van Duijn, Cornelia M., Mazoyer, Bernard, von Sarnowski, Bettina, Gottesman, Rebecca F., Levy, Daniel, Sigurdsson, Sigurdur, Vernooij, Meike W., Turner, Stephen T., Schmidt, Reinhold, Wardlaw, Joanna M., Psaty, Bruce M., Mosley, Thomas H., DeCarli, Charles S., Saykin, Andrew J., Bowden, Donald W., Becker, Diane M., Deary, Ian J., Schmidt, Helena, Kardia, Sharon L.R., Ikram, M. Arfan, Debette, Stéphanie, Grabe, Hans J., Longstreth, W.T., Seshadri, Sudha, Launer, Lenore J., and Fornage, Myriam
- Abstract
Supplemental Digital Content is available in the text.
- Published
- 2018
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46. Sensitivity analysis for high-contrast imaging with segmented space telescopes
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Lystrup, Makenzie, MacEwen, Howard A., Fazio, Giovanni G., Batalha, Natalie, Siegler, Nicholas, Tong, Edward C., Leboulleux, Lucie, Pueyo, Laurent, Sauvage, Jean-François, Fusco, Thierry, Mazoyer, Johan, Sivaramakrishnan, Anand, N'Diaye, Mamadou, and Soummer, Rémi
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- 2018
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47. Apodized Pupil Lyot coronagraphs with arbitrary aperture telescopes: novel designs using hybrid focal plane masks
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Lystrup, Makenzie, MacEwen, Howard A., Fazio, Giovanni G., Batalha, Natalie, Siegler, Nicholas, Tong, Edward C., N'Diaye, Mamadou, Fogarty, Kevin, Soummer, Rémi, Carlotti, Alexis, Dohlen, Kjetil, Mazoyer, Johan, Pueyo, Laurent, St. Laurent, Kathryn, and Zimmerman, Neil
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- 2018
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48. Review of high-contrast imaging systems for current and future ground- and space-based telescopes I: coronagraph design methods and optical performance metrics
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Lystrup, Makenzie, MacEwen, Howard A., Fazio, Giovanni G., Batalha, Natalie, Siegler, Nicholas, Tong, Edward C., Ruane, G., Riggs, A., Mazoyer, J., Por, E. H., N’Diaye, M., Huby, E., Baudoz, P., Galicher, R., Douglas, E., Knight, J., Carlomagno, B., Fogarty, K., Pueyo, L., Zimmerman, N., Absil, O., Beaulieu, M., Cady, E., Carlotti, A., Doelman, D., Guyon, O., Haffert, S., Jewell, J., Jovanovic, N., Keller, C., Kenworthy, M. A., Kuhn, J., Miller, K., Sirbu, D., Snik, F., Wallace, J. Kent, Wilby, M., and Ygouf, M.
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- 2018
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49. Apodized pupil Lyot coronagraphs designs for future segmented space telescopes
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Lystrup, Makenzie, MacEwen, Howard A., Fazio, Giovanni G., Batalha, Natalie, Siegler, Nicholas, Tong, Edward C., St. Laurent, Kathryn, Fogarty, Kevin, Zimmerman, Neil T., N'Diaye, Mamadou, Stark, Christopher C., Mazoyer, Johan, Sivaramakrishnan, Anand, Pueyo, Laurent, Shaklan, Stuart, Vanderbei, Robert, and Soummer, Rémi
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- 2018
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50. High-contrast imager for complex aperture telescopes (HiCAT): 5. first results with segmented-aperture coronagraph and wavefront control
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Lystrup, Makenzie, MacEwen, Howard A., Fazio, Giovanni G., Batalha, Natalie, Siegler, Nicholas, Tong, Edward C., Soummer, Rémi, Brady, Gregory R., Brooks, Keira, Comeau, Thomas, Choquet, Élodie, Dillon, Tom, Egron, Sylvain, Gontrum, Rob, Hagopian, John, Laginja, Iva, Leboulleux, Lucie, Perrin, Marshall D., Petrone, Peter, Pueyo, Laurent, Mazoyer, Johan, N'Diaye, Mamadou, Riggs, A. J. Eldorado, Shiri, Ron, Sivaramakrishnan, Anand, St. Laurent, Kathryn, Valenzuela, Ana-Maria, and Zimmerman, Neil T.
- Published
- 2018
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