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Abstract: Eighty-two patients with farmer’s lung were given a bronchial challenge with histamine. In 22 of them, a positive reaction occurred during the acute phase of the disease. None of these subjects had asthma or chronic bronchitis. In 16 of the 20 positive reactors who were re-challenged the result was negative after 1–2 months. Our results suggest the existence of a subgroup of patients with bronchial hyperreactivity to inhaled histamine. This may reflect the individual location of the inflammatory process in patients with allergic bronchioloalveolitis.