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Organic–inorganic hybrid ferroelastic materials have emerged as promising candidates for various applications such as mechanical switches, signal conversions, and memory materials because of their convenient processing, structural flexibility, and environmental friendliness. Here, we reported a supramolecular assembly hybrid perovskite (15-crown-5·NH4)2TeCl6(1) semiconductor containing stator ammonium and rotor 15-crown-5 as cations and TeCl6as an anionic part. This hybrid perovskite shows a ferroelastic phase transition and dielectric switch induced by the motions of the crown rotor. In addition, it shows an X-ray detection response with a clear switching ratio of photocurrent 0.011 and dark current 0.001 nA cm–2. This study reveals the advantages of a supramolecular rotor strategy in discovering novel molecular ferroelastic semiconductor materials and provides a new avenue to explore functional hybrid molecular materials.

Accurate identification of single nucleotide variants (SNVs) in key driver genes holds a significant value for disease diagnosis and treatment. Fluorescent probes exhibit tremendous potential in specific, high-resolution, and rapid detection of SNVs. However, additional steps are required in most post-PCR assays to convert double-stranded DNA (dsDNA) products into single-stranded DNA (ssDNA), enabling them to possess hybridization activity to trigger subsequent reactions. This process not only prolongs the complexity of the experiment but also introduces the risk of losing target information. In this study, we proposed two strategies for enriching active double-stranded DNA, involving PCR based on obstructive groups and cleavable units. Building upon this, we explored the impact of modified units on the strand displacement reaction (SDR) and assessed their discriminatory efficacy for mutations. The results showed that detection of low variant allele frequencies (VAF) as low as 0.1% can be achieved. The proposed strategy allowed orthogonal identification of 45 clinical colorectal cancer tissue samples with 100% specificity, and the results were generally consistent with sequencing results. Compared to existing methods for enriching active targets, our approach offers a more diverse set of enrichment strategies, characterized by the advantage of being simple and fast and preserving original information to the maximum extent. The objective of this study is to offer an effective solution for the swift and facile acquisition of active double-stranded DNA. We anticipate that our work will facilitate the practical applications of SDR based on dsDNA.

Organic–inorganic hybrid perovskites (OIHPs) have received particular attention due to their characteristic structural tunability and flexibility. These features make OIHPs behave with excellent modifications on macroscopic properties, such as ferroicity or semiconductor performances, etc. Herein, we report two 2D hybrid stibium-based halide perovskite (C3H7N)3Sb2X9(X = Br, 1; Cl, 2) ferroelastic semiconductor possessing dual switching properties of dielectric and second harmonic generation (SHG). Notably, these two hybrids exhibit halogen-regulated ferroelasticity and semiconductor properties. There is a significant difference in Curie temperature (Tc) and X-ray radiation detection sensitivity (S), i.e., the ΔTcand ΔSare 38 K and 87 μC Gyair–1cm–2, respectively. Meanwhile, crystals 1and 2do not show dark current drift in cyclic measurements of different radiation doses with stable switching ratios of 30 and 10, separately. Meanwhile, these results were proven by scientific experimental results and density functional theory (DFT) calculations. Our work presents a facile and practical method to regulate macroproperties on the molecular level, providing a new vision to develop hybrid perovskite ferroic-photoelectric materials.

The metal magnetic memory (MMM) nondestructive testing (NDT) method is widely accepted for its strong environmental adaptability, high sensitivity, and simple measurement operation; nevertheless, due to the complex environmental factors and the influence of detection distance, it is still a technical challenge to perform high-accuracy pipeline inspection at high lift-off values, where the lift-off value is the distance between the magnetic probe and the surface of the pipe. To better study the MMM field model, this article puts forward the high lift-off distance MMM–3-D (HDMMM-3-D) differential method of ${G}_{z}$ . Through the COMSOL software simulation of the finite element method, we performed practical tests with the low-noise acquisition equipment in an independent design. The finite element method simulation and the results of the numerical, analytical image features and numerical sizes are similar. In the field pipeline test, the waveform signal undergoes a change of first rising and then falling at the damage location; comparing the waveform of magnetic gradient and ${G}_{z}$ at the 3 m damage location of the pipeline, the ${G}_{z}$ has a more detailed differentiation of the number of damages, and the peak size of the damage signal is more obvious. It is effective to verify the HDMMM-3-D differential method, which provides the theoretical basis and application support for the in-depth study of high separation value in the field of nondestructive testing.

Multifunctional magnetometers enable high-precision observations of the geomagnetic direction and total magnetic field, which have broad applications in geoscience research and space weather forecasting. However, inconsistencies still occur between the optical and magnetic axes of classic multifunctional magnetometers, and few studies have investigated their direct detection. To address this issue, we propose a novel method for the detection of the optical-magnetic axis inconsistency. The magnetic azimuths for the magnetic axis and the optical axis of the multifunctional magnetometer are determined through the bias field loading and fluxgate theodolite, thereby allowing direct detection of the inconsistency. The proposed method is also modeled to quantify the detection errors introduced by the total-field sensor and the observation operation. In addition, we develop a dedicated experimental platform and conduct comparative tests at a geomagnetic observatory to validate the practicality and performance of the method. The experimental results show that the proposed method can significantly reduce the deviation of the declination curve measured by the multifunctional magnetometer relative to the curve measured by the fluxgate theodolite from $3959{}^{\prime \prime }$ to $19{}^{\prime \prime }$ , achieving a 99.5% reduction rate.

The absolute measurement of geomagnetic parameters can be applied directly not only in magnetic navigation and target detection but also in the correction of relative measurement. The absolute geomagnetic measurement generally adopts a combined measurement mode. Owing to differences in the principles of different magnetometers, it is difficult to comprehensively apply absolute data. To address this problem, we propose a novel automatic measurement model for the absolute geomagnetic total field and directions. Gearing toward field mobile measurement, we developed an integrated vector magnetometer using an improved Overhauser total-field sensor and a miniaturized spherical magnetic field generator. Component test results obtained for an artificial magnetic field generator show that the expanded uncertainty of Overhauser sensor with reduced dimensions was still below 0.10 nT, and the magnetic gradient formed by the applied bias fields had no negative effect on the performance of Overhauser sensor. In overall tests conducted in geomagnetic observatories, between the proposed magnetometer and a standard manually operated declination–inclination magnetometer, the differences of inclination and declination were only 14.40” and 12.96”, respectively. The noises of total field, horizontal component, and declination measured by the proposed magnetometer were 0.02 nT, 0.08 nT, and 0.47”, respectively, which are much lower than those of a state-of-the-art standard variometer. The proposed magnetometer is expected to be applied to unattended monitoring of geomagnetic field for the geomagnetic navigation, exploration of weak magnetic anomaly produced by the deep mineral resources, automatic remote detection of moving magnetic targets, fine-scale characterization of the plate tectonics, etc.

Accurate measurement of geomagnetic field inhomogeneity commonly necessitates the use of two or more magnetic sensors for differential measurements, and most of the geomagnetic sensors are unusable in large inhomogeneous fields. To address these issues, this article presents a new approach for estimating the geomagnetic field’s inhomogeneities based on a single Overhauser magnetometer. First, we establish the improved free induction decay (FID) signal model by integrating the phases of all protons over the entire Overhauser sensor in arbitrary inhomogeneous fields, which enables the inversion of the geomagnetic field gradient using the relaxation characteristics of the FID signal. Then, we propose a composite algorithm designed to accurately derive the relaxation parameters of the FID signal by carefully extracting and denoising its envelope and after that calculate the gradient of the geomagnetic field by the above FID signal model. Moreover, we designed a specialized Overhauser magnetic sensor prototype for measuring geomagnetic gradients and conducted experiments on a dedicated experimental platform. The designed prototype successfully measured the magnetic gradient even under high gradients of up to 10 005 nT/m, yielding a measurement error of 15.83%, with one sensor in the experiments. In addition, we employed this method to successfully detect unexploded ordnance (UXO) using the transverse relaxation time of the FID signal as an indicator. This application further validates the effectiveness and practicality of our proposed methodology.

Magnetic field sensing is of great significance for marine geoscience research and industrial engineering. This article proposes a high-precision and dual-mode Overhauser marine magnetometer, which integrates base station monitoring mode and towed mobile survey mode. To accurately extract the frequency of weak free induction decay (FID) signals in complex marine environments, a precision narrowband resonant pickup circuit is adopted to enhance the signal, and a short-time precision frequency measuring method is presented. In addition, in terms of long-range underwater power supply and communication, we propose an interactive communication method for the Overhauser marine magnetometer based on low-voltage power line carrier, which not only provides power supply but also supports reliable duplex communication at 2.4 kbps baud rate within 3 km in the case of twin-core cable. The effectiveness and superiority of the developed Overhauser marine magnetometer were validated through extensive laboratory and field experiments. Results from a standard magnetic metrology laboratory indicate that the proposed magnetometer covers a field range from 20 to $100 \mu \text{T}$ , while the indicated value error is less than 0.09 nT and the noise is less than 0.06 nT. The geomagnetic observation experiment demonstrates the reliability and the advanced performance of the magnetometer under base station monitoring mode. Furthermore, the comparison results of the marine magnetism survey under towed mobile survey mode show that the agreement of the magnetometer and the commercial instrument installed on board is 0.95, which proves the feasibility and effectiveness of the proposed instrument for the marine magnetism survey.

For proton precession magnetometers, the influence of free induction decay (FID) signal noise on the frequency measurement procedure is a significant impediment to improving the precision of geomagnetic field measurements. However, the existing noise suppression methods treat the noise as a system, aiming to reduce its impact on frequency estimation without directly addressing the specific noise interference. To address this issue, an intelligent full-wavenumber fitting algorithm for measuring the FID signal frequency is proposed. It entails converting all the FID signal waves within the sampling cycle into a time series with the signal period as the independent variable. Effectively determining the frequency of the FID signal by fitting a linear regression on this time series of the full-wavenumber FID signal. Moreover, we introduce an intelligent noisy point detection method by analyzing the deviation between the time series and the fit curve. This enables targeted and localized noise elimination, resulting in improved noise suppression. To validate the effectiveness and character of the performance of the proposed algorithm, we conducted rigorous testing on a purpose-built experimental platform and the standard magnetism laboratory. Using a simulated FID signal, the results demonstrate that the proposed algorithm can obtain a precision greater than ${1.47} \times {10}^{-{5}}$ Hz and a resolution greater than ${3} \times {10}^{-{6}}$ Hz within a measurement time of 1000 ms. When aligned the sensor of the proposed prototype is with a standard artificial magnetic field, it demonstrates a 0.0667-nT measurement precision.

Organic–inorganic hybrid perovskites (OIHPs) with switchable properties are believed to be important as stimuli-responsive materials. Herein, we report two ABX2-type OIHPs: [(CH3)3NCH2R]2[Eu(H2O)]2[CH2(SO3)2]4·2H2O (R = H, 1; F, 2) by using [CH2(SO3)2]2–bridged rare-earth (RE) ions. Meanwhile, these self-assembled host–guest compounds display structural phase transition with a dielectric switch and fluorescent response. Notably, H/F substitution enhanced the intermolecular interactions between the anionic host and the cationic guest. This results in skeleton deformation and changes in the spatial arrangement and symmetry of Eu3+. As a result, the phase transition temperature (Ttr) moved up, and the fluorescence quantum yield (FQY) increased by 4.73%. The molecular assembly strategy proposed in this work will benefit the construction of new multifunctional stimuli-responsive materials.

Coil vector magnetometer is an advanced instrument that can perform integrated multielement geomagnetic measurements and has excellent prospects for geoscience research and resource exploration applications. The attitude deviation is one of the main error sources of magnetic direction measurements of the coil vector magnetometer. The existing attitude determination method requires the use of additional auxiliary instruments (e.g., a spirit level). Furthermore, this method cannot be used to perform direct determination of the directional shift of the bias field caused by attitude deviation, and the magnetism of the detection instrument inevitably introduces new measurement errors. Therefore, it is difficult to achieve high-precision attitude deviation correction. To address this issue, we propose a novel electrical method to enable direct, high-precision determination of the attitude deviation and the corresponding correction indicator for the coil vector magnetometer using only a single rotation of the magnetometer and applying bias fields, thereby realizing comprehensive high-precision hard and soft corrections of the attitude deviation via indicator alignment without relying on auxiliary detection instruments. In addition, we developed a dedicated experimental platform and then validated both the practicality and the performance of the proposed method in a geomagnetic observatory. Comparative experimental results for two coil vector magnetometers indicate that when the correction indicator’s alignment inaccuracy is less than 1 nT, the magnetic direction measurement error caused by the attitude deviation can be less than 6 in.

The information on the high-precision and multidirectional magnetic gradient is highly relevant to detecting and locating shallow subsurface unexploded ordnance (UXO). In this article, the design of a 3-D Overhauser magnetic gradiometer is presented. Taking the sensor array interferences and working efficiency into account, a time slice overlapping based operating time sequence is devised. A precision narrowband tuning capacitance network based on a cascaded subdivision strategy is constructed to improve the signal-to-noise ratio (SNR) of free induction decay (FID) signals. Additionally, a frequency measuring approach combining multiphase clock and multichannel is developed to suppress counting errors and improve the frequency measuring accuracy of FID signals. The 3-D Overhauser magnetic gradiometer’s effectiveness was validated through extensive laboratory and field experiments. The laboratory test results show that the magnetic measuring performance of each sensor from the Overhauser magnetic sensor array is consistent. The proposed 3-D Overhauser magnetic gradiometer is able to measure magnetic fields from 20 to $100~\mu \text{T}$ with an indicating error of less than 0.1 nT. The field exploration demonstrates the applicability of the gradiometer for shallow subsurface UXO detection within the urban complex electromagnetic surroundings. Overall, this study can provide support for the accurate detection and localization of shallow subsurface UXO under strong interference surroundings.

Macrophages are well known for their phagocytic functions in innate immunity across species. In mammals, they rapidly consume a large amount of energy by shifting their metabolism from mitochondrial oxidative phosphorylation toward aerobic glycolysis, to perform the effective bactericidal function upon infection. Meanwhile, they strive for sufficient energy resources by restricting systemic metabolism. In contrast, under nutrient deprivation, the macrophage population is down-regulated to save energy for survival. Drosophila melanogasterpossesses a highly conserved and comparatively simple innate immune system. Intriguingly, recent studies have shown that Drosophilaplasmatocytes, the macrophage-like blood cells, adopt comparable metabolic remodeling and signaling pathways to achieve energy reassignment when challenged by pathogens, indicating the conservation of such metabolic strategies between insects and mammals. Here, focusing on Drosophilamacrophages (plasmatocytes), we review recent advances regarding their comprehensive roles in local or systemic metabolism under homeostasis or stress, emphasizing macrophages as critical players in the crosstalk between the immune system and organic metabolism from a Drosophilaperspective.

ABSTRACTOxaliplatin is an effective chemotherapeutic agent for the treatment of malignant tumors. However, severe oxaliplatin-induced neurotoxicity has been well documented. Memantine is a drug for the management of Alzheimer’s Disease (AD) due to its promising neuroprotective properties. We hypothesize that Memantine possesses a beneficial role against chemotherapy-induced neuronal damages. In this study, we established an oxaliplatin-induced neurotoxicity assay model in human SHSY-5Y neuronal cells and investigated the protective effect of Memantine. We showed that Memantine treatment ameliorated oxaliplatin-elevated intracellular production of reactive oxygen species (ROS), lipid product malondialdehyde (MDA), and NOX-2 expression. Memantine alleviated impairment of the mitochondrial membrane potential and ATP production by oxaliplatin. As a result, Memantine showed a protective role against oxaliplatin-induced cytotoxicity. Moreover, the terminal deoxynucleotidyl Transferase-mediated dUTP nick end labeling (TUNEL) apoptosis assay revealed that Memantine protected oxaliplatin-induced apoptosis through mitigating the ratio of Bax/Bcl-2 and Caspase-3 cleavage. We concluded Memantine ameliorated the neurotoxicity of oxaliplatin in a mitochondrial-dependent pathway.

Coal spontaneous combustion is one of the disasters occurring in underground coal mines. As a typical case, the spontaneous combustion of broken coal left in the longwall gobs often happen which could greatly interrupt the normal mining production. Such concealed thermal event is featured as rapid development and difficulty in locating “hot” spots. If such spontaneous combustion fails to be timely prevented and controlled, a large amount of toxic gases (mainly CO) and smoke could flow and diffuse in the underground working sections, which could present safety hazards for coal miners. In this paper, based on an coal spontaneous combustion event happened in a Chinese gassy mine, the fire ratios derived from the gas composition data obtained through the tube bundle mine atmospheric monitoring system are used in determining the fire status. A comprehensive and collaborative fire extinguishing effort including inert gas injection, underground pressure balance, and sealing enhancement are made to control the fire progress. Simultaneously, the effects of such works to control the spontaneous combustion event have also been quantified using the fire ratios to justify again. Finally, the danger of coal spontaneous combustion in gob is eliminated, and the longwall panel is successfully re-opened for normal production.

Ferroelastic hybrid perovskite materials have been revealed the significance in the applications of switches, sensors, actuators, etc. However, it remains a challenge to design high-temperature ferroelastic to meet the requirements for the practical applications. Herein, we reported an one-dimensional organic-inorganic hybrid perovskites (OIHP) (3-methylpyrazolium)CdCl3(3-MBCC), which possesses a mmmF2/mferroelastic phase transition at 263 K. Moreover, utilizing crystal engineering, we replace ‒CH3with ‒NH2and ‒H, which increases the intermolecular force between organic cations and inorganic frameworks. The phase transition temperature of (3-aminopyrazolium)CdCl3(3-ABCC), and (pyrazolium)CdCl3(BCC) increased by 73 K and 10 K, respectively. Particularly, BCC undergoes an unconventional inverse temperature symmetry breaking (ISTB) ferroelastic phase transition around 273 K. Differently, it transforms from a high symmetry low-temperature paraelastic phase (point group 2/m) to a low symmetry high-temperature ferroelastic phase (point group 1¯) originating from the rare mechanism of displacement of organic cations phase transition. It means that crystal BCC retains in ferroelastic phase above 273 K until melting point (446 K). Furthermore, characteristic ferroelastic domain patterns on crystal BCC are confirmed with polarized optical microscopy. Our study enriches the molecular mechanism of ferroelastics in the family of organic-inorganic hybrids and opens up a new avenue for exploring high-temperature ferroic materials.

During the gas extraction drilling process, especially the soft coal seam drilling process, due to the constraints of geological conditions, technical conditions, and other factors, it is easy to encounter stuck holes, blowout, lost circulation, and hole collapse, which affect the realization of efficient gas management. In the petroleum industry, microfoam drilling fluid has unique advantages as a drilling and flushing medium. Through the response surface method, this study conducts a preliminary experimental study on the types of foaming agents, foam stabilizers, modified bentonite materials, and filtrate reducers and determines the optimal formula as 3.98% modified bentonite + 0.586% compound foaming agent + 0.776% foam stabilizer + 1% sulfonated phenolic resin + 2% carboxymethyl starch sodium. The performance of the microfoam drilling fluid system is tested. Subsequently, a simulated soft coal seam drilling test is carried out to verify the effectiveness of the developed directional microfoam drilling fluid for protecting coal rock holes. This microfoam drilling fluid system technology can improve the drilling quality of the sealing section of coal seam gas extraction drilling and effectively improve the gas extraction rate of coal mines.

Organic–inorganic hybrid materials (OIHMs) have become a powerful platform for exploring ferroic materials due to the advantages of directional design on the molecular level. Here, based on a hybrid uniaxial ferroelectric (Quinuclidinium)GaCl4(QGC), a chiral hybrid (R-3-hydroxylquinuclidinium)GaCl4(R3HQGC) was successfully synthesized through a molecular strategy of H/OH substitution. R3HQGCexhibits a much higher Curie temperature (318 K) than QGC(284 K) because hydroxyl modification enhances intermolecular interactions, increasing the movement energy barrier. Meanwhile, R3HQGCshows multiaxiality and multiferroicity (the coexistence of ferroelectricity and ferroelasticity). Notably, R3HQGChas a large spontaneous polarization (19.4 μC·cm–2) exceeding those of most multiferroics and multiaxial ferroelectrics. Our study presents an effective approach to promote ferroelectric properties and gives deep insight into exploring high-performance hybrid multiferroic materials.

Organic-inorganic hybrid molecular fluorescent materials have attracted much attention due to their application potential in white LEDs and high-definition displays. However, achieving high thermal stability for the fields of lighting/displays remains greatly challenging based on the hybrid molecular materials. Herein, we reported a crystalline state 1D rigid rare-earth hybrid coordinate polymer molecular crystal [(CH3CH2)4N]Tb[CH2(SO3)2] (1) along with high quantum yield (QY) 75.2%. Interestingly, this hybrid molecular crystal remains stable up to 728 K (∼455 °C). Remarkably, it exhibits excellent fluorescence thermal stability at high temperatures (150 °C, >95% and 150–200 °C, >82%) and a high thermal activation energy of 568.7 meV. Besides, the fabricated n-UV chips based white-LED by 1, commercial red Y2O3:Eu3+and blue BaMgAl10O17:Eu2+phosphor emits white light with color coordinates (CIE, 0.33, 0.32), high color rendering index (CRI) of 91.2, and correlated color temperature (CCT) 5623 K. These results reveal that this ultrahigh thermal stability hybrid molecular crystal as a green phosphor has great potential applications for displays or WLEDs. Therefore, this study opens a new avenue to develop novel rare-earth phosphors and gives new visions for hybrid molecular fluorescent materials.

Stimuli-responsive multifunctional materials (SRMMs) have attracted tremendous attention due to their dynamic responses to external stimuli. However, it remains challenging to simultaneously achieve solvent-induced single-crystal to single-crystal (SCSC) transformation and structural phase transition after desolvation. Here, we report a two-dimensional (2D) rare-earth organic-inorganic hybrid coordinate polymer [(CH3)3NCH2Cl]2[Eu·H2O]2[CH2(SO3)2]4·2H2O (1) that exhibits a reversible SCSC transformation by changing to 2([(CH3)3NCH2Cl][Eu·H2O][CH2(SO3)2]2). Impressively, the SCSC transformation process couples with large changes in quantum efficiency dropped from 33.68% of 1to 20.07% that of 2. Furthermore, polymer 2shows an isomorphic structural phase transition associated with switching dielectric. Notably, the distance of the 2D layers shows reversible change during the two successive transition processes displaying a crystal sponge behavior. This work reveals the potential of rare-earth 2D hybrid coordination polymers in the design of multifunctional responsive materials and opens a new prospect to explore the construction of novel SRMMs.

In this paper, we present a hierarchical method of activity recognition for sleeping at the desk in business hall. The method consists of three steps. First, the reference points such as body joints are obtained from workers in business hall. Second, we build the dependency graph to represent the relationships between reference points. Third, the multidimensional output regressions along the dependency paths are used to estimate the positions of these reference body points. Experimental results demonstrate that our method achieves comparable accuracy to state-of-the-art results.

In this paper, we propose a blind image quality assessment (IQA) method under latent Dirichlet allocation (LDA) model. To assess the image quality, firstly, we learn topic-specific word distribution by training a set of pristine and distorted images without human subjective scores. Secondly, LDA model is used to estimate probability distribution of topic for the regions in the test images. Finally, we calculate the perceptual quality score of the test image by comparing the estimated probabilities of topics of the test image with that for the pristine images. Note that the quality-aware visual words are used to represent the images, which generated with respect to the natural scene statistic features. Experimental evaluation on the publicly available subjective-rated database LIVE demonstrates that our proposed method correlates reasonably well with different mean opinion scores (DMOS).

DNA strand displacement plays an essential role in the field of dynamic DNA nanotechnology. However, flexible regulation of strand displacement remains a significant challenge. Most previous regulatory tools focused on controllable activation of toehold and thus limited the design flexibility. Here, we introduce a regulatory tool termed cooperative branch migration (CBM), through which DNA strand displacement can be controlled by regulating the complementarity of branch migration domains. CBM shows perfect compatibility with the majority of existing regulatory tools, and when combined with forked toehold, it permits continuous fine-tuning of the strand displacement rate spanning 5 orders of magnitude. CBM manifests multifunctional regulation ability, including rate fine-tuning, continuous dynamic regulation, reaction resetting, and selective activation. To exemplify the powerful function, we also constructed a nested if-function signal processing system on the basis of cascading CBM reactions. We believe that the proposed regulatory strategy would effectively enrich the DNA strand displacement toolbox and ultimately promote the construction of DNA machines of higher complexity in nucleic acid research and biomedical applications.

Segment 8 is considered the largest liver segment, and its portal vein branches are generally divided into four parts, including ventral, dorsal, dorsolateral and medial branches (Shindoh et al., 2010; Takayasu et al., 1985) [1,2]. An anatomic combined subsegmentectomy could satisfy both the oncological quality of anatomical resection and the safety of parenchyma sparing principle if a small hepatocellular carcinoma is located between the hepatic subsegments (Berardi et al., 2021) [3]. Yet, laparoscopic anatomic combined subsegmentectomy of segment 8 is still technically challenging. The development of digital intelligent technology has made it possible to tailored preoperative planning and accurate intraoperative navigation in laparoscopic surgery.