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We aimed to discuss the correlation between the Hemophilia Early Detection Ultrasound in China (HEAD‐US‐C) score and the Hemophilia Joint Health Score version 2.1 (HJHS 2.1) of the knee joint in patients with hemophilia. We included 70 male patients with hemophilia admitted to The Second Hospital of Shanxi Medical University; the patients' bilateral knee joints were evaluated using the HEAD‐US‐C score and HJHS. We analyzed factors influencing hemophilia arthropathy of the knee and examined the correlation between the HEAD‐US‐C score and HJHS. The joint injury severity was positively correlated with age and the number of bleeds (P< .001). Further, the HEAD‐US‐C score and HJHS differed according to the severity (both P< .001), but not type (P= .163 and P= .283, respectively), of hemophilia. There was a significant correlation between the HEAD‐US‐C score and HJHS (P< .001). Overall, all joint lesions observed on ultrasound corresponded to clinical joint functional abnormalities. Therefore, the HEAD‐US‐C is important for hemophilic arthropathy evaluation and is useful in explaining abnormal joint function.

The synthesis of Cu catalysts for hydrazine oxidation has been an important focus for study. Herein, Cu nanorod arrays on Cu foam (Cu NRAs/CF) were synthesized. Profiting from its structural characteristics, hydrazine oxidation began at −1.03 V and the current density attained 178.8 mA cm−2at −0.6 V. Compared with CF and Cu NPs/CF, Cu NRAs/CF presented a lower charge transfer resistance (Rct) and apparent activation energy (Ea), indicating that hydrazine oxidation on Cu NRAs/CF was associated with comparatively fast kinetics.Graphical AbstractThe slow kinetics of the hydrazine oxidation reaction and the high price of noble metal electrocatalysts are the main reasons hindering the development of direct hydrazine fuel cells. The design and synthesis of non-precious-metal catalysts with excellent catalytic performance for hydrazine oxidation are the key to solving this challenge. Herein, Cu nanorod arrays on Cu foam (Cu NRAs/CF) were fabricated. The Cu NRAs/CF electrode displayed a low onset potential (−1.03 V vs. Ag/AgCl) and a high current density (178.8 mA cm−2at −0.6 V).

Although the functions of WRKY transcription factors in drought resistance are well known, their regulatory mechanisms in response to drought by stabilising photosynthesis remain unclear. Here, a differentially expressed PoWRKY71gene that was highly expressed in drought-treated Paeonia ostiileaves was identified through transcriptome analysis. PoWRKY71positively responded to drought stress with significantly enhanced expression patterns and overexpressing PoWRKY71in tobacco greatly improved plant tolerance to drought stress, whereas silencing PoWRKY71in P. ostiiresulted in a drought-intolerant phenotype. Furthermore, lower chlorophyll contents, photosynthesis, and inhibited expression of photosynthesis-related light-harvesting chlorophyll a/b-binding 151 (CAB151) gene were found in PoWRKY71-silenced P. ostii. Meanwhile, a homologous system indicated that drought treatment increased PoCAB151promoter activity. Interactive assays revealed that PoWRKY71 directly bound on the W-box element of PoCAB151promoter and activated its transcription. In addition, PoCAB151overexpressing plants demonstrated increased drought tolerance, together with significantly higher chlorophyll contents and photosynthesis, whereas these indices were dramatically lower in PoCAB151-silenced P. ostii.The above results indicated that PoWRKY71 activated the expression of PoCAB151, thus stabilising photosynthesis via regulating chloroplast homeostasis and chlorophyll content in P. ostiiunder drought stress. This study reveals a novel drought-resistance mechanism in plants and provides a feasible strategy for improving plant drought resistance via stabilising photosynthesis.

ABSTRACTPancreatic liposarcoma is a malignant tumor originated from the pancreas mesenchymal tissue and mostly presented in skin, subcutaneous, periosteum, and long bone on both sides. Both conventional chemotherapy and radiotherapy have limited efficacy and poor prognosis for advanced pancreatic liposarcoma. Here, we reported a case of advanced pancreatic liposarcoma and reviewed the literature specific for liposarcoma of the pancreas and discuss the emerging options of treatment. The patient was treated with apatinib and a cross-line rescue therapy combined with paclitaxel after progressive disease. The therapeutic effect of the combination regimen has been evaluated. Apatinib is an oral tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2 (VEGFR-2), which has dual effects of anti-angiogenesis and anti-tumor cell proliferation. To our knowledge, this is the first case to report the successful use of apatinib for advanced pancreatic liposarcoma.

This paper proposes a telecom big data based user offloading self-optimisation (TBDUOS) scheme. Its aim is to assist telecom operators to effectively balancing the load distribution with achieving good service performance and customer management in heterogeneous relay cellular systems. To achieve these objectives, in the cell-level offloaded traffic analysis stage, the optimal offloaded traffic is calculated to minimise the total blocking probability. In the user-level offloading stage, the user portrait is drawn and the K-MEANS algorithm is employed to manage the users clustering in the heavily loaded cell, and finally shifting users to assistant cells. Simulation results show the TBDUOS scheme can effectively reduce the handover failure and call dropping of specific users, especially voice/stream users, high consumption users, high level users. The TBDUOS scheme can also reduce the blocking probability.

Nitrogen and phosphorus dual-doped multilayer graphene (NPG) was prepared by arc discharge process.NPG exhibits good rate capability and stable cycling performance in both lithium and potassium ion batteries.Full carbon-based lithium/potassium ion capacitors are assembled and show excellent electrochemical performance.