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17 results on '"Lombardi, Carlo Mario"'

5. Machine learning for prediction of in-hospital mortality in coronavirus disease 2019 patients: results from an Italian multicenter study

Author

Vezzoli, Marika, Inciardi, Riccardo Maria, Oriecuia, Chiara, Paris, Sara, Murillo, Natalia Herrera, Agostoni, Piergiuseppe, Ameri, Pietro, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Pagnesi, Matteo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Senni, Michele, Sinagra, Gianfranco, Tomasoni, Daniela, Adamo, Marianna, Volterrani, Maurizio, Maroldi, Roberto, Metra, Marco, Lombardi, Carlo Mario, and Specchia, Claudia

Published
2022
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6. Sex-related differences in patients with coronavirus disease 2019: results of the Cardio-COVID-Italy multicentre study

Author

Lombardi, Carlo Mario, Specchia, Claudia, Conforti, Fabio, Rovere, Maria Teresa La, Carubelli, Valentina, Agostoni, Piergiuseppe, Carugo, Stefano, Danzi, Gian Battista, Guazzi, Marco, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Ameri, Pietro, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Iorio, Annamaria, Bellasi, Antonio, Canale, Claudia, Camporotondo, Rita, Catagnano, Francesco, Dalla Vecchia, Laura Adelaide, Di Pasquale, Mattia, Giovinazzo, Stefano, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Oriecuia, Chiara, Pala, Laura, Peveri, Giulia, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Adamo, Marianna, Tomasoni, Daniela, Inciardi, Riccardo Maria, Senni, Michele, and Metra, Marco

Published
2022
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7. A national survey on prevalence of possible echocardiographic red flags of amyloid cardiomyopathy in consecutive patients undergoing routine echocardiography: study design and patients characterization — the first insight from the AC-TIVE Study

Author

Merlo, Marco, Porcari, Aldostefano, Pagura, Linda, Cameli, Matteo, Vergaro, Giuseppe, Musumeci, Beatrice, Biagini, Elena, Canepa, Marco, Crotti, Lia, Imazio, Massimo, Forleo, Cinzia, Cappelli, Francesco, Favale, Stefano, Di Bella, Gianluca, Dore, Franca, Lombardi, Carlo Mario, Pavasini, Rita, Rella, Valeria, Palmiero, Giuseppe, Caiazza, Martina, Albanese, Miriam, Guaricci, Andrea Igoren, Branzi, Giovanna, Caponetti, Angelo Giuseppe, Saturi, Giulia, La Malfa, Giovanni, Merlo, Andrea Carlo, Andreis, Alessandro, Bruno, Francesco, Longo, Francesca, Sfriso, Enrico, Di Ienno, Luca, De Carli, Giuseppe, Giacomin, Elisa, Spini, Valentina, Milidoni, Antonino, Limongelli, Giuseppe, Autore, Camillo, Olivotto, Iacopo, Badano, Luigi, Parati, Gianfranco, Perlini, Stefano, Metra, Marco, Emdin, Michele, Rapezzi, Claudio, and Sinagra, Gianfranco

Published
2022
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8. Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study

Author

Lombardi, Carlo Mario, Carubelli, Valentina, Iorio, Annamaria, Inciardi, Riccardo M., Bellasi, Antonio, Canale, Claudia, Camporotondo, Rita, Catagnano, Francesco, Dalla Vecchia, Laura A., Giovinazzo, Stefano, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Oriecuia, Chiara, Peveri, Giulia, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Tomasoni, Daniela, Ameri, Pietro, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Agostoni, Piergiuseppe, Carugo, Stefano, Danzi, Gian Battista, Guazzi, Marco, La Rovere, Maria Teresa, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Specchia, Claudia, Metra, Marco, and Senni, Michele

Abstract

IMPORTANCE: Myocardial injury, detected by elevated plasma troponin levels, has been associated with mortality in patients hospitalized with coronavirus disease 2019 (COVID-19). However, the initial data were reported from single-center or 2-center studies in Chinese populations. Compared with these patients, European and US patients are older, with more comorbidities and higher mortality rates. OBJECTIVE: To evaluate the prevalence and prognostic value of myocardial injury, detected by elevated plasma troponin levels, in a large population of White Italian patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This is a multicenter, cross-sectional study enrolling consecutive patients with laboratory-confirmed COVID-19 who were hospitalized in 13 Italian cardiology units from March 1 to April 9, 2020. Patients admitted for acute coronary syndrome were excluded. Elevated troponin levels were defined as values greater than the 99th percentile of normal values. MAIN OUTCOMES AND MEASURES: Clinical characteristics and outcomes stratified as elevated or normal cardiac troponin levels at admission, defined as troponin T or troponin I at a level greater than the 99th percentile of normal values. RESULTS: A total of 614 patients with COVID-19 were included in this study (mean age [SD], 67 [13] years; 70.8% male), of whom 148 patients (24.1%) died during the hospitalization. Elevated troponin levels were found in 278 patients (45.3%). These patients were older (mean [SD] age, 64.0 [13.6] years vs 71.3 [12.0] years; P < .001) and had higher prevalence of hypertension (168 patients [50.5%] vs 182 patients [65.9%]; P < .001), heart failure (24 [7.2%]; 63 [22.8%]; P < .001), coronary artery disease (50 [15.0%] vs 87 [31.5%]; P < .001), and atrial fibrillation (33 [9.9%] vs 67 [24.3%]; P < .001). Elevated troponin levels were associated with an increased in-hospital mortality (37% vs 13%; HR, 1.71 [95% CI, 1.13-2.59]; P = .01 via multivariable Cox regression analysis), and this was independent from concomitant cardiac disease. Elevated troponin levels were also associated with a higher risk of in-hospital complications: heart failure (44 patients [19.2%] vs 7 patients [2.9%]; P < .001), sepsis (31 [11.7%] vs 21 [6.4%]; P = .03), acute kidney failure (41 [20.8%] vs 13 [6.2%]; P < .001), multiorgan failure (21 [10.9%] vs 6 [2.9%]; P = .003), pulmonary embolism (27 [9.9%] vs 17 [5.2%]; P = .04), delirium (13 [6.8%] vs 3 [1.5%]; P = .02), and major bleeding (16 [7.0%] vs 4 [1.6%]; P = .008). CONCLUSIONS AND RELEVANCE: In this multicenter, cross-sectional study of Italian patients with COVID-19, elevated troponin was an independent variable associated with in-hospital mortality and a greater risk of cardiovascular and noncardiovascular complications during a hospitalization for COVID-19.

Published
2020
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9. Is There a Role for Ivabradine Beyond its Conventional Use?

Author

Bonadei, Ivano, Vizzardi, Enrico, Sciatti, Edoardo, Carubelli, Valentina, Lombardi, Carlo Mario, D'Aloia, Antonio, and Metra, Marco

Abstract

Results of recent clinical trials in patients with stable angina and chronic heart failure have successfully demonstrated a beneficial role of use of ivabradine in addition to the conventional therapy. Based on the results of these trials, the aim of our review was to give an overview of the literature about the use of ivabradine in clinical settings outside its usual purpose.

Published
2014
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14. 554 Machine learning for prediction of in-hospital mortality in COVID-19 patients: results from an Italian multicentre study

Author

Paris, Sara, Inciardi, Riccardo Maria, Specchia, Claudia, Vezzoli, Marika, Oriecuia, Chiara, Lombardi, Carlo Mario, Murillo, Natalia Herrera, Pagnesi, Matteo, Tomasoni, Daniela, Ameri, Pietro, Carubelli, Valentina, Agostoni, Piergiuseppe, Canale, Claudia, Carugo, Stefano, Danzi, Giambattista, Pasquale, Mattia Di, Sarullo, Filippo, Rovere, Maria Teresa La, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Iorio, Annamaria, Giovinazzo, Stefano, Bellasi, Antonio, Zaccone, Gregorio, Camporotondo, Rita, Catagnano, Francesco, Vecchia, Laura Dalla, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Pozzi, Andrea, Provenzale, Giovanni, Tedino, Chiara, Guazzi, Marco, Senni, Michele, and Metra, Marco

Published
2021
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16. 380 Left heart disease phenotype and use of pulmonary vasodilators in elderly patients with pulmonary arterial hypertension: the Patriarca registry

Author

Toma, Matteo, Miceli, Roberta, Bonsante, Edoardo, Confalonieri, Marco, Garascia, Andrea, Ghio, Stefano, Lattanzio, Mariangela, Lombardi, Carlo Mario, Paciocco, Giuseppe, Piccinino, Cristina, Rota, Irene, Scelsi, Laura, Scuri, Piermario, Stolfo, Davide, Vincenzi, Antonella, Vicenzi, Marco, and Ameri, Pietro

Published
2021
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17. Congestion in Patients with Advanced Heart Failure

Author

Lombardi, Carlo Mario, Cimino, Giuliana, Pellicori, Pierpaolo, Bonelli, Andrea, Inciardi, Riccardo, Pagnesi, Matteo, Tomasoni, Daniela, Ravera, Alice, Adamo, Marianna, Carubelli, Valentina, and Metra, Marco

Abstract

Heart failure (HF) is characterized by frequent hospital admissions due to acute decompensation and shortened life span with a progressive clinical course leading to an advanced stage where traditional therapies become ineffective. Due to aging of the population and improved therapies, only a small of proportion of patients with advanced HF are candidates for surgical treatments, such as mechanical circulatory support or heart transplantation. In most cases, prompt identification and management of congestion is paramount to improving symptoms and quality of life and avoiding progression to severe multiorgan dysfunction and death.

Published
2021
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