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Background:Short-term variability of repolarization derived from the QT-interval (STV-QT) has previously been demonstrated to increase prior to arrhythmias in both humans and animals. To continuously monitor the arrhythmic risk by a cardiovascular implantable electronic device (CIED), a fully automatic method to determine STV on intracardiac electrograms (STV-EGMauto) has been developed. This method demonstrated high effectiveness in monitoring and predicting Torsade de Pointes arrhythmias in the CAVB dog model. However, this technique has not been evaluated in arrhythmias related to ischemia yet.Purpose:To assess the novel automatic method of arrhythmic risk monitoring by CIEDs through STV-EGMautomeasurements in a porcine model of ischemia-induced ventricular fibrillation (VF).Methods:Myocardial infarction was induced in 8 anesthetized pigs by balloon occlusion of the left anterior descending coronary artery for 75 minutes, followed by reperfusion. Monitoring included a 12-lead ECG and a duodecapolar EGM catheter in the right ventricle. STV-EGMautoand STV-QT, our gold standard calculated by the method of fiducial segment averaging, were assessed at baseline, occlusion, one minute before VF and just before VF. The STV values and the percentual changes from baseline to the successive three timepoints were compared between STV-EGMautoand STV-QT.Results:VF occurred 21±8.8 minutes after occlusion. Both STV-EGMautoand STV-QT increased significantly from baseline to VF (1.1±0.8 ms vs2.4±1.5 ms, p<0.05; 1.0±0.5 ms vs2.2±0.9 ms, p<0.05, respectively). The percentual change in STV-EGMautofrom baseline to occlusion, one minute before VF and VF showed an excellent correlation with the changes in STV-QT from baseline to the successive timepoints (r2= 0.94; p<0.001). Bland-Altman analysis of the values showed a small bias of 0.26 ms and 95% limits of agreement between -1.1 and 1.6 ms.Conclusion:The STV values derived from the fully-automatic method for continuous STV measurements on intracardiac EGM signals (STV-EGMauto) show values and trends similar to the clinically validated STV-QT in a porcine model of ischemia-related VF. Future integration of this technique in CIEDs can furnish continuous monitoring of arrhythmic risk.