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The performance of high baud-rate fiber optical transmission with the use of advanced modulation formats is sensitive to the imperfection arising in transmitter optical sub-assembly (TOSA), and thus the effective calibration of the TOSA full-field response is essential. However, traditional TOSA frequency response characterization solutions are either inconvenient for the on-field measurement or unable to obtain the phase frequency response (PFR). Here, we report a simple and precise scheme to characterize the full-field frequency response of broadband TOSA, including both amplitude frequency response (AFR) and PFR, when only a single photodetector (PD) with narrow bandwidth is employed. A multiple dual-tone signals with specially designed frequency positions are implemented for electrical-to-optical modulation. Then, a few beat signals after direct detection occur at unique frequencies without the spectral overlapping. Thus, it is feasible to extract the full-field frequency response of broadband TOSA, under the single-shot measurement. Moreover, the in-phase and quadrature (IQ) skew can be obtained by comparing PFRs between I and Q tributaries. In the experiment, we successfully characterize a coherent TOSA with a 10 dB bandwidth of 40 GHz, when a single PD with a 3 dB bandwidth of 2 GHz is used. In comparison with the optical spectrum analyzer (OSA) based scheme, the measured AFR deviation is less than 1 dB over the 10 dB bandwidth. When multiple single-shot measurements are implemented within 1 minute, the fluctuation of measured PFR and IQ skew are less than 0.2 rad and 1 ps, respectively. With the help of the measured full-field frequency response, the coherent TOSA can be calibrated to realize 64 GBaud 16-quadrature amplitude modulation (QAM) back-to-back transmission, when the threshold of 7% hard-decision forward error correction (HD-FEC) is set.

Short-time Fourier transform (STFT) is a vital tool to observe spectral dynamics of non-stationary signals. Conventional STFT based on digital signal processing (DSP) usually suffers from a limited acquisition frame rate within 106 Fourier transforms per second (FTs/s). Thus, it is unable to fully intercept transient information in time and frequency shorter than a few microseconds. Further extending the acquisition frame rate can be achieved by employing the dispersion-based all-optical spectral analysis approach, while the optical dispersion usually introduces a large latency. Here, we experimentally report a low-latency STFT of microwave photonic processing, where a passive fiber loop is used to provide high value equivalent dispersion. Consequently, the latency of the STFT processing can be greatly reduced. The spectrograms of microwave signals, including instantaneous information in both time and frequency, are acquired in a real-time manner, with an acquisition frame rate of about $5 \times {10}^8$ FTs/s and a processing latency of less than 0.2 ${{\bf \mu s}}$. High temporal resolution within tens of nanosecond range can be achieved, allowing us to capture 30-ns duration frequency transients in real time with a instantaneous bandwidth of about 530 MHz. Our proposed STFT processing scheme is promising for real-time and high-speed spectral dynamic analysis for non-stational signals.

Phase-retrieval (PR) receivers can reconstruct complex-valued signals from two de-correlated intensity measurements by the use of iterative PR algorithm, without the assistance of any optical carriers. However, both the computational complexity with hundreds of iterations and the limited PR accuracy prevent it from being applied to high-speed photonic interconnections. In current submission, we propose a weighted decision enhanced PR receiver with adaptive intensity transformation (WD_AIT_PR). The weighted decision based on a compressed sigmoid nonlinear function is helpful to avoid the hard-decision (HD) errors, leading to the performance enhancement of the PR receiver, in terms of both convergence speed and PR accuracy. When the 56 GBaud 16QAM signal after transmission over 80 km standard single mode fiber (SSMF) is reconstructed, the WD_AIT_PR receiver is numerically verified to possess the faster convergency speed with only 70 iterations and the best steady BER performance by reducing the required optical signal-to-noise ratio (OSNR) by 0.8 dB, 1.8 dB and 1.8 dB in order to reach 7% HD forward error correction (HD-FEC), in comparison with the HD_AIT_PR receiver by replacing WD with HD, the PR receiver with the phase reset (PR_PR) and the PR receiver with adaptive intensity transformation (AIT_PR), respectively. Meanwhile, the WD_AIT_PR receiver is robust to transmission impairments, including transmitter-side I/Q imbalance, receiver-side skew, the noise imbalance between two intensity measurements, laser phase noise, and laser wavelength drift. Finally, the enhanced performance of the WD_AIT_PR receiver is experimentally verified through recovering 25 GBaud 16QAM signals under the condition of 40 km SSMF transmission.

In this letter, we propose a joint multi-service (MS) transmission scheme based on cell-free (CF) massive MIMO architecture. Based on the user-centric (UC) principle, we perform access point (AP) selection and form broadcast, multicast, and unicast messages at each AP according to the rate splitting multiple access (RSMA) technique, then we carry out the joint transmission of MS signals. In terms of system optimization, a novel three-step resource allocation algorithm is proposed to deal with the non-convex problem of achievable sum-rate maximization which downscales multidimensional variables to solve the one-dimensional problems of AP selection, intra-AP power ratio determination, and inter-AP power allocation in steps. We provide achievable sum-rate analyses backed by numerical results to show the superiority of the proposed scheme and optimization algorithm compared with the baselines.

Photonic fractional Fourier transformation (FRFT) based on discrete-frequency processing is proposed to overcome the limitations of processing latency, resolution, and tunability. Typical applications of FRFT, such as de-chirp processing, separation of two linear frequency modulated waveforms (LFMWs) in fractional domain and filtering of a LFMW from a noisy background, are experimentally demonstrated. The operation bandwidth and spectral resolution are 4 GHz and 60 MHz, respectively. Both the phase and amplitude can be measured by the proposal without relying on complex algorithms, while the processing latency is close to the minimum delay required in the FRFT. All optical devices employed in our system shows great potential in integration.

A scientific delineation of geographical boundaries reflects the cognitive level of scientific abstraction and systematic analysis of the spatial variation of geographical objects and is a basic scientific issue of geography. From the perspective of earth system science, this study first explicates the core issues (e.g., basic concepts, scientific contents, and basic properties) of geographical boundaries. Based on the principles of scientificity and systematicness, we then classify geographical boundaries in terms of intrinsic mechanisms, extrinsic appearance and scientific attributes. Furthermore, this paper analyzes the mathematical connotation and representation methods of geographical boundaries, discusses the characteristics of and differences between traditional and modern methods for geographical boundary delineation. Finally, we present a framework for a “geographical boundary model” with an integration of qualitative, quantitative, and positioning methods. Focusing on geographical boundary (a basic theoretical problem in geography), this study engaged in concept definition and method analysis, with the findings enriching the theory and methodology of geographical information science.

Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain. In this study, we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2 (PGE2) concentration in response to mechanical loading. Bone PGE2 levels are in proportion to their weight bearing. When weight bearing changes in the tail-suspension mice, the PGE2 concentrations in bones change in line with their weight bearing changes. Deletion of cyclooxygenase-2 (COX2)in the osteoblast lineage cells or knockout of receptor 4 (EP4)in sensory nerve blunts bone formation in response to mechanical loading. Moreover, knockout of TrkAin sensory nerve also significantly reduces mechanical load-induced bone formation. Moreover, mechanical loading induces cAMP-response element binding protein (CREB) phosphorylation in the hypothalamic arcuate nucleus (ARC) to inhibit sympathetic tyrosine hydroxylase (TH) expression in the paraventricular nucleus (PVN) for osteogenesis. Finally, we show that elevated PGE2 is associated with ankle osteoarthritis (AOA) and pain. Together, our data demonstrate that in response to mechanical loading, skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis, while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.

Tunable microwave dispersion is highly desired for a wide field of microwave signal processing. However, a conventional microwave dispersive delay line usually suffers from either a small dispersion value or a narrow operation bandwidth. Here, we experimentally demonstrate the optically magnified dispersion of a microwave signal with a wide and flexible tunable range, based on a bandwidth-scaling microwave photonic system. The obtained microwave dispersion can therefore be magnified from the corresponding optical dispersion with a magnification factor that can be continuously tuned from 10,000 to 85,000. Meanwhile, a proof-of-concept experiment that includes both compression and stretching of chirped microwave pulses is reported. Microwave dispersion from 1.34?ns/GHz to 10.92?ns/GHz can be secured by the corresponding magnification of an optical dispersion value of 16 ps/nm.

This paper presents the experimental and finite element analysis of parametric research of precast reinforced concrete U-shaped box culvert subject to loading conditions at the roof and both sidewalls of the culvert through beam support steel bar. This culvert was investigated based on two ways. Firstly, the experiment was tested with seventeen different trial load tests with four controlling load trials. The variables in the test including the deflection and crack width were presented and interpreted. The test specimen result showed similar crack patterns with respect to the initiation and propagation as well as the load–deflection plot. Generally, the initial superficial flexural cracks occurred on the roof, floor slab, and sidewalls directly. Flexural cracks continued to occur in these places throughout the testing. This paper proposes a series of crack sensors in contact with the culvert to completely meet the requirements of the culverts, and their carrying capacity due to sensing performance. Secondly, the finite element method was used to analyze the structural behaviors and crack strains of the standard three-dimensional U-shaped box culverts under different loading conditions using brick elements in ABAQUS-V6.14-4 software. The culvert was modeled using three-dimensional solid elements for concrete and wire elements for reinforcement being geometric and material linearity besides the reinforcement was modeled as rebar elements embedded in the surface elements. Finally, the typical load–deflection plots obtained from the experiments are compared with those obtained from finite element modeling analyses and the effects of with and without distribution reinforcement on the culvert are insignificant.

The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying genetic aberrations1–4as well as the makeup of the tumour microenvironment5,6. Quantifying the contributions of these factors requires new technologies that can accurately measure the spatial location of genomic sequence together with phenotypic readouts. Here we developed slide-DNA-seq, a method for capturing spatially resolved DNA sequences from intact tissue sections. We demonstrate that this method accurately preserves local tumour architecture and enables the de novo discovery of distinct tumour clones and their copy number alterations. We then apply slide-DNA-seq to a mouse model of metastasis and a primary human cancer, revealing that clonal populations are confined to distinct spatial regions. Moreover, through integration with spatial transcriptomics, we uncover distinct sets of genes that are associated with clone-specific genetic aberrations, the local tumour microenvironment, or both. Together, this multi-modal spatial genomics approach provides a versatile platform for quantifying how cell-intrinsic and cell-extrinsic factors contribute to gene expression, protein abundance and other cellular phenotypes.

Utilizing a gene evolution-oriented approach for gene cluster mining, a cryptic cytochalasin-like gene cluster (sla) in Antarctic-derived Simplicillium lamelliciolaHDN13430 was identified. Compared with the canonical cytochalasin biosynthetic gene clusters (BGCs), the slagene cluster lacks the key α,β-hydrolase gene. Heterologous expression of the slagene cluster led to the discovery of a new compound, slamysin (1), characterized by an N-acylated amino acid structure and demonstrating weak anti-Bacillus cereusactivity. These findings underscore the potential of genetic evolution in uncovering novel compounds and indicating specific adaptive evolution within specialized habitats.

Lyophilized keratinocyte-targeted nanocarriers (TLNκ) loaded with locked nucleic acid (LNA) modified anti-miR were developed for topical application to full thickness burn injury. TLNκwere designed to selectively deliver LNA-anti-miR-107 to keratinocytes using the peptide sequence ASKAIQVFLLAG. TLNκemployed DOTAP/DODAP combination pH-responsive lipid components to improve endosomal escape. To minimize interference of clearance by non-targeted cells, especially immune cells in the acute wound microenvironment, surface charge was neutralized. Lyophilization was performed to extend the shelf life of the lipid nanoparticles (LNPs). Encapsulation efficiency of anti-miR in lyophilized TLNκwas estimated to be 96.54%. Cargo stability of lyophilized TLNκwas tested. After 9 days of loading with anti-miR-210, TLNκwas effective in lowering abundance of the hypoxamiR miR-210 in keratinocytes challenged with hypoxia. Keratinocyte uptake of DiD-labeled TLNκwas selective and exceeded 90% within 4 hr. Topical application of hydrogel-dispersed lyophilized TLNκencapsulating LNA anti-miR-107 twice a week significantly accelerated wound closure and restoration of skin barrier function. TLNκ/anti-miR-107application depleted miR-107 and upregulated dicer expression, which accelerated differentiation of keratinocytes. Expression of junctional proteins such as claudin-1, loricrin, filaggrin, ZO-1, and ZO-2 were significantly upregulated following TLNκ/anti-miR-107treatment. These LNPs are promising as topical therapeutic agents in the management of burn injury.

A novel microwave shaper is proposed and demonstrated, of which the microwave spectral transfer function could be fully programmable with high resolution. We achieve this by bandwidth-compressed mapping a programmable optical wave-shaper, which has a lower frequency resolution of tens of gigahertz, to a microwave one with resolution of tens of megahertz. This is based on a novel technology of “bandwidth scaling,” which employs bandwidth-stretched electronic-to-optical conversion and bandwidth-compressed optical-to-electronic conversion. We demonstrate the high resolution and full reconfigurability experimentally. Furthermore, we show the group delay variation could be greatly enlarged after mapping; this is then verified by the experiment with an enlargement of 194 times. The resolution improvement and group delay magnification significantly distinguish our proposal from previous optics-to-microwave spectrum mapping.

We demonstrate a novel real-time Fourier transformation scheme with megahertz-level resolution realized by bandwidth magnification of radio frequency (RF) signals. Before the frequency-to-time mapping, the RF signal is modulated on an optical frequency comb, and then extracted by a Vernier comb filter. As a result, RF components can be separated in the spectrum with a greatly magnified optical bandwidth. Thus, even with limited dispersion provided by an ordinary optical fiber, the frequency-dependent pulses can be distinguished in the time domain. Experimentally, the RF signal with the frequency difference of 60 MHz is separated by around 123 ps in the time domain, equivalent to the dispersion of 1975.5 ps/GHz (2.47×10^5  ps/nm), while the physical dispersion is 1500 ps/nm. Thus, based on the bandwidth magnification of signals, the dispersion is equivalently amplified by 165 times.

It was studied the optimization of power control strategy parameters for reduction of gas consumption of a series-parallel LNG-electricity hybrid bus. The control parameters included the up and low limit value of SOC of super-capacitor, limited speed of vehicle in pure electric model, shutoff torque coefficient of engine and charging coefficient. The optimization was carried out by joint simulation by coupling the performance simulation model of vehicle and the optimization model of control parameters. It was applied DOE of Latin hypercube in simulation test, and set up relationship between control parameters with gas consumption by approximate model of quadratic response. The optimal value of control parameters was gotten with Multi-island genetic algorithm, and the gas consumption of bus was reduced effectively.

SAPO-11 molecular sieves were synthesized using silica sol, hydrophilic fumed silica, and tetraethyl orthosilicate (TEOS) as silicon precursors. Their physicochemical properties were characterized using XRD, SEM, nitrogen adsorption-desorption, Py-IR, NH3-TPD, EDS, and 27Al, 31P, 29Si MAS NMR techniques. The catalytic performance was assessed in the hydroisomerization of n-octane. The results showed that the silicon precursors influenced the physicochemical properties and catalytic performance of SAPO-11. SAPO-11 synthesized using hydrophilic fumed silica as silicon precursor showed higher silicon distribution and had more medium acid sites. SAPO-11 synthesized using TEOS as silicon precursor had more silicon content, but more silicon islands formed in its framework. The depolymerization of silicon precursors might affect the silicon content and distribution in SAPO-11. In the hydroisomerization of n-octane, the catalytic activity strongly depended on the number of medium acid sites instead of the number of total acid sites. SAPO-11 synthesized using hydrophilic fumed silica as silicon precursor exhibited higher catalytic activity than the other samples because it has more medium acid sites.

The 2022 MS6.8 Luding earthquake is the strongest earthquake in Sichuan Province, Western China, since the 2017 MS7.0 Jiuzhaigou earthquake. It occurred on the Moxi fault in the southeastern segment of the Xianshuihe fault, a tectonically active and mountainous region with severe secondary earthquake disasters. To better understand the seismogenic mechanism and provide scientific support for future hazard mitigation, we summarize the preliminary results of the Luding earthquake, including seismotectonic background, seismicity and mainshock source characteristics and aftershock properties, and direct and secondary damage associated with the mainshock. The peak ground displacements in the NS and EW directions observed by the nearest GNSS station SCCM are ∼35 mm and ∼55 mm, respectively, resulting in the maximum coseismic dislocation of 20 mm along the NWW direction, which is consistent with the sinistral slip on the Xianshuihe fault. Back-projection of teleseismic P waves suggest that the mainshock rupture propagated toward south-southeast. The seismic intensity of the mainshock estimated from the back-projection results indicates a Mercalli scale of VIII or above near the ruptured area, consistent with the results from instrumental measurements and field surveys. Numerous aftershocks were reported, with the largest being MS4.5. Aftershock locations (up to September 18, 2022) exhibit 3 clusters spanning an area of 100 km long and 30 km wide. The magnitude and rate of aftershocks decreased as expected, and the depths became shallower with time. The mainshock and two aftershocks show left-lateral strike-slip focal mechanisms. For the aftershock sequence, the b-value from the Gutenberg-Richter frequency-magnitude relationship, h-value, and p-value for Omori's law for aftershock decay are 0.81, 1.4, and 1.21, respectively, indicating that this is a typical mainshock-aftershock sequence. The low b-value implies high background stress in the hypocenter region. Analysis from remote sensing satellite images and UAV data shows that the distribution of earthquake-triggered landslides was consistent with the aftershock area. Numerous small-size landslides with limited volumes were revealed, which damaged or buried the roads and severely hindered the rescue process.

Planation surface, a surface that is almost flat, is a kind of low-relief landforms. Planation surface is the consequence of the denudation and planation processes under a tectonic stable condition. The quantitative expression of the characteristics of planation surface plays a key role in reconstructing and describing the evolutionary process of landforms. In this study, Landform Planation Index (LPI), a new terrain derivative, was proposed to quantify the characteristics of planation surface. The LPIs were calculated based on the summit surfaces formed according to the clustering results of peaks. Ten typical areas in the Ordos Platform located in the central part of the Loess Plateau of China are chosen as the test areas for investigating their planation characteristics with the LPI. The experimental results indicate that the LPI can be effectively used to quantify the characteristics of planation surfaces. In addition, the LPI can be further used to depict the patterns of spatial differentiation in the Ordos Platform. Although the present Ordos Platform area is full of the high-density gullies, its planation characteristics is found to be well preserved. Furthermore, the characteristics of the planation surfaces can also reflect the original morphology of the Ordos Platform before the loess dusts deposition process evolved in this area. The statistical results of the LPI show that there is a gradually increasing tendency along with the increasing of slope gradient of summit surface. It indicates that the characteristics of planation surfaces vary among test areas with different landforms. These findings help to deepen the understanding of planation characteristics of the loess landform and its underlying paleotopography. Results of this study can be also served as an important theoretical reference value for revealing the evolutionary process of loess landform.

microRNA-21 (miR-21) is an oncomiR that is frequently upregulated in human cancers. AntimiR-21 (AM-21) is an oligonucleotide complementary to miR-21 that is designed to inhibit its gene silencing activities. To facilitate efficient delivery of AM-21, a novel lipid nanoparticle formulation called QTsome, based on a combination of quaternary amine and tertiary amine cationic lipids, with a distinctive pH-responsive profile, was developed. QTsome/AM-21 comprising DODMA/DOTAP/DOPC/CHOL/mPEG-DPPE and AM-21 oligonucleotide exhibited a mean particle diameter of below 150 nm, moderate zeta potential (+13.2 mV), excellent colloidal stability, and high drug loading efficiency (above 80%). In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets, including PTEN and DDAH1, in A549 cells while increasing their sensitivity toward paclitaxel (PTX). Finally, tumor regression, prolonged survival, and miR-21 target upregulation were demonstrated in an A549 xenograft mouse model. These data suggest that QTsome/AM-21 warrants further evaluation as an anticancer agent.

Most computational protein structure prediction methods are designed for either templatebased or template-free (ab initio) structure prediction. The approaches that integrate the prediction capabilities of both template-based modeling and template-free modeling are needed to synergistically combine the two kinds of methods to improve protein structure prediction. In this work, we develop a new method to integrate several protein structure prediction methods including our template-based MULTICOM server, our ab initio contact-based protein structure prediction method CONFOLD, our multi-template-based model generation tool MTMG, and locally installed external Rosetta, I-TASSER and RaptorX protein structure prediction tools to improve protein structure prediction of a fullspectrum difficulty ranging from easy, to medium and to hard. Our method participated in the 11thcommunity-wide Critical Assessment of Techniques for Protein Structure Prediction (CASP11) in 2014 as MULTICOM-NOVEL server. It was ranked among top 10 methods for protein tertiary structure prediction according to the official CASP11 assessment, which demonstrates that integrating complementary modeling methods is useful for advancing protein structure prediction.

S-Nitrosylation is a redox-based protein post-translational modification in response to nitric oxide signaling and is involved in a wide range of biological processes. Detection and quantification of protein S-nitrosylation have been challenging tasks due to instability and low abundance of the modification. Many studies have used mass spectrometry (MS)-based methods with different thiol-reactive reagents to label and identify proteins with S-nitrosylated cysteine (SNO-Cys). In this study, we developed a novel iodoTMT switch assay (ISA) using an isobaric set of thiol-reactive iodoTMTsixplex reagents to specifically detect and quantify protein S-nitrosylation. Irreversible labeling of SNO-Cys with the iodoTMTsixplex reagents enables immune-affinity detection of S-nitrosylated proteins, enrichment of iodoTMT-labeled peptides by anti-TMT resin, and importantly, unambiguous modification site-mapping and multiplex quantification by liquid chromatography–tandem MS. Additionally, we significantly improved anti-TMT peptide enrichment efficiency by competitive elution. Using ISA, we identified a set of SNO-Cys sites responding to lipopolysaccharide (LPS) stimulation in murine BV-2 microglial cells and revealed effects of S-allyl cysteine from garlic on LPS-induced protein S-nitrosylation in antioxidative signaling and mitochondrial metabolic pathways. ISA proved to be an effective proteomic approach for quantitative analysis of S-nitrosylation in complex samples and will facilitate the elucidation of molecular mechanisms of nitrosative stress in disease.

Atrazine (ATR) and chlorpyrifos (CPF) are widely used in agriculture, but have resulted in a series of toxicological and environmental problems. They were heavily used which have potential threat to fish and rodents. Several recent laboratory studies have shown ATR and CPF could lead to oxidative damage, immunocyte reduced and inhibit acetylcholinesterase (AChE). In order to clarify the toxicity of ATR and CPF, this paper summarized the adverse effects of ATR and CPF on reproduction, nerve and immune systems in fish.

Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their dynamics in the native context of seminiferous tubules, the spatially confined functional units of spermatogenesis. Here, we use Slide-seq, a spatial transcriptomics technology, to generate an atlas that captures the spatial gene expression patterns at near-single-cell resolution in the mouse and human testis. Using Slide-seq data, we devise a computational framework that accurately localizes testicular cell types in individual seminiferous tubules. Unbiased analysis systematically identifies spatially patterned genes and gene programs. Combining Slide-seq with targeted in situRNA sequencing, we demonstrate significant differences in the cellular compositions of spermatogonial microenvironment between mouse and human testes. Finally, a comparison of the spatial atlas generated from the wild-type and diabetic mouse testis reveals a disruption in the spatial cellular organization of seminiferous tubules as a potential mechanism of diabetes-induced male infertility.

The need to effectively and selectively remove radioactive 137Cs and 90Sr from nuclear waste solutions persists to mitigate their environmental mobility and high radiotoxicity. Because it is difficult to effectively remove them from acidic environments that degrade most sorbents, new sorbent materials are highly desirable. Here, efficient removal of Cs+and Sr2+is achieved by the composite of layered tin sulfide (Me2NH2)4/3(Me3NH)2/3Sn3S7·1.25H2O (FJSM-SnS) and polyacrylonitrile (PAN) (FJSM-SnS/PAN). The granulous composite possesses regular particle morphology and good mechanical strength as an engineered form. It shows excellent acid–base and γ-irradiation resistance, high maximum adsorption capacities (qm) of 296.12 and 62.88 mg/g for Cs+and Sr2+ions, respectively, and high selectivity even in the presence of excess Na+ions or using lake water. Impressively, qmCsof FJSM-SnS/PAN reaches 89.29 mg/g under even acidic conditions (pH = 2.5). The column loaded with FJSM-SnS/PAN granules exhibits high removal rates (R) toward low-concentration Cs+and Sr2+ions under both neutral and acidic conditions. Moreover, the composite can be recycled and reused with high RCsand RSr. This work highlights the great potential of metal sulfide ion-exchangers in engineered form for the efficient removal of Cs+or Sr2+ions, especially under acidic conditions, for radionuclide remediation.