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The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metabolite that can be oxidized in the mitochondria and could potentially stimulate T cells. Here we show that the lactate-lowering mood stabilizer lithium carbonate (LC) can inhibit LA-mediated CD8+T cell immunosuppression. Cytoplasmic LA increased the pumping of protons into lysosomes. LC interfered with vacuolar ATPase to block lysosomal acidification and rescue lysosomal diacylglycerol–PKCθ signaling to facilitate monocarboxylate transporter 1 localization to mitochondrial membranes, thus transporting LA into the mitochondria as an energy source for CD8+T cells. These findings indicate that targeting LA metabolism using LC could support cancer immunotherapy.

Cold storage is a widely employed technique for prolonging the post-harvest shelf life of ‘Nanguo’ pear. Nonetheless, this method has been observed to diminish the fruit’s aromatic properties. Given the significance of aroma in determining the volatile quality, this research endeavors to examine the impact of methyl jasmonate (MeJA) in preserving aroma content, while also delving into the underlying molecular mechanisms that contribute to its efficacy. Upon observing the metabolic changes, it was found that the pear, sprayed MeJA, could keep higher the content of aroma, ascorbic acid, polyphenol, oleic acid, linoleic acid, and linolenic acid than the control, but stearic acid and H2O2were decreased. The enzyme activities of lipoxygenase (LOX), alcohol acyl transferase (AAT), and catalase (CAT) were enhanced by MeJA treatment, but the polyphenol oxidase (PPO) was inhibited. Moreover, the gene expression levels of LOX, AAT, CAT, stearoyl-ACP desaturase (SAD), and fatty acid desaturase 2 (FAD2)were promoted by MeJA. It is reasonable that sprayed MeJA was a reliable method for inhibiting aroma loss and triggered unsaturated fatty acid and reactive oxygen metabolisms.

ABSTRACT To better recycle the waste oil, it has been introduced into asphalt binder as a type of modifier. In this study, the effects of petroleum-based, re-refined, and bio-based oil [...]

ABSTRACT Rubber modified asphalt (RA) has been generally used to improve the high temperature performance of asphalt mixtures in the past decades. This study is to investigate the high temperature [...]

ABSTRACT This study was carried out to investigate the effect of the warm compaction modifier on the physical and rheological properties of High-viscosity High-elasticity modified asphalt and SBS modified asphalt. [...]

ABSTRACT Asphalt pavements around the world are generally subjected to water from different sources which may eventually make them susceptible to moisture damage. However, most of tests used to investigate [...]

ABSTRACT Oils can be used as modifiers to improve low temperature performance of asphalt. However, the relationship between phase transition of oil modified asphalt and their low temperature properties still [...]

ABSTRACT Thermally induced cracking of asphalt pavement continues to be a serious issue in cold climate regions. As a modifier, oil can be used to improve the low temperature performance [...]

ABSTRACT It is hardly to address the mechanical behavior with the classic measurement techniques accurately, which is very important for asphalt mixture and pavement deign. To obtain more experimental information [...]

ABSTRACT To protect the environment and reduce the consumption of energy, warm asphalt has been used widely in recent years. In this paper, Brookfield rotational viscometer test and dynamic mechanical [...]

ABSTRACT The laboratory experiment results of diatomite modified asphalt mixtures are inconsistent with the observed results of the trial road. To find the reason of this, Scanning Electron Microscope (SEM), [...]

Light heterogeneity leads to anatomically and physiologically heterogeneous features in leaves. However, little attention has been paid to the effects of nonuniform illumination on the anatomical and photosynthetic performance on both sides along the leaf main vein. This study explored such effects by combining in situdetermination in the field with shading simulation in the phytotron, on pima cotton that has cupping leaves. Photosynthetic characteristics and morphological structures were measured in the field on both sides along the main vein of eastward, westward, southward, and northward leaves. The results showed that the difference in photosynthetic capacity between the two sides along the main vein in different directions was closely related to the daily photo irridiance (DPI). This result indicates that the photosynthetic heterogeneity between the two sides is related to their intercepted light energy. The conclusion was further verified by the shading simulation experiments. Photosynthetic capacity and leaf thickness of the unshaded sides of leaves in the half-shaded treatment decreased, compared to those in the unshaded treatment. Therefore, it is conjectured that the development of photosynthetic characteristics on one side is systematically regulated by that on the other side. The study provides theoretical guidance on accessing the feasibility of sampling and directional planting.

Objective: To investigate HIV/sexually transmitted infections (STIs) among female sex workers (FSWs) and clients in a mining region of China. Goal: To estimate HIV/STI prevalence and to identify HIV risk factors among FSWs and miner clients. Study Design: A cross-sectional study of 96 FSWs and 339 miner clients. Results: In FSWs, prevalence of HIV was 8.3%, herpes simplex virus-2 70.8%, syphilis 12.5%, Neisseria gonorrhoeae 36.8%, Chlamydia trachomatis 46.3%, Trichomonas vaginalis 22.1%, and 90.6% were infected with any STI. Illegal drug use was associated with HIV [adjusted odds ratio (OR) = 45.1, 95% confidence interval, 6.4-317.9] in FSWs, and 45.8% reported no condom use with the last client. In miner clients, HIV prevalence was 1.8%, herpes simplex virus-2 14.9%, syphilis 2.4%, N. gonorrhoeae 2.1%, C. trachomatis 6.5%, and 23.2% were infected with any STI. Never using condoms with FSWs and regular partners were reported in 61.2% and 84.1%, respectively. Independent risk factors for HIV in miner clients were illegal drug use (OR 190.2), symptoms of urethral discharge or frequent urination (OR 32.9), early sexual debut (OR 7.1), and visiting 4 or more FSWs in the last 12 months (OR 11.5). Conclusions: HIV/STI prevalence is high among FSWs and moderate among clients in mining regions of Gejiu City. Drug use is the most important factor placing FSWs and miner clients at risk for HIV in Gejiu City: risky sexual characteristics such as early sexual debut, frequent visits to FSWs, and STI symptoms are also important factors for miner clients. FSWs and miner clients may constitute bridging groups for HIV to low-risk populations.

Primary porcine tracheal epithelial cells (PTECs) are an appropriate model for studying the molecular mechanism of various porcine respiratory diseases, including swine-origin mycoplasmas, which are isolated from respiratory tract of pigs and mainly found on the mucosal surface surrounding swine trachea. However, the short proliferation ability of primary PTECs greatly limits their lifespan. In this study, primary PTECs were carefully isolated and cultured, and immortal PTECs were constructed by transfecting primary PTECs with the recombinant constructed plasmid pEGFP-hTERT containing human telomerase reverse transcriptase (hTERT). Immortal PTECs (hTERT-PTECs) maintained both the morphological and functional characteristics of primary PTECs, as indicated by the expression of cytokeratin 18, cell-cycle analysis, proliferation assay, Western blotting, telomerase activity assay, karyotype analysis and quantitative RT-PCR. Compared to primary PTECs, hTERT-PTECs had an extended replicative lifespan, higher telomerase activity, and enhanced proliferative activity. In addition, this cell line resulted in a lack of transformed and grown tumors in nude mice, suggesting that it could be safely applied in further studies. Moreover, hTERT-PTECs were vulnerable to all swine-origin mycoplasmas through quantitative analysis as indicated by 50% color changing unit (CCU50) calculation, and no significant differences of adhesion ability between primary and immortal PTECs were observed. For the representative swine mycoplasma Mycoplasma hyopneumoniae(Mhp), except for DNA copies quantitative real-time PCR assay, indirect immunofluorescence assay and Western blotting analysis also depicted that hTERT-PTECs was able to adhere to different Mhp strains of different virulence. In summary, like primary PTECs, hTERT-PTECs could be widely used as an adhesion cell model for swine-origin mycoplasmas and in infection studies of various porcine respiratory pathogens.

Before a wide range of enhanced oil recovery (EOR) techniques were implemented for an oilfield, the EOR potential and economic evaluation of the techniques should be evaluated in advance for each reservoir to determine which EOR technique was proper. In an oilfield developed with fluvial delta reservoirs, the complicated distribution of scattered small reservoirs in vertical and horizontal directions brought trouble for evaluation work. A rapid and reliable evaluation model for EOR techniques applicability was necessary to deal with the evaluation simulation for many small reservoirs of an oilfield. Combining fraction theory model with auxiliary equations, which describe the effect of formation heterogeneity and mechanism of different EOR technique on fractional flow rate, an evaluation analysis method for EOR techniques applicability of gas flooding, foam flooding and surfactant flooding was proposed. In the gas flooding model, the minimum miscible pressure of impure gas was introduced, and the relative permeability was modified by the minimum miscible factor. In the foam flooding model, changes in the mobility ratio and chemical adsorption were considered and a reduction factor of mobility ratio was introduced. In the surfactant flooding model, calculation formulas of viscosity and interfacial tension as well as the relative permeability were introduced. Finally, the model was simulated for a low permeability reservoir, and the simulation results were compared with that from Eclipse software. The similar results, little calculation time and feasibility of predicting optimal injection parameter had shown the reliability of the rapid evaluation model.

The relationship between impact cavitation characteristics and cavitation damage of a pure water hydraulic control check valve under high pressure and high flow was investigated to prevent cavitation damage. The surface shape, phase, chemical state, and polarization curve of the hydraulic control check valve after pure water impact at high pressure and high flow were analyzed. The results indicate that the greater the impact pressure, the more pronounced the pressure drop at the throttle and the greater and more intense the cavitation range at the flow passage's rear end. Less impact pressure results in a quicker unloading process, and impact pressure has a significant effect on unloading time. With the improvement of impact characteristics, both the cavitation index and cavitation damage intensify. Cavitation collapse can rapidly transfer high temperatures to the surface of stainless steel, resulting in a martensitic structure through the rapid cooling of a pure water medium. After cavitation collapse, the passivation film of the stainless steel surface appears with early cracks and pores, which are more fragile than the surrounding area, resulting in a higher current density in the contained area, resulting in more H+in ionization, thus an acidic corrosive solution, and accelerating the destruction of the passivation film.

Terahertz (THz) computed tomography (THz CT) exhibits the potential to provide a wealth of data, surpassing that of THz tomographic imaging in applications such as detecting embedded defects, particularly defect evolution within a glass fiber-reinforced polymer. To realize high-resolution THz CT, a systematic approach guided by wave propagation simulation was employed. First, the front wave of the THz beam was fine-tuned to realize a beam diameter of <2 mm. To mitigate the strong refractive effect and minimize Fresnel reflection loss, a refractive-index-matching material was fabricated and utilized as a rounded enclosure for samples with sharp corners. To further improve the reconstruction resolution, a flat surface enclosure was applied to collect all incident beams at the detector. To realize comparable results to those of full-angle CT, a limited-angle CT approach was implemented, and the frequency range 0.1–3 THz was used in the image reconstruction study. The experimental and simulated images were used to validate the findings, and conductive and non-conductive defects measuring 200 µm were successfully visualized. Additionally, a custom-built user interface enabled us to visualize the field spatial distribution of the THz beam with respect to frequency.

The flourishing subgrade widening and reconstruction is one of the important challenges facing the highway industry at present. In this paper, focusing on the research progress of highway subgrade widening and reconstruction, the existing classification methods of subgrade widening and reconstruction projects are comprehensively summarized to propose a new classification corresponding to the comprehensive design of subgrade and pavement. The design indexes and standards under different types of subgrade widening are systematically reviewed, and the corresponding main control measures are classified. Then the next research focus of the subgrade widening and reconstruction is proposed from the improvement of the design index system, the composition and calculation analysis of differential settlement, and the active adaptation of the pavement structure. This study is of great reference significance in guiding the scientific decision-making on design indexes, standards, and treatment measures for different types of subgrade widening and reconstruction.

Identifying the causes of congestion is the key to solving traffic congestion. To improve the efficiency of congestion control, this paper establishes a congestion cause identification method based on the three stages of pattern recognition, source tracing, and cause discrimination. The K-means algorithm was proposed to calculate the frequency threshold of recurrent congestion, trace the sources of congestion according to the rules of congestion propagation time sequences, build a congestion fault tree based on causal logic relationships, and determine the occurrence probability and importance of each cause by using the expert scoring method and cloud model. The test results showed that the method is promising and could provide support for scientific congestion control.

In order to overcome the problems of low accuracy and high time cost of traditional methods of power grid intrusion feature extraction, a method of power grid intrusion feature extraction based on fuzzy c-means clustering is proposed, and a power statistical sequence model is established. The structure of intrusion statistical feature sequence is reconstructed by using fuzzy association rule scheduling method. Extract the spectrum density feature of power grid intrusion sequence, realise the optimal clustering processing of Power Grid Intrusion Feature by fuzzy c-means clustering method, and realise the automatic clustering processing of Power Grid Intrusion Feature by global optimisation method. The experimental results show that this method can achieve the automatic clustering of intrusion feature extraction and improve the anti attack ability of power grid.

After haunting all the software engineers for more than 26 years since it was discovered and classified in 2002, SQL injection still poses a most serious threat to developers, maintainers and users of web applications even into the brand new cloud era. SaaS, PaaS and IaaS virtualisation technologies which are widely used by cloud computing seemed to fail the enhancement of security against such an attack. We strive to study the mechanism and principles of SQL injection attack in order to help the information security personnel to understand and manage such risks.

This paper used an equal volume impregnation method to produce egg yolk-egg white bimetallic-supported catalyst. Phase structure and crystal morphologies were characterized by X-ray diffraction, scanning electron microscopy, temperature programmed reduction (TPR), and inductive coupling plasma methods, and the paper discussed the effect of different metal loading, calcination temperature, and calcination time on the desulfurization activity. The experimental results showed that desulfurization performance increased first and then gradually decreased as metal loading, calcination temperature, and calcination time increased. The optimum preparation conditions of bimetallic catalyst were 8% NiO and 5% MnO2, the most suitable calcination temperature was 400°C, and the most suitable calcination time was 4 h. Finally, the eggshell, the egg white, and the egg yolk catalysts had its own different characteristics in the desulfurization processing: the eggshell catalyst showed a rapid reaction rate but lasted for a short time, the egg yolk catalyst showed a slow reaction rate but lasted for a long time, and the reaction rate and lasting time of the egg white were between the eggshell and the egg yolk.

Three-dimensional (3D) human pose recognition techniques based on spatial data have gained attention. However, existing models and algorithms fail to achieve desired precision. We propose a 3D human motion pose recognition method using deep contrastive learning and an improved Transformer. The improved Transformer removes noise between human motion RGB and depth images, addressing orientation correlation in 3D models. Two-dimensional (2D) pose features are extracted from de-noised RGB images using a kernel generation module in a graph convolutional network (GCN). Depth features are extracted from de-noised depth images. The 2D pose features and depth features are fused using a regression module in the GCN to obtain 3D pose recognition results. The results demonstrate that the proposed method captures RGB and depth images, achieving high recognition accuracy and fast speed. The proposed method demonstrates good accuracy in 3D human motion pose recognition.

The past decade has seen remarkable progress made in the field of environmental information disclosure in China. While the overall institutional changes and the motivation/willingness of the government to open up information are important conditions, China’s encounter with revolutionary Information and Communication Technological (ICT) advancement and rapidly emerging big data quickly changed China from an “information poor environment” to an “information complex environment.” While most previous studies centered on those drives/constraints that were recognized in established informational governance framework, recent advancement in ICTs and emerging big data posed new challenges, opportunities and research questions. When increasing information disclosure became a new game changer in environmental governance, China has had to cope with risks and pitfalls in a new technology-empowered information environment as well. This article updated previous studies on legislation/regulations/policies regarding environmental information disclosure in China and their implementation effectiveness, and paid special attention to China’s recent informatization progress and emerging big data. Information disclosure was treated as a process that includes data/information generation/collection, disclosure, functional pathways of communication, and direct/indirect impacts. Changes in environmental information disclosure should be understood in a broader context of overall changing environmental governance and informatization in China. It is important to understand ICTs and information disclosure as a double-edged sword. Normative, substantive, and instrumental benefits of disclosure as well as collection and reporting costs, the issue of targeted transparency, and the risk of unintended use should be strategically considered. Principles and guidelines need to be developed to avoid pitfalls while maximizing benefits.

Autonomous underwater vehicle (AUV) plays an important role in ocean research. Compared with single AUV system, multi-AUV system has higher stability, robustness and high efficiency. Multiple AUVs give greater credibility than a single AUV in decision making. In this paper, the problem of multiple AUV making dangerous decisions in dangerous environments is studied. Single AUV can not make an accurate decision when facing some complex situations. We propose to fuse multiple AUV data to obtain more accurate dangerous decisions. The multi-AUV system adopts a distributed multi-robot structure, each AUV is an individual. A transferable information model and Dempster-Shafer evidence theory are used. A new multi-AUV hazard discrimination model is proposed for the final hazard decisionmaking. Verification by calculation, new decision-making method can effectively improve the discriminant ability of multi-AUV system when facing danger. This new hazard decision method improves the survivability of multiple AUVs in actual ocean exploration.

Objective To analyze factors related to antibiotic-associated diarrhea (AAD) in patients in the intensive care unit (ICU) receiving antifungals with the aim of informing rational antibiotic use.Methods Sex, age, medical history, use of proton pump inhibitors, administration of parenteral nutrition, albumin level, occurrence of AAD, type of antibiotics, duration of ICU admission, and prognosis were retrospectively analyzed. The associations of age, sex, medical history, and other factors with AAD were associated by logistic regression.Results In total, 284 patients were enrolled (antifungals, n = 110; no antifungals, n = 174). The total incidence of AAD was 32.39%. The incidence of AAD was significantly different between the groups (52.73% vs. 19.54%). The duration of proton pump inhibitor therapy, duration of antifungal therapy, enzyme inhibitor antibiotic use, and azithromycin use were associated with AAD in ICU patients receiving antifungal therapy. The mean duration of ICU admission was higher in patients receiving antifungal therapy (20.14 ± 11.50 vs. 14.48 ± 8.54 days). There was no significant difference in ICU mortality rates.Conclusion The duration of proton pump inhibitor therapy, duration of antifungal therapy, use of enzyme inhibitor antibiotics, and use of azithromycins were associated with AAD in ICU patients receiving antifungal therapy.

The geometrical morphologies fabricated by continuous and interlacing printing modes on untreated multi-crystalline solar cells are quantitively explored for uniform and high aspect-ratio finger electrodes. The voltage waveform of printhead is well modulated by in-house developed inkjet prototype printer for optimizing the droplet volume and velocity. As the fingers are fabricated with continuous printing mode by varying printing parameters, the bulging and coffee ring morphologies could not be eliminated resulting from the rough and anisotropic features. The interlacing printing mode is first introduced for finger electrodes fabrication. Results show that the width of the printed finger is not influenced by the printing layers and maintains the stable values of ∼60 μm with pre-heating temperature 80 °C. Moreover, the interlacing printing mode has a high tolerance of droplet spacing variance (30–45 μm) and suppresses the coffee ring morphology which obtains uniform finger electrodes. The study not only offers good guidance of finger electrodes fabrication for multi-crystalline solar cell manufacturing, but also proposes in-depth insights for the three-dimensional circuit structures fabrication of the emerging printed electronics.

This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as having NSCLC were enrolled in this study. The expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative real-time polymerase chain reaction (RT-qPCR) method. We found that the expression of miR-200c was significantly reduced in NSCLC tissues and cell lines compared with normal lung tissues and the human bronchial epithelial cell line. Overexpression of miR-200c using the miR-200c mimic significantly suppressed cell proliferation and migration of NSCLC cell lines. The results of the luciferase reporter assay identified lactate dehydrogenase A (LDHA) as a direct target of miR-200c. The expression of LDHA was shown to be suppressed in NSCLC cell lines with miR-200c mimic transfection. Furthermore, the transfection of small interfering RNA (siRNA) targeting LDHA suppressed the proliferation and migration of NSCLC cell lines. In summary, our results presented in this study suggested that miR-200c was able to inhibit the proliferation and migration of NSCLC cells by downregulating LDHA. Therefore, miR-200c may be considered as a potential candidate for the treatment of NSCLC.

To better understand oil modifiers’ effects on the performance of asphalt binders at low and intermediate temperatures and the mechanisms of the modification, laboratory tests including mechanical property tests and microscopy tests are performed. It is found that oil modifiers can improve the performance of asphalt binders at low and intermediate temperatures significantly. By comparing the absorption peaks of oil modifiers, neat binder and oil-modified asphalt, it is found that the oil modification of asphalt is mainly by physical modification. In addition, a new partition method using gel permeation chromatography spectrum is recommended to investigate the modification mechanism of oil-modified asphalts. With this new method, it is found that the large molecular size (LMS) content correlates well with low-temperature performance; parameter B calculated from fatigue equation correlates well with the content of medium molecular size (MMS), and fatigue life also has a relatively good relationship with LMS. Overall, it is shown that oil modifiers improve the performance of binders at low and intermediate temperatures by decreasing the LMS and MMS of contents.

To investigate the effects of Qingshen granules (QSG) on janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in a rat model of unilateral ureteral obstruction (UUO).

A steep seam similar simulation system was developed based on the geological conditions of a steep coal seam in the Xintie Coal Mine. Basing on similar simulation, together with theoretical analysis and field measurement, an in-depth study was conducted to characterize the fracture and stability of the roof of steep working face and calculate the width of the region backfilled with gangue in the goaf. The results showed that, as mining progressed, the immediate roof of the steep face fell upon the goaf and backfilled its lower part due to gravity. As a result, the roof in the lower part had higher stability than the roof in the upper part of the working face. The deformation and fracture of main roof mainly occurred in the upper part of the working face; the fractured main roof then formed a “voussoir beam” structure in the strata’s dip direction, which was subjected to the slip- and deformation-induced instability. The stability analysis indicated that, when the dip angle increased, the rock masses had greater capacity to withstand slip-induced instability but smaller capacity to withstand deformation-induced instability. Finally, the field measurement of the forces exerted on the hydraulic supports proved the characteristics of the roof’s behaviors during the mining of a steep seam.

Six new taccalonolides, taccalonolides AT-AY (1-6), and two new withanolides, chantriolides D and E (7 and 8), together with ten known compounds (9-18), have been isolated from whole plants of Tacca chantrieri. The structures, including the absolute configurations of some of the compounds, were determined by spectroscopic and chemical methods. All compounds were evaluated for their in vitro cytotoxicity against five tumor cell lines. Compounds 9, 10, 13-15, and 17 exhibited cytotoxic activity, with IC50 values of 1.13-5.71 μM, while compound 7 showed selective cytotoxicity. The results indicated that taccalonolides with a six-membered lactone moiety located at C-15 and C-24 were devoid of cytotoxicity against five tumor cell lines (> 10 μM). [ABSTRACT FROM AUTHOR]

Two new triterpenes and five new triterpene saponins, named ilexpusons A-G(1-7), as well as eight known compounds were isolated from Ilex pubescens. The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, 1H-NMR, 13C-NMR, ¹H-¹H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds 1-15 against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds, 1, 2, 5, 6, 8, 13, 14,and 15 exhibited significant inhibition of platelet aggregation in vitro. [ABSTRACT FROM AUTHOR]

In this paper, the reliability of thermoplastic ACF in the process of OGS touch panel manufacturing was studied. The fourier transform infrared spectroscopy (FTIR), volume removal gel permeation chromatography (GPC) and weighing method research were used to characterize the structure of functional group, molecular weight and the change of absorption rate of ACF colloid materials under different curing condition. The thermal decomposition temperature and glass transition temperature were characterized by thermo gravimetric and differential thermal (TG-DSC) analysis. The effect of high temperature and high humidity on the bond strength of ACF was studied by the failure test of adhesion mode. The results showed that, under high temperature and high humidity environment, because of the erosion of water molecules, the plasticity of ACF materials became stronger, the glass transition temperature (Tg) decreased and the thermal stability became worse. As a result, the bond strength of the material was greatly influenced by the humidity. In addition, the comparison of different aging time pull out force test after the thermoplastic ACF sample scanning electron microscope (SEM) images could be indicated that the peeling effect of ACF with damp heat aging time was more and more obvious.

In this paper, two ESD phenomenon of OGS touch panel were analyzed, that are electrostatic breakdown of black matrix and bridge. Firstly analyzed the principle of electrostatic breakdown of black matrix and metal bridge. Then, Using two-level factorial designs methods, take the ESD ability of glass surface and sensor surface as response variables, these influence parameters were optimized with factors of cost, transmittance, electrical uniformity etc. and obtained the optimal parameter combination is SiO2 thickness 400 Å,ITO space 100pm, bridge width 10µm, OC2 thickness 2.0µm. Experiment results show that, using the optimized parameters, the ESD ability of glass surface by the original 7 kV up 10 23 kV and sensor surface by the original 2 kV up to 7 kV, as well as, the electrical properties and optical property are all spec in.

To study the effect of early comprehensive therapy of Traditional Chinese Medicine (TCM) on motor function of in patients with spinal cord injury.