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Quasi-1-dimensional (q1D) materials have attracted significant interest for experimentally realizing fundamental physical models. A plethora of q1D systems have been discovered in previous decades, although many have not been extensively examined with modern computational or experimental techniques. Herein, we reexamine the Au2MP2q1D system (formerly, M = Hg, Tl, and Pb) and extend the range of M substituents to Pb0.53Bi0.43and Bi. Remarkably, this q1D system resists changing its highly anisotropic structure type over a range of three valence electrons per formula unit. However, at the highest valence electron count, we find that Au2BiP2exhibits polymorphism: in addition to the previously reported orthorhombic phase, a slight distortion generates a closely related monoclinic structure type, which is found more frequently. Analysis of local packing tensions in the orthorhombic phase reveals strains within the [Au2P2] framework hold open channel spaces for the chains of M atoms, which are relatively free to move as a group within the channels. Consistent with this picture, the calculated phonon dispersions show that the monoclinic distortion in Au2BiP2resolves imaginary phonon frequencies seen in the orthorhombic structure type. Using density functional theory computations, we determine that this structural change is driven through rectifying both electronic and atomic packing frustrations. Furthermore, electronic transport measurements substantiate calculations of the band structures and density of states of these materials, which suggest that the compositions within this series can be tuned to band structure and property design.

Over the past few decades, inadvertent consequences have stemmed from the intensified use of neonicotinoids in agroecosystems. Neonicotinoid applications can result in both positive (e.g., reduced persistent virus transmission) and negative (e.g., increased host susceptibility) repercussions exhibiting ambiguity for their use in crop production. In soybean, aspects of neonicotinoid usage such as the impact on nonpersistent virus transmission and efficacy against nontarget herbivores have not been addressed. This study evaluated the interaction between the neonicotinoid thiamethoxam and soybean variety and the impact on different pest feeding guilds. Feeding and behavioral bioassays were conducted in the laboratory to assess the effect of thiamethoxam on the mortality and weight gain of the defoliator, Chrysodeixis includens(Walker). Bioassays evaluated impacts dependent and independent of soybean tissue, in addition to both localized and systemic efficacy within the soybean plant. Additionally, using the electrical penetration graph technique (EPG), the probing behavior of 2 piercing-sucking pests, Aphis gossypiiGlover and Myzus persicae(Sulzer), was observed. Results from defoliator bioassays revealed thiamethoxam had insecticidal activity against C. includens. Distinctions in thiamethoxam-related mortality between bioassays dependent and independent of soybean tissue (~98% versus ~30% mortality) indicate a contribution of the plant towards defoliator-related toxicity. Observations of defoliator feeding behavior showed a preference for untreated soybean tissue relative to thiamethoxam-treated tissue, suggesting a deterrent effect of thiamethoxam. EPG monitoring of probing behavior exhibited a minimal effect of thiamethoxam on piercing-sucking herbivores. Findings from this study suggest neonicotinoids like thiamethoxam may provide some benefit via insecticidal activity against nontarget defoliators.

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This article discusses the problems caused by the inconsistent explanations generated from different model-agnostic techniques for software analytics. We propose a method to integrate inconsistent explanations to derive information that can provide more useful and reliable software analytics to practitioners.

Dynamic random-access memory (DRAM) is a key driver of performance and cost in public cloud servers. At the same time, a significant amount of DRAM is underutilized due to fragmented use across servers. Emerging interconnects such as Compute Express Link (CXL) offers a path toward improving utilization through memory pooling. However, the design space of CXL-based memory systems is large, with key questions around the size, reach, and topology of the memory pool. At the same time, using pools require navigating complex design constraints around performance, virtualization, and management. This article discusses why cloud providers should deploy CXL memory pools, key design constraints, and observations in designing toward practical deployment. We identify configuration examples with significant positive return of investment.

Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment. Results: Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0–80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4–92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6–83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03–1.00, p = 0.050). No other selection effects were observed. Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling.

A vaccine against group B streptococci that is linked to tetanus toxoid appears to be more effective than other vaccines in preventing serious infection in newborn babies. In a study of pregnant rabbits, the vaccine did not completely prevent the bacteria from being passed from mother to baby but did reduce the severity of the illness.

Ischemic cardiomyopathy (ICM) is one of the most common causes of congestive heart failure. In patients with ICM, tissue characterization with cardiac magnetic resonance imaging (CMR) allows for evaluation of myocardial abnormalities in acute and chronic settings. Myocardial edema, microvascular obstruction (MVO), intracardiac thrombus, intramyocardial hemorrhage, and late gadolinium enhancement of the myocardium are easily depicted using standard CMR sequences. In the acute setting, tissue characterization is mainly focused on assessment of ventricular thrombus and MVO, which are associated with poor prognosis. Conversely, in chronic ICM, it is important to depict late gadolinium enhancement and myocardial ischemia using stress perfusion sequences. Overall, with CMR’s ability to accurately characterize myocardial tissue in acute and chronic ICM, it represents a valuable diagnostic and prognostic imaging method for treatment planning. In particular, tissue characterization abnormalities in the acute setting can provide information regarding the patients that may develop major adverse cardiac event and show the presence of ventricular thrombus; in the chronic setting, evaluation of viable myocardium can be fundamental for planning myocardial revascularization. In this review, the main findings on tissue characterization are illustrated in acute and chronic settings using qualitative and quantitative tissue characterization.

Supplemental Digital Content is Available in the Text.Multimodal imaging demonstrates an uncommon finding of bacillary layer detachment in eyes with Type 2 macular neovascularization. Intravitreal antivascular endothelial growth factor treatment results in rapid resolution of this optical coherence tomography finding, restoration of outer retinal photoreceptor layers, and visual improvement in most eyes.

We report the case of a 51-year-old male with Crohn’s disease (CD) who developed a reproducible pustular rash after ustekinumab (UST) administration. The patient first presented with a pustular rash on his hands, body, extremities, and scalp starting 5 weeks after his initial weight-based UST induction. The rash resolved spontaneously, then recurred 4 weeks after his first subcutaneous maintenance dose of UST 90 mg. Biopsy of the affected area demonstrated subcorneal pustular dermatosis (SPD). UST was discontinued and the rash resolved. Unfortunately, the patient experienced clinical recurrence of CD, and given prior failure of multiple CD medications, UST was restarted with premedication. Two weeks after UST re-induction, the rash recurred, though less severe. Given improvement in CD symptoms, UST was continued and the rash managed with topical corticosteroids. This is the first case of drug-induced SPD associated with UST. One case report has previously described de novo pustular psoriasis associated with UST in a patient with CD and enteropathic arthritis. Notably, SPD and pustular psoriasis can be histologically indistinguishable. The development of a paradoxical psoriasiform rash is thought to be one of the few dose and duration dependent side effects of TNF-antagonist therapy but has not previously been established as a side effect of UST. This case demonstrates a new potential side effect of UST.

Le roman Trois jours chez ma tante (2017) d’Yves Ravey met en scène un personnage qui s’inscrit bien dans la lignée des narrateurs de l’œuvre de l’auteur : peu fiable et en proie à une manie qui l’amène à trahir les êtres qui lui sont proches. Je me propose d’expliquer le comportement insolite de ce narrateur, un certain Marcello Martini, en recourant à la psychanalyse, en l’occurrence aux théories de Jacques Lacan relatives à la névrose obsessionnelle. On verra que la tendance à la trahison et à l’autodestruction chez Marcello se révèle être une jouissance, effet de la place qu’il occupe dans une structure familiale ou il se trouve aliéné de la mère et assujetti à la loi paternelle. Plus largement, cette étude s’interroge sur la présence du mal dans l’œuvre de Ravey, et qui relèverait moins d’un phénomène arbitraire ou intrinsèque que de la conséquence d’une structure psychologique qui met en question l’existence même du sujet humain.

Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. Challenges in acquiring early brain tissue have incentivized the use of three-dimensional human pluripotent stem cell (hPSC)-derived neural organoids to recapitulate neurodevelopment. To elucidate the molecular programs that drive this highly dynamic process, here, we generate a comprehensive trans-omic map of the phosphoproteome, proteome, and transcriptome of the exit of pluripotency and neural differentiation toward human cerebral organoids (hCOs). These data reveal key phospho-signaling events and their convergence on transcriptional factors to regulate hCO formation. Comparative analysis with developing human and mouse embryos demonstrates the fidelity of our hCOs in modeling embryonic brain development. Finally, we demonstrate that biochemical modulation of AKT signaling can control hCO differentiation. Together, our data provide a comprehensive resource to study molecular controls in human embryonic brain development and provide a guide for the future development of hCO differentiation protocols.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajo.2006.09.032 Byline: Brett L. Shapiro (a), Velimir Petrovic (b), Scott E. Lee (c), Allan Flach (c), Sharon McCaffery (c), Joan M. O'Brien (a)(c) Abstract: To report choroidal detachment following tamsulosin (Flomax, an [alpha].sub.1A-adrenoceptor antagonist) treatment of benign prostatic hyperplasia (BPH). Author Affiliation: (a) University of California San Francisco, School of Medicine, San Francisco, California (b) Kaiser Permanente, Sacramento, California (c) University of California San Francisco, Department of Ophthalmology, San Francisco, California Article History: Accepted 12 September 2006 Article Note: (footnote) This study was supported in part by a Lew R. Wasserman Merit Award from Research to Prevent Blindness, New York, New York. The authors indicate no financial conflict of interest. Involved in design of study (B.L.S., V.P., J.M.O.); Involved in collection, management, analysis and interpretation of data, and preparation of the data (B.L.S., V.P., S.E.L., A.F., S.M., J.M.O.); Involved in collection of data (B.L.S., V.P., S.E.L., S.M., J.M.O.); and involved in management, statistical analysis and interpretation of the data, and preparation of the manuscript (B.L.S., V.P., S.E.L., A.F., S.M., J.M.O.).

Automated bone and muscle imaging biomarkers derived from abdominal CT compared favorably with an established clinical assessment tool for fracture risk for presymptomatic prediction of osteoporotic fractures in a cohort of 9223 adults.

While elemental substitution is the most common way of tuning properties in solid state compounds, this approach can break down in fantastic ways when the stability range of a structure type is exceeded. In this article, we apply the Frustrated and Allowed Structural Transitions (FAST) principle to understand how structural complexity, in this case incommensurate modulations, can emerge at the composition limits of one common intermetallic framework, the BaAl4type. While the Dy-Ga binary intermetallic system contains no phases related to the BaAl4archetype, adding Cu to form a ternary system creates a composition region that is rich in such phases, including some whose structures remain unknown. We begin with an analysis of electronic and atomic packing issues faced by the hypothetical BaAl4-type phase DyGa4and a La3Al11-type variant (in which a fraction of Ga2pairs are substituted by single Ga atoms). Through an inspection of its electronic density of states (DOS) distribution and DFT–Chemical Pressure (CP) scheme, we see that the stability of BaAl4-type DyGa4is limited by an excess of electrons and overly large coordination environments around the Dy atoms, with the latter factor being particularly limiting. The inclusion of Cu into the system is anticipated to soothe both issues through the lowering of the valence electron count and the release of positive CPs between atoms surrounding the Dy atoms. With this picture in mind, we then move to an experimental investigation of the Dy-Cu-Ga system, elucidating the structure of Dy(Cu0.18Ga0.82)3.71(1). In this compound, the BaAl4type is subject to a 2D incommensurate modulation (q1= 0.31a*+ 0.2b*, q2= 0.31a*– 0.2b*), which can be modeled in the (3+2)D superspace group Pmmm(αβ0)000(α–β0)000. The resulting structure solution contains blocks of the La3Al11type, with the corners of these domains serving to shrink the Dy coordination environments. These results highlight how the addition of a well-chosen third element to a binary system with a missing—but plausible—compound (BaAl4-type DyGa4) can bring it to the cusp of stability with intriguing structural consequences.

Body CT scans are frequently done for a wide range of clinical indications, but potentially valuable biometric information typically goes unused. We aimed to compare the prognostic ability of automated CT-based body composition biomarkers derived from previously developed deep-learning and feature-based algorithms with that of clinical parameters (Framingham risk score [FRS] and body-mass index [BMI]) for predicting major cardiovascular events and overall survival in an adult screening cohort.

The article titled "FROM THE AGS PRESIDENT" is from the Arkansas Family Historian journal. It includes various sections such as local news notes, pre-Civil War abstracts, court records, and more. The article also announces the upcoming annual fall conference of the Arkansas Genealogical Society, featuring Cyndi Ingle, the creator of Cyndi's List. The conference will be held on October 19th, 2024, and will be hosted on Zoom, with the possibility of watch parties in different cities. The conference is expected to be free or very low cost, and attendees are encouraged to provide their email addresses for membership renewal notifications. [Extracted from the article]

HxCrS2−δis produced by the proton exchange of NaCrS2and features alternating layers of crystalline and amorphous lamella. It exhibits superior performance as a Na-ion battery electrode compared with its parent compound with faster Na+diffusion, higher capacity, and better cyclability. This work explores the nature of the unique biphasic structure of HxCrS2−δusing both powder and single-crystal X-ray diffraction, as well as electron microscopy. Additionally, ex situcharacterizations using X-ray absorption spectroscopy, X-ray total scattering, and magnetometry are employed to study the mechanism by which this superiority arises. These reveal that migration of Cr does not impede battery performance and may, in fact, be crucial to the observed performance improvements. These studies show that Cr redox is not only possible but abundant in HxCrS2−δwhile accessing it in NaCrS2at lower voltages results in irreversible structural transitions that limit cycling stability. Additionally, we highlight the potential of biphasic structures such as HxCrS2−δto enable high performance in energy storage electrodes.

Cyanide coordination polymers (CCPs) and their products made via thermolysis make up a promising class of materials for a variety of energy and analytical applications. While the chemistry of hexacyanometallate-based CCPs is well developed, that of their octacyanometallate [M(CN)8]4–(M = Mo, W) analogues is underexplored. This work compares the synthesis, morphology, and thermolytic properties of two types of cyanide coordination polymers: the amorphous [PdCl4]2–-based cyanogel, Pd–Mo/W, and the nanocrystalline CoCl2-based Prussian blue analogue, Co–Mo/W. The general decomposition pathways and products for [M(CN)8]4–-containing polymers are comparable to their hexacyanometallate analogues. All four coordination polymers can be converted to mixed oxide and ternary phosphide systems and generally retain morphology upon heating. Notably, the reduction under inert gas generates alloys in the cyanogel systems and complex reduced mixtures in the Prussian blue analogue (PBA) systems.

This article reviews therapeutic drug monitoring (TDM) use for current inflammatory bowel disease (IBD) treatments. IBD comprises Crohn’s disease and ulcerative colitis-chronic gastrointestinal inflammatory disorders. Treatment options for moderate to severe IBD include thiopurines; methotrexate; biologic agents targeting tumor necrosis factor, α4β7integrin or interleukins 12 and 23; and Janus kinase inhibitors. TDM is recommended to guide treatment decisions for some of these agents. Published literature concerning TDM for IBD treatments was reviewed. S.D.L., R.S., and E.V.L. drew on their clinical experiences. Polymorphisms resulting in altered enzymatic activity inactivating thiopurine metabolites can lead to myelotoxicity and hepatotoxicity. Increased elimination of biologic agents can result from immunogenicity or higher disease activity, leading to low drug concentration and consequent nonresponse or loss of response. TDM may aid treatment and dose decisions for individual patients, based on monitoring metabolite levels for thiopurines, or serum drug trough concentration and antidrug antibody levels for biologic agents. Challenges remain around TDM implementation in IBD, including the lack of uniform assay methods and guidance for interpreting results. The Janus kinase inhibitor tofacitinib is not impacted by enzyme polymorphisms or disease activity, and is not expected to stimulate the formation of neutralizing antidrug antibodies. TDM is associated with implementation challenges, despite the recommendation of its use for guiding many IBD treatments. Newer small molecules with less susceptibility to patient variability factors may fulfill the unmet need of treatment options that do not require TDM, although further study is required to confirm this.

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Histamine plays an important role in neuromodulation and the biological immune response. Although many electrochemical methods have been developed for histamine detection, the mechanism of its redox reaction has not been directly investigated. Here, we studied the mechanism of histamine oxidation at carbon electrodes and used that mechanistic information to design better fast-scan cyclic voltammetry (FSCV) methods for histamine. Using amperometry, cyclic voltammetry (CV), and X-ray photoelectron spectroscopy (XPS), we demonstrate that histamine oxidation requires a potential of at least +1.1 V vs Ag/AgCl. We propose that histamine undergoes one-electron oxidation on an imidazole nitrogen that produces a radical. The radical species dimerize and continue to undergo oxidation, leading to electropolymerization, which fouls the electrode. CV shows a peak at 1.3 V that is pH dependent, consistent with a one-proton, one-electron oxidation reaction. This mechanism is confirmed using 1- and 3-methylhistamine, which do not electropolymerize, compared to Nα-methylhistamine, which does. XPS also revealed a nitrogen-containing product adsorbed on the electrode surface after histamine oxidation. For FSCV detection of histamine at carbon-fiber microelectrodes, histamine oxidation was adsorption-controlled, and the anodic peak was observed at +1.2 V on the backward scan because of the rapid scan rate. However, the oxidation fouled the electrode and convoluted the FSCV temporal response; therefore, we implemented Nafion coating to alleviate the electrode fouling and preserve the time response of FSCV. Knowing the mechanism of histamine oxidation will facilitate design of better electrochemical methods for real-time monitoring of histamine.

Our study provides normative values of L1 vertebra trabecular attenuation, which can serve as a quick reference for opportunistic osteoporosis screening at routine CT to identify adults with low bone mineral density who are at risk for osteoporosis, and who could potentially benefit from further evaluation and possible intervention.

Microelectrodes are typically used for neurotransmitter detection, but nanoelectrodes are not because there is a trade-off between spatial resolution and sensitivity that is dependent on surface area. Cavity carbon-nanopipette electrodes (CNPEs), with tip diameters of a few hundred nanometers, have been developed for nanoscale electrochemistry. Here, we characterize the electrochemical performance of CNPEs with fast-scan cyclic voltammetry (FSCV) for the first time. Dopamine detection using cavity CNPEs, with a depth equivalent to a few radii, is compared with that using open-tube CNPEs, an essentially infinite geometry. Open-tube CNPEs have very slow temporal responses that change over time as the liquid rises in the CNPE. However, a cavity CNPE has a fast temporal response to a bolus of dopamine that is not different from that of a traditional carbon-fiber microelectrode. Cavity CNPEs, with tip diameters of 200–400 nm, have high currents because the small cavity traps and increases the local dopamine concentration. The trapping also leads to an FSCV frequency-independent response and the appearance of cyclization peaks that are normally observed only with large concentrations of dopamine. CNPEs have high dopamine selectivity over ascorbic acid (AA) because of the repulsion of AA by the negative electric field at the holding potential and the irreversible redox reaction. In mouse-brain slices, cavity CNPEs detected exogenously applied dopamine, showing they do not clog in tissue. Thus, cavity CNPEs are promising neurochemical sensors that provide spatial resolution on the scale of hundreds of nanometers, which is useful for small model organisms or for locations near specific cells.

Cot based sequence discovery represents a powerful means by which both low-copy and repetitive sequences can be selectively and efficiently divided, cloned, and characterized. Based upon its results, hydroxyapatite chromatography was used to divide sorghum genomic DNA into highly repetitive (HR), moderately repetitive (MR) and single copy (SL) sequence components that were consequently cloned to produce HRCot, MRCot, and SLCot genomic libraries.

A Novel Gene Involved in the Regulation of Energy Balance The hypothalamus plays a major role in the control of energy balance via the coordination of several neuropeptides and their [...]

Mechanics' liens grew out of common law but are now creatures of state statutes throughout the United States. The purpose of these statutes is to protect those who provide labor, [...]

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Herein, the authors present two cases of macular ischemia in sickle cell disease. Compared with spectral domain, swept source optical coherence tomography angiography provides a more expansive view with similar detailed depth resolution of the retinal ischemia to the superficial and deep capillary plexuses in sickle cell maculopathy.

ObjectiveThis phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, in patients with moderate-to-severe Crohn’s disease (CD).DesignEligible adults were aged 18–75 years, with active moderate-to-severe CD (Crohn’s Disease Activity Index (CDAI) 220–450), a history of failure or intolerance to antitumour necrosis factor and/or immunosuppressive agents, high-sensitivity C reactive protein >3.0 mg/L and ulcers on colonoscopy. Patients were randomised to PF-00547659 22.5 mg, 75 mg or 225 mg or placebo. The primary endpoint was CDAI 70-point decrease from baseline (CDAI-70) at week 8 or 12.ResultsIn all, 265 patients were eligible for study entry. Although CDAI-70 response was not significantly different with placebo versus PF-00547659 treatment at weeks 8 or 12, remission rate was greater in patients with higher baseline C reactive protein (>5 mg/L vs >18.8 mg/L, respectively). Soluble MAdCAM decreased significantly from baseline to week 2 in a dose-related manner and remained low during the study in PF-00547659-treated patients. Circulating β7+ CD4+ central memory T-lymphocytes increased at weeks 8 and 12 with PF-00547659 treatment. No safety signal was seen.ConclusionsClinical endpoint differences between PF-00547659 and placebo did not reach statistical significance in patients with moderate-to-severe CD. PF-00547659 was pharmacologically active, as shown by a sustained dose-related decrease in soluble MAdCAM and a dose-related increase in circulating β7+ central memory T cells.Trial registration numberNCT01276509; Results.

'Now which one is clearer: number 571 or number 572?' By Scott Lee, [...]

Abstract We report a case of unilateral tonsillar lymphoepithelioma with extension into the ipsilateral parapharyngeal space, and we review the clinical, histologic, and radiographic findings of the case. The patient [...]

'Hey, buster! My eyes are up here!' by Scott Lee, [...]

Renal transplantation (RTx) is the modality of choice for ESRD due to ANCA associated vasculitis (AAV). The significance of ANCA positivity (ANCA+) at the time of RTx on recurrent disease is controversial. We evaluated clinical outcomes and predictors of vasculitis relapse in sixteen transplanted AAV patients who were ANCA+ at RTx at a single University Medical Center. Allograft function, vasculitis relapse, and predictors of vasculitis relapse were assessed using descriptive statistics and logistic regression analysis. Our cohort had a median age of 64 years, 88 % Caucasians, 63 % males, 50 % PR3+. All patients were in remission at the time of RTx. Twelve received induction therapy and all were on mycophenolate mofetil, prednisone and tacrolimus. The mean (SD) serum creatinine was 1.2 (0.3) mg/dl at 1 year and 1.8 (1.7) mg/dl at last follow up. Six developed vasculitis relapse at post-transplant. All relapses were treated with escalation in immunosuppression. One non-compliant patient suffered graft loss while the remaining patients achieved remission. In adjusted logistic regression analysis, PR3 ANCA+ patients were two times (OR 2.19, p = 0.71) more likely to experience a relapse compared to MPO ANCA+ patients. This study demonstrates that PR3 ANCA+ patients may be more likely to experience relapse post-transplant. Further investigation of the predictors of vasculitis relapse among AAV patients who are ANCA+ at the time of RTx needs to be pursued.

In this study, the authors present a case of panuveitis and bilateral serous retinal detachments (SRDs) secondary to graft-versus-host disease after allogenic bone marrow transplant for acute myeloid leukemia. Multimodal imaging with autofluorescence, spectral domain optical coherence tomography, fluorescein angiography, and swept-source optical coherence tomographic angiography demonstrated inflammation and SRDs that resolved after high-dose corticosteroid immunosuppression.