Search

A recent study conducted by researchers at McGill University in Quebec, Canada, examined the association between elevated amyloid and tau positron emission tomography (PET) signals and the development of Alzheimer's disease symptoms in older adults without cognitive impairment. The study used data from four independent population-based cohorts collected between 2003 and 2021. The results showed that older individuals without cognitive impairment who had elevated amyloid and tau PET signals were at near-term risk of developing symptomatic Alzheimer's disease within 2 to 3 years. The findings confirm the clinical prognostic value of the National Institute on Aging-Alzheimer's Association (NIA-AA) research criteria. [Extracted from the article]

A recent study conducted by researchers at the Douglas Mental Health University Institute in Quebec, Canada, has focused on white matter hyperintensities (WMHs) and their association with cerebrovascular dysfunction and Alzheimer's disease. The researchers used multimodal magnetic resonance imaging (MRI) to assess the severity of WMHs and their impact on various clinical outcomes. The study found that the qT2 signal, a measure of tissue microstructure, was particularly sensitive to WMH-specific tissue deterioration. The findings suggest that combining volumetric and signal measures of WMHs could improve prognosis and treatment outcomes. [Extracted from the article]