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Revisar la categoría de riesgo de los medicamentos durante el embarazo y establecer el grado de concordancia entre los dos sistemas de clasificación más empleados: FDA (Food and Drug Administration) y ACPM (advisory Committee on Prescription Medicines).

Coronary heart disease (CHD) is the leading cause of morbidity and mortality across the entire world, in which reversion of angina or improvement of ECG remains an unrealistic therapeutic option for most patients, suggesting that microvascular dysfunction or impaired oxygen delivery might be critical factors in CHD. This research article, thus presents the rationale basis, clinical and experimental, for the first therapeutic innovation addressing the role of red blood cell (RBC) H/K and O2/CO2 exchanges in CHD. It is followed by a randomized single-blind trial of Amiloride and Optimal Medical Therapy (OMT, n35 cases) vs OMT alone (n35 cases) in patients having angina, ST-T alteration and a defective RBC-K transport. All patients had serial clinical evaluation, Ion Transport Studies, ECGs and non-invasive aortic waveform and cardiovascular hemodynamic recordings. Statistical analysis was performed by SAS. Results: Amiloride rapidly improved RBC-K (93.5 ±4 vs 84.5 ±4 mmol/lc, p < 0.001), angina (80 of cases, 1.5 ±0.3 weeks, CI:1.72 to 1.45), CCS Class (1.3 ±0.5 vs 3.1 ±0.8, p < 0.001) vs patients with OMT alone CCS Class (3.2 ± 0.4 vs 3.3 ± 0.5, p 0.21). Reversion of angina was sustained through the next 6-months (87 vs 26 in OMT, RR 2.1, odds ratio 6.31, Pearson x2 34.6,p < 0.0001 at 95 CI) and 1-year (85 vs 37 OMT). At 6-months of amiloride, ECG became normal (29 vs 0, RR ∞ uncalculated-time, odds ratio ∞, Pearson x2 42.4 at 95 CI, p < 0.0001), improved (55 vs 29; RR2.1, odds ratio 3.16, 95 CI, p < 0.0001) or unchanged (15 vs 67 OMT). At 1-year, seven patients on amiloride (18) exhibited evidence of electrical regeneration of the heart, not observed with placebo. In Conclusion: This therapeutical innovation of amiloride improves RBC H/K and O2/CO2 function, and reverses angina, ST-T alterations while inducing electrical regeneration of the heart, in patients receiving optimal medical treatment for angina. The article has short discussion on the relevant patents to the topic.

• We extend a previous code to solve also the relativistic Schrödinger equation, with a non-exclusive focus on lattice-QCD. • The non-relativistic and the relativistic Schrödinger equation with arbitrary potential is solved in a box. • Solvers: finite-difference time-domain, with Dirichlet boundary conditions; fast fourier transform, with periodic ones. • The different solvers are compared and discretization and finite volume effects are studied. • With lattice-QCD and heavy quarkonia in mind, we focus on small lattices, but large ones were previously tested. In order to solve the time-independent three-dimensional Schrödinger equation, one can transform the time-dependent Schrödinger equation to imaginary time and use a parallelized iterative method to obtain the full three-dimensional eigen-states and eigen-values on very large lattices. In the case of the non-relativistic Schrödinger equation, there exists a publicly available code called quantumfdtd which implements this algorithm. In this paper, we (a) extend the quantumfdtd code to include the case of the relativistic Schrödinger equation and (b) add two optimized Fast Fourier Transform (FFT) based kinetic energy terms for non-relativistic cases. The new kinetic energy terms (two non-relativistic and one relativistic) are computed using the parallelized FFT-algorithm provided by the FFTW 3 library. The resulting quantumfdtd v3 code, which is publicly released with this paper, is backwards compatible with version 2, supporting explicit finite-differences schemes in addition to the new FFT-based schemes. Finally, we (c) extend the original code so that it supports arbitrary external file-based potentials and the option to project out distinct parity eigen-states from the solutions. Herein, we provide details of the quantumfdtd v3 implementation, comparisons and tests of the three new kinetic energy terms, and code documentation. Program Title: quantumfdtd v3 CPC Library link to program files: https://doi.org/10.17632/9p8zyvmdy2.1 Developer's repository link: https://github.com/quantumfdtd/quantumfdtd%5fv3 Licensing provisions: GPLv3 Programming language: C++, Python, Shell Journal reference of previous version: [1–4] Does the new version supersede the previous version?: Yes Reasons for the new version: We extended the previous version of quantumfdtd, which solves the time-independent non-relativistic three-dimensional Schrödinger equation, to the case of the relativistic kinetic energy. Additionally, we have added the capability of using arbitrary three-dimensional potentials from external files. This functionality is required, for instance, in order to interface with lattice QCD code. Summary of revisions: (a) Include the case of the relativistic Schrödinger equation, (b) add two optimized Fast Fourier Transform (FFT) based kinetic energy terms for non-relativistic cases, and (c) support arbitrary external file-based potentials and the option to project out distinct parity eigen-states from the solutions. The new kinetic energy terms (two non-relativistic and one relativistic) are computed using the parallelized FFT-algorithm provided by the FFTW 3 library. Nature of problem: We compute the ground, first, and second excited states of the time-independent three-dimensional Schrödinger equation. As input, we accept a number of hard-coded, analytical, three-dimensional potentials, as well as arbitrary potentials via external files. The outputs of the program are the corresponding eigen-values and eigen-vectors (energies and wave-functions). We can also project out distinct parity eigen-states of the solutions. Solution method: The time-dependent Schrödinger equation is transformed to imaginary time. We use a parallelized iterative method to obtain the full three-dimensional time-independent eigen-states and eigen-values on large lattices. The new kinetic energy terms (two non-relativistic and one relativistic) are computed using the parallelized FFT-algorithm provided by the FFTW 3 library. The old non-relativistic kinetic term is computed using the finite-difference time-domain (FDTD) algorithm. Finally, we provide several Python and Shell scripts for the analysis steps. This includes a Python program for projecting out distinct parity eigen-states from the solutions. Additional comments including restrictions and unusual features: We require the number of MPI processes being a divisor of the number N of spatial grid points. The following external programs/libraries are used and thus required: • MPI library • FFTW_MPI, version 3 • GNU Scientific Library (GSL), linked to CBLAS • For some of the post-processing scripts, Python 3 is required [1] A. Dumitru, Y. Guo, M. Strickland, Phys. Rev. D 79 (2009) 114003, https://doi.org/10.1103/PhysRevD.79.114003 [2] A. Dumitru, Y. Guo, A. Mocsy, M. Strickland, Phys. Rev. D 79 (2009) 054019, https://doi.org/10.1103/PhysRevD.79.054019 [3] M. Strickland, and D. Yager-Elorriaga, J. Compt. Phys. 229 (2010) 6015, https://doi.org/10.1016/j.jcp.2010.04.032 [4] M. Margotta, K. McCarty, C. McGahan, M. Strickland, D. Yager-Elorriaga, Phys. Rev. D 83 (2011) 105019; Erratum: Phys. Rev. D 84 (2011) 069902, https://doi.org/10.1103/PhysRevD.83.105019 [ABSTRACT FROM AUTHOR]