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We examine temperature-dependent picosecond dynamics of two benchmarking proteins lysozyme and cytochrome cusing temperature-dependent terahertz permittivity measurements. We find that a double Arrhenius temperature dependence with activation energies E1∼ 0.1 kJ/mol and E2∼ 10 kJ/mol fits the folded and ligand-free state response. The higher activation energy is consistent with the so-called protein dynamical transition associated with beta relaxations at the solvent–protein interface. The lower activation energy is consistent with correlated structural motions. When the structure is removed by denaturing, the lower-activation-energy process is no longer present. Additionally, the lower-activation-energy process is diminished with ligand binding but not for changes in the internal oxidation state. We suggest that the lower-energy activation process is associated with collective structural motions that are no longer accessible with denaturing or binding.

Presents a case report involving the use of hydroxycarbamide as treatment for thrombocytopenia. Reference to a study conducted by J. Dissemond, D. Hoeft, J. Knab, T. Frankson, K. Kroger and M. Goos, published in the February 2006 issue of the "International Journal of Dermatology"; Association of the treatment with hydroxycarbamide with leg ulcerationl; Comment of the author on the study.

Presents a case report involving the development of skin diseases in using herbal medicine/mucolytics. Reference to a study conducted by J. Sánchez-Pérez, M. B. Diez, A. A. Pérez, Y.D. Jiménez and G. Diez published in the February 2006 issue of "Contact Dermatitis"; Development of allergic contact dermatitis after applying capsicum oleoresine gel; Comments of the author on the study.

Background. Increasing evidence supports the use of cognitive-behavioral therapy (CBT) for patients with chronic pain. Objective. This study determined whether physical therapists incorporate CBT techniques (eg, relaxation, activity pacing) when treating older patients with chronic pain, ascertained their interest in and barriers to using CBT, and identified participant-related factors associated with interest in CBT. Design. This cross-sectional study used a telephone survey. Methods. One hundred fifty-two members of the Geriatrics and Orthopaedics sections of the American Physical Therapy Association completed the survey. Associations between participant-related factors and interest in CBT were assessed in statistical general linear models. Results. Commonly used CBT interventions included activity pacing and pleasurable activity scheduling, frequently used by 81% and 30% of the respondents, respectively. Non-CBT treatments included exercises focusing on joint stability (94%) and mobility (94%), and strengthening and stretching programs (91%). Respondents' overall interest in CBT techniques was 12.70 (SD = 3.4, scale range=5-20). Barriers to use of CBT included lack of knowledge of and skill in the techniques, reimbursement concerns, and time constraints. Practice type and the interaction of percentage of patients with pain and educational degree of the physical therapist were independently associated with provider interest in CBT in a general linear model that also included 6 other variables specified a priori. Limitations. Data are based on self-report without regard to treatment emphasis. Conclusions. Although only a minority of physical therapists reported use of some CBT techniques when treating older patients with chronic pain, their interest in incorporating these techniques into practice is substantial. Concerns with their skill level using the techniques, time constraints, and reimbursement constitute barriers to use of the interventions., Chronic pain is a highly prevalent and often disabling condition among older adults. (1-3) Prior research has demonstrated strong associations between chronic pain and substantial morbidity, including depression and functional [...]

2017 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Oncology - Glioblastomas. According to news reporting [...]