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ABSTRACTDespite a burgeoning interest in studying the effects that traditional leaders have on service delivery and political accountability, scholars have paid little attention to political competition and its role in accountability for the unelected leaders. This article investigates these questions leveraging original surveys collected from 684 village-level traditional leaders (658 for the second round), 680 members of their ruling family, and 669 secretaries of the leaders in Central Malawi. This study first establishes that leadership contestation appeared in 14 percent of the leadership positions, which challenges the conventional belief that such disputes occur who exceptionally rarely for such hereditary positions. The in-depth analyses in this article demonstrate that traditional leaders’ legitimacy stems from the support from their ruling family, and that the family wields significant power in the installation and removal of the leader as selectors. This work further finds that traditional leaders who experienced competitive challenges exhibit a higher propensity to share the resources at their disposal with their ruling family than other leaders who did not encounter the challenges. The findings align with the theoretical expectation that leaders who undergo competitive challenges adopt a heightened sense of the importance of the ruling family and are incentivized to buy their loyalty because securing this support or the lack thereof significantly affects the leaders’ fate and authority. Finally, this article expands on the recent studies concerning competition in traditional leadership by shifting the focus to the ruling family – the kingmakers behind the scenes – and discusses the ramifications of this phenomenon on political accountability.

AbstractThis study examines whether politicians exhibit gender bias in responsiveness to constituents’ requests for public service delivery improvements in Uganda. We leverage an in-person survey experiment conducted with 333 subnational politicians, of which one-third are elected to women’s reserved seats. Politicians hear two constituents request improvements in staff absenteeism in their local school and health clinic and must decide how to allocate a fixed (hypothetical) budget between the two improvements. The voices of the citizens are randomly assigned to be (1) male-school, female-health or (2) female-school, male-health. We find no evidence of gender bias toward men versus women, or toward same-gender constituents. This study expands on the mixed results of prior studies examining gender bias in politician responsiveness (typically over email) by adding a critical new case: a low-income context with women’s reserved seats.

This methods tutorial introduces the Tool for the Automatic Analysis of Syntactic Sophistication and Complexity (TAASSC), a linguistic analysis tool developed by Kyle (2016). In the first part, the tutorial offers an accessible introduction to the key concepts and considerations for using the syntactic complexity and sophistication measures provided by TAASSC. It also overviews the incorporation of new lexico-grammatical features in more recent versions of TAASSC and compares the new versions with earlier versions. The second part of the tutorial guides users through the tool's application by demonstrating a case study of applying TAASSC to a linguistic analysis. It details the process of utilising TAASSC to obtain initial index profiles and conducting mixed-effects modelling using R. The focus is on analysing one aspect of the phrasal complexity development in British school children's writing across academic years, employing mixed-effects models to account for complex data structures and observation interdependence. This tutorial equips researchers with the knowledge to effectively employ TAASSC in linguistic analysis and showcases its utility in exploring syntactic complexity development.

Most nanoparticle-based bioresearch for clinical applications is unable to overcome the clinical barriers of efficacy (e.g., sensitivity and selectivity), safety for human use, and scalability for mass-production processes. Here, we proposed a promising concept of using a biocompatible nanocarrier that delivers natural fluorescent precursors into cancerous cells. The nanocarrier is a biopolymeric nanoparticle that can be easily loaded with fluorescent precursors to form a fluorescent moiety via a biosynthesis pathway. Once delivered into cancerous cells, the nanocarriers are selectively turned on and distinctively fluoresce upon excitation. We, therefore, demonstrated the efficacy of the selective turn-on fluorescence of the nanocarriers in in vitro coculture models and in vivo tumor-bearing models.

The forkhead box O (FOXO) family has been extensively investigated in aging and metabolism, but its role in tissue-repair processes remains largely unknown. Herein, we clarify the molecular aspect of the FOXO family in skin wound healing. We demonstrated that Foxo1 and Foxo3a were both up-regulated during murine skin wound healing. Partial knockout of Foxo1in Foxo1+/−mice throughout the body led to accelerated skin wound healing with enhanced keratinocyte migration, reduced granulation tissue formation, and decreased collagen density, accompanied by an attenuated inflammatory response, but we observed no wound phenotype in Foxo3a−/−mice. Fibroblast growth factor 2, adiponectin, and notch1 genes were significantly increased at wound sites in Foxo1+/−mice, along with markedly altered extracellular signal–regulated kinase 1/2 and AKT phosphorylation. Similarly, transient knockdown of Foxo1 at the wound site by local delivery of antisense oligodeoxynucleotides enhanced skin wound healing. The link between FOXO1 and scarring extends to patients, in particular keloid scars, where we see FOXO1 expression markedly increased in fibroblasts and inflammatory cells within the otherwise normal dermis. This occurs in the immediate vicinity of the keloid by comparison to the center of the mature keloid, indicating that FOXO1 is associated with the overgrowth of this fibrotic response into adjacent normal skin. Overall, our data indicate that molecular targeting of FOXO1 may improve the quality of healing and reduce pathological scarring.