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Charged particles have been extensively utilized in medical physics as well as in numerous radiation investigations, including cosmic radiation, which is formed of nearly 99% alpha and protons. In this study, lithium-borotellurite glasses strengthened through cerium (IV) oxide (TBLC groups) and gadolinium (III) oxide (TBLG group) are examined on mass stopping power, projected range, and KERMA parameters over the kinetic energy range from 0 to 10 MesV. SRIM and PAGEX code are utilized for determining the critical parameters. The TBLG20 sample with the greatest material density as well as Gd reinforcement is reported with the highest KERMA value. TBLG20 sample consistently yields the lowest values for the mass stopping power values obtained for alpha and protons. Moreover, alpha and proton mass stopping power values are reported to be the lowest for the TBLG20 sample. The lowest projected range values are observed for the TBLG20 sample with the greatest amount of Gd addition. This noticeable difference confirms the superiority observed in KERMA and mass stopping power values and is attributed to the maximal Gd contribution. It can be concluded that Gd reinforcement into tellurite glasses may provide a non-decreasing monotonic effect on stopping power properties of high-density tellurite glasses.

Byline: Serdar E. Bulun, Khaled M. Zeitoun, Gokhan Kilic Keywords: Ahr; Arnt; CYP1A1; CYP1A2; CYP1B1; endometrium; endometriosis; dioxin; TCDD Abstract: Objective: Although an association between dioxin exposure and endometriosis has been proposed, the effects of this environmental toxin on human endometriosis are not known. To understand the potential underlying molecular mechanisms we studied the expressions of cytochrome P-450 genes (CYP1A1, CYP1A2, and CYP1B1), which are induced by dioxin, and the expressions of cytosolic receptor for dioxin, aryl hydrocarbon receptor, and its nuclear translocator, aryl hydrocarbon receptor nuclear translocator protein, in endometriotic and eutopic endometrial tissues. Study Design: Levels of transcripts of CYP1A1, CYP1A2, CYP1B1, aryl hydrocarbon receptor, and aryl hydrocarbon receptor nuclear translocator protein were determined by a quantitative reverse transcriptase-polymerase chain reaction and Southern blot assay in total ribonucleic acid samples from endometriotic and eutopic endometrial tissues. Eutopic endometrial tissue samples (n = 33) and endometriotic tissue samples (n = 10) were obtained at the time of uterine curettage and laparoscopy from disease-free women and from patients with endometriosis. Portions of these eutopic endometrial and endometriotic tissues were obtained simultaneously from the same patients (n = 8 pairs of samples). Levels of transcripts of CYP1A1, CYP1A2, CYP1B1, aryl hydrocarbon receptor, and aryl hydrocarbon receptor nuclear translocator protein were determined in endometrial and endometriotic tissues during follicular and luteal phases of the cycle and in cultured endometriotic stromal cells treated with forskolin, phorbol diacetate, medroxyprogesterone acetate,and serum. Results: Transcripts of dioxin receptor, its nuclear translocator, and two dioxin-induced target genes (CYP1A2 and CYP1B1) were demonstrated during follicular and luteal phases of the cycle in both eutopic endometrial tissues and tissues affected by pelvic endometriosis, with no readily detectable differences between these tissues. On the other hand, levels of transcripts of another dioxin-induced gene, CYP1A1, were found to be strikingly higher in endometriotic tissues than in the eutopic endometrium. Mean levels in endometriotic tissues were 8.7 times those found in eutopic endometrium. Various hormonal treatments of endometriotic stromal cells did not significantly alter these levels. Conclusion: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells. Strikingly elevated CYP1A1 transcripts in endometriosis may give rise to significantly increased P-4501A1 enzyme activity and thus promote the development and growth of endometriosis by either activating procarcinogens or inducing the formation of catechol estrogens or both. In fact, the proposed link between dioxin exposure and endometriosis may be explained in part by the up-regulation of the CYP1A1 gene expression in endometriotic tissues. (Am J Obstet Gynecol 2000;182:767-75.) Author Affiliation: Chicago, Illinois, and Dallas, Texas From the Department of Obstetrics and Gynecology, University of Illinois at Chicago,.sup.a and the Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas..sup.b Article Note: (footnote) [star] Supported by an American Society for Reproductive Medicine-Organon unrestricted research grant to Serdar E. Bulun, MD., [star][star] Reprint requests: Serdar E. Bulun, MD, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 S Wood St M/C 808, Chicago, IL 60612.

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In this study, we extensively analyzed the structural, physical and gamma-ray attenuation properties of α-TeO2CMS, which has unexpectedly been observed as a part of Sm2O3doped TeO2–B2O3–V2O5glasses synthesis process. The shape of α-TeO2CMS was obtained from SEM analyses. Moreover, EDX, XRD and Raman examinations were utilized for systematic characterization of α-TeO2CMS. In addition to experimental physical and structural studies on α-TeO2CMSs, gamma-ray attenuation properties were also determined and compared with Quartz and some novel glasses such as PNCKM5, C25, SCNZ7 along with some commercial glasses such as RS253, RS253G18, RS323G19, RS360, RS520 using FLUKA general-purpose Monte Carlo code. EDX results indicated that only Te and O elements were available in the α-TeO2CMS. The finding showed that gamma-ray attenuation competencies of α-TeO2CMS is higher than many novel and commercial glasses in addition to traditional concrete shields. It can be concluded that further comparison studies can be done between normal glass structure and α-TeO2CMS (or similar) occurred glass structures in terms of better understanding the total gamma-ray attenuation and the effect of α-TeO2 CMS.

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Glutograph is a relatively new instrument to determine the stretch (GS) and relaxation (GR) properties of wheat gluten. The aims of this research were to determine heritability values of GS and GR and to investigate the effects of genotype and environment on some quality parameters and yield. The relationship between Glutograph parameters and other traits was also investigated by using correlation and biplot analyses. Wide ranges of variability values were observed among both genotypes and environments for Glutograph parameters and other investigated characteristics. Genotype was found to be the most significant source of variation (~69%), and high heritability values (~0.95) were calculated for Glutograph parameters. Glutograph parameters had strong relationships with gluten index (GI) and Alveograph deformation energy (W) based on correlation and biplot analyses. Biplot analysis performed on 24 genotypes and nineteen traits demonstrated that especially eight genotypes had similar responses for GS, GI, grain protein content, Alveograph elasticity index, W, and Zeleny sedimentation values. Glutograph could be a beneficial quick screening test especially in early stages of breeding programs for improving the baking quality of wheat. The high heritability values indicate that Glutograph has a great potential for evaluation of gluten quality, especially in breeding programs.

The study aimed to contribute to condition assessments of historic bridges in Izmir, Turkey and the estimation of their predictable functional lifetime after the Samos earthquake. This document is a summary of the study into the reliability of Non-Destructive Techniques (NDT) for testing the state of different historic bridges impacted by the October 30, 2020 Earthquake. Besides providing data on material characteristics, NDT can help identify hidden bridge structure defects, such as cavities and moisture. This study also used FTIR (Fourier Transform Infrared Spectroscopy) spectral data analysis in conjunction with NDT as a multidisciplinary evaluation technique and demonstrates the value of this approach in the field. This study is of special relevance to bridge engineers.

Objective.The aim of this case report was to evaluate the impact of immunohistochemical markers in diagnosing the primary site of adenocarcinoma in the abdominopelvic region.

Medico-legal review of a litigation technique often used by attorneys in transvaginal mesh law suits.Vaginal mesh has been a valuable tool in the treatment of stress urinary incontinence and pelvic organ prolapse. As our knowledge of the long-term outcomes and complications of this product has evolved, however, vaginal mesh has become the subject of legal scrutiny. Therefore, it is imperative that physicians understand pertinent litigation techniques to optimize their informed consent and documentation processes and protect themselves.

Hysterectomy is a commonly performed procedure with widely variable costs. As gynecologists divert from invasive to minimally invasive approaches, many factors come into play in determining hysterectomy cost and efforts should be sought to minimize it. Our objective was to identify the predictors of hysterectomy cost.

Ovarian vein embolotherapy is a relatively new treatment for pelvic congestion syndrome that is claimed to be safe and effective. A 36-year-old woman underwent ovarian (without internal iliac) vein embolotherapy for pelvic congestion syndrome. Her pain was improved following the procedure. Within three months of the procedure, she started experiencing distressing abnormal uterine bleeding. Specifically, she developed profuse bleeding after intercourse. After thorough evaluation and counseling, a total abdominal hysterectomy was eventually performed. The use of ovarian vein embolization for treatment of pelvic congestion syndrome may be associated with abnormal uterine bleeding.